[Hub]/) : Traits : Whole body fat-free mass :

chr7:1,787,236-3,581,391

Best TWAS P=3.57e-40 · Best GWAS P=4.46e-39 conditioned to 0.441

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex AMZ1 0.19 0.12 enet 22 0.13 5.7e-16 6.3 8.0 1.6e-15 -0.43 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous GNA12 0.11 0.08 lasso 4 0.07 1.3e-06 -8.2 -9.0 1.6e-19 0.76 0.16 0.84 FALSE
3 GTEx Artery Tibial GNA12 0.24 0.13 enet 20 0.22 3.5e-17 -13.1 -11.2 2.7e-29 0.84 0.02 0.98 FALSE
4 GTEx Cells EBV-transformed lymphocytes GNA12 0.46 0.51 lasso 5 0.50 7.9e-19 -13.1 -13.0 1.0e-38 0.99 0.00 1.00 FALSE
5 GTEx Cells Transformed fibroblasts GNA12 0.21 0.11 lasso 11 0.15 1.7e-11 -13.0 -10.7 1.2e-26 0.86 0.02 0.98 FALSE
6 GTEx Colon Sigmoid GNA12 0.14 0.05 lasso 3 0.03 3.6e-02 -8.0 -10.8 2.5e-27 0.87 0.03 0.91 FALSE
7 GTEx Colon Transverse GNA12 0.19 0.08 lasso 4 0.10 2.3e-05 6.6 -7.6 2.8e-14 0.58 0.27 0.70 FALSE
8 GTEx Esophagus Gastroesophageal Junction GNA12 0.20 0.12 lasso 6 0.12 3.4e-05 -8.2 -10.9 8.1e-28 0.86 0.04 0.94 FALSE
9 GTEx Esophagus Mucosa GNA12 0.16 0.13 lasso 3 0.13 3.0e-09 -12.9 -11.9 1.7e-32 0.87 0.02 0.98 FALSE
10 GTEx Esophagus Muscularis GNA12 0.32 0.31 lasso 3 0.34 2.1e-21 -13.1 -12.6 1.3e-36 0.94 0.00 1.00 FALSE
11 GTEx Lung GNA12 0.16 0.08 enet 21 0.12 1.2e-09 -12.8 -10.6 5.0e-26 0.78 0.01 0.99 FALSE
12 GTEx Nerve Tibial GNA12 0.31 0.34 lasso 7 0.36 9.6e-27 -8.2 -10.7 1.4e-26 0.86 0.81 0.19 FALSE
13 GTEx Skin Not Sun Exposed Suprapubic GNA12 0.10 0.15 lasso 3 0.12 4.2e-07 6.2 -7.0 3.5e-12 0.54 0.33 0.65 FALSE
14 GTEx Skin Sun Exposed Lower leg GNA12 0.17 0.16 lasso 3 0.18 1.3e-14 -8.0 -10.6 2.1e-26 0.87 0.13 0.87 FALSE
15 GTEx Skin Sun Exposed Lower leg AC004840.9 0.18 0.01 enet 36 0.02 3.7e-03 2.8 -5.4 5.9e-08 0.15 0.18 0.22 TRUE
16 GTEx Small Intestine Terminal Ileum GNA12 0.34 0.20 lasso 5 0.16 2.4e-04 -8.2 -8.9 7.0e-19 0.72 0.06 0.79 FALSE
17 GTEx Stomach GNA12 0.18 0.16 lasso 2 0.13 6.6e-07 -8.0 -8.1 3.9e-16 0.70 0.36 0.64 FALSE
18 GTEx Whole Blood GNA12 0.09 0.01 enet 4 0.00 3.3e-01 -12.7 -12.8 2.6e-37 0.94 0.02 0.91 FALSE
19 METSIM Adipose GNA12 0.07 0.05 lasso 3 0.05 3.3e-08 -8.2 -8.3 1.1e-16 0.72 0.27 0.73 FALSE
20 NTR Blood GNA12 0.07 0.03 bslmm 597 0.06 1.3e-17 -9.5 -9.2 2.6e-20 0.63 0.91 0.09 FALSE
21 ROSMAP Brain Pre-frontal Cortex AMZ1 0.09 0.05 lasso 6 0.04 2.4e-06 -13.1 13.3 3.6e-40 -0.90 0.01 0.99 TRUE
22 YFS Blood GNA12 0.23 0.15 bslmm 570 0.25 4.5e-82 6.0 -8.2 1.6e-16 0.52 1.00 0.00 FALSE
23 The Cancer Genome Atlas Esophageal Carcinoma AMZ1 0.18 0.05 blup 69 0.05 1.4e-02 8.1 -11.2 3.5e-29 0.71 0.01 0.70 FALSE
24 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma GNA12 0.03 0.04 lasso 1 0.04 3.0e-05 -8.2 -8.2 3.5e-16 0.72 0.08 0.78 FALSE
25 The Cancer Genome Atlas Brain Lower Grade Glioma AMZ1 0.04 0.04 lasso 3 0.02 1.3e-03 8.1 9.4 7.5e-21 -0.60 0.03 0.92 FALSE
26 The Cancer Genome Atlas Lung Adenocarcinoma GNA12 0.03 0.01 enet 7 0.02 1.5e-03 5.3 -10.5 8.8e-26 0.78 0.06 0.74 FALSE
27 The Cancer Genome Atlas Prostate Adenocarcinoma AMZ1 0.08 0.01 blup 71 0.05 1.3e-05 -8.2 5.8 7.5e-09 -0.60 0.04 0.79 FALSE
28 The Cancer Genome Atlas Thyroid Carcinoma AMZ1 0.32 0.04 enet 19 0.20 3.3e-19 -9.5 5.8 9.2e-09 -0.52 0.16 0.84 FALSE