[Hub]/) : Traits : Whole body fat-free mass : ← →

chr12:14,220,891-15,743,444

Best TWAS P=1.18e-12 · Best GWAS P=6.74e-12 conditioned to 0.0125

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	C12orf60	0.28	0.25	lasso	4	0.24	2.0e-29	5.4	6.0	1.4e-09	-0.49	0.91	0.09	FALSE
2	GTEx	Artery Tibial	WBP11	0.09	0.06	lasso	2	0.06	3.8e-05	-5.7	5.9	3.2e-09	-0.48	0.75	0.20	FALSE
3	GTEx	Brain Caudate basal ganglia	C12orf60	0.39	0.34	lasso	3	0.32	5.4e-10	5.4	5.5	4.5e-08	-0.37	0.88	0.09	FALSE
4	GTEx	Brain Cerebellum	C12orf60	0.19	0.17	lasso	3	0.13	1.2e-04	5.4	5.2	2.6e-07	-0.35	0.17	0.08	FALSE
5	GTEx	Brain Cortex	C12orf60	0.44	0.28	lasso	3	0.29	1.2e-08	5.5	6.0	1.8e-09	-0.42	0.66	0.18	FALSE
6	GTEx	Brain Hypothalamus	C12orf60	0.28	0.27	lasso	4	0.19	3.8e-05	5.4	5.3	8.7e-08	-0.36	0.23	0.12	FALSE
7	GTEx	Brain Nucleus accumbens basal ganglia	RP11-174G6.5	0.23	0.13	lasso	4	0.11	8.9e-04	-6.1	6.0	2.4e-09	-0.48	0.18	0.22	FALSE
8	GTEx	Brain Putamen basal ganglia	C12orf60	0.33	0.32	lasso	3	0.29	1.5e-07	5.5	5.6	1.7e-08	-0.37	0.32	0.24	FALSE
9	GTEx	Breast Mammary Tissue (Female)	C12orf60	0.19	0.17	lasso	3	0.12	2.6e-04	5.4	5.5	5.0e-08	-0.36	0.14	0.23	FALSE
10	GTEx	Cells Transformed fibroblasts	C12orf60	0.10	0.10	lasso	2	0.09	1.8e-07	4.8	5.3	9.6e-08	-0.36	0.93	0.06	FALSE
11	GTEx	Heart Left Ventricle	C12orf60	0.24	0.23	lasso	5	0.26	7.1e-14	5.4	5.6	1.8e-08	-0.42	0.91	0.09	FALSE
12	GTEx	Heart Left Ventricle	H2AFJ	0.16	0.07	lasso	8	0.05	1.1e-03	-6.5	-6.5	1.2e-10	0.85	0.03	0.96	FALSE
13	GTEx	Liver	H2AFJ	0.18	0.11	lasso	8	0.04	2.7e-02	-6.5	-5.6	1.9e-08	0.79	0.04	0.72	FALSE
14	GTEx	Nerve Tibial	C12orf60	0.39	0.27	enet	11	0.30	9.6e-22	5.4	5.4	7.1e-08	-0.37	0.91	0.09	FALSE
15	GTEx	Skin Not Sun Exposed Suprapubic	C12orf60	0.15	0.16	lasso	2	0.13	1.6e-07	5.5	5.5	3.7e-08	-0.36	0.90	0.08	FALSE
16	GTEx	Skin Sun Exposed Lower leg	C12orf60	0.09	0.06	enet	11	0.05	4.0e-05	5.4	5.7	1.6e-08	-0.44	0.76	0.19	FALSE
17	GTEx	Thyroid	C12orf60	0.16	0.10	enet	9	0.12	8.1e-10	4.8	5.8	5.2e-09	-0.37	0.96	0.04	FALSE
18	METSIM	Adipose	C12orf60	0.14	0.10	lasso	4	0.08	1.2e-12	5.4	5.3	9.0e-08	-0.37	0.90	0.10	FALSE
19	METSIM	Adipose	MGP	0.04	0.04	bslmm	359	0.04	6.2e-07	-4.0	5.3	1.2e-07	-0.37	0.98	0.02	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	WBP11	0.10	0.05	lasso	4	0.06	1.2e-08	-5.7	7.1	1.2e-12	-0.72	0.08	0.92	TRUE
21	ROSMAP	Brain Pre-frontal Cortex	C12orf60	0.26	0.29	lasso	5	0.29	1.9e-37	5.5	5.4	8.1e-08	-0.33	0.88	0.12	FALSE
22	YFS	Blood	H2AFJ	0.05	0.02	bslmm	360	0.03	2.9e-10	-6.5	-6.2	5.7e-10	0.68	0.02	0.98	FALSE
23	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C12orf60	0.17	0.03	blup	56	0.07	2.9e-06	4.8	5.5	3.7e-08	-0.63	0.05	0.85	FALSE
24	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C12orf60	0.10	0.04	enet	7	0.05	2.0e-06	-4.8	5.6	2.1e-08	-0.49	0.30	0.48	FALSE
25	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C12orf60	0.12	0.07	enet	8	0.07	5.4e-05	5.5	6.5	9.6e-11	-0.64	0.07	0.82	FALSE
26	The Cancer Genome Atlas	Brain Lower Grade Glioma	C12orf60	0.14	0.14	lasso	4	0.13	2.2e-14	5.5	5.9	4.0e-09	-0.43	0.88	0.12	FALSE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	WBP11	0.03	0.03	blup	57	0.02	2.3e-03	-6.5	6.8	9.3e-12	-0.90	0.01	0.94	FALSE
28	The Cancer Genome Atlas	Lung Adenocarcinoma	C12orf60	0.07	0.05	enet	7	0.05	1.5e-06	5.5	5.7	1.1e-08	-0.42	0.86	0.13	FALSE
29	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C12orf60	0.05	0.05	lasso	3	0.04	1.1e-05	5.5	5.8	7.3e-09	-0.43	0.84	0.14	FALSE
30	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C12orf60	0.10	0.01	blup	56	0.07	1.6e-05	4.8	6.0	1.7e-09	-0.49	0.08	0.17	FALSE
31	The Cancer Genome Atlas	Prostate Adenocarcinoma	C12orf60	0.05	0.03	lasso	1	0.01	1.2e-02	5.5	5.5	3.2e-08	-0.36	0.10	0.10	FALSE
32	The Cancer Genome Atlas	Thyroid Carcinoma	C12orf60	0.16	0.16	enet	10	0.18	1.3e-17	5.5	6.7	2.0e-11	-0.61	0.89	0.11	FALSE