TWAS hub - FTO

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.110	0.032	1.4e-04	0.005	0.020	0.006	0.02	0.007	7.9e-02	1.7e-03	5.9e-02	0.0016	4.7e-02
2	TCGA	Glioblastoma Multiforme	0.271	0.095	5.1e-03	0.158	0.121	0.135	NA	0.114	1.6e-05	1.6e-04	6.7e-05	NA	2.5e-04
3	TCGA	Brain Lower Grade Glioma	0.090	0.028	6.4e-05	0.075	0.046	0.072	NA	0.067	7.5e-09	5.5e-06	1.4e-08	NA	4.6e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
BMI	33.8	196.0	309.8	17.6	15.9	5.0
Comparative body size at age 10	27.3	75.5	144.0	12.0	9.1	0.7
Body mass index (BMI)	25.2	107.5	174.8	13.2	11.7	3.4
Leg fat mass (right)	23.4	90.6	153.8	12.4	10.4	3.1
Arm fat mass (left)	22.6	92.8	158.8	12.6	10.5	3.1
Leg fat mass (left)	22.6	88.3	148.8	12.2	10.3	3.1
Hip circumference	22.2	95.7	163.8	12.8	10.7	3.0
Arm fat mass (right)	22.0	90.4	158.8	12.6	10.2	2.9
Weight	21.0	103.3	187.7	13.7	10.8	2.3
Waist circumference	19.7	72.3	110.2	10.5	9.9	2.8
Whole body fat mass	19.2	80.3	139.2	11.8	9.7	2.8
Arm fat percentage (left)	16.7	66.5	108.2	10.4	9.1	2.9
Trunk fat mass	16.2	69.5	121.0	11.0	9.0	2.7
Leg fat-free mass (left)	16.1	85.1	158.8	12.6	9.8	1.3
Leg predicted mass (left)	16.1	85.2	158.8	12.6	9.8	1.3
Arm fat percentage (right)	15.5	61.2	106.1	10.3	8.4	2.6
Leg fat percentage (right)	15.5	56.2	88.0	9.4	8.5	2.9
Basal metabolic rate	15.4	85.5	163.8	12.8	9.6	1.1
Impedance of whole body	15.4	78.1	148.8	-12.2	-9.2	-1.1
Leg fat percentage (left)	14.8	53.4	80.6	9.0	8.4	2.9
Arm fat-free mass (left)	14.8	75.1	146.4	12.1	8.9	0.5
Arm predicted mass (left)	14.5	73.7	141.6	11.9	8.9	0.7
Impedance of leg (left)	14.4	69.9	132.2	-11.5	-8.8	-0.8
Leg predicted mass (right)	14.1	75.2	139.2	11.8	9.2	1.1
Arm fat-free mass (right)	14.0	72.0	134.6	11.6	9.0	0.7
Arm predicted mass (right)	14.0	71.7	132.2	11.5	9.1	0.6
Leg fat-free mass (right)	14.0	74.8	136.9	11.7	9.3	1.1
Body Mass Index (BMI) (2010)	13.6	18.6	43.1	6.6	3.5	0.9
Body fat percentage	13.3	52.5	82.8	9.1	8.1	2.9
Whole body water mass	13.3	75.9	148.8	12.2	8.9	0.5
Whole body fat-free mass	13.0	74.1	144.0	12.0	8.8	0.4
Impedance of leg (right)	12.7	61.7	112.4	-10.6	-8.5	-1.0
Impedance of arm (left)	11.9	55.3	98.8	-9.9	-8.1	-1.4
Impedance of arm (right)	11.7	54.7	92.4	-9.6	-8.3	-1.5
Trunk fat percentage	11.5	45.9	74.3	8.6	7.4	2.8
Trunk predicted mass	10.8	61.6	127.7	11.3	7.6	-0.0
Trunk fat-free mass	10.6	60.7	125.4	11.2	7.5	-0.1
Type 2 Diabetes (T2D) (2018)	6.9	13.0	20.4	3.6	4.5	2.3
Medication: Atorvastatin	6.1	7.5	8.1	2.8	2.8	2.6
Type 2 Diabetes (T2D) (2012)	5.7	6.5	9.9	3.1	2.4	2.0
Age when periods started (menarche)	5.5	13.3	24.6	-5.0	-3.8	0.9
Illnesses of siblings: Diabetes	5.5	6.8	9.7	3.1	2.2	2.4
Breast cancer (self-reported)	5.1	6.0	14.9	-3.9	-1.7	-0.4
Average weekly red wine intake	4.9	7.2	14.5	2.7	3.8	0.1
Relative age of first facial hair	4.6	9.5	14.0	-3.7	-3.5	-1.6
Chronotype (morning person)	4.4	10.3	20.4	4.5	2.2	-2.3
Shortness of breath walking on level ground	4.4	5.2	9.2	3.0	1.6	1.9
Prostate Cancer	4.3	6.0	9.9	-3.2	-1.1	-2.6
Alcohol intake frequency.	4.1	9.5	13.3	3.4	1.9	3.6
Neuroticism	4.0	9.7	12.4	3.5	3.0	2.8
Sensitivity / hurt feelings	3.8	6.6	13.6	3.7	2.0	1.4
Breast Cancer	3.7	8.8	21.7	4.7	0.8	-2.0
Depressed Affect (Nagel 2018)	3.6	7.6	11.8	3.4	2.9	1.7
Relative age voice broke	3.6	5.4	12.5	-3.5	-1.9	-0.1
Qualifications: NVQ or HND or HNC or equivalent	3.5	4.2	8.3	-2.9	-1.5	-1.4
Diabetes (father)	3.4	4.1	6.6	2.6	2.4	0.1
Commuting to job workplace: Walk	3.4	3.7	6.6	-1.9	-2.6	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	3.3	7.6	14.0	1.7	3.7	2.4
Health satisfaction	3.2	4.2	8.7	2.9	1.1	1.6
Osteoporosis (self-reported)	3.2	4.0	6.3	-2.0	-2.5	-1.2
Medication for hormone replacement therapy	3.1	3.5	8.4	-1.4	-2.9	-0.3
Diabetes diagnosed by doctor	3.1	5.1	10.2	1.9	3.2	1.3
Hair/balding pattern: Pattern 2	3.0	3.8	10.5	-1.0	-3.2	-0.0
Rheumatoid Arthritis	2.9	4.0	9.7	-3.1	-1.2	-1.0
Cardiovascular Disease	2.8	9.4	16.3	4.0	3.4	0.5
Neuroticism (Nagel 2018)	2.7	6.4	11.2	3.4	2.1	1.8
Smoking Status	2.7	6.4	9.1	1.6	2.8	3.0
Average weekly spirits intake	2.7	3.3	5.4	2.3	2.1	-0.1
Fed-up feelings	2.7	4.8	7.0	2.6	2.6	0.9
Hayfever, allergic rhinitis or eczema	2.7	5.8	10.4	-2.1	-1.6	-3.2
Supplements: Glucosamine	2.6	3.4	5.2	1.8	1.3	2.3
Medication: Metformin	2.5	3.5	6.7	1.5	2.6	1.2
Age at last live birth	2.5	3.6	9.1	-0.2	3.0	1.3
Average weekly beer plus cider intake	2.5	3.7	9.0	-3.0	-0.6	1.3
Alzheimer’s Disease (including proxy)	2.4	3.4	6.1	0.0	2.1	2.5
Vitamin and mineral supplements	2.4	3.3	6.5	-0.6	2.5	1.7
Illnesses of mother	2.4	3.0	5.7	-1.4	-2.4	-1.2
Blood clot in the leg (DVT)	2.4	3.1	6.5	2.5	1.2	1.1
Commuting to job workplace: Car/motor vehicle	2.4	2.8	4.0	1.4	1.5	2.0
Medication: Gliclazide	2.4	2.7	5.7	1.4	2.4	0.7
Alzheimer’s Disease (in mother)	2.3	2.7	5.0	-0.4	1.7	2.2
Medication: Co-codamol	2.3	2.7	6.8	2.6	-1.1	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	2.3	5.4	7.7	1.9	2.8	2.2
Chronic bronchitis/emphysema (mother)	2.3	2.6	4.6	-0.2	1.8	2.1
Worry too long after embarrassment	2.3	3.9	9.9	3.1	1.1	0.8
Qualifications: nursing, teaching	2.3	3.6	6.5	2.6	2.0	0.1
Alcohol drinker status: Never	2.3	2.7	4.1	-0.1	2.0	2.0
Risk taking	2.3	3.3	9.3	-3.1	0.1	-0.8
Ever used hormone-replacement therapy (HRT)	2.2	2.8	4.5	-1.3	-2.1	-1.5
Diverticular disease/diverticulitis (self-reported)	2.2	2.7	7.1	-2.7	0.1	0.9
Diabetes (self-reported)	2.2	3.4	7.7	1.4	2.8	0.7
Neuroticism score	2.2	4.6	7.8	2.8	1.8	1.7
Serious illness, injury or assault of a close relative in last 2 years	2.2	2.5	5.1	0.4	2.2	1.5
Ever smoked	2.2	3.9	6.5	2.5	2.1	0.9
Diabetes (mother)	2.1	2.7	7.4	2.7	0.8	-0.0
Pulse rate	2.0	3.3	6.8	-1.6	-2.6	-0.7
Medication: Blood pressure	2.0	3.5	6.1	2.5	2.0	-0.4
Loneliness, isolation	2.0	2.7	3.3	1.8	1.8	1.2
Ever had hysterectomy (womb removed)	1.9	2.2	5.9	-2.4	-0.7	-0.3
Smoking status: Current	1.9	3.0	5.2	0.8	2.3	1.8
Supplements: Zinc	1.8	2.0	4.8	-2.2	-0.5	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.3	3.3	1.3	1.3	1.8
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	4.7	2.2	1.1	1.0
Heel T-Score	1.7	13.3	23.4	2.3	4.8	3.4
Waist Hip Ratio (WHR)	1.7	7.6	22.0	-4.7	-0.5	0.6
Allergy or Eczema	1.7	4.6	10.4	-1.3	-1.3	-3.2
Townsend deprivation index at recruitment	1.7	2.4	5.6	-1.0	-0.7	-2.4
Maternal smoking around birth	1.7	2.5	4.4	-1.7	0.3	2.1
Worrier / anxious feelings	1.7	3.1	7.4	2.7	0.6	1.3
Overall health rating	1.7	3.6	8.7	3.0	0.9	1.1
Medication: Bendroflumethiazide	1.7	2.5	6.4	2.5	1.0	0.5
Neuroticism (2016)	1.6	2.3	6.2	2.5	0.8	0.4
Blood White Count	1.6	12.1	14.0	3.7	3.7	2.9
Systolic blood pressure, automated reading	1.6	4.7	9.9	3.2	-1.8	-1.0
Alcohol usually taken with meals	1.6	2.6	4.4	2.1	1.8	0.3
Medication for cholesterol, blood pressure or diabetes	1.6	2.7	3.2	-1.8	-1.6	1.5
Hypothyroidism/myxoedema (self-reported)	1.6	3.0	4.5	0.9	-1.9	-2.1
Comparative height size at age 10	1.6	8.7	15.1	3.9	0.3	-3.3
Illness, injury, bereavement, stress in last 2 years	1.6	2.0	3.6	-0.2	-1.9	-1.5
Long-standing illness, disability or infirmity	1.6	2.4	3.8	2.0	1.3	1.3
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	3.1	1.1	1.8	0.8
Multivitamins +/- minerals	1.5	2.0	2.3	1.5	-1.4	-1.3
Medication: Amlodipine	1.5	2.0	3.3	1.8	1.7	0.0
Knee pain experienced in last month	1.5	2.3	6.0	2.5	-0.5	-0.8
Hypertension (Self-reported)	1.5	4.2	7.8	2.8	2.2	0.0
Medication: Lisinopril	1.5	2.0	5.3	0.5	-0.6	-2.3
High blood pressure	1.4	4.0	7.9	2.8	2.0	0.1
Past tobacco smoking	1.4	2.5	4.7	-2.2	-1.4	-0.9
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	5.3	0.8	2.3	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	2.9	0.4	-1.4	1.7
Mean Putamen Volume	1.3	1.5	2.9	0.6	1.7	1.1
Medication: Simvastatin	1.3	1.8	3.4	1.4	-0.2	-1.9
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	3.7	-0.3	1.0	1.9
Lung cancer (father)	1.3	1.5	3.0	-1.1	-0.6	1.7
Age at first live birth	1.3	2.3	6.4	0.4	2.5	0.7
Medication: Omeprazole	1.3	1.5	3.1	1.1	1.8	0.6
Medication: Paracetamol	1.3	2.0	4.6	1.2	-0.3	-2.1
Age started oral contraceptive pill	1.3	1.6	3.9	2.0	0.6	-0.7
Vascular/heart problems diagnosed by doctor	1.3	3.4	7.1	-2.7	-1.6	0.8
Medication: Omeprazole (e.g. Zanprol)	1.3	1.5	4.0	0.4	2.0	0.7
Major Depression (MDD)	1.2	1.4	4.1	2.0	0.2	-0.4
Current tobacco smoking	1.2	2.0	3.6	0.2	1.9	1.5
Mean time to correctly identify matches	1.2	2.2	5.6	-0.2	-2.4	-1.0
Illnesses of father: None of the above (group 1)	1.2	1.5	2.7	-1.7	0.1	1.3
Intelligence (Savage-Jansen 2018)	1.1	3.4	6.6	2.6	1.8	0.6
Crohns Disease (2017)	1.1	2.4	4.6	1.4	-0.8	-2.1
HDL Cholesterol	1.1	1.8	4.6	-0.3	-2.1	-0.9
Hearing difficulty/problems: Yes	1.1	1.7	3.9	-0.8	-2.0	0.7
Medication: Levothyroxine sodium	1.1	1.8	3.4	1.3	-0.7	-1.8
Chronic bronchitis/emphysema (father)	1.1	1.3	3.6	-1.9	0.1	0.6
Financial difficulties in last 2 years	1.1	1.4	2.8	0.3	1.7	1.2
Depression (self-reported)	1.1	1.3	2.6	1.6	-0.3	1.1
Length of working week for main job	1.1	1.2	2.5	-1.0	-0.3	1.6
Mood swings	1.1	1.9	4.5	2.1	1.1	0.2
Medication: Aspirin	1.1	1.5	1.6	1.3	1.2	1.2
Fractured/broken bones in last 5 years	1.1	1.4	4.2	-2.1	0.0	0.2
Unable to work because of sickness or disability	1.1	1.4	2.1	1.3	-0.7	1.4
Depression (Nagel 2018)	1.0	1.5	2.1	1.5	1.2	1.0
Alzheimer’s Disease (in father)	1.0	1.1	2.5	0.5	1.6	-0.7
Coronary Artery Disease (CAD)	1.0	1.2	2.3	-1.5	1.0	0.5
Systolic Blood Pressure	1.0	4.9	11.0	1.0	-3.3	-1.7
Frequency of depressed mood in last 2 weeks	1.0	1.5	2.5	1.6	1.3	-0.3
Qualifications: A levels/AS levels or equivalent	1.0	2.1	5.8	0.7	2.4	-0.3
Breastfed as a baby	1.0	1.2	1.5	-1.2	-0.8	-1.2
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.1	0.6	0.4	1.8
Gout (self-reported)	1.0	1.3	2.1	0.6	1.4	1.3
Medication: Ibuprofen	1.0	1.2	2.4	-0.5	1.6	0.9
Leg pain on walking	1.0	1.2	3.1	1.8	-0.0	0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	5.3	0.8	-0.5	-2.3
Crohns Disease (2012)	0.9	1.4	4.2	-0.1	-0.3	-2.0
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.2	1.5	-1.0	0.2
Allergy	0.9	2.0	4.1	1.1	0.8	2.0
Peak expiratory flow (PEF)	0.9	2.0	3.6	1.6	1.9	0.3
Exposure to tobacco smoke outside home	0.9	1.3	3.2	0.1	1.8	0.8
Number of full brothers	0.9	1.2	1.7	-1.2	0.6	1.3
Number of children fathered	0.9	1.0	1.6	1.3	0.8	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	1.6	-1.3	1.1	-0.4
Handedness (chirality/laterality): Left-handed	0.9	1.1	3.0	0.6	1.7	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	3.4	-0.9	-0.4	1.9
Wears glasses or contact lenses	0.9	1.1	2.1	-0.4	-1.5	-1.0
Medication: Blood pressure	0.9	1.7	4.8	2.2	0.5	-0.3
Commuting to job workplace: Cycle	0.9	1.1	2.1	1.1	1.4	-0.0
Bipolar Disorder (2011)	0.8	0.8	1.4	-0.9	-1.2	0.4
Number of treatments/medications taken	0.8	1.5	2.2	1.5	-0.2	-1.5
Father’s age at death	0.8	1.1	2.8	-1.7	-0.7	0.1
Medication: Cholesterol lowering	0.8	1.2	2.2	0.8	0.9	-1.5
Pulse wave reflection index	0.8	1.0	2.7	0.3	1.6	-0.5
High blood pressure (siblings)	0.8	1.2	2.3	1.5	1.1	0.1
Wheeze or whistling in the chest in last year	0.8	1.4	2.0	1.3	0.5	1.4
Commuting to job workplace: Public transport	0.8	0.9	2.7	-0.2	0.1	-1.6
Pain type(s) experienced in last month: Hip pain	0.8	0.9	2.0	-0.3	1.4	0.8
High cholesterol (Self-reported)	0.8	1.4	2.2	1.5	0.3	-1.4
Number of operations (self-reported)	0.8	1.1	2.3	-0.9	-1.5	-0.6
Cholesterol lowering medication	0.8	1.2	2.7	1.6	0.9	-0.1
Bipolar Disorder (2018)	0.7	1.1	1.8	-1.2	0.1	1.4
Triglycerides	0.7	1.2	2.5	0.1	1.1	1.6
Hypothyroidism (self reported)	0.7	1.6	3.4	0.3	-1.9	-1.2
Hand grip strength (right)	0.7	2.0	2.9	0.6	1.6	1.7
Medication: Atenolol	0.7	0.9	1.3	1.1	1.2	-0.6
Medication: Ramipril	0.7	0.9	2.2	1.5	0.0	-0.7
Happiness	0.7	0.8	2.0	1.4	0.6	0.1
Mouth/teeth dental problems: Dentures	0.7	1.3	2.8	1.7	0.5	-0.9
Exposure to tobacco smoke at home	0.7	0.8	1.0	-0.7	1.0	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.8	1.7	0.0	0.5
Medication: Paracetamol	0.7	1.2	1.9	0.6	-1.4	-1.2
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.5	0.6	1.2	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.4	1.0	1.2	0.0
Emphysema/chronic bronchitis	0.7	0.8	1.4	-1.2	-0.3	0.9
Angina (self-reported)	0.7	0.9	1.3	1.2	0.9	0.7
Heart disease (mother)	0.7	0.9	1.6	0.7	1.2	-0.7
Smoking status: Previous	0.7	1.0	2.9	1.7	0.4	0.1
Ever taken oral contraceptive pill	0.7	0.8	2.1	-0.5	0.4	1.4
Financial situation satisfaction	0.7	0.9	2.3	0.6	0.3	1.5
Illnesses of father: High blood pressure	0.7	0.9	2.4	0.5	0.0	-1.6
Ever depressed for a whole week	0.7	0.8	1.3	1.1	0.1	1.1
Alcohol drinker status: Previous	0.7	0.8	1.2	0.4	-1.0	1.1
Irritable Bowel Disease (IBD)	0.6	1.4	2.9	1.7	0.1	-1.1
Reaction Time	0.6	1.2	3.6	-0.1	-1.9	0.2
Verbal and Numeric Reasoning (VNR)	0.6	1.4	2.1	1.4	1.5	-0.1
Fasting Glucose	0.6	0.8	1.5	-0.3	-0.9	-1.2
HbA1C	0.6	0.6	0.9	0.9	0.9	-0.3
Lung FEV1/FVC ratio	0.6	2.8	3.6	1.6	1.9	1.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.1	-1.1	0.4	-0.8
Serious illness, injury or assault to yourself	0.6	0.8	2.1	-0.4	-0.3	1.5
Stomach or abdominal pain in last month	0.6	0.7	1.6	0.7	0.4	1.3
Had menopause	0.6	0.8	1.6	-0.4	-0.8	-1.3
Pain all over the body in last month	0.6	0.7	1.0	1.0	0.4	1.0
Illnesses of siblings	0.6	0.9	1.9	-1.4	-0.4	-0.7
Asthma	0.6	1.2	3.6	-1.9	-0.1	0.0
Medication: Aspirin	0.6	0.8	1.3	1.2	0.6	0.8
Back pain experienced in last month	0.6	0.8	1.6	0.6	0.7	-1.3
Number of self-reported non-cancer illnesses	0.6	1.1	2.9	1.7	-0.3	0.5
Heart disease (siblings)	0.6	0.7	1.7	1.3	-0.0	0.6
Worry (Nagel 2018)	0.5	1.0	1.6	1.3	-0.3	1.1
Age at First Birth	0.5	0.8	0.9	1.0	1.0	-0.7
Lung FVC	0.5	2.5	4.0	-2.0	-1.7	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.5	1.6	-0.1	0.1
Hearing difficulty/problems with background noise	0.5	0.9	2.1	-0.3	-1.4	0.7
Qualifications: None of the above	0.5	1.0	1.6	1.1	-0.3	1.3
Medication: Lansoprazole	0.5	0.5	0.9	-1.0	-0.7	-0.4
Prospective memory result	0.5	0.6	1.0	0.5	0.8	1.0
Birth weight	0.5	1.0	2.1	1.0	-0.1	-1.4
Migraine (self-reported)	0.5	0.6	1.4	-1.2	0.1	0.7
Medication: Allopurinol	0.5	0.7	1.8	1.4	0.2	0.5
Medication: Seretide 50 evohaler	0.5	0.6	0.6	-0.8	0.7	0.7
Family relationship satisfaction	0.5	0.6	1.2	-0.4	0.6	1.1
Friendships satisfaction	0.5	0.6	1.2	0.0	0.7	1.1
Asthma (self-reported)	0.5	1.1	3.2	-1.8	-0.0	0.2
Osteoarthritis (self-reported)	0.5	0.7	1.7	-1.3	-0.5	-0.3
Average weekly champagne plus white wine intake	0.5	0.7	1.3	1.1	0.6	-0.7
Guilty feelings	0.5	0.8	1.0	0.8	0.9	1.0
Supplements: Calcium	0.5	0.6	1.3	-0.7	-1.1	-0.1
Bipolar Disorder or Schizophrenia	0.4	1.0	1.5	-1.2	0.6	1.0
Schizophrenia vs Biploar Disorder	0.4	0.5	1.6	-0.0	0.3	-1.2
Height	0.4	8.0	10.2	3.0	-2.2	-3.2
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.7	0.3	-0.8	0.8
Angina	0.4	0.6	0.7	0.9	0.6	0.7
Severe depression (siblings)	0.4	0.5	1.3	-0.3	1.1	0.1
Average weekly fortified wine intake	0.4	0.5	1.5	0.0	0.3	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.8	0.8	0.9	-0.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.1	-0.0	-1.1	0.2
Sitting height	0.4	2.5	5.0	2.2	1.2	1.0
Number of incorrect matches in round	0.4	0.6	0.7	-0.9	-0.6	-0.8
Nervous feelings	0.4	0.8	2.4	0.2	-1.5	0.0
Had other major operations	0.4	0.4	1.1	0.0	0.5	1.0
Heart attack	0.4	0.5	0.9	-0.2	-1.0	-0.7
Fluid intelligence score	0.4	0.9	1.8	0.9	1.3	0.1
Alcohol intake versus 10 years previously	0.4	0.6	0.9	-0.0	0.9	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.1	1.0	0.7	0.7
Qualifications: College or University degree	0.4	1.3	2.1	0.8	1.1	-1.4
Pulse rate, automated reading	0.4	1.4	2.6	-1.2	-1.6	-0.3
Number of full sisters	0.4	0.5	1.4	-0.3	-0.3	1.2
Chest pain or discomfort	0.4	0.6	1.4	-0.6	0.3	1.2
Supplements: Vitamin C	0.4	0.5	0.7	-0.4	-0.8	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.2	1.1	-0.2	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.2	0.0	-0.0	1.1
Mineral and other dietary supplements	0.4	0.5	0.8	0.5	0.8	-0.9
Mother’s age at death	0.4	0.5	1.2	0.6	-1.1	0.2
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.9	1.0	-0.8	0.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.3	-0.1	-0.5	1.1
Irritability	0.4	0.7	0.9	0.9	0.7	0.9
Diastolic blood pressure, automated reading	0.4	1.1	1.5	0.7	-1.2	-1.1
Ovarian Cancer	0.3	0.4	0.6	-0.8	-0.5	0.6
LDL Cholesterol	0.3	0.4	0.8	-0.3	-0.9	-0.6
Schizophrenia (2014)	0.3	0.8	1.6	-1.3	0.6	0.5
Blood Red Count	0.3	2.7	7.3	2.7	0.7	-0.3
Respiratory disease	0.3	0.6	1.5	-0.5	0.1	1.2
Hand grip strength (left)	0.3	0.9	1.4	0.3	1.2	1.0
Pack years adult smoking proportion	0.3	0.5	1.4	0.3	-0.2	1.2
Mouth/teeth dental problems	0.3	0.5	0.9	-0.1	-0.7	-0.9
Time employed in main current job	0.3	0.3	0.7	-0.5	0.8	-0.3
Falls in the last year	0.3	0.4	0.9	0.9	-0.1	-0.5
Hair/balding pattern: Pattern 3	0.3	0.4	0.7	-0.9	0.5	0.4
Number of live births	0.3	0.5	0.6	-0.7	-0.6	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	2.3	1.5	0.3	-0.2
Pulse wave Arterial Stiffness index	0.3	0.4	0.8	-0.1	0.9	-0.5
Standing height	0.3	3.4	6.7	2.6	-0.4	-1.9
Hair/balding pattern: Pattern 4	0.3	0.7	1.2	-0.2	1.1	1.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.4	0.6	0.6	0.7
Eye problems/disorders: None of the above	0.3	0.3	0.7	0.8	0.2	-0.4
Neck or shoulder pain in last month	0.3	0.4	0.7	0.5	-0.5	-0.8
Suffer from ‘nerves’	0.3	0.5	1.2	0.6	-1.1	0.1
Ever had bowel cancer screening	0.3	0.3	0.9	1.0	-0.2	-0.1
Myopia	0.3	0.4	1.0	0.4	0.4	-1.0
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.6	0.1	-0.8	-0.7
Pack years of smoking	0.3	0.4	0.9	0.4	-0.4	1.0
Schizophrenia (2018)	0.2	0.3	0.5	-0.7	0.7	0.2
Ulcerative Colitis (UC)	0.2	0.3	0.9	1.0	0.3	-0.1
Ulcerative Colitis	0.2	0.3	0.7	-0.2	0.5	0.8
Blood Eosinophil Count	0.2	1.9	4.1	-0.6	1.1	2.0
Blood Platelet Count	0.2	2.1	4.8	-2.2	-0.4	-1.1
Hair Pigment	0.2	5.8	12.4	0.2	-2.2	-3.5
Tanning	0.2	2.4	4.9	0.2	-1.5	-2.2
Qualifications: CSEs or equivalent	0.2	0.3	0.5	0.7	0.2	0.5
Birth weight of first child	0.2	0.4	0.8	0.9	0.1	-0.6
Headache pain in last month	0.2	0.3	0.4	-0.2	-0.6	0.6
Forced vital capacity (FVC), Best measure	0.2	0.8	1.2	0.9	-0.6	-1.1
Pulse wave peak to peak time	0.2	0.3	0.5	0.4	-0.7	0.4
Had major operations	0.2	0.2	0.3	0.5	-0.2	-0.5
Illnesses of father: Heart disease	0.2	0.3	0.6	0.5	0.2	-0.7
Eye problems/disorders: Cataract	0.2	0.3	0.6	-0.5	-0.8	-0.0
Medication for cholesterol	0.2	0.3	0.5	-0.7	0.7	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.7	0.6	0.0	-0.8
Miserableness	0.2	0.4	0.7	0.8	0.1	-0.8
Eye problems/disorders: Glaucoma	0.2	0.3	0.5	-0.3	-0.7	0.5
Pain experienced in last month	0.2	0.4	0.5	-0.6	0.6	0.7
Basal cell carcinoma (self-reported)	0.2	0.2	0.3	0.5	-0.4	0.5
Lupus	0.1	0.2	0.3	0.4	-0.6	-0.0
Primary Biliary Cirrhosis	0.1	0.2	0.6	0.1	0.8	-0.2
Forced vital capacity (FVC)	0.1	0.3	1.0	0.2	-1.0	-0.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.1	-0.2	0.3	0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.6	0.8	0.1	0.4
Tense / ‘highly strung’	0.1	0.1	0.3	-0.0	0.2	0.6
Loud music exposure frequency	0.1	0.1	0.2	0.4	-0.2	0.3
Glaucoma (self-reported)	0.1	0.1	0.2	-0.5	-0.4	-0.1
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	0.2	-0.5	0.1
Medication for pain relief, constipation, heartburn	0.1	0.1	0.2	-0.4	0.2	-0.2
Hearing aid user	0.1	0.1	0.2	-0.2	-0.5	0.0
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.4	0.2	0.6	-0.3
Taking other prescription medications	0.0	0.1	0.2	0.4	-0.1	0.2
High blood pressure (mother)	0.0	0.0	0.0	0.1	0.2	-0.1
Noisy workplace	0.0	0.0	0.1	-0.2	-0.2	0.0

Hub : Genes

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Trait associations