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chr19:17,512,412-19,190,906

Best TWAS P=2.41e-17 · Best GWAS P=1.92e-18 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	MAST3	0.02	0.02	lasso	3	0.01	1.5e-02	8.4	-8.5	2.4e-17	-0.95	0.01	0.93	TRUE
11	ROSMAP	Brain Pre-frontal Cortex	JUND	0.17	0.17	lasso	5	0.20	2.7e-25	6.9	5.9	3.9e-09	0.13	1.00	0.00	TRUE
23	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CRTC1	0.33	0.08	lasso	5	0.12	3.6e-05	-4.2	-5.9	4.0e-09	0.04	0.04	0.52	TRUE
26	The Cancer Genome Atlas	Thyroid Carcinoma	MAST3	0.04	0.02	lasso	2	0.00	3.4e-01	8.4	-8.4	3.8e-17	-0.95	0.02	0.86	FALSE
12	YFS	Blood	MAST3	0.06	0.04	lasso	5	0.04	4.2e-12	8.5	-8.1	7.4e-16	-0.56	0.04	0.96	FALSE
15	The Cancer Genome Atlas	Glioblastoma Multiforme	JUND	0.17	0.00	blup	57	0.03	5.4e-02	6.9	7.1	1.2e-12	0.25	0.01	0.59	FALSE
24	The Cancer Genome Atlas	Testicular Germ Cell Tumors	IL12RB1	0.10	0.01	enet	10	0.06	2.6e-03	2.0	-7.1	1.4e-12	-0.62	0.02	0.56	FALSE
7	GTEx	Thyroid	KIAA1683	0.11	0.07	enet	14	0.12	2.1e-09	4.5	7.0	1.8e-12	0.23	0.58	0.41	FALSE
19	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	JUND	0.11	0.03	blup	58	0.04	1.4e-03	-3.9	7.0	3.2e-12	0.22	0.04	0.08	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	JUND	0.05	0.04	lasso	1	0.04	4.3e-05	6.9	6.9	3.9e-12	0.20	0.14	0.13	FALSE
8	GTEx	Vagina	LRRC25	0.63	0.02	enet	2	0.04	5.3e-02	6.9	-6.9	4.1e-12	-0.20	0.04	0.14	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAST3	0.04	0.02	blup	65	0.01	7.3e-02	8.5	-6.9	6.9e-12	-0.53	0.01	0.30	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	JUND	0.04	0.03	lasso	2	0.02	7.9e-04	6.9	6.8	7.9e-12	0.19	0.19	0.04	FALSE
9	NTR	Blood	IFI30	0.03	0.02	lasso	6	0.02	8.8e-08	8.0	6.4	2.0e-10	0.31	0.15	0.85	FALSE
22	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IL12RB1	0.07	0.04	blup	58	0.06	4.9e-07	5.1	-6.3	2.8e-10	-0.57	0.88	0.10	FALSE
6	GTEx	Testis	AC068499.10	0.38	0.41	lasso	3	0.40	6.8e-19	-6.0	-6.1	1.2e-09	-0.41	1.00	0.00	FALSE
5	GTEx	Testis	PDE4C	0.39	0.44	lasso	2	0.43	5.8e-21	-6.0	-6.0	2.4e-09	-0.39	1.00	0.00	FALSE
2	GTEx	Colon Transverse	KIAA1683	0.15	0.02	lasso	3	0.02	3.3e-02	-3.5	5.8	8.6e-09	0.15	0.32	0.17	FALSE
25	The Cancer Genome Atlas	Thyroid Carcinoma	IL12RB1	0.08	0.04	lasso	3	0.05	8.9e-06	4.1	-5.5	3.0e-08	-0.46	0.41	0.35	FALSE
4	GTEx	Pancreas	AC007192.6	0.19	0.00	enet	28	0.01	1.3e-01	8.5	-5.5	4.9e-08	-0.29	0.04	0.54	FALSE
10	ROSMAP	Brain Pre-frontal Cortex	PDE4C	0.18	0.12	enet	17	0.19	3.3e-24	-2.5	-5.4	6.2e-08	-0.22	0.80	0.20	FALSE
16	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IL12RB1	0.05	0.03	enet	11	0.05	2.3e-06	-2.7	-5.3	9.8e-08	-0.44	0.48	0.41	FALSE
1	CommonMind	Brain Pre-frontal Cortex	KIAA1683	0.09	0.06	enet	14	0.10	6.6e-12	-3.1	5.3	1.2e-07	0.13	0.87	0.13	FALSE
13	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IL12RB1	0.07	0.02	lasso	3	0.01	6.4e-02	5.1	-5.3	1.2e-07	-0.43	0.14	0.04	FALSE
14	The Cancer Genome Atlas	Colon Adenocarcinoma	IL12RB1	0.11	0.03	blup	58	0.03	7.3e-03	5.1	-5.3	1.3e-07	-0.49	0.18	0.15	FALSE
3	GTEx	Nerve Tibial	KIAA1683	0.25	0.22	lasso	9	0.28	5.2e-20	6.9	5.2	2.5e-07	0.08	1.00	0.00	FALSE