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chr7:75,913,086-78,122,616

Best TWAS P=3.18e-13 · Best GWAS P=4.18e-10 conditioned to 0.594

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
32	ROSMAP	Brain Pre-frontal Cortex	RSBN1L	0.09	0.07	enet	42	0.08	9.9e-11	-5.2	-7.3	3.2e-13	-0.68	0.08	0.92	TRUE
1	CommonMind	Brain Pre-frontal Cortex	DTX2P1-UPK3BP1-PMS2P11	0.18	0.09	enet	21	0.12	6.1e-15	5.2	6.6	3.9e-11	0.02	0.00	1.00	TRUE
11	GTEx	Brain Frontal Cortex BA9	GSAP	0.38	0.22	lasso	6	0.21	3.0e-06	5.5	-6.0	2.1e-09	0.06	0.13	0.29	TRUE
5	GTEx	Artery Aorta	GSAP	0.19	0.07	lasso	2	0.04	2.8e-03	5.3	-5.8	9.0e-09	0.04	0.19	0.29	TRUE
31	ROSMAP	Brain Pre-frontal Cortex	GSAP	0.36	0.27	lasso	7	0.28	1.5e-35	5.5	-5.5	4.9e-08	0.03	0.26	0.74	TRUE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	RSBN1L	0.02	0.02	blup	58	0.02	3.4e-03	-6.2	6.4	1.8e-10	0.89	0.02	0.87	FALSE
19	GTEx	Muscle Skeletal	TMEM60	0.11	0.12	lasso	4	0.12	4.6e-12	-6.2	6.3	2.5e-10	0.88	0.01	0.99	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM60	0.02	0.02	lasso	1	0.02	2.3e-05	6.2	-6.2	5.0e-10	-0.88	0.01	0.99	FALSE
26	GTEx	Skin Sun Exposed Lower leg	TMEM60	0.10	0.10	lasso	3	0.09	1.4e-07	-6.2	-6.2	6.1e-10	-0.83	0.01	0.99	FALSE
21	GTEx	Nerve Tibial	TMEM60	0.14	0.14	lasso	8	0.12	1.1e-08	-6.2	-6.2	7.0e-10	-0.86	0.03	0.97	FALSE
30	METSIM	Adipose	TMEM60	0.10	0.07	enet	9	0.08	2.1e-12	6.1	-6.2	7.0e-10	-0.97	0.01	0.99	FALSE
12	GTEx	Cells Transformed fibroblasts	TMEM60	0.25	0.20	lasso	4	0.20	1.5e-14	-6.2	-6.2	7.8e-10	-0.83	0.01	0.99	FALSE
17	GTEx	Esophagus Mucosa	TMEM60	0.06	0.04	lasso	2	0.04	1.0e-03	-6.2	-6.1	1.1e-09	-0.84	0.02	0.98	FALSE
24	GTEx	Pituitary	TMEM60	0.19	0.06	lasso	6	0.04	2.8e-02	5.4	-6.0	2.2e-09	-0.96	0.04	0.89	FALSE
40	The Cancer Genome Atlas	Soft Tissue Sarcoma	PHTF2	0.06	0.04	blup	72	0.04	2.0e-03	5.6	-5.9	3.5e-09	-0.90	0.04	0.73	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	RSBN1L-AS1	0.38	0.41	lasso	12	0.44	1.2e-17	-6.1	-5.9	3.6e-09	-0.81	0.04	0.96	FALSE
3	GTEx	Adipose Subcutaneous	TMEM60	0.08	0.05	lasso	4	0.05	7.3e-05	-6.0	-5.9	3.9e-09	-0.79	0.04	0.96	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RSBN1L	0.09	0.09	enet	9	0.09	2.0e-11	-5.7	-5.9	4.2e-09	-0.82	0.07	0.93	FALSE
39	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM60	0.02	0.03	blup	29	0.02	6.8e-03	6.2	-5.9	4.4e-09	-0.77	0.01	0.88	FALSE
25	GTEx	Skin Not Sun Exposed Suprapubic	TMEM60	0.14	0.08	lasso	4	0.03	1.4e-02	-6.2	-5.8	8.6e-09	-0.82	0.02	0.97	FALSE
29	GTEx	Whole Blood	TMEM60	0.05	0.04	enet	7	0.03	5.4e-04	-5.7	-5.7	1.0e-08	-0.79	0.04	0.96	FALSE
27	GTEx	Testis	RSBN1L-AS1	0.16	0.12	lasso	8	0.16	1.5e-07	-5.6	-5.7	1.1e-08	-0.69	0.10	0.89	FALSE
13	GTEx	Colon Sigmoid	RSBN1L	0.17	0.09	lasso	2	0.05	5.5e-03	-5.8	-5.7	1.3e-08	-0.79	0.06	0.78	FALSE
8	GTEx	Artery Tibial	FAM185BP	0.11	0.02	enet	22	0.02	1.1e-02	5.0	5.7	1.4e-08	0.19	0.05	0.50	FALSE
10	GTEx	Brain Cerebellum	RSBN1L	0.14	0.12	lasso	2	0.13	1.3e-04	5.5	5.7	1.4e-08	0.94	0.04	0.92	FALSE
4	GTEx	Adipose Visceral Omentum	TMEM60	0.20	0.13	lasso	8	0.11	2.3e-06	-6.1	-5.7	1.5e-08	-0.74	0.06	0.94	FALSE
33	YFS	Blood	TMEM60	0.14	0.16	lasso	4	0.18	1.8e-55	-6.2	-5.7	1.5e-08	-0.82	0.02	0.98	FALSE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PHTF2	0.02	0.03	lasso	1	0.02	8.0e-04	5.5	-5.5	2.9e-08	-0.69	0.08	0.74	FALSE
23	GTEx	Ovary	RSBN1L-AS1	0.21	0.22	enet	20	0.16	8.1e-05	-5.2	-5.5	3.7e-08	-0.75	0.05	0.85	FALSE
20	GTEx	Muscle Skeletal	GSAP	0.20	0.12	lasso	2	0.12	1.8e-11	5.5	-5.5	3.9e-08	0.04	0.26	0.74	FALSE
9	GTEx	Brain Cerebellum	GSAP	0.38	0.30	lasso	4	0.31	6.4e-10	5.5	-5.5	4.2e-08	0.04	0.34	0.64	FALSE
15	GTEx	Colon Transverse	RSBN1L-AS1	0.32	0.24	lasso	9	0.22	5.7e-11	-5.2	-5.4	5.3e-08	-0.82	0.06	0.94	FALSE
14	GTEx	Colon Sigmoid	RSBN1L-AS1	0.46	0.48	lasso	6	0.50	5.0e-20	-5.2	-5.4	7.3e-08	-0.76	0.12	0.88	FALSE
7	GTEx	Artery Tibial	TMEM60	0.07	0.05	enet	12	0.02	6.6e-03	-6.2	-5.4	7.7e-08	-0.64	0.02	0.95	FALSE
6	GTEx	Artery Tibial	PTPN12	0.25	0.13	lasso	8	0.12	1.8e-09	5.3	-5.3	9.7e-08	-0.63	0.48	0.52	FALSE
18	GTEx	Esophagus Muscularis	RSBN1L-AS1	0.35	0.51	lasso	5	0.52	3.8e-36	-5.2	-5.3	1.1e-07	-0.74	0.30	0.70	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	PHTF2	0.02	0.01	lasso	1	0.01	3.0e-03	5.3	-5.3	1.4e-07	-0.66	0.23	0.62	FALSE
36	The Cancer Genome Atlas	Glioblastoma Multiforme	TMEM60	0.10	0.10	blup	29	0.09	1.4e-03	5.8	-5.2	1.5e-07	-0.95	0.01	0.78	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	PTPN12	0.04	0.04	enet	4	0.04	1.0e-04	5.1	-5.2	1.5e-07	-0.66	0.01	0.98	FALSE
28	GTEx	Thyroid	GSAP	0.19	0.08	lasso	3	0.07	3.3e-06	5.3	-5.2	1.7e-07	0.03	0.38	0.58	FALSE
22	GTEx	Ovary	GSAP	0.27	-0.01	lasso	7	0.02	1.3e-01	5.5	-5.2	2.1e-07	0.15	0.05	0.07	FALSE