Hub : Genes

STRADA

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0360	0.0180	0.0017	0.030	0.021	0.017	0.019	0.027	1.3e-04	0.00130	0.0032	0.0018	0.00027
2	GTEx	Esophagus Mucosa	0.0460	0.0240	0.0064	0.070	NA	0.032	NA	0.053	1.9e-05	NA	0.0032	NA	0.00020
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0480	0.0363	0.0054	0.027	0.020	0.008	NA	0.021	4.4e-04	0.00250	0.0410	NA	0.00170
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0715	0.0585	0.0011	0.009	0.026	0.018	NA	0.024	2.9e-02	0.00055	0.0036	NA	0.00085
5	TCGA	Brain Lower Grade Glioma	0.0325	0.0234	0.0083	0.003	0.007	0.003	NA	0.001	1.3e-01	0.05200	0.1300	NA	0.24000

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.1	0.1	0.2	0.5	-0.3	-0.2	0.2	0.1
Bipolar Disorder or Schizophrenia	0.1	0.2	0.5	-0.7	-0.5	-0.3	-0.0	0.0
Depressed Affect (Nagel 2018)	3.0	6.4	8.2	-1.0	2.7	2.8	-2.7	-2.9
Depression (Nagel 2018)	1.3	1.9	2.5	-0.6	1.4	1.5	-1.6	-1.6
Intelligence (Savage-Jansen 2018)	0.7	2.1	4.1	-2.0	-1.6	-1.6	0.6	1.0
Neuroticism (Nagel 2018)	3.1	7.2	9.2	-2.2	2.5	2.6	-3.0	-3.0
Schizophrenia (2018)	0.2	0.4	1.7	-1.3	-0.4	-0.2	-0.2	-0.0
Schizophrenia vs Biploar Disorder	1.3	1.7	2.1	-1.1	1.2	1.3	-1.5	-1.4
Worry (Nagel 2018)	0.0	0.1	0.2	-0.4	0.3	0.2	-0.3	-0.3
Alzheimer’s Disease (in mother)	1.7	2.0	3.0	-1.7	1.0	1.1	-1.6	-1.5
Alzheimer’s Disease (in father)	0.5	0.5	0.8	0.5	0.9	0.9	-0.6	-0.7
Alzheimer’s Disease (including proxy)	1.2	1.7	2.3	-1.4	1.1	1.1	-1.5	-1.3
Crohns Disease (2017)	1.9	4.2	4.9	1.9	-1.9	-2.1	2.1	2.2
Irritable Bowel Disease (IBD)	1.3	3.1	4.3	0.6	-2.1	-2.1	1.8	1.9
Ulcerative Colitis (UC)	0.5	1.0	1.7	-1.3	-1.2	-1.1	0.4	0.6
Major Depression (MDD)	0.7	0.8	1.2	0.6	-0.9	-0.8	1.1	1.0
Reaction Time	1.4	2.6	4.0	-2.0	1.3	1.3	-1.8	-1.6
Verbal and Numeric Reasoning (VNR)	0.5	1.2	5.7	-2.4	-0.4	-0.3	-0.5	-0.2
Breast Cancer	0.5	1.1	1.6	0.1	1.3	1.3	-1.0	-1.2
Ovarian Cancer	0.9	1.2	3.6	1.9	-0.4	-0.3	1.2	0.8
Prostate Cancer	7.6	10.6	13.0	-1.6	3.6	3.6	-3.5	-3.6
Age at First Birth	0.7	1.0	3.5	-1.9	-0.7	-0.8	0.2	0.5
Bipolar Disorder (2011)	2.2	2.2	3.1	0.3	-1.8	-1.7	1.5	1.6
Body Mass Index (BMI) (2010)	0.9	1.3	5.4	2.3	0.6	0.7	0.3	-0.1
Coronary Artery Disease (CAD)	0.3	0.4	1.3	-1.1	0.3	0.1	-0.6	-0.5
Crohns Disease (2012)	1.7	2.7	3.4	1.7	-1.4	-1.5	1.9	1.8
Mean Putamen Volume	0.5	0.6	0.9	-0.2	0.9	0.8	-0.8	-0.8
Fasting Glucose	0.3	0.4	0.6	0.7	0.7	0.8	-0.3	-0.6
HbA1C	0.2	0.2	0.8	0.9	-0.2	-0.0	0.3	0.2
HDL Cholesterol	1.3	2.1	2.2	-1.4	1.5	1.4	-1.5	-1.5
LDL Cholesterol	1.4	2.3	3.6	-0.3	1.9	1.7	-1.5	-1.6
Lupus	2.1	3.1	4.1	-0.8	2.0	2.0	-1.8	-1.9
Neuroticism (2016)	0.4	0.5	0.7	-0.7	0.6	0.8	-0.8	-0.8
Primary Biliary Cirrhosis	0.1	0.1	0.6	0.8	-0.0	0.1	0.1	0.0
Rheumatoid Arthritis	2.4	3.2	3.9	-1.5	1.7	1.8	-2.0	-2.0
Schizophrenia (2014)	0.6	1.4	4.0	-2.0	0.3	0.6	-1.2	-1.0
Triglycerides	0.2	0.3	0.7	0.8	-0.4	-0.1	0.6	0.5
Type 2 Diabetes (T2D) (2012)	1.1	1.3	2.1	1.0	1.2	1.4	-0.8	-1.1
Ulcerative Colitis	0.2	0.4	0.8	-0.7	-0.9	-0.7	0.3	0.3
Blood Eosinophil Count	0.6	4.5	9.9	3.1	-1.6	-1.4	2.2	1.9
Blood Platelet Count	0.2	2.9	8.1	2.9	1.6	1.6	-0.4	-1.0
Blood Red Count	5.1	49.4	56.6	7.5	-6.3	-6.4	7.5	7.3
Blood White Count	1.2	8.6	35.6	6.0	-0.3	-0.4	2.2	1.5
Heel T-Score	0.4	2.9	10.6	3.2	1.4	1.3	0.2	-0.5
BMI	0.8	4.5	10.3	3.2	1.9	2.2	-1.0	-1.5
Height	13.9	267.6	408.0	-4.8	-20.0	-20.2	14.3	17.4
Waist Hip Ratio (WHR)	5.1	23.0	27.4	-2.9	5.2	5.1	-5.1	-5.2
Systolic Blood Pressure	0.1	0.4	0.5	0.5	-0.5	-0.7	0.7	0.6
Smoking Status	2.8	6.7	8.3	-1.2	2.7	2.9	-2.8	-2.9
Allergy or Eczema	0.2	0.6	2.2	1.5	-0.4	-0.2	0.8	0.5
Cardiovascular Disease	1.9	6.1	21.8	4.7	-0.8	-0.9	2.1	1.6
Hypothyroidism (self reported)	0.8	1.9	3.3	-1.8	1.2	1.0	-1.5	-1.3
Respiratory disease	0.6	1.4	2.0	1.4	1.2	1.4	-0.6	-1.0
Type 2 Diabetes (T2D) (2018)	0.3	0.5	2.0	1.4	0.4	0.4	-0.0	-0.3
Lung FEV1/FVC ratio	0.3	1.4	6.2	2.5	0.6	0.8	0.0	-0.3
Lung FVC	3.8	19.2	26.0	1.2	-5.0	-5.1	4.5	4.9
Neuroticism	2.9	6.9	8.6	-1.9	2.7	2.6	-2.9	-2.9
Chronotype (morning person)	0.1	0.2	0.4	0.6	-0.2	-0.3	0.3	0.3
Hair Pigment	0.3	7.7	10.1	-1.2	3.2	3.1	-2.8	-3.0
Tanning	0.0	0.3	1.5	-1.2	-0.2	-0.4	-0.2	0.1
Hand grip strength (left)	8.3	21.8	30.2	1.5	-5.5	-5.5	4.6	5.1
Number of treatments/medications taken	2.5	4.4	6.2	0.0	2.3	2.5	-2.2	-2.4
Average weekly spirits intake	0.1	0.1	0.2	0.4	-0.3	-0.2	0.3	0.3
Sensitivity / hurt feelings	7.8	13.4	16.1	-2.7	3.7	3.8	-4.0	-4.0
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.4	0.0	0.5	0.4	-0.7	-0.5
Hearing difficulty/problems: Yes	1.6	2.4	3.3	-1.8	1.2	1.3	-1.7	-1.6
Relative age of first facial hair	5.2	10.7	12.3	-2.5	3.4	3.4	-3.4	-3.5
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.4	0.6	0.2	0.1	-0.0	-0.1
Ever used hormone-replacement therapy (HRT)	0.5	0.6	0.8	0.9	-0.7	-0.8	0.9	0.8
Ever had hysterectomy (womb removed)	1.1	1.3	2.3	-1.5	0.9	0.8	-1.2	-1.1
Systolic blood pressure, automated reading	0.2	0.5	0.8	-0.1	0.9	0.8	-0.7	-0.8
Eye problems/disorders: Diabetes related eye disease	6.0	6.6	7.7	2.8	-2.5	-2.4	2.6	2.5
Angina	1.5	2.0	2.7	-0.3	1.6	1.6	-1.5	-1.6
Medication for hormone replacement therapy	0.0	0.0	0.1	-0.1	-0.0	-0.3	0.1	0.2
Vitamin and mineral supplements	1.5	2.1	2.5	1.6	-1.1	-1.3	1.6	1.6
Supplements: Zinc	2.4	2.6	2.9	-1.6	1.6	1.6	-1.6	-1.7
Medication: Co-codamol	1.6	1.8	2.9	0.0	1.6	1.7	-1.2	-1.5
Medication: Metformin	3.3	4.6	5.8	-1.2	2.3	2.2	-2.4	-2.4
Diabetes (father)	3.7	4.6	6.0	-1.5	2.5	2.1	-2.3	-2.3
Diabetes (mother)	0.8	1.0	1.5	-0.3	1.0	1.2	-1.0	-1.1
Severe depression (siblings)	0.4	0.5	1.7	-1.3	-0.0	0.1	-0.6	-0.4
Pack years adult smoking proportion	0.1	0.1	0.3	0.6	0.3	0.3	-0.1	-0.2
Impedance of leg (right)	7.2	34.9	42.4	-3.5	6.5	6.5	-6.0	-6.4
Leg fat-free mass (left)	10.5	55.7	82.6	0.7	-9.1	-9.0	6.9	8.1
Trunk fat percentage	4.2	16.7	22.2	-1.3	4.4	4.7	-4.3	-4.6
Hand grip strength (right)	11.6	31.4	44.9	0.9	-6.6	-6.7	5.4	6.1
Townsend deprivation index at recruitment	0.4	0.5	0.8	-0.2	0.9	0.8	-0.8	-0.8
Current tobacco smoking	3.0	4.9	6.1	-2.0	2.1	2.1	-2.5	-2.4
Average weekly fortified wine intake	0.4	0.5	1.8	-1.3	-0.5	-0.5	-0.1	0.2
Maternal smoking around birth	0.8	1.2	3.2	1.8	-0.3	-0.8	1.1	1.0
Fed-up feelings	0.5	0.9	1.3	1.1	1.2	1.1	-0.5	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.7	0.8	0.8	0.9	-0.5	-0.6
Relative age voice broke	2.0	3.1	3.8	-1.1	1.9	1.9	-1.8	-1.9
Taking other prescription medications	4.6	7.1	10.2	0.2	3.2	3.1	-2.6	-2.9
Age when periods started (menarche)	0.3	0.8	1.2	-0.3	1.1	1.0	-0.9	-0.9
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.4	-0.7	0.2	0.1	-0.3	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.0	1.3	1.3	1.4	-0.5	-0.9
Tinnitus: Yes, but not now, but have in the past	9.1	9.7	12.0	-1.6	3.4	3.4	-3.4	-3.5
Qualifications: CSEs or equivalent	0.6	0.8	1.1	0.2	1.0	1.1	-0.9	-1.0
Serious illness, injury or assault to yourself	2.7	3.3	4.3	-0.9	1.9	2.0	-2.0	-2.1
High blood pressure	0.5	1.4	3.6	1.9	1.2	1.2	-0.2	-0.6
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.8	1.3	-0.5	-0.4	0.9	0.7
Multivitamins +/- minerals	2.9	3.7	4.7	-1.8	1.7	1.9	-2.1	-2.2
Stomach or abdominal pain in last month	0.8	1.0	1.3	0.3	-1.2	-1.1	0.9	1.1
Supplements: Glucosamine	0.0	0.0	0.0	0.1	-0.1	0.0	0.2	0.1
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	-0.2	-0.5	-0.7	0.2	0.4
Medication: Atenolol	0.2	0.2	0.8	0.9	0.3	0.2	0.4	0.1
Medication: Levothyroxine sodium	1.1	1.9	2.6	-0.9	1.6	1.3	-1.4	-1.4
Sitting height	18.0	127.8	182.2	1.3	-13.5	-13.5	10.8	12.5
Chronic bronchitis/emphysema (father)	1.0	1.2	1.6	-0.4	1.3	1.2	-1.1	-1.2
High blood pressure (mother)	0.4	0.5	1.5	1.2	-0.4	-0.3	0.7	0.6
Body mass index (BMI)	0.8	3.4	4.4	2.0	1.9	2.1	-1.4	-1.7
Impedance of leg (left)	6.8	32.9	40.1	-3.4	6.3	6.3	-5.8	-6.3
Leg predicted mass (left)	10.4	54.9	81.5	0.6	-9.0	-9.0	6.8	8.1
Trunk fat mass	0.3	1.1	1.8	-0.8	0.7	1.0	-1.4	-1.2
Waist circumference	0.8	2.8	3.9	-0.5	1.7	1.8	-2.0	-1.9
Number of incorrect matches in round	0.7	1.1	2.2	1.5	-0.8	-0.8	1.1	1.0
Past tobacco smoking	1.0	1.9	2.7	0.2	-1.5	-1.6	1.5	1.5
Alcohol usually taken with meals	2.4	3.9	4.8	1.3	-2.2	-2.2	2.0	2.1
Nervous feelings	1.4	2.6	3.4	-1.9	1.4	1.4	-1.7	-1.6
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	2.0	-0.7	1.4	1.2	-1.4	-1.3
Hearing difficulty/problems with background noise	1.4	2.2	3.6	-1.9	1.2	1.2	-1.6	-1.5
Hair/balding pattern: Pattern 2	0.7	0.9	2.2	1.5	-0.6	-0.4	1.0	0.8
Had menopause	0.4	0.5	0.9	-0.5	0.9	0.7	-0.6	-0.8
Had other major operations	2.3	2.8	3.7	1.7	-1.4	-1.5	1.9	1.8
Forced vital capacity (FVC)	14.4	55.6	83.2	-0.9	-9.1	-9.1	6.8	8.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	1.6	1.3	1.1	1.2	-0.3	-0.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.6	1.3	-0.0	0.1	0.2	0.1
Qualifications: None of the above	0.2	0.4	1.0	1.0	0.7	0.7	-0.1	-0.4
Financial difficulties in last 2 years	0.3	0.4	0.7	0.8	0.8	0.6	-0.2	-0.3
Mouth/teeth dental problems	0.0	0.0	0.1	0.1	0.3	0.2	-0.0	-0.2
Heart attack	2.6	3.3	5.1	0.2	2.2	2.3	-1.6	-2.0
Allergy	0.8	1.8	5.0	-2.2	0.8	0.6	-1.4	-1.1
Pain all over the body in last month	0.4	0.4	0.6	0.3	0.7	0.8	-0.7	-0.7
Diabetes (self-reported)	0.6	0.9	1.3	0.5	1.0	1.1	-0.9	-1.1
Hayfever/allergic rhinitis (self-reported)	1.4	1.8	2.4	-0.5	1.4	1.6	-1.4	-1.6
Medication: Ramipril	1.6	2.0	3.1	0.1	1.7	1.8	-1.3	-1.6
Medication: Simvastatin	0.9	1.3	2.0	0.9	1.4	1.3	-0.7	-1.1
Fluid intelligence score	0.4	0.9	3.7	-1.9	-0.6	-0.6	-0.1	0.1
Illnesses of siblings	1.8	2.5	7.0	-2.7	1.0	0.9	-1.5	-1.3
Neuroticism score	1.8	3.8	4.6	-1.7	2.0	1.8	-2.1	-2.1
Weight	2.8	13.8	21.7	0.3	-4.7	-4.5	3.3	4.0
Impedance of arm (right)	8.0	37.5	42.7	-5.4	6.1	6.2	-6.3	-6.5
Arm fat percentage (right)	4.3	17.1	24.5	-0.1	4.7	5.0	-4.1	-4.6
Trunk fat-free mass	19.2	110.3	158.8	1.4	-12.5	-12.6	10.0	11.6
Hip circumference	1.0	4.3	7.0	0.6	-2.7	-2.5	1.8	2.2
Time employed in main current job	1.0	1.2	1.7	1.2	-0.8	-0.9	1.3	1.1
Alcohol intake versus 10 years previously	0.8	1.2	3.7	1.9	-0.3	-0.5	1.1	0.9
Father’s age at death	0.2	0.3	1.1	-1.1	0.1	0.0	-0.6	-0.3
Worrier / anxious feelings	0.1	0.1	0.4	-0.6	-0.3	-0.3	-0.1	0.0
Frequency of tiredness / lethargy in last 2 weeks	3.4	5.5	6.9	-1.2	2.6	2.5	-2.5	-2.5
Falls in the last year	0.0	0.1	0.1	-0.4	0.0	0.2	-0.3	-0.2
Hair/balding pattern: Pattern 3	2.8	4.1	11.7	-3.4	1.1	1.0	-2.0	-1.6
Number of live births	0.8	1.1	1.6	-1.3	0.9	0.9	-1.0	-1.0
Forced expiratory volume in 1-second (FEV1)	13.7	46.3	68.4	0.2	-8.3	-8.1	6.5	7.4
Pulse rate	0.0	0.0	0.1	0.4	0.2	0.2	-0.2	-0.2
Happiness	1.4	1.7	2.2	0.8	-1.5	-1.4	1.3	1.4
Noisy workplace	0.6	0.8	1.2	-0.1	1.1	1.0	-0.8	-1.0
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.0	-1.3	-1.4	-1.3	0.8	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.0	0.1	-0.2	-0.2	0.2	0.2
Mouth/teeth dental problems: Dentures	2.3	3.9	4.3	2.0	-1.9	-1.8	2.1	2.0
Asthma	0.4	0.7	2.7	1.6	0.6	0.7	0.1	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.6	0.1	-0.8	-0.5	0.4	0.5
Medication: Cholesterol lowering	1.2	1.8	2.8	0.5	1.7	1.6	-1.2	-1.4
Depression (self-reported)	1.1	1.4	1.8	0.6	-1.3	-1.3	1.1	1.3
Medication: Lansoprazole	1.4	1.6	2.5	0.1	1.6	1.5	-1.2	-1.4
Prospective memory result	1.2	1.5	3.6	1.9	-0.6	-1.0	1.2	1.1
Lung cancer (father)	1.7	2.0	5.2	-2.3	0.8	1.0	-1.3	-1.2
Illnesses of mother	4.3	5.3	8.0	0.1	-2.7	-2.8	2.2	2.5
Forced expiratory volume in 1-second (FEV1), Best measure	13.8	43.9	62.3	0.8	-7.9	-7.9	6.4	7.3
Pulse wave Arterial Stiffness index	2.8	3.3	3.7	-1.5	1.8	1.8	-1.9	-1.9
Impedance of arm (left)	5.9	27.1	30.7	-4.7	5.2	5.2	-5.3	-5.5
Arm fat mass (right)	0.1	0.3	0.6	0.8	0.4	0.6	-0.5	-0.5
Trunk predicted mass	19.5	111.3	161.3	1.5	-12.5	-12.7	10.1	11.6
Standing height	14.6	145.2	219.0	-3.0	-14.8	-14.8	10.6	12.9
Length of working week for main job	0.1	0.1	0.5	0.7	0.2	-0.0	0.1	0.1
Exposure to tobacco smoke at home	0.5	0.6	1.3	1.1	0.5	1.0	-0.1	-0.5
Breastfed as a baby	0.7	0.8	0.9	-0.9	0.9	0.8	-0.9	-0.9
Tense / ‘highly strung’	0.1	0.2	0.8	0.9	-0.1	-0.2	0.4	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	1.9	1.3	-0.9	-1.2	1.3	1.4
Hair/balding pattern: Pattern 4	1.8	4.4	6.4	0.1	-2.5	-2.5	2.1	2.3
Birth weight of first child	1.3	2.4	3.1	0.5	-1.8	-1.7	1.7	1.7
Peak expiratory flow (PEF)	11.7	27.1	36.1	2.2	-6.0	-5.8	5.3	5.7
Pulse wave reflection index	2.8	3.4	5.0	-0.3	2.2	2.2	-1.8	-2.0
Ever highly irritable/argumentative for 2 days	1.0	1.2	1.9	-0.8	0.8	1.1	-1.4	-1.3
Loud music exposure frequency	0.0	0.0	0.0	-0.1	0.0	0.0	-0.1	-0.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.3	-1.2	-0.8	-0.9	0.2	0.6
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.6	0.7	0.7	0.6	-0.2	-0.3
Blood clot in the leg (DVT)	0.1	0.2	0.2	-0.1	-0.5	-0.5	0.4	0.4
Medication: Paracetamol	1.8	2.9	4.1	0.0	2.0	2.0	-1.7	-1.9
Headache pain in last month	0.2	0.4	0.7	0.8	0.6	0.8	-0.4	-0.6
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	1.8	-1.3	-1.3	-1.3	0.6	0.9
Glaucoma (self-reported)	0.2	0.2	0.5	0.7	0.6	0.4	-0.3	-0.4
Gout (self-reported)	0.4	0.5	0.8	0.3	-0.9	-0.8	0.7	0.8
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	3.9	-2.0	1.3	1.1	-1.6	-1.5
Medication: Amlodipine	0.9	1.2	1.6	0.4	1.3	1.3	-1.1	-1.2
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.5	0.2	0.7	0.7	-0.5	-0.7
Birth weight	0.9	2.0	3.1	-0.8	-1.6	-1.8	1.2	1.5
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.8	0.4	0.9	0.7	-0.4	-0.5
High blood pressure (siblings)	3.9	5.7	10.4	3.2	-1.9	-1.9	2.5	2.2
Forced vital capacity (FVC), Best measure	15.6	57.0	83.9	-0.2	-9.1	-9.2	7.1	8.3
Body fat percentage	5.4	21.4	29.7	-0.8	5.2	5.5	-4.8	-5.2
Leg fat percentage (right)	7.1	25.7	36.6	-0.1	5.8	6.0	-5.1	-5.7
Arm fat-free mass (right)	16.1	82.5	116.6	1.8	-10.8	-10.8	8.7	10.0
Exposure to tobacco smoke outside home	1.1	1.5	2.7	1.4	1.6	1.3	-0.5	-0.9
Comparative body size at age 10	0.1	0.4	1.2	-1.1	-0.6	-0.6	-0.2	0.2
Number of full brothers	0.8	1.0	1.5	-0.4	1.2	1.1	-1.0	-1.1
Worry too long after embarrassment	4.3	7.1	15.2	-3.9	1.9	1.8	-2.8	-2.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.2	1.6	-0.6	1.3	1.2	-1.2	-1.2
Wheeze or whistling in the chest in last year	1.7	3.1	4.6	0.2	2.1	2.1	-1.7	-1.9
Number of children fathered	0.2	0.2	0.3	0.3	-0.6	-0.6	0.5	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.0	-1.4	0.6	0.5	-1.0	-0.7
Age at first live birth	0.8	1.5	1.9	0.5	-1.3	-1.3	1.3	1.4
Pulse wave peak to peak time	6.7	7.9	10.1	1.3	-3.2	-3.2	2.9	3.1
Health satisfaction	0.7	0.9	1.3	1.1	-0.9	-0.7	0.9	0.9
Shortness of breath walking on level ground	0.9	1.1	1.9	0.3	1.2	1.4	-0.9	-1.1
Qualifications: College or University degree	0.8	2.7	12.2	-3.5	-0.6	-0.5	-0.7	-0.2
Eye problems/disorders: None of the above	0.5	0.6	2.2	-1.5	-0.5	-0.6	0.0	0.3
Mouth/teeth dental problems: Loose teeth	1.2	1.5	3.3	-1.8	0.8	0.7	-1.2	-1.1
Emphysema/chronic bronchitis	2.4	2.7	3.0	1.7	-1.4	-1.6	1.7	1.7
Medication for pain relief, constipation, heartburn	2.3	4.0	5.7	-0.1	-2.4	-2.4	1.9	2.2
Neck or shoulder pain in last month	1.0	1.4	1.9	-0.7	1.1	1.4	-1.2	-1.3
Medication: Blood pressure	1.9	3.4	5.0	0.1	2.2	2.2	-1.7	-2.1
Angina (self-reported)	1.8	2.3	3.1	-0.4	1.8	1.7	-1.6	-1.7
Migraine (self-reported)	0.1	0.1	0.4	0.6	0.3	0.3	-0.2	-0.2
Medication: Ibuprofen	0.0	0.0	0.1	-0.1	-0.4	-0.1	-0.1	0.1
Medication: Allopurinol	0.2	0.3	0.6	0.2	-0.8	-0.5	0.5	0.5
Medication: Omeprazole	1.9	2.2	3.6	0.2	1.7	1.9	-1.4	-1.6
Medication: Seretide 50 evohaler	0.1	0.1	0.2	0.5	0.3	0.5	-0.2	-0.3
Mean time to correctly identify matches	3.9	7.4	10.7	-3.3	2.4	2.2	-2.9	-2.7
Heart disease (mother)	1.3	1.6	2.5	0.8	1.5	1.6	-1.0	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.6	5.5	6.9	-1.6	2.3	2.5	-2.5	-2.6
Whole body fat mass	0.2	1.0	1.6	-0.3	0.8	1.1	-1.3	-1.2
Leg fat mass (right)	0.5	2.0	2.7	0.1	1.4	1.6	-1.6	-1.6
Arm predicted mass (right)	15.3	78.2	110.2	1.9	-10.5	-10.5	8.5	9.8
Pulse rate, automated reading	0.2	0.8	0.9	0.8	-0.9	-1.0	0.8	0.9
Alcohol intake frequency.	0.3	0.7	1.2	0.4	1.1	1.0	-0.7	-0.9
Comparative height size at age 10	11.4	62.7	96.0	-2.1	-9.6	-9.8	7.0	8.5
Number of full sisters	0.4	0.5	0.8	0.9	-0.7	-0.6	0.7	0.6
Suffer from ‘nerves’	0.3	0.5	1.0	-0.2	1.0	0.8	-0.6	-0.7
Overall health rating	0.8	1.7	2.7	0.4	1.4	1.6	-1.3	-1.5
Chest pain or discomfort	2.8	4.0	5.7	-0.4	2.4	2.3	-2.0	-2.2
Had major operations	0.4	0.4	0.5	-0.6	0.7	0.6	-0.7	-0.7
Age at last live birth	0.3	0.4	0.5	-0.1	-0.7	-0.7	0.7	0.7
Family relationship satisfaction	0.4	0.5	1.2	-0.1	-1.1	-0.9	0.5	0.7
Leg pain on walking	0.3	0.4	1.3	-1.1	0.2	0.2	-0.7	-0.5
Qualifications: NVQ or HND or HNC or equivalent	3.1	3.7	4.8	-0.5	2.1	2.1	-2.1	-2.2
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.0	0.0	-0.2	0.0	0.0	-0.0
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	1.6	-1.2	-0.5	-0.5	-0.1	0.2
Medication: Aspirin	0.7	1.0	1.6	0.7	1.3	1.1	-0.8	-0.9
Supplements: Vitamin C	0.1	0.1	0.2	-0.4	0.1	0.2	-0.2	-0.2
Knee pain experienced in last month	0.9	1.3	2.2	0.5	1.5	1.4	-1.0	-1.1
Hypertension (Self-reported)	0.4	1.2	4.1	2.0	1.0	1.0	-0.0	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.8	2.9	0.9	1.5	1.7	-1.0	-1.3
Illnesses of father: Heart disease	0.9	1.3	2.4	0.8	1.6	1.3	-0.9	-1.1
Illnesses of siblings: Diabetes	0.3	0.4	1.2	1.1	0.5	0.5	-0.2	-0.3
Smoking status: Previous	0.1	0.1	0.5	0.7	0.2	0.3	-0.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	7.5	15.6	24.2	-1.5	-4.9	-4.9	3.3	4.1
Whole body fat-free mass	15.9	91.1	132.2	1.2	-11.4	-11.5	9.0	10.5
Leg fat-free mass (right)	12.2	65.1	95.6	0.8	-9.8	-9.7	7.5	8.8
Arm fat percentage (left)	3.7	14.6	21.1	0.1	4.4	4.6	-3.8	-4.3
Average weekly red wine intake	1.2	1.8	2.6	0.2	-1.6	-1.6	1.4	1.4
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.0	-0.4	0.8	1.0	-0.8	-0.9
Mood swings	0.4	0.7	0.9	0.3	0.9	1.0	-0.9	-0.9
Loneliness, isolation	0.7	1.0	1.4	1.2	-0.9	-0.9	1.0	0.9
Long-standing illness, disability or infirmity	0.5	0.7	3.3	1.8	-0.1	0.0	0.4	0.2
Ever had bowel cancer screening	0.2	0.2	0.4	-0.6	-0.4	-0.6	0.2	0.4
Diabetes diagnosed by doctor	1.0	1.6	2.3	-0.2	1.4	1.4	-1.4	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.2	-0.7	-1.1	-1.1	0.6	0.8
Friendships satisfaction	0.4	0.5	1.0	-0.1	-1.0	-0.9	0.5	0.7
Qualifications: nursing, teaching	0.2	0.3	0.9	-0.9	-0.5	-0.4	0.1	0.2
Commuting to job workplace: Walk	1.9	2.0	2.6	0.9	-1.6	-1.6	1.3	1.5
Eye problems/disorders: Cataract	4.4	5.1	6.4	-1.3	2.3	2.5	-2.4	-2.5
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	4.9	-2.2	-0.0	0.1	-0.8	-0.5
Medication for cholesterol	1.1	1.6	7.3	-2.7	-0.3	-0.1	-0.7	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	2.0	-1.4	0.7	0.7	-1.2	-1.1
Back pain experienced in last month	1.4	2.0	3.6	1.9	-1.2	-1.0	1.5	1.3
Mineral and other dietary supplements	0.4	0.6	0.8	-0.3	0.9	0.8	-0.9	-0.8
Breast cancer (self-reported)	3.1	3.8	4.5	1.2	-2.0	-2.1	2.1	2.1
Asthma (self-reported)	0.4	0.8	3.0	1.7	0.5	0.7	0.2	-0.3
Osteoporosis (self-reported)	0.9	1.2	1.5	0.8	-1.1	-1.1	1.2	1.1
Osteoarthritis (self-reported)	0.5	0.7	1.1	0.0	1.0	1.0	-0.7	-0.9
Medication: Aspirin	0.8	1.0	1.7	0.6	1.3	1.1	-0.8	-1.0
Medication: Gliclazide	3.5	4.0	4.9	-1.1	2.1	2.2	-2.1	-2.2
Illnesses of father: None of the above (group 1)	2.2	2.7	4.3	-0.1	-2.1	-1.9	1.6	1.7
Smoking status: Current	3.3	5.2	6.5	-2.0	2.1	2.2	-2.5	-2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	5.7	12.0	15.7	1.2	-4.0	-3.9	3.6	3.8
Whole body water mass	16.2	92.3	132.2	1.3	-11.5	-11.5	9.1	10.6
Leg predicted mass (right)	12.1	64.6	95.1	0.8	-9.8	-9.7	7.5	8.8
Arm fat mass (left)	0.1	0.4	0.5	0.5	0.5	0.7	-0.7	-0.7
Number of self-reported non-cancer illnesses	2.4	4.1	6.4	1.1	2.5	2.5	-1.6	-2.1
Average weekly champagne plus white wine intake	0.8	1.1	1.3	1.0	-1.0	-1.1	1.0	1.1
Miserableness	3.7	6.4	8.2	-2.1	2.4	2.4	-2.9	-2.7
Guilty feelings	1.3	1.9	4.2	-2.0	0.9	0.9	-1.5	-1.3
Wears glasses or contact lenses	0.7	0.8	1.2	-0.5	1.1	0.9	-0.8	-1.0
Ever taken oral contraceptive pill	0.3	0.3	1.0	-1.0	0.3	0.1	-0.5	-0.3
Hearing aid user	0.6	0.6	1.0	0.2	0.9	1.0	-0.7	-0.9
Mother’s age at death	0.1	0.2	0.5	-0.7	-0.4	-0.4	0.1	0.2
Financial situation satisfaction	0.6	0.7	1.0	1.0	-0.9	-0.8	0.8	0.9
Tinnitus: Yes, now most or all of the time	3.0	3.5	5.7	-0.2	-2.4	-2.2	1.7	2.0
Commuting to job workplace: Public transport	0.3	0.3	0.6	-0.2	-0.6	-0.8	0.5	0.7
Eye problems/disorders: Glaucoma	0.4	0.5	0.7	0.9	0.8	0.8	-0.4	-0.7
Medication: Blood pressure	1.2	2.4	7.3	2.7	-0.8	-0.7	1.4	1.2
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.3	1.1	0.2	0.2	0.2	-0.0
Supplements: Fish oil (including cod liver oil)	1.0	1.3	1.9	-0.2	-1.4	-1.4	1.2	1.2
High cholesterol (Self-reported)	1.1	1.9	8.2	2.9	-0.1	-0.2	1.0	0.6
Medication: Bendroflumethiazide	0.2	0.2	0.4	-0.0	0.5	0.5	-0.5	-0.6
Medication: Paracetamol	2.4	3.7	4.8	-0.8	2.1	2.1	-2.1	-2.2
Medication: Lisinopril	0.3	0.3	0.5	0.7	0.6	0.7	-0.3	-0.4
Medication: Atorvastatin	0.5	0.6	2.7	1.6	-0.0	0.2	0.4	0.2
Illnesses of father: High blood pressure	0.2	0.2	1.0	1.0	-0.2	-0.1	0.2	0.2
Alcohol drinker status: Never	3.4	4.1	4.9	-2.2	1.7	1.8	-2.2	-2.2
Ever smoked	1.0	1.8	2.5	-0.1	1.5	1.6	-1.4	-1.5
Basal metabolic rate	12.5	69.0	100.0	1.1	-10.0	-10.0	7.8	9.1
Leg fat percentage (left)	6.3	22.7	32.9	0.2	5.5	5.7	-4.7	-5.3
Arm fat-free mass (left)	13.5	68.6	97.2	1.7	-9.9	-9.8	7.9	9.1
Number of operations (self-reported)	0.0	0.1	0.1	0.2	0.3	0.3	0.0	-0.2
Average weekly beer plus cider intake	1.2	1.7	2.7	0.3	1.6	1.6	-1.2	-1.3
Irritability	3.5	5.9	7.3	-2.7	2.1	2.1	-2.7	-2.5
Risk taking	0.3	0.5	0.8	-0.7	0.9	0.6	-0.8	-0.7
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.6	0.0	0.8	0.7	-0.6	-0.6
Fractured/broken bones in last 5 years	0.9	1.1	2.3	-0.2	-1.5	-1.3	0.8	1.0
Age started oral contraceptive pill	0.6	0.7	1.0	-0.7	0.8	0.9	-0.9	-1.0
Diastolic blood pressure, automated reading	0.0	0.1	0.3	-0.6	-0.3	-0.4	0.1	0.2
Ever depressed for a whole week	0.2	0.3	0.5	0.3	-0.5	-0.7	0.5	0.6
Unable to work because of sickness or disability	0.0	0.0	0.1	-0.1	-0.3	-0.2	0.0	0.1
Commuting to job workplace: Cycle	0.1	0.1	0.2	-0.3	-0.4	-0.4	0.4	0.4
Myopia	0.7	1.0	1.8	-1.3	0.9	0.8	-1.1	-0.9
Vascular/heart problems diagnosed by doctor	0.7	1.9	3.7	-1.9	-1.5	-1.5	0.5	1.0
Cholesterol lowering medication	1.4	2.0	9.0	3.0	0.6	0.6	0.5	0.1
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	3.5	0.5	1.7	1.9	-1.2	-1.5
Pain experienced in last month	0.7	1.1	4.0	-2.0	0.4	0.3	-0.9	-0.7
Supplements: Calcium	0.8	0.9	1.5	0.1	-1.2	-1.1	0.9	1.0
Basal cell carcinoma (self-reported)	0.3	0.4	0.6	0.4	-0.5	-0.7	0.8	0.7
Heart attack/myocardial infarction (self-reported)	2.4	3.1	4.6	-0.0	2.0	2.1	-1.6	-2.0
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.3	-0.0	-0.6	-0.5	0.5	0.5
Heart disease (siblings)	0.0	0.1	0.1	0.3	-0.3	-0.2	0.2	0.2
Alcohol drinker status: Previous	1.9	2.1	2.7	-0.9	1.6	1.5	-1.5	-1.6
Pack years of smoking	0.1	0.2	0.9	0.9	0.1	0.1	0.2	0.1
Impedance of whole body	6.8	34.7	40.9	-4.2	6.2	6.3	-6.0	-6.4
Leg fat mass (left)	0.3	1.1	1.5	0.5	1.0	1.2	-1.2	-1.2
Arm predicted mass (left)	12.9	65.6	93.1	1.9	-9.7	-9.6	7.8	8.9