Best TWAS P=1.32e-12 · Best GWAS P=2.65e-09 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | SLC26A1 | 0.12 | 0.06 | bslmm | 400 | 0.08 | 8.0e-10 | 5.2 | 6.2 | 4.6e-10 | 0.51 | 0.08 | 0.92 | TRUE |
2 | GTEx | Adipose Subcutaneous | SLC26A1 | 0.37 | 0.32 | lasso | 4 | 0.32 | 5.7e-27 | 5.3 | 5.4 | 6.9e-08 | 0.55 | 0.06 | 0.94 | FALSE |
3 | GTEx | Adipose Subcutaneous | CPLX1 | 0.20 | 0.11 | lasso | 6 | 0.11 | 2.5e-09 | -5.2 | 5.2 | 2.1e-07 | 0.08 | 0.08 | 0.92 | FALSE |
4 | GTEx | Adipose Subcutaneous | RP11-440L14.1 | 0.58 | 0.38 | enet | 36 | 0.48 | 1.9e-43 | -2.8 | 5.2 | 1.9e-07 | 0.16 | 0.99 | 0.00 | FALSE |
5 | GTEx | Adipose Visceral Omentum | SLC26A1 | 0.47 | 0.36 | lasso | 7 | 0.36 | 1.8e-19 | 5.3 | 5.4 | 6.8e-08 | 0.59 | 0.06 | 0.94 | FALSE |
6 | GTEx | Artery Aorta | SLC26A1 | 0.42 | 0.37 | lasso | 6 | 0.38 | 6.4e-22 | 5.2 | 5.4 | 5.4e-08 | 0.54 | 0.06 | 0.94 | FALSE |
7 | GTEx | Artery Tibial | SLC26A1 | 0.33 | 0.35 | lasso | 3 | 0.36 | 3.2e-29 | 5.3 | 5.2 | 1.8e-07 | 0.56 | 0.06 | 0.94 | FALSE |
8 | GTEx | Artery Tibial | GAK | 0.19 | 0.03 | enet | 29 | 0.10 | 2.4e-08 | -3.0 | 6.0 | 2.1e-09 | 0.59 | 0.01 | 0.99 | FALSE |
9 | GTEx | Brain Caudate basal ganglia | SLC26A1 | 0.27 | 0.13 | lasso | 2 | 0.18 | 6.8e-06 | 5.3 | 5.1 | 2.8e-07 | 0.50 | 0.06 | 0.85 | FALSE |
10 | GTEx | Brain Cerebellar Hemisphere | SLC26A1 | 0.33 | 0.14 | lasso | 8 | 0.15 | 1.0e-04 | 5.3 | 5.5 | 3.1e-08 | 0.55 | 0.09 | 0.67 | FALSE |
11 | GTEx | Brain Cerebellum | SLC26A1 | 0.61 | 0.41 | enet | 22 | 0.46 | 2.1e-15 | 5.2 | 6.2 | 5.2e-10 | 0.57 | 0.07 | 0.93 | FALSE |
12 | GTEx | Brain Cortex | SLC26A1 | 0.45 | 0.35 | lasso | 3 | 0.33 | 6.9e-10 | 5.2 | 5.5 | 3.6e-08 | 0.54 | 0.06 | 0.93 | FALSE |
13 | GTEx | Brain Frontal Cortex BA9 | SLC26A1 | 0.30 | 0.24 | lasso | 3 | 0.15 | 8.0e-05 | 5.3 | 5.3 | 1.4e-07 | 0.56 | 0.06 | 0.82 | FALSE |
14 | GTEx | Breast Mammary Tissue | SLC26A1 | 0.34 | 0.31 | lasso | 4 | 0.29 | 2.7e-15 | 5.3 | 5.3 | 8.9e-08 | 0.62 | 0.06 | 0.94 | FALSE |
15 | GTEx | Breast Mammary Tissue (Male) | SLC26A1 | 0.17 | 0.24 | lasso | 1 | 0.19 | 4.4e-05 | 5.3 | 5.3 | 1.4e-07 | 0.56 | 0.05 | 0.54 | FALSE |
16 | GTEx | Cells Transformed fibroblasts | SLC26A1 | 0.36 | 0.22 | enet | 24 | 0.26 | 1.4e-19 | 5.3 | 5.3 | 8.7e-08 | 0.62 | 0.09 | 0.91 | FALSE |
17 | GTEx | Colon Sigmoid | SLC26A1 | 0.45 | 0.48 | lasso | 3 | 0.48 | 6.7e-19 | 5.3 | 5.4 | 8.4e-08 | 0.56 | 0.06 | 0.94 | FALSE |
18 | GTEx | Colon Transverse | SLC26A1 | 0.26 | 0.23 | lasso | 4 | 0.22 | 9.7e-11 | 5.2 | 5.2 | 1.9e-07 | 0.58 | 0.08 | 0.92 | FALSE |
19 | GTEx | Esophagus Gastroesophageal Junction | SLC26A1 | 0.44 | 0.33 | lasso | 6 | 0.35 | 1.8e-13 | 5.3 | 5.2 | 2.5e-07 | 0.44 | 0.07 | 0.93 | FALSE |
20 | GTEx | Esophagus Mucosa | SLC26A1 | 0.45 | 0.39 | enet | 15 | 0.40 | 2.5e-28 | 5.2 | 5.2 | 2.2e-07 | 0.52 | 0.07 | 0.93 | FALSE |
21 | GTEx | Esophagus Muscularis | SLC26A1 | 0.38 | 0.37 | lasso | 4 | 0.36 | 4.3e-23 | 5.3 | 5.5 | 4.9e-08 | 0.57 | 0.06 | 0.94 | FALSE |
22 | GTEx | Heart Atrial Appendage | SLC26A1 | 0.44 | 0.39 | lasso | 6 | 0.37 | 8.0e-18 | 4.9 | 5.3 | 8.8e-08 | 0.60 | 0.14 | 0.86 | FALSE |
23 | GTEx | Heart Left Ventricle | SLC26A1 | 0.22 | 0.13 | enet | 10 | 0.17 | 1.4e-09 | 5.2 | 5.3 | 1.2e-07 | 0.49 | 0.07 | 0.93 | FALSE |
24 | GTEx | Lung | SLC26A1 | 0.51 | 0.41 | lasso | 9 | 0.42 | 1.2e-34 | 5.3 | 5.4 | 5.9e-08 | 0.56 | 0.06 | 0.94 | FALSE |
25 | GTEx | Muscle Skeletal | DGKQ | 0.15 | 0.07 | enet | 15 | 0.09 | 6.6e-09 | 5.3 | 5.4 | 6.7e-08 | 0.57 | 0.06 | 0.94 | TRUE |
26 | GTEx | Muscle Skeletal | SLC26A1 | 0.16 | 0.12 | lasso | 6 | 0.12 | 1.7e-11 | 5.3 | 5.3 | 1.1e-07 | 0.63 | 0.07 | 0.93 | FALSE |
27 | GTEx | Nerve Tibial | SLC26A1 | 0.55 | 0.49 | lasso | 4 | 0.50 | 1.0e-40 | 5.2 | 5.3 | 9.7e-08 | 0.56 | 0.07 | 0.93 | FALSE |
28 | GTEx | Nerve Tibial | CPLX1 | 0.26 | 0.05 | lasso | 5 | 0.09 | 1.1e-06 | -5.3 | 5.4 | 5.6e-08 | 0.16 | 0.09 | 0.91 | FALSE |
29 | GTEx | Pituitary | SLC26A1 | 0.37 | 0.38 | enet | 14 | 0.33 | 3.9e-09 | 5.3 | 5.8 | 8.2e-09 | 0.65 | 0.06 | 0.93 | TRUE |
30 | GTEx | Skin Not Sun Exposed Suprapubic | SLC26A1 | 0.55 | 0.38 | lasso | 8 | 0.40 | 2.7e-23 | 5.2 | 5.2 | 1.5e-07 | 0.52 | 0.06 | 0.93 | FALSE |
31 | GTEx | Skin Sun Exposed Lower leg | SLC26A1 | 0.48 | 0.38 | lasso | 5 | 0.41 | 6.2e-36 | 5.2 | 5.2 | 2.3e-07 | 0.57 | 0.08 | 0.92 | FALSE |
32 | GTEx | Spleen | SLC26A1 | 0.35 | 0.19 | lasso | 4 | 0.25 | 4.7e-07 | 5.3 | 5.5 | 2.8e-08 | 0.56 | 0.08 | 0.86 | FALSE |
33 | GTEx | Stomach | SLC26A1 | 0.26 | 0.17 | enet | 14 | 0.16 | 4.0e-08 | 5.2 | 6.5 | 7.8e-11 | 0.63 | 0.06 | 0.94 | TRUE |
34 | GTEx | Thyroid | SLC26A1 | 0.53 | 0.46 | lasso | 8 | 0.46 | 1.3e-38 | 5.2 | 5.3 | 1.4e-07 | 0.58 | 0.06 | 0.93 | FALSE |
35 | GTEx | Vagina | SLC26A1 | 0.26 | 0.41 | lasso | 1 | 0.37 | 2.4e-09 | 5.3 | 5.3 | 1.4e-07 | 0.56 | 0.07 | 0.91 | FALSE |
36 | GTEx | Whole Blood | SLC26A1 | 0.07 | 0.05 | enet | 13 | 0.07 | 3.0e-07 | -4.4 | 5.3 | 9.3e-08 | 0.53 | 0.23 | 0.76 | TRUE |
37 | METSIM | Adipose | SLC26A1 | 0.16 | 0.13 | enet | 10 | 0.13 | 2.1e-18 | 5.2 | 5.5 | 4.4e-08 | 0.48 | 0.06 | 0.94 | FALSE |
38 | NTR | Blood | PCGF3 | 0.07 | 0.00 | enet | 33 | 0.02 | 7.7e-08 | 4.2 | 5.5 | 3.4e-08 | 0.27 | 0.36 | 0.58 | TRUE |
39 | ROSMAP | Brain Pre-frontal Cortex | DGKQ | 0.37 | 0.36 | lasso | 6 | 0.38 | 1.9e-51 | 5.2 | 5.3 | 9.1e-08 | 0.57 | 0.07 | 0.93 | FALSE |
40 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SLC26A1 | 0.05 | 0.01 | blup | 53 | 0.02 | 1.2e-02 | 4.1 | 5.5 | 5.1e-08 | 0.58 | 0.06 | 0.47 | FALSE |
41 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PCGF3 | 0.03 | 0.00 | blup | 69 | 0.01 | 3.7e-03 | 4.2 | 7.1 | 1.3e-12 | 0.34 | 0.02 | 0.40 | TRUE |
42 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PCGF3 | 0.08 | 0.02 | lasso | 4 | 0.07 | 1.9e-08 | -4.1 | 5.2 | 2.3e-07 | 0.14 | 0.03 | 0.86 | FALSE |
43 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PCGF3 | 0.13 | 0.00 | blup | 69 | 0.04 | 1.4e-02 | -5.3 | 5.6 | 1.8e-08 | 0.10 | 0.01 | 0.76 | FALSE |