Best TWAS P=4.43e-08 · Best GWAS P=1.83e-10 conditioned to 0.00039
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Colon Sigmoid | MAP2K2 | 0.20 | 0.11 | lasso | 3 | 0.13 | 3.0e-05 | -5.0 | -5.5 | 4.4e-08 | 0.71 | 0.02 | 0.85 | TRUE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | PIAS4 | 0.14 | 0.12 | lasso | 6 | 0.11 | 1.6e-13 | -5.2 | -5.2 | 2.1e-07 | 0.66 | 0.64 | 0.36 | FALSE |