TWAS
hub
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Usage
Models
Genes
Traits
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Traits
:
Whole body fat mass
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chr16:52,772,129-54,846,383
Best TWAS P=9.34e-35 · Best GWAS P=9.21e-140 conditioned to 3.08e-70
53M
53.5M
54M
54.5M
0
50
100
150
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
GTEx
Testis
AKTIP
0.19
0.00
enet
26
0.00
1.9e-01
1.2
12.3
9.3e-35
0.51
0.03
0.40
TRUE
1
CommonMind
Brain Pre-frontal Cortex
FTO
0.11
0.00
bslmm
739
0.02
1.6e-03
-1.5
11.8
2.9e-32
0.38
0.09
0.55
TRUE
4
The Cancer Genome Atlas
Glioblastoma Multiforme
FTO
0.27
0.16
enet
13
0.14
6.7e-05
-1.8
9.7
3.8e-22
0.33
0.11
0.32
TRUE
2
GTEx
Muscle Skeletal
RBL2
0.11
0.00
lasso
5
0.00
2.9e-01
2.0
-5.4
8.1e-08
-0.10
0.28
0.23
FALSE