TWAS
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Usage
Models
Genes
Traits
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Traits
:
Whole body fat mass
:
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chr13:30,336,006-31,886,850
Best TWAS P=1.31e-08 · Best GWAS P=9.42e-10 conditioned to 0.0214
30.4M
30.6M
30.8M
31M
31.2M
31.4M
31.6M
31.8M
0
2
4
6
8
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Breast Mammary Tissue
HMGB1
0.26
0.02
lasso
6
0.03
9.1e-03
-6.1
5.7
1.3e-08
-0.90
0.00
0.98
TRUE
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
HMGB1
0.08
0.04
lasso
1
0.04
6.9e-05
-5.4
5.4
8.0e-08
-0.78
0.04
0.94
FALSE
2
GTEx
Muscle Skeletal
HMGB1
0.21
0.05
lasso
6
0.08
7.1e-08
-5.0
5.3
1.3e-07
-0.74
0.04
0.96
FALSE