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chr3:87,495,550-88,911,119

Best TWAS P=3.79e-13 · Best GWAS P=4.2e-13 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
5	GTEx	Cells Transformed fibroblasts	ZNF654	0.08	0.09	enet	6	0.10	3.1e-08	-7.2	-7.3	3.8e-13	0.99	0.00	1.00	TRUE
18	The Cancer Genome Atlas	Thyroid Carcinoma	CGGBP1	0.30	0.07	enet	11	0.09	2.3e-09	-7.1	-5.8	7.5e-09	0.23	0.00	1.00	TRUE
1	CommonMind	Brain Pre-frontal Cortex	C3orf38	0.08	0.00	enet	14	0.04	2.3e-05	-6.2	-7.0	2.1e-12	0.63	0.05	0.91	FALSE
6	GTEx	Esophagus Mucosa	C3orf38	0.11	0.06	lasso	7	0.07	1.5e-05	-6.3	6.9	4.8e-12	-0.91	0.09	0.91	FALSE
7	GTEx	Nerve Tibial	C3orf38	0.09	0.05	lasso	4	0.04	6.3e-04	-6.3	6.4	2.0e-10	-0.80	0.44	0.40	FALSE
3	GTEx	Artery Aorta	C3orf38	0.06	0.06	lasso	7	0.05	6.0e-04	-6.3	6.3	2.1e-10	-0.80	0.39	0.43	FALSE
19	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF654	0.03	0.04	lasso	3	0.03	4.6e-04	-6.2	-6.3	2.4e-10	0.80	0.12	0.66	FALSE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C3orf38	0.02	0.03	lasso	1	0.03	1.9e-04	-6.3	6.2	4.0e-10	-0.79	0.05	0.46	FALSE
16	The Cancer Genome Atlas	Prostate Adenocarcinoma	C3orf38	0.03	0.05	lasso	1	0.05	8.1e-06	-6.3	6.2	4.0e-10	-0.79	0.28	0.64	FALSE
10	GTEx	Testis	C3orf38	0.11	0.01	enet	12	0.00	1.9e-01	-6.2	6.2	4.5e-10	-0.42	0.12	0.21	FALSE
11	GTEx	Thyroid	C3orf38	0.12	0.08	lasso	18	0.07	1.0e-05	-6.2	6.2	4.9e-10	-0.80	0.74	0.24	FALSE
14	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C3orf38	0.02	0.01	blup	24	0.02	2.0e-03	-6.2	6.2	7.5e-10	-0.82	0.06	0.27	FALSE
9	GTEx	Skin Not Sun Exposed Suprapubic	C3orf38	0.09	0.07	lasso	6	0.04	2.8e-03	-6.2	6.2	7.6e-10	-0.78	0.34	0.26	FALSE
13	The Cancer Genome Atlas	Breast Invasive Carcinoma	C3orf38	0.01	0.01	lasso	3	0.01	1.2e-03	-6.2	6.1	1.1e-09	-0.80	0.03	0.39	FALSE
2	GTEx	Adipose Visceral Omentum	C3orf38	0.09	0.00	lasso	5	0.00	5.2e-01	-2.6	5.9	3.1e-09	-0.72	0.04	0.34	FALSE
8	GTEx	Skin Not Sun Exposed Suprapubic	ZNF654	0.09	0.01	lasso	7	0.06	2.7e-04	-6.4	-5.9	3.1e-09	0.74	0.10	0.28	FALSE
12	GTEx	Uterus	ZNF654	0.29	-0.01	lasso	4	0.01	1.7e-01	-6.4	-5.6	2.2e-08	0.71	0.09	0.17	FALSE
17	The Cancer Genome Atlas	Thyroid Carcinoma	C3orf38	0.05	0.05	blup	24	0.05	1.1e-05	-6.4	5.3	1.3e-07	-0.76	0.33	0.52	FALSE
4	GTEx	Artery Tibial	C3orf38	0.11	0.03	lasso	6	0.04	3.7e-04	-6.2	5.1	2.8e-07	-0.70	0.35	0.30	FALSE