Best TWAS P=3.99e-09 · Best GWAS P=2.07e-07 conditioned to 0.000996
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellum | PDPR | 0.23 | 0.06 | enet | 20 | 0.11 | 3.7e-04 | -4.9 | -5.4 | 7.1e-08 | 0.21 | 0.03 | 0.57 | FALSE |
| 2 | GTEx | Brain Cerebellum | RP11-296I10.3 | 0.20 | 0.03 | enet | 12 | 0.14 | 8.8e-05 | -4.9 | -5.7 | 9.3e-09 | 0.28 | 0.02 | 0.46 | FALSE |
| 3 | GTEx | Brain Nucleus accumbens basal ganglia | RP11-296I10.6 | 0.15 | 0.11 | lasso | 3 | 0.08 | 3.0e-03 | -4.9 | -5.4 | 6.5e-08 | 0.38 | 0.01 | 0.86 | FALSE |
| 4 | GTEx | Breast Mammary Tissue | EXOSC6 | 0.38 | 0.34 | enet | 8 | 0.34 | 2.0e-18 | -4.9 | -5.1 | 3.0e-07 | 0.19 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Female) | EXOSC6 | 0.52 | 0.26 | enet | 21 | 0.27 | 1.4e-08 | -4.9 | -5.9 | 4.0e-09 | 0.36 | 0.01 | 0.98 | TRUE |
| 6 | GTEx | Cells Transformed fibroblasts | RP11-296I10.6 | 0.10 | 0.09 | enet | 9 | 0.10 | 6.1e-08 | -4.9 | -5.2 | 1.5e-07 | 0.29 | 0.01 | 0.98 | FALSE |