TWAS
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Usage
Models
Genes
Traits
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Traits
:
Whole body fat-free mass
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chr11:198,510-1,534,852
Best TWAS P=2.02e-08 · Best GWAS P=4.16e-08 conditioned to 0.0056
0.2M
0.4M
0.6M
0.8M
1M
1.2M
1.4M
1.6M
0
2
4
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
METSIM
Adipose
POLR2L
0.03
0.02
bslmm
413
0.01
5.0e-03
-3.6
-5.6
2.0e-08
0.57
0.20
0.15
TRUE
2
GTEx
Testis
POLR2L
0.16
0.03
enet
10
0.03
1.9e-02
-5.5
-5.6
2.4e-08
0.85
0.00
0.99
FALSE
4
The Cancer Genome Atlas
Head and Neck Squamous Cell Carcinoma
PNPLA2
0.07
0.00
blup
51
0.03
1.4e-04
-3.6
5.5
3.2e-08
-0.61
0.01
0.50
FALSE
1
GTEx
Heart Left Ventricle
CD151
0.27
0.10
enet
47
0.10
5.5e-06
-4.4
5.2
2.0e-07
-0.49
0.27
0.65
FALSE