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chr6:25,266,147-26,689,223

Best TWAS P=3.17e-27 · Best GWAS P=4.57e-45 conditioned to 2.33e-26

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
27	GTEx	Ovary	U91328.19	0.37	0.17	enet	18	0.34	4.7e-09	-7.9	10.8	3.2e-27	-0.41	0.75	0.03	TRUE
3	GTEx	Adrenal Gland	U91328.19	0.28	0.12	lasso	10	0.14	1.3e-05	-7.8	10.1	8.3e-24	-0.34	0.95	0.00	FALSE
24	GTEx	Lung	U91328.19	0.20	0.22	enet	15	0.24	2.9e-18	-8.9	9.2	5.2e-20	-0.34	1.00	0.00	FALSE
4	GTEx	Artery Aorta	U91328.19	0.32	0.24	lasso	7	0.25	8.3e-14	-8.8	9.2	5.4e-20	-0.35	1.00	0.00	FALSE
8	GTEx	Brain Cerebellar Hemisphere	U91328.19	0.47	0.33	enet	44	0.26	2.8e-07	-7.7	9.0	2.6e-19	-0.37	0.98	0.00	FALSE
20	GTEx	Esophagus Muscularis	U91328.19	0.36	0.30	lasso	10	0.30	1.7e-18	-8.8	8.9	6.1e-19	-0.34	1.00	0.00	FALSE
18	GTEx	Esophagus Mucosa	U91328.19	0.45	0.42	lasso	7	0.44	6.3e-32	-7.9	8.8	1.1e-18	-0.35	1.00	0.00	FALSE
37	METSIM	Adipose	U91328.19	0.19	0.24	lasso	23	0.25	1.7e-36	-7.9	8.7	3.7e-18	-0.31	1.00	0.00	FALSE
29	GTEx	Skin Not Sun Exposed Suprapubic	U91328.19	0.39	0.37	lasso	11	0.34	2.4e-19	-7.9	8.6	8.7e-18	-0.35	1.00	0.00	FALSE
35	GTEx	Uterus	U91328.19	0.38	0.05	enet	21	0.04	6.2e-02	-8.9	8.5	2.0e-17	-0.24	0.17	0.16	FALSE
10	GTEx	Brain Cortex	U91328.19	0.36	0.14	lasso	10	0.15	7.1e-05	-7.9	8.4	3.0e-17	-0.31	0.64	0.03	FALSE
19	GTEx	Esophagus Muscularis	TRIM38	0.06	0.04	lasso	4	0.02	1.7e-02	-8.8	8.4	3.4e-17	-0.36	0.53	0.03	FALSE
2	GTEx	Adipose Visceral Omentum	U91328.19	0.21	0.25	lasso	8	0.27	3.7e-14	-7.9	8.4	6.1e-17	-0.32	1.00	0.00	FALSE
30	GTEx	Skin Sun Exposed Lower leg	U91328.19	0.29	0.34	lasso	6	0.34	5.6e-29	-7.9	8.4	6.1e-17	-0.34	1.00	0.00	FALSE
14	GTEx	Breast Mammary Tissue (Female)	U91328.19	0.39	0.27	lasso	6	0.23	1.4e-07	-7.9	8.3	7.5e-17	-0.35	0.95	0.00	FALSE
21	GTEx	Heart Atrial Appendage	U91328.19	0.25	0.17	enet	6	0.13	2.0e-06	-7.9	8.3	8.3e-17	-0.32	1.00	0.00	FALSE
6	GTEx	Artery Tibial	U91328.19	0.26	0.32	lasso	5	0.31	1.6e-24	-7.9	8.3	1.1e-16	-0.33	1.00	0.00	FALSE
7	GTEx	Brain Caudate basal ganglia	U91328.19	0.23	0.16	lasso	10	0.16	3.1e-05	-8.2	8.3	1.1e-16	-0.25	0.73	0.02	FALSE
12	GTEx	Breast Mammary Tissue	U91328.19	0.38	0.39	lasso	5	0.38	2.2e-20	-7.9	8.2	2.3e-16	-0.32	1.00	0.00	FALSE
11	GTEx	Brain Frontal Cortex BA9	U91328.19	0.17	0.16	lasso	4	0.18	1.8e-05	-7.9	8.2	3.4e-16	-0.32	0.45	0.04	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	U91328.20	0.16	0.13	enet	16	0.13	2.0e-05	-5.8	8.1	5.9e-16	-0.34	0.45	0.04	FALSE
25	GTEx	Muscle Skeletal	U91328.19	0.28	0.26	enet	15	0.32	1.3e-31	-7.9	8.1	8.6e-16	-0.29	1.00	0.00	FALSE
26	GTEx	Nerve Tibial	U91328.19	0.46	0.38	lasso	10	0.36	1.4e-26	-7.9	8.0	1.2e-15	-0.32	1.00	0.00	FALSE
15	GTEx	Cells Transformed fibroblasts	U91328.19	0.58	0.62	lasso	8	0.60	6.2e-56	-7.9	8.0	1.6e-15	-0.32	1.00	0.00	FALSE
28	GTEx	Prostate	U91328.19	0.30	0.39	lasso	2	0.37	3.0e-10	-7.9	7.9	2.3e-15	-0.32	0.96	0.01	FALSE
1	GTEx	Adipose Subcutaneous	U91328.19	0.40	0.46	lasso	8	0.46	4.2e-41	-7.9	7.8	4.2e-15	-0.31	1.00	0.00	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	U91328.19	0.28	0.07	lasso	7	0.21	4.3e-08	-7.9	7.8	5.3e-15	-0.33	0.71	0.02	FALSE
36	GTEx	Vagina	U91328.19	0.45	0.27	lasso	4	0.26	9.4e-07	-7.9	7.8	6.5e-15	-0.33	0.63	0.04	FALSE
38	METSIM	Adipose	U91328.20	0.07	0.04	bslmm	658	0.04	8.9e-07	-2.2	7.8	6.7e-15	-0.45	0.84	0.12	FALSE
22	GTEx	Heart Left Ventricle	U91328.19	0.20	0.18	lasso	5	0.15	2.4e-08	-7.9	7.6	2.5e-14	-0.32	0.99	0.00	FALSE
9	GTEx	Brain Cerebellum	U91328.19	0.13	0.15	lasso	2	0.09	1.1e-03	-7.8	7.6	3.3e-14	-0.33	0.36	0.04	FALSE
33	GTEx	Thyroid	U91328.19	0.21	0.17	lasso	5	0.17	6.4e-13	-7.9	7.5	6.5e-14	-0.31	1.00	0.00	FALSE
39	YFS	Blood	TRIM38	0.37	0.31	bslmm	672	0.34	3.8e-115	-7.8	-7.1	9.3e-13	0.18	1.00	0.00	FALSE
13	GTEx	Breast Mammary Tissue (Male)	U91328.19	0.35	0.15	enet	25	0.15	2.9e-04	-7.9	7.0	2.3e-12	-0.33	0.38	0.04	FALSE
32	GTEx	Thyroid	TRIM38	0.14	0.16	lasso	4	0.17	8.5e-13	-6.1	6.7	2.6e-11	-0.23	1.00	0.00	FALSE
34	GTEx	Thyroid	U91328.21	0.08	0.04	lasso	3	0.05	5.5e-05	-6.1	6.5	8.0e-11	-0.25	0.74	0.01	FALSE
31	GTEx	Stomach	U91328.19	0.17	0.05	lasso	5	0.05	1.7e-03	-7.9	6.5	9.1e-11	-0.24	0.56	0.07	FALSE
23	GTEx	Liver	U91328.19	0.16	0.14	lasso	2	0.05	1.9e-02	-6.3	6.3	2.9e-10	-0.39	0.25	0.18	FALSE
5	GTEx	Artery Coronary	U91328.19	0.32	0.16	enet	44	0.23	3.7e-08	-7.9	5.4	6.0e-08	-0.06	0.79	0.01	FALSE