Best TWAS P=9e-11 · Best GWAS P=2.98e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellum | PHLDB1 | 0.32 | 0.17 | lasso | 7 | 0.20 | 1.4e-06 | 6.2 | -6.5 | 9.1e-11 | -0.76 | 0.01 | 0.97 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | DDX6 | 0.12 | 0.08 | lasso | 5 | 0.10 | 1.2e-07 | 6.3 | 6.5 | 9.0e-11 | 0.95 | 0.01 | 0.99 | TRUE |
| 3 | GTEx | Esophagus Mucosa | RPL5P30 | 0.07 | 0.01 | lasso | 5 | 0.02 | 1.6e-02 | 4.2 | 5.2 | 2.0e-07 | 0.64 | 0.12 | 0.63 | FALSE |
| 4 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PHLDB1 | 0.15 | 0.11 | lasso | 4 | 0.17 | 9.3e-19 | 6.2 | 5.6 | 1.8e-08 | 0.67 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TREH | 0.06 | 0.01 | blup | 15 | 0.02 | 5.3e-03 | 4.7 | 5.9 | 3.0e-09 | 0.82 | 0.00 | 0.72 | FALSE |