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chr6:129,638,583-131,163,098

Best TWAS P=8.39e-36 · Best GWAS P=1.08e-32 conditioned to 0.12

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
28	GTEx	Thyroid	L3MBTL3	0.40	0.39	enet	9	0.43	2.8e-35	11.7	12.5	8.4e-36	0.90	0.02	0.98	TRUE
13	GTEx	Lung	L3MBTL3	0.37	0.34	lasso	4	0.38	4.1e-30	11.7	12.4	2.6e-35	0.89	0.02	0.98	FALSE
2	GTEx	Adipose Visceral Omentum	L3MBTL3	0.14	0.12	lasso	2	0.15	2.8e-08	11.7	12.4	4.2e-35	0.90	0.01	0.98	FALSE
5	GTEx	Breast Mammary Tissue (Male)	L3MBTL3	0.31	0.24	lasso	6	0.23	5.5e-06	11.7	12.3	4.9e-35	0.91	0.01	0.95	FALSE
14	GTEx	Lung	RP11-73O6.3	0.15	0.08	lasso	5	0.12	2.2e-09	11.7	12.3	6.1e-35	0.91	0.02	0.98	FALSE
29	GTEx	Thyroid	RP11-73O6.3	0.18	0.15	lasso	3	0.20	2.3e-15	11.0	12.3	6.5e-35	0.91	0.03	0.97	FALSE
22	GTEx	Small Intestine Terminal Ileum	L3MBTL3	0.37	0.20	lasso	4	0.17	1.3e-04	11.7	12.3	7.3e-35	0.86	0.01	0.93	FALSE
10	GTEx	Colon Transverse	L3MBTL3	0.27	0.13	lasso	8	0.20	8.0e-10	11.7	12.3	8.2e-35	0.87	0.01	0.99	FALSE
16	GTEx	Pancreas	L3MBTL3	0.32	0.17	lasso	4	0.23	4.4e-10	11.7	12.3	1.0e-34	0.88	0.02	0.98	FALSE
26	GTEx	Stomach	RP11-73O6.3	0.21	0.12	lasso	6	0.06	5.9e-04	11.8	12.2	1.8e-34	0.89	0.01	0.95	FALSE
15	GTEx	Nerve Tibial	L3MBTL3	0.30	0.23	lasso	4	0.22	2.3e-15	11.7	12.2	2.6e-34	0.87	0.02	0.98	FALSE
23	GTEx	Spleen	L3MBTL3	0.64	0.34	enet	14	0.48	6.4e-14	10.1	12.2	3.6e-34	0.88	0.03	0.97	FALSE
30	GTEx	Whole Blood	L3MBTL3	0.22	0.20	lasso	9	0.20	5.1e-18	11.7	12.2	3.6e-34	0.86	0.02	0.98	FALSE
3	GTEx	Breast Mammary Tissue	L3MBTL3	0.31	0.25	lasso	7	0.23	2.8e-12	11.7	12.1	7.3e-34	0.89	0.01	0.99	FALSE
1	GTEx	Adipose Subcutaneous	L3MBTL3	0.20	0.08	lasso	4	0.09	1.1e-07	11.7	12.1	8.3e-34	0.89	0.02	0.98	FALSE
11	GTEx	Colon Transverse	RP11-73O6.3	0.19	0.09	lasso	2	0.06	1.2e-03	11.7	12.1	1.4e-33	0.88	0.01	0.98	FALSE
21	GTEx	Skin Sun Exposed Lower leg	L3MBTL3	0.25	0.25	lasso	9	0.24	1.4e-19	11.7	12.1	1.7e-33	0.86	0.02	0.98	FALSE
31	GTEx	Whole Blood	RP11-73O6.3	0.15	0.06	lasso	8	0.04	1.1e-04	11.7	12.0	2.0e-33	0.85	0.02	0.95	FALSE
4	GTEx	Breast Mammary Tissue	RP11-73O6.3	0.27	0.22	lasso	9	0.22	1.5e-11	11.7	12.0	2.2e-33	0.85	0.02	0.98	FALSE
19	GTEx	Prostate	L3MBTL3	0.35	0.27	lasso	5	0.17	5.9e-05	11.7	11.9	7.7e-33	0.87	0.02	0.94	FALSE
8	GTEx	Breast Mammary Tissue (Female)	RP11-73O6.3	0.29	0.08	lasso	5	0.10	5.7e-04	10.1	11.9	2.1e-32	0.85	0.02	0.94	FALSE
12	GTEx	Esophagus Mucosa	L3MBTL3	0.26	0.18	lasso	2	0.23	2.7e-15	10.1	11.8	5.3e-32	0.82	0.04	0.96	FALSE
7	GTEx	Breast Mammary Tissue (Female)	L3MBTL3	0.30	0.13	lasso	5	0.14	4.5e-05	8.3	11.7	8.8e-32	0.86	0.01	0.97	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	L3MBTL3	0.26	0.12	lasso	4	0.12	4.0e-07	9.5	11.7	1.1e-31	0.79	0.03	0.96	FALSE
6	GTEx	Breast Mammary Tissue (Male)	RP11-73O6.3	0.33	0.17	lasso	4	0.12	1.3e-03	11.7	11.2	2.4e-29	0.84	0.03	0.83	FALSE
27	GTEx	Testis	L3MBTL3	0.41	0.22	lasso	8	0.30	9.2e-14	11.7	11.2	2.4e-29	0.78	0.01	0.98	FALSE
24	GTEx	Spleen	RP11-73O6.3	0.45	0.43	enet	21	0.42	7.7e-12	10.1	11.1	1.1e-28	0.80	0.15	0.85	FALSE
25	GTEx	Stomach	L3MBTL3	0.36	0.18	enet	27	0.20	1.1e-09	11.8	11.0	5.4e-28	0.85	0.01	0.99	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	L3MBTL3	0.28	0.08	lasso	10	0.03	4.4e-02	11.7	11.0	5.6e-28	0.86	0.02	0.90	FALSE
17	GTEx	Pituitary	L3MBTL3	0.45	0.31	lasso	8	0.29	5.1e-08	8.3	10.3	9.4e-25	0.74	0.07	0.92	FALSE
36	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	L3MBTL3	0.06	0.01	blup	114	0.04	4.0e-03	10.1	9.8	1.4e-22	0.78	0.06	0.57	FALSE
34	YFS	Blood	L3MBTL3	0.28	0.22	blup	614	0.27	1.2e-88	10.1	9.1	7.6e-20	0.67	1.00	0.00	FALSE
32	METSIM	Adipose	L3MBTL3	0.13	0.12	enet	22	0.12	4.8e-18	10.1	9.1	1.0e-19	0.68	0.92	0.08	FALSE
33	ROSMAP	Brain Pre-frontal Cortex	L3MBTL3	0.14	0.07	blup	609	0.08	3.8e-10	11.7	9.1	1.1e-19	0.67	0.02	0.98	FALSE
18	GTEx	Pituitary	RP11-73O6.3	0.48	0.07	lasso	7	0.16	8.2e-05	8.3	8.3	9.5e-17	0.62	0.08	0.81	FALSE
35	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	L3MBTL3	0.05	0.00	blup	114	0.01	1.0e-02	8.3	5.7	9.7e-09	0.51	0.02	0.32	FALSE