[Hub]/) : Traits : Whole body fat-free mass :

chr12:14,220,891-15,743,444

Best TWAS P=1.18e-12 · Best GWAS P=6.74e-12 conditioned to 0.0125

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex C12orf60 0.28 0.25 lasso 4 0.24 2.0e-29 5.4 6.0 1.4e-09 -0.49 0.91 0.09 FALSE
2 GTEx Artery Tibial WBP11 0.09 0.06 lasso 2 0.06 3.8e-05 -5.7 5.9 3.2e-09 -0.48 0.75 0.20 FALSE
3 GTEx Brain Caudate basal ganglia C12orf60 0.39 0.34 lasso 3 0.32 5.4e-10 5.4 5.5 4.5e-08 -0.37 0.88 0.09 FALSE
4 GTEx Brain Cerebellum C12orf60 0.19 0.17 lasso 3 0.13 1.2e-04 5.4 5.2 2.6e-07 -0.35 0.17 0.08 FALSE
5 GTEx Brain Cortex C12orf60 0.44 0.28 lasso 3 0.29 1.2e-08 5.5 6.0 1.8e-09 -0.42 0.66 0.18 FALSE
6 GTEx Brain Hypothalamus C12orf60 0.28 0.27 lasso 4 0.19 3.8e-05 5.4 5.3 8.7e-08 -0.36 0.23 0.12 FALSE
7 GTEx Brain Nucleus accumbens basal ganglia RP11-174G6.5 0.23 0.13 lasso 4 0.11 8.9e-04 -6.1 6.0 2.4e-09 -0.48 0.18 0.22 FALSE
8 GTEx Brain Putamen basal ganglia C12orf60 0.33 0.32 lasso 3 0.29 1.5e-07 5.5 5.6 1.7e-08 -0.37 0.32 0.24 FALSE
9 GTEx Breast Mammary Tissue (Female) C12orf60 0.19 0.17 lasso 3 0.12 2.6e-04 5.4 5.5 5.0e-08 -0.36 0.14 0.23 FALSE
10 GTEx Cells Transformed fibroblasts C12orf60 0.10 0.10 lasso 2 0.09 1.8e-07 4.8 5.3 9.6e-08 -0.36 0.93 0.06 FALSE
11 GTEx Heart Left Ventricle C12orf60 0.24 0.23 lasso 5 0.26 7.1e-14 5.4 5.6 1.8e-08 -0.42 0.91 0.09 FALSE
12 GTEx Heart Left Ventricle H2AFJ 0.16 0.07 lasso 8 0.05 1.1e-03 -6.5 -6.5 1.2e-10 0.85 0.03 0.96 FALSE
13 GTEx Liver H2AFJ 0.18 0.11 lasso 8 0.04 2.7e-02 -6.5 -5.6 1.9e-08 0.79 0.04 0.72 FALSE
14 GTEx Nerve Tibial C12orf60 0.39 0.27 enet 11 0.30 9.6e-22 5.4 5.4 7.1e-08 -0.37 0.91 0.09 FALSE
15 GTEx Skin Not Sun Exposed Suprapubic C12orf60 0.15 0.16 lasso 2 0.13 1.6e-07 5.5 5.5 3.7e-08 -0.36 0.90 0.08 FALSE
16 GTEx Skin Sun Exposed Lower leg C12orf60 0.09 0.06 enet 11 0.05 4.0e-05 5.4 5.7 1.6e-08 -0.44 0.76 0.19 FALSE
17 GTEx Thyroid C12orf60 0.16 0.10 enet 9 0.12 8.1e-10 4.8 5.8 5.2e-09 -0.37 0.96 0.04 FALSE
18 METSIM Adipose C12orf60 0.14 0.10 lasso 4 0.08 1.2e-12 5.4 5.3 9.0e-08 -0.37 0.90 0.10 FALSE
19 METSIM Adipose MGP 0.04 0.04 bslmm 359 0.04 6.2e-07 -4.0 5.3 1.2e-07 -0.37 0.98 0.02 FALSE
20 ROSMAP Brain Pre-frontal Cortex WBP11 0.10 0.05 lasso 4 0.06 1.2e-08 -5.7 7.1 1.2e-12 -0.72 0.08 0.92 TRUE
21 ROSMAP Brain Pre-frontal Cortex C12orf60 0.26 0.29 lasso 5 0.29 1.9e-37 5.5 5.4 8.1e-08 -0.33 0.88 0.12 FALSE
22 YFS Blood H2AFJ 0.05 0.02 bslmm 360 0.03 2.9e-10 -6.5 -6.2 5.7e-10 0.68 0.02 0.98 FALSE
23 The Cancer Genome Atlas Bladder Urothelial Carcinoma C12orf60 0.17 0.03 blup 56 0.07 2.9e-06 4.8 5.5 3.7e-08 -0.63 0.05 0.85 FALSE
24 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma C12orf60 0.10 0.04 enet 7 0.05 2.0e-06 -4.8 5.6 2.1e-08 -0.49 0.30 0.48 FALSE
25 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma C12orf60 0.12 0.07 enet 8 0.07 5.4e-05 5.5 6.5 9.6e-11 -0.64 0.07 0.82 FALSE
26 The Cancer Genome Atlas Brain Lower Grade Glioma C12orf60 0.14 0.14 lasso 4 0.13 2.2e-14 5.5 5.9 4.0e-09 -0.43 0.88 0.12 FALSE
27 The Cancer Genome Atlas Brain Lower Grade Glioma WBP11 0.03 0.03 blup 57 0.02 2.3e-03 -6.5 6.8 9.3e-12 -0.90 0.01 0.94 FALSE
28 The Cancer Genome Atlas Lung Adenocarcinoma C12orf60 0.07 0.05 enet 7 0.05 1.5e-06 5.5 5.7 1.1e-08 -0.42 0.86 0.13 FALSE
29 The Cancer Genome Atlas Lung Squamous Cell Carcinoma C12orf60 0.05 0.05 lasso 3 0.04 1.1e-05 5.5 5.8 7.3e-09 -0.43 0.84 0.14 FALSE
30 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma C12orf60 0.10 0.01 blup 56 0.07 1.6e-05 4.8 6.0 1.7e-09 -0.49 0.08 0.17 FALSE
31 The Cancer Genome Atlas Prostate Adenocarcinoma C12orf60 0.05 0.03 lasso 1 0.01 1.2e-02 5.5 5.5 3.2e-08 -0.36 0.10 0.10 FALSE
32 The Cancer Genome Atlas Thyroid Carcinoma C12orf60 0.16 0.16 enet 10 0.18 1.3e-17 5.5 6.7 2.0e-11 -0.61 0.89 0.11 FALSE