TWAS
hub
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Usage
Models
Genes
Traits
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Traits
:
Whole body fat mass
:
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chr2:26,223,547-27,689,899
Best TWAS P=5.22e-13 · Best GWAS P=1.91e-12 conditioned to 1
26.2M
26.4M
26.6M
26.8M
27M
27.2M
27.4M
27.6M
0
2
4
6
8
10
12
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
ROSMAP
Brain Pre-frontal Cortex
KCNK3
0.24
0.15
lasso
3
0.15
6.5e-19
7.0
-7.2
5.2e-13
-0.99
0.00
1.00
TRUE
2
ROSMAP
Brain Pre-frontal Cortex
SLC35F6
0.05
0.04
enet
11
0.04
8.0e-06
-5.1
5.5
4.6e-08
0.73
0.24
0.75
FALSE