[Hub]/) : Traits : Whole body fat-free mass : ← →

chr7:1,787,236-3,581,391

Best TWAS P=3.57e-40 · Best GWAS P=4.46e-39 conditioned to 0.441

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
21	ROSMAP	Brain Pre-frontal Cortex	AMZ1	0.09	0.05	lasso	6	0.04	2.4e-06	-13.1	13.3	3.6e-40	-0.90	0.01	0.99	TRUE
15	GTEx	Skin Sun Exposed Lower leg	AC004840.9	0.18	0.01	enet	36	0.02	3.7e-03	2.8	-5.4	5.9e-08	0.15	0.18	0.22	TRUE
4	GTEx	Cells EBV-transformed lymphocytes	GNA12	0.46	0.51	lasso	5	0.50	7.9e-19	-13.1	-13.0	1.0e-38	0.99	0.00	1.00	FALSE
18	GTEx	Whole Blood	GNA12	0.09	0.01	enet	4	0.00	3.3e-01	-12.7	-12.8	2.6e-37	0.94	0.02	0.91	FALSE
10	GTEx	Esophagus Muscularis	GNA12	0.32	0.31	lasso	3	0.34	2.1e-21	-13.1	-12.6	1.3e-36	0.94	0.00	1.00	FALSE
9	GTEx	Esophagus Mucosa	GNA12	0.16	0.13	lasso	3	0.13	3.0e-09	-12.9	-11.9	1.7e-32	0.87	0.02	0.98	FALSE
3	GTEx	Artery Tibial	GNA12	0.24	0.13	enet	20	0.22	3.5e-17	-13.1	-11.2	2.7e-29	0.84	0.02	0.98	FALSE
23	The Cancer Genome Atlas	Esophageal Carcinoma	AMZ1	0.18	0.05	blup	69	0.05	1.4e-02	8.1	-11.2	3.5e-29	0.71	0.01	0.70	FALSE
8	GTEx	Esophagus Gastroesophageal Junction	GNA12	0.20	0.12	lasso	6	0.12	3.4e-05	-8.2	-10.9	8.1e-28	0.86	0.04	0.94	FALSE
6	GTEx	Colon Sigmoid	GNA12	0.14	0.05	lasso	3	0.03	3.6e-02	-8.0	-10.8	2.5e-27	0.87	0.03	0.91	FALSE
5	GTEx	Cells Transformed fibroblasts	GNA12	0.21	0.11	lasso	11	0.15	1.7e-11	-13.0	-10.7	1.2e-26	0.86	0.02	0.98	FALSE
12	GTEx	Nerve Tibial	GNA12	0.31	0.34	lasso	7	0.36	9.6e-27	-8.2	-10.7	1.4e-26	0.86	0.81	0.19	FALSE
14	GTEx	Skin Sun Exposed Lower leg	GNA12	0.17	0.16	lasso	3	0.18	1.3e-14	-8.0	-10.6	2.1e-26	0.87	0.13	0.87	FALSE
11	GTEx	Lung	GNA12	0.16	0.08	enet	21	0.12	1.2e-09	-12.8	-10.6	5.0e-26	0.78	0.01	0.99	FALSE
26	The Cancer Genome Atlas	Lung Adenocarcinoma	GNA12	0.03	0.01	enet	7	0.02	1.5e-03	5.3	-10.5	8.8e-26	0.78	0.06	0.74	FALSE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	AMZ1	0.04	0.04	lasso	3	0.02	1.3e-03	8.1	9.4	7.5e-21	-0.60	0.03	0.92	FALSE
20	NTR	Blood	GNA12	0.07	0.03	bslmm	597	0.06	1.3e-17	-9.5	-9.2	2.6e-20	0.63	0.91	0.09	FALSE
2	GTEx	Adipose Subcutaneous	GNA12	0.11	0.08	lasso	4	0.07	1.3e-06	-8.2	-9.0	1.6e-19	0.76	0.16	0.84	FALSE
16	GTEx	Small Intestine Terminal Ileum	GNA12	0.34	0.20	lasso	5	0.16	2.4e-04	-8.2	-8.9	7.0e-19	0.72	0.06	0.79	FALSE
19	METSIM	Adipose	GNA12	0.07	0.05	lasso	3	0.05	3.3e-08	-8.2	-8.3	1.1e-16	0.72	0.27	0.73	FALSE
22	YFS	Blood	GNA12	0.23	0.15	bslmm	570	0.25	4.5e-82	6.0	-8.2	1.6e-16	0.52	1.00	0.00	FALSE
24	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GNA12	0.03	0.04	lasso	1	0.04	3.0e-05	-8.2	-8.2	3.5e-16	0.72	0.08	0.78	FALSE
17	GTEx	Stomach	GNA12	0.18	0.16	lasso	2	0.13	6.6e-07	-8.0	-8.1	3.9e-16	0.70	0.36	0.64	FALSE
1	CommonMind	Brain Pre-frontal Cortex	AMZ1	0.19	0.12	enet	22	0.13	5.7e-16	6.3	8.0	1.6e-15	-0.43	1.00	0.00	FALSE
7	GTEx	Colon Transverse	GNA12	0.19	0.08	lasso	4	0.10	2.3e-05	6.6	-7.6	2.8e-14	0.58	0.27	0.70	FALSE
13	GTEx	Skin Not Sun Exposed Suprapubic	GNA12	0.10	0.15	lasso	3	0.12	4.2e-07	6.2	-7.0	3.5e-12	0.54	0.33	0.65	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	AMZ1	0.08	0.01	blup	71	0.05	1.3e-05	-8.2	5.8	7.5e-09	-0.60	0.04	0.79	FALSE
28	The Cancer Genome Atlas	Thyroid Carcinoma	AMZ1	0.32	0.04	enet	19	0.20	3.3e-19	-9.5	5.8	9.2e-09	-0.52	0.16	0.84	FALSE