TWAS
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Traits
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Whole body fat mass
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chr12:49,569,311-50,991,370
Best TWAS P=5.52e-16 · Best GWAS P=1.69e-29 conditioned to 5.35e-08
49.6M
49.8M
50M
50.2M
50.4M
50.6M
50.8M
51M
0
5
10
15
20
25
30
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Testis
FAIM2
0.27
0.09
lasso
5
0.06
0.00093
8.937
-8.1
5.5e-16
-0.77
0.04
0.85
TRUE
2
The Cancer Genome Atlas
Breast Invasive Carcinoma
FAIM2
0.02
0.00
blup
71
0.01
0.00853
0.017
-6.0
1.4e-09
-0.36
0.16
0.13
TRUE