[Hub]/) : Traits : Whole body fat mass : ← →

chr2:24,324,172-26,088,769

Best TWAS P=4.05e-36 · Best GWAS P=2.99e-28 conditioned to 0.281

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ADCY3	0.16	0.12	lasso	10	0.14	3.2e-17	10.63	-12.5	4.1e-36	-0.87	0.01	0.99	TRUE
25	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	POMC	0.22	0.05	blup	37	0.03	2.1e-02	-3.23	-6.9	5.9e-12	-0.12	0.01	0.29	TRUE
13	GTEx	Whole Blood	RP11-443B20.1	0.21	0.17	enet	32	0.20	1.8e-18	9.62	11.5	1.8e-30	0.86	0.78	0.22	FALSE
9	GTEx	Nerve Tibial	ADCY3	0.09	0.05	enet	6	0.03	2.2e-03	9.41	-11.3	1.3e-29	-0.91	0.01	0.99	FALSE
10	GTEx	Nerve Tibial	RP11-443B20.1	0.07	0.03	enet	6	0.02	1.1e-02	9.41	-11.2	3.7e-29	-0.81	0.03	0.96	FALSE
12	GTEx	Whole Blood	ADCY3	0.23	0.24	enet	24	0.27	5.5e-25	9.96	11.0	4.5e-28	0.86	0.98	0.02	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	ADCY3	0.17	0.26	enet	32	0.26	6.8e-33	9.96	-10.8	5.1e-27	-0.89	0.80	0.20	FALSE
5	GTEx	Artery Tibial	ADCY3	0.21	0.14	lasso	6	0.15	4.3e-12	9.41	10.5	7.5e-26	0.69	0.98	0.02	FALSE
8	GTEx	Cells EBV-transformed lymphocytes	RP11-443B20.1	0.13	0.13	enet	9	0.05	9.2e-03	9.85	-10.0	2.3e-23	-0.93	0.01	0.96	FALSE
11	GTEx	Whole Blood	DNAJC27	0.08	0.10	lasso	1	0.10	2.2e-09	9.62	9.6	6.6e-22	0.80	0.90	0.10	FALSE
3	GTEx	Adipose Subcutaneous	ADCY3	0.07	0.04	lasso	6	0.01	3.2e-02	9.85	9.3	1.2e-20	0.86	0.07	0.91	FALSE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADCY3	0.03	0.02	blup	81	0.02	7.1e-04	5.85	-9.2	2.7e-20	-0.87	0.04	0.93	FALSE
6	GTEx	Artery Tibial	RP11-443B20.1	0.17	0.08	enet	40	0.09	8.2e-08	9.41	8.9	4.3e-19	0.59	0.45	0.52	FALSE
20	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EFR3B	0.03	0.05	lasso	1	0.04	1.9e-05	-8.29	-8.3	1.2e-16	-0.67	0.55	0.06	FALSE
4	GTEx	Adipose Subcutaneous	RP11-443B20.1	0.04	0.00	enet	10	0.00	1.2e-01	6.31	8.2	3.4e-16	0.81	0.04	0.90	FALSE
2	CommonMind	Brain Pre-frontal Cortex	CENPO	0.07	0.03	bslmm	322	0.03	7.0e-05	6.82	-7.6	2.1e-14	-0.49	0.46	0.28	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	ADCY3	0.25	0.23	enet	10	0.12	9.2e-05	9.85	-7.6	3.2e-14	-0.84	0.03	0.97	FALSE
23	The Cancer Genome Atlas	Lung Adenocarcinoma	POMC	0.14	0.04	enet	7	0.08	5.3e-10	-2.44	-7.0	2.2e-12	-0.22	0.38	0.62	FALSE
16	YFS	Blood	ADCY3	0.07	0.02	bslmm	343	0.04	7.3e-14	10.95	-6.8	1.1e-11	-0.61	0.00	1.00	FALSE
26	The Cancer Genome Atlas	Prostate Adenocarcinoma	POMC	0.11	0.08	enet	7	0.09	1.6e-09	-2.44	-6.6	3.8e-11	-0.24	0.92	0.06	FALSE
14	METSIM	Adipose	EFR3B	0.04	0.00	bslmm	357	0.00	9.7e-02	-0.58	-6.5	8.5e-11	-0.37	0.06	0.08	FALSE
19	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	POMC	0.06	0.00	enet	12	0.03	9.3e-05	-2.44	-6.1	1.0e-09	-0.27	0.01	0.41	FALSE
17	YFS	Blood	POMC	0.35	0.05	enet	71	0.19	5.7e-59	-6.29	-5.9	3.8e-09	-0.31	1.00	0.00	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	POMC	0.08	0.05	lasso	3	0.06	2.6e-12	-2.44	-5.8	5.1e-09	-0.20	0.97	0.03	FALSE
22	The Cancer Genome Atlas	Lung Adenocarcinoma	DNAJC27	0.05	0.01	blup	46	0.04	3.2e-05	2.67	-5.5	3.0e-08	-0.55	0.35	0.60	FALSE
24	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	POMC	0.19	0.01	blup	38	0.05	1.5e-04	-6.29	-5.5	3.0e-08	-0.33	0.01	0.56	FALSE