Best TWAS P=6.02e-11 · Best GWAS P=9.69e-12 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DPYSL4 | 0.09 | 0.03 | enet | 16 | 0.05 | 9.9e-07 | 6.8 | 5.4 | 5.3e-08 | 0.80 | 0.00 | 1.00 | FALSE |
2 | GTEx | Cells Transformed fibroblasts | DPYSL4 | 0.53 | 0.39 | enet | 14 | 0.58 | 1.1e-52 | 6.8 | 5.4 | 6.5e-08 | 0.88 | 0.00 | 1.00 | FALSE |
3 | GTEx | Pituitary | DPYSL4 | 0.24 | 0.11 | lasso | 4 | 0.26 | 3.0e-07 | 3.6 | 5.9 | 3.5e-09 | 0.63 | 0.02 | 0.81 | FALSE |
4 | GTEx | Testis | STK32C | 0.46 | 0.42 | lasso | 6 | 0.42 | 3.4e-20 | 4.4 | -5.2 | 2.6e-07 | -0.09 | 1.00 | 0.00 | TRUE |
5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DPYSL4 | 0.19 | 0.30 | enet | 19 | 0.37 | 3.1e-79 | 6.5 | 5.4 | 8.5e-08 | 0.89 | 0.01 | 0.99 | FALSE |
6 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | DPYSL4 | 0.31 | 0.19 | lasso | 10 | 0.18 | 3.4e-09 | 6.5 | 6.2 | 5.0e-10 | 0.91 | 0.00 | 1.00 | FALSE |
7 | The Cancer Genome Atlas | Glioblastoma Multiforme | STK32C | 0.13 | -0.01 | blup | 107 | 0.08 | 1.6e-03 | 2.9 | -6.0 | 2.3e-09 | -0.35 | 0.04 | 0.07 | FALSE |
8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DPYSL4 | 0.16 | 0.24 | blup | 60 | 0.27 | 7.6e-31 | -5.9 | 5.3 | 1.5e-07 | 0.91 | 0.02 | 0.98 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DPYSL4 | 0.16 | 0.21 | enet | 16 | 0.24 | 7.1e-27 | 6.5 | 5.7 | 1.4e-08 | 0.91 | 0.00 | 1.00 | FALSE |
10 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | DPYSL4 | 0.17 | 0.24 | lasso | 3 | 0.23 | 2.4e-13 | 6.8 | 6.5 | 6.0e-11 | 0.98 | 0.00 | 1.00 | TRUE |
11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DPYSL4 | 0.13 | 0.12 | lasso | 7 | 0.16 | 3.1e-17 | 6.8 | 6.0 | 2.1e-09 | 0.93 | 0.00 | 1.00 | FALSE |
12 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | DPYSL4 | 0.13 | 0.11 | enet | 7 | 0.08 | 2.0e-04 | 6.5 | 6.5 | 7.2e-11 | 0.96 | 0.01 | 0.97 | FALSE |
13 | The Cancer Genome Atlas | Lung Adenocarcinoma | DPYSL4 | 0.17 | 0.16 | enet | 18 | 0.23 | 1.5e-26 | 6.8 | 5.7 | 1.2e-08 | 0.86 | 0.00 | 1.00 | FALSE |
14 | The Cancer Genome Atlas | Lung Adenocarcinoma | GPR123 | 0.05 | 0.00 | blup | 56 | 0.02 | 8.0e-04 | 3.7 | 6.2 | 7.2e-10 | 0.00 | 0.00 | 0.26 | TRUE |
15 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | DPYSL4 | 0.24 | 0.21 | lasso | 7 | 0.28 | 2.5e-19 | 6.5 | 5.3 | 1.0e-07 | 0.84 | 0.00 | 1.00 | FALSE |
16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DPYSL4 | 0.34 | 0.37 | enet | 15 | 0.46 | 2.2e-53 | -5.9 | 5.7 | 1.3e-08 | 0.92 | 0.01 | 0.99 | FALSE |
17 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | DPYSL4 | 0.27 | 0.07 | blup | 64 | 0.07 | 7.1e-03 | 6.5 | 5.4 | 8.5e-08 | 0.88 | 0.01 | 0.73 | FALSE |
18 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | DPYSL4 | 0.17 | 0.12 | blup | 64 | 0.11 | 1.3e-04 | -5.9 | 5.4 | 7.8e-08 | 0.85 | 0.02 | 0.96 | FALSE |
19 | The Cancer Genome Atlas | Thyroid Carcinoma | DPYSL4 | 0.30 | 0.24 | enet | 15 | 0.38 | 1.7e-38 | 2.2 | 5.3 | 1.5e-07 | 0.77 | 0.01 | 0.99 | FALSE |