TWAS
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Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Whole body fat-free mass
:
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chr7:5,753,101-7,186,554
Best TWAS P=7.93e-10 · Best GWAS P=3.09e-10 conditioned to 1
5.8M
6M
6.2M
6.4M
6.6M
6.8M
7M
7.2M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
ROSMAP
Brain Pre-frontal Cortex
DAGLB
0.09
0.06
lasso
5
0.06
4.8e-08
6.2
-6.2
7.9e-10
-0.98
0.00
1.00
TRUE
3
The Cancer Genome Atlas
Thyroid Carcinoma
DAGLB
0.06
0.02
blup
71
0.03
7.4e-04
4.7
-5.7
1.4e-08
-0.72
0.01
0.77
FALSE
2
The Cancer Genome Atlas
Breast Invasive Carcinoma
RAC1
0.03
0.02
enet
7
0.02
6.8e-05
4.3
5.6
2.0e-08
0.62
0.17
0.68
FALSE