Best TWAS P=1.35e-10 · Best GWAS P=4.02e-08 conditioned to 0.854
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue (Female) | CD79B | 0.04 | 0.07 | lasso | 2 | 0.03 | 4.2e-02 | 5.5 | -5.7 | 1.5e-08 | -0.92 | 0.02 | 0.56 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | PSMC5 | 0.19 | 0.09 | lasso | 5 | 0.10 | 7.1e-08 | 5.5 | 5.5 | 4.8e-08 | 0.90 | 0.01 | 0.99 | TRUE |
| 3 | GTEx | Esophagus Mucosa | STRADA | 0.05 | 0.07 | lasso | 2 | 0.05 | 1.9e-04 | 5.2 | 5.2 | 2.4e-07 | 0.95 | 0.02 | 0.92 | TRUE |
| 4 | GTEx | Stomach | DCAF7 | 0.24 | 0.00 | enet | 33 | 0.08 | 1.2e-04 | -1.6 | -6.4 | 1.3e-10 | -0.22 | 0.07 | 0.16 | TRUE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | STRADA | 0.05 | 0.03 | lasso | 1 | 0.02 | 1.7e-03 | 5.5 | 5.5 | 5.0e-08 | 0.95 | 0.00 | 0.89 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | STRADA | 0.03 | 0.00 | blup | 57 | 0.01 | 5.2e-02 | 5.5 | -5.2 | 1.9e-07 | -0.94 | 0.00 | 0.80 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PSMC5 | 0.04 | 0.03 | lasso | 1 | 0.03 | 5.6e-04 | 5.4 | 5.4 | 8.0e-08 | 0.97 | 0.00 | 0.96 | FALSE |