Best TWAS P=3.17e-27 · Best GWAS P=4.57e-45 conditioned to 2.33e-26
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | U91328.19 | 0.40 | 0.46 | lasso | 8 | 0.46 | 4.2e-41 | -7.9 | 7.8 | 4.2e-15 | -0.31 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | U91328.19 | 0.21 | 0.25 | lasso | 8 | 0.27 | 3.7e-14 | -7.9 | 8.4 | 6.1e-17 | -0.32 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adrenal Gland | U91328.19 | 0.28 | 0.12 | lasso | 10 | 0.14 | 1.3e-05 | -7.8 | 10.1 | 8.3e-24 | -0.34 | 0.95 | 0.00 | FALSE |
| 4 | GTEx | Artery Aorta | U91328.19 | 0.32 | 0.24 | lasso | 7 | 0.25 | 8.3e-14 | -8.8 | 9.2 | 5.4e-20 | -0.35 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Artery Coronary | U91328.19 | 0.32 | 0.16 | enet | 44 | 0.23 | 3.7e-08 | -7.9 | 5.4 | 6.0e-08 | -0.06 | 0.79 | 0.01 | FALSE |
| 6 | GTEx | Artery Tibial | U91328.19 | 0.26 | 0.32 | lasso | 5 | 0.31 | 1.6e-24 | -7.9 | 8.3 | 1.1e-16 | -0.33 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Brain Caudate basal ganglia | U91328.19 | 0.23 | 0.16 | lasso | 10 | 0.16 | 3.1e-05 | -8.2 | 8.3 | 1.1e-16 | -0.25 | 0.73 | 0.02 | FALSE |
| 8 | GTEx | Brain Cerebellar Hemisphere | U91328.19 | 0.47 | 0.33 | enet | 44 | 0.26 | 2.8e-07 | -7.7 | 9.0 | 2.6e-19 | -0.37 | 0.98 | 0.00 | FALSE |
| 9 | GTEx | Brain Cerebellum | U91328.19 | 0.13 | 0.15 | lasso | 2 | 0.09 | 1.1e-03 | -7.8 | 7.6 | 3.3e-14 | -0.33 | 0.36 | 0.04 | FALSE |
| 10 | GTEx | Brain Cortex | U91328.19 | 0.36 | 0.14 | lasso | 10 | 0.15 | 7.1e-05 | -7.9 | 8.4 | 3.0e-17 | -0.31 | 0.64 | 0.03 | FALSE |
| 11 | GTEx | Brain Frontal Cortex BA9 | U91328.19 | 0.17 | 0.16 | lasso | 4 | 0.18 | 1.8e-05 | -7.9 | 8.2 | 3.4e-16 | -0.32 | 0.45 | 0.04 | FALSE |
| 12 | GTEx | Breast Mammary Tissue | U91328.19 | 0.38 | 0.39 | lasso | 5 | 0.38 | 2.2e-20 | -7.9 | 8.2 | 2.3e-16 | -0.32 | 1.00 | 0.00 | FALSE |
| 13 | GTEx | Breast Mammary Tissue (Male) | U91328.19 | 0.35 | 0.15 | enet | 25 | 0.15 | 2.9e-04 | -7.9 | 7.0 | 2.3e-12 | -0.33 | 0.38 | 0.04 | FALSE |
| 14 | GTEx | Breast Mammary Tissue (Female) | U91328.19 | 0.39 | 0.27 | lasso | 6 | 0.23 | 1.4e-07 | -7.9 | 8.3 | 7.5e-17 | -0.35 | 0.95 | 0.00 | FALSE |
| 15 | GTEx | Cells Transformed fibroblasts | U91328.19 | 0.58 | 0.62 | lasso | 8 | 0.60 | 6.2e-56 | -7.9 | 8.0 | 1.6e-15 | -0.32 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Esophagus Gastroesophageal Junction | U91328.20 | 0.16 | 0.13 | enet | 16 | 0.13 | 2.0e-05 | -5.8 | 8.1 | 5.9e-16 | -0.34 | 0.45 | 0.04 | FALSE |
| 17 | GTEx | Esophagus Gastroesophageal Junction | U91328.19 | 0.28 | 0.07 | lasso | 7 | 0.21 | 4.3e-08 | -7.9 | 7.8 | 5.3e-15 | -0.33 | 0.71 | 0.02 | FALSE |
| 18 | GTEx | Esophagus Mucosa | U91328.19 | 0.45 | 0.42 | lasso | 7 | 0.44 | 6.3e-32 | -7.9 | 8.8 | 1.1e-18 | -0.35 | 1.00 | 0.00 | FALSE |
| 19 | GTEx | Esophagus Muscularis | TRIM38 | 0.06 | 0.04 | lasso | 4 | 0.02 | 1.7e-02 | -8.8 | 8.4 | 3.4e-17 | -0.36 | 0.53 | 0.03 | FALSE |
| 20 | GTEx | Esophagus Muscularis | U91328.19 | 0.36 | 0.30 | lasso | 10 | 0.30 | 1.7e-18 | -8.8 | 8.9 | 6.1e-19 | -0.34 | 1.00 | 0.00 | FALSE |
| 21 | GTEx | Heart Atrial Appendage | U91328.19 | 0.25 | 0.17 | enet | 6 | 0.13 | 2.0e-06 | -7.9 | 8.3 | 8.3e-17 | -0.32 | 1.00 | 0.00 | FALSE |
| 22 | GTEx | Heart Left Ventricle | U91328.19 | 0.20 | 0.18 | lasso | 5 | 0.15 | 2.4e-08 | -7.9 | 7.6 | 2.5e-14 | -0.32 | 0.99 | 0.00 | FALSE |
| 23 | GTEx | Liver | U91328.19 | 0.16 | 0.14 | lasso | 2 | 0.05 | 1.9e-02 | -6.3 | 6.3 | 2.9e-10 | -0.39 | 0.25 | 0.18 | FALSE |
| 24 | GTEx | Lung | U91328.19 | 0.20 | 0.22 | enet | 15 | 0.24 | 2.9e-18 | -8.9 | 9.2 | 5.2e-20 | -0.34 | 1.00 | 0.00 | FALSE |
| 25 | GTEx | Muscle Skeletal | U91328.19 | 0.28 | 0.26 | enet | 15 | 0.32 | 1.3e-31 | -7.9 | 8.1 | 8.6e-16 | -0.29 | 1.00 | 0.00 | FALSE |
| 26 | GTEx | Nerve Tibial | U91328.19 | 0.46 | 0.38 | lasso | 10 | 0.36 | 1.4e-26 | -7.9 | 8.0 | 1.2e-15 | -0.32 | 1.00 | 0.00 | FALSE |
| 27 | GTEx | Ovary | U91328.19 | 0.37 | 0.17 | enet | 18 | 0.34 | 4.7e-09 | -7.9 | 10.8 | 3.2e-27 | -0.41 | 0.75 | 0.03 | TRUE |
| 28 | GTEx | Prostate | U91328.19 | 0.30 | 0.39 | lasso | 2 | 0.37 | 3.0e-10 | -7.9 | 7.9 | 2.3e-15 | -0.32 | 0.96 | 0.01 | FALSE |
| 29 | GTEx | Skin Not Sun Exposed Suprapubic | U91328.19 | 0.39 | 0.37 | lasso | 11 | 0.34 | 2.4e-19 | -7.9 | 8.6 | 8.7e-18 | -0.35 | 1.00 | 0.00 | FALSE |
| 30 | GTEx | Skin Sun Exposed Lower leg | U91328.19 | 0.29 | 0.34 | lasso | 6 | 0.34 | 5.6e-29 | -7.9 | 8.4 | 6.1e-17 | -0.34 | 1.00 | 0.00 | FALSE |
| 31 | GTEx | Stomach | U91328.19 | 0.17 | 0.05 | lasso | 5 | 0.05 | 1.7e-03 | -7.9 | 6.5 | 9.1e-11 | -0.24 | 0.56 | 0.07 | FALSE |
| 32 | GTEx | Thyroid | TRIM38 | 0.14 | 0.16 | lasso | 4 | 0.17 | 8.5e-13 | -6.1 | 6.7 | 2.6e-11 | -0.23 | 1.00 | 0.00 | FALSE |
| 33 | GTEx | Thyroid | U91328.19 | 0.21 | 0.17 | lasso | 5 | 0.17 | 6.4e-13 | -7.9 | 7.5 | 6.5e-14 | -0.31 | 1.00 | 0.00 | FALSE |
| 34 | GTEx | Thyroid | U91328.21 | 0.08 | 0.04 | lasso | 3 | 0.05 | 5.5e-05 | -6.1 | 6.5 | 8.0e-11 | -0.25 | 0.74 | 0.01 | FALSE |
| 35 | GTEx | Uterus | U91328.19 | 0.38 | 0.05 | enet | 21 | 0.04 | 6.2e-02 | -8.9 | 8.5 | 2.0e-17 | -0.24 | 0.17 | 0.16 | FALSE |
| 36 | GTEx | Vagina | U91328.19 | 0.45 | 0.27 | lasso | 4 | 0.26 | 9.4e-07 | -7.9 | 7.8 | 6.5e-15 | -0.33 | 0.63 | 0.04 | FALSE |
| 37 | METSIM | Adipose | U91328.19 | 0.19 | 0.24 | lasso | 23 | 0.25 | 1.7e-36 | -7.9 | 8.7 | 3.7e-18 | -0.31 | 1.00 | 0.00 | FALSE |
| 38 | METSIM | Adipose | U91328.20 | 0.07 | 0.04 | bslmm | 658 | 0.04 | 8.9e-07 | -2.2 | 7.8 | 6.7e-15 | -0.45 | 0.84 | 0.12 | FALSE |
| 39 | YFS | Blood | TRIM38 | 0.37 | 0.31 | bslmm | 672 | 0.34 | 3.8e-115 | -7.8 | -7.1 | 9.3e-13 | 0.18 | 1.00 | 0.00 | FALSE |