Best TWAS P=5.71e-08 · Best GWAS P=7.38e-07 conditioned to 0.141
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Esophagus Mucosa | FBXO27 | 0.66 | 0.36 | enet | 33 | 0.55 | 4.1e-43 | 4.1 | 5.4 | 5.7e-08 | 0.73 | 0.16 | 0.70 | TRUE |
2 | GTEx | Esophagus Mucosa | CTB-189B5.3 | 0.61 | 0.34 | enet | 18 | 0.51 | 3.5e-39 | 3.8 | 5.3 | 1.1e-07 | 0.71 | 0.23 | 0.58 | FALSE |
3 | GTEx | Skin Not Sun Exposed Suprapubic | CTB-189B5.3 | 0.47 | 0.48 | enet | 22 | 0.44 | 4.5e-26 | -4.7 | 5.3 | 1.3e-07 | 0.69 | 0.01 | 0.97 | FALSE |
4 | GTEx | Skin Sun Exposed Lower leg | FBXO27 | 0.46 | 0.56 | enet | 26 | 0.58 | 2.3e-58 | -4.7 | 5.2 | 2.2e-07 | 0.71 | 0.01 | 0.97 | FALSE |
5 | GTEx | Skin Sun Exposed Lower leg | CTB-189B5.3 | 0.39 | 0.44 | enet | 26 | 0.51 | 2.1e-48 | -4.7 | 5.4 | 6.5e-08 | 0.75 | 0.01 | 0.97 | FALSE |
6 | GTEx | Vagina | FBXO27 | 0.33 | 0.25 | enet | 24 | 0.21 | 1.2e-05 | 4.7 | 5.4 | 6.8e-08 | 0.66 | 0.03 | 0.90 | FALSE |
7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FBXO27 | 0.26 | 0.25 | lasso | 11 | 0.31 | 3.9e-33 | 4.1 | 5.2 | 2.5e-07 | 0.72 | 0.21 | 0.62 | FALSE |