Hub : Genes

RP11-174G6.5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.193	0.0767	0.00790	0.034	NA	0.004	NA	0.036	0.0220	NA	2.2e-01	NA	0.02000
2	GTEx	Brain Nucleus accumbens basal ganglia	0.233	0.0800	0.00055	0.126	NA	0.106	NA	0.106	0.0003	NA	9.2e-04	NA	0.00089
3	GTEx	Thyroid	0.166	0.0720	0.00820	0.001	NA	0.067	NA	0.005	0.2800	NA	7.4e-06	NA	0.13000

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.3	0.4	0.8	-0.3	0.6	0.9
Bipolar Disorder or Schizophrenia	0.5	1.2	3.0	-1.7	-0.5	0.6
Depressed Affect (Nagel 2018)	0.2	0.5	0.9	-1.0	-0.2	-0.7
Depression (Nagel 2018)	0.3	0.5	1.5	-1.2	-0.0	-0.0
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.3	0.9	0.0	1.5
Neuroticism (Nagel 2018)	0.4	0.8	2.1	-1.4	-0.6	-0.3
Schizophrenia (2018)	0.8	1.7	3.9	-2.0	-1.1	-0.1
Schizophrenia vs Biploar Disorder	0.9	1.2	3.3	-1.8	-0.4	-0.2
Worry (Nagel 2018)	0.5	1.0	2.5	-1.6	-0.7	-0.1
Alzheimer’s Disease (in mother)	0.0	0.0	0.1	0.1	0.3	0.1
Alzheimer’s Disease (in father)	0.5	0.5	0.7	0.6	-0.8	0.7
Alzheimer’s Disease (including proxy)	0.3	0.4	1.2	1.1	-0.2	0.2
Crohns Disease (2017)	0.8	1.8	4.8	-0.7	2.2	0.5
Irritable Bowel Disease (IBD)	0.2	0.5	1.5	-0.2	1.2	-0.1
Ulcerative Colitis (UC)	0.1	0.2	0.2	-0.3	-0.4	-0.5
Major Depression (MDD)	0.2	0.3	0.4	-0.2	-0.7	0.6
Reaction Time	1.1	2.1	5.2	0.1	2.3	-1.0
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.7	0.4	1.3	0.7
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.6	0.8	1.8	1.3	-0.0	0.8
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.3	0.4	0.7	0.6	0.8	0.3
Bipolar Disorder (2011)	0.1	0.1	0.4	-0.2	-0.6	0.1
Body Mass Index (BMI) (2010)	0.4	0.5	1.4	-0.1	1.2	0.4
Coronary Artery Disease (CAD)	2.0	2.4	4.8	0.8	-2.2	-1.3
Crohns Disease (2012)	1.8	3.0	5.5	-1.7	2.4	0.6
Mean Putamen Volume	0.5	0.5	1.3	0.5	-0.2	1.1
Fasting Glucose	0.2	0.3	0.8	-0.9	0.0	-0.4
HbA1C	1.3	1.4	4.0	-0.4	-0.4	-2.0
HDL Cholesterol	0.8	1.3	2.7	-0.9	0.6	-1.6
LDL Cholesterol	0.4	0.6	1.3	0.3	1.1	0.6
Lupus	1.3	2.0	3.6	1.9	-0.6	1.4
Neuroticism (2016)	0.1	0.2	0.3	-0.6	-0.4	-0.2
Primary Biliary Cirrhosis	0.9	1.2	1.5	1.2	0.9	-1.1
Rheumatoid Arthritis	0.6	0.9	1.5	0.7	1.2	-0.8
Schizophrenia (2014)	0.9	1.9	4.2	-2.1	-1.2	-0.3
Triglycerides	1.1	1.8	5.1	-2.3	-0.6	-0.1
Type 2 Diabetes (T2D) (2012)	2.9	3.3	3.7	-1.9	-1.9	-1.6
Ulcerative Colitis	0.0	0.1	0.2	0.4	-0.0	0.0
Blood Eosinophil Count	0.2	1.8	3.2	-1.8	-1.1	-0.9
Blood Platelet Count	0.1	1.7	4.7	0.6	-0.3	2.2
Blood Red Count	0.1	1.2	2.1	-1.2	-0.3	1.5
Blood White Count	0.8	5.7	8.5	-2.4	-2.9	1.7
Heel T-Score	1.9	15.1	40.1	-2.1	6.3	1.0
BMI	0.1	0.5	1.6	0.1	1.3	0.2
Height	1.5	29.8	73.3	-1.4	8.6	3.8
Waist Hip Ratio (WHR)	0.1	0.5	1.0	-0.6	1.0	-0.5
Systolic Blood Pressure	0.2	1.0	2.2	0.4	-0.8	-1.5
Smoking Status	0.9	2.2	2.9	-1.7	-1.7	-0.9
Allergy or Eczema	0.6	1.6	4.0	-0.0	0.8	2.0
Cardiovascular Disease	0.2	0.6	1.1	0.2	-1.1	-0.8
Hypothyroidism (self reported)	0.3	0.6	1.1	1.0	0.6	0.6
Respiratory disease	0.6	1.4	3.5	-0.7	-1.9	-0.6
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.0	1.1	-0.3	-1.4
Lung FEV1/FVC ratio	0.4	2.2	5.2	0.4	1.1	2.3
Lung FVC	0.2	0.9	2.4	0.1	0.6	1.6
Neuroticism	0.7	1.8	3.8	-1.9	-1.2	-0.4
Chronotype (morning person)	0.6	1.3	2.1	-1.2	0.4	-1.5
Hair Pigment	0.1	2.6	7.1	0.7	2.7	-0.6
Tanning	0.3	3.3	7.2	1.1	-2.7	-1.2
Hand grip strength (left)	10.4	27.5	81.0	-0.7	9.0	0.9
Number of treatments/medications taken	1.2	2.2	5.6	-0.9	-2.4	-0.6
Average weekly spirits intake	0.6	0.7	1.2	0.9	-0.4	-1.1
Sensitivity / hurt feelings	0.9	1.6	2.4	-0.1	-1.5	-1.5
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.4	-0.4	0.0	-0.6
Hearing difficulty/problems: Yes	1.2	1.9	4.9	0.7	-0.4	-2.2
Relative age of first facial hair	0.1	0.1	0.3	-0.3	-0.1	0.6
Other serious medical condition/disability diagnosed by doctor	3.1	4.1	7.3	1.9	-2.7	1.1
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.2	0.2	-1.1	-0.4
Ever had hysterectomy (womb removed)	2.4	2.7	4.4	-0.0	-1.9	-2.1
Systolic blood pressure, automated reading	0.5	1.3	3.5	0.1	-0.7	-1.9
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	0.3	0.6	0.4
Angina	0.6	0.8	1.3	0.8	0.7	1.1
Medication for hormone replacement therapy	0.1	0.1	0.3	-0.1	-0.0	-0.6
Vitamin and mineral supplements	0.7	0.9	2.2	0.6	1.5	-0.3
Supplements: Zinc	2.0	2.2	6.5	-0.1	-0.3	2.5
Medication: Co-codamol	3.0	3.4	5.9	0.3	-2.4	-2.1
Medication: Metformin	1.8	2.6	7.0	0.8	-0.3	-2.6
Diabetes (father)	3.8	4.7	8.1	-1.5	-1.9	-2.8
Diabetes (mother)	0.7	0.9	1.6	1.3	0.5	-0.8
Severe depression (siblings)	0.3	0.4	0.8	0.9	-0.6	-0.1
Pack years adult smoking proportion	2.7	4.1	8.2	1.0	-1.7	-2.9
Impedance of leg (right)	0.4	1.9	4.2	0.5	-2.0	1.1
Leg fat-free mass (left)	1.4	7.7	21.8	-0.3	4.7	1.0
Trunk fat percentage	0.0	0.2	0.2	0.5	-0.2	-0.4
Hand grip strength (right)	10.0	27.3	78.3	0.7	8.8	1.7
Townsend deprivation index at recruitment	1.3	1.8	3.2	-1.0	-1.1	-1.8
Current tobacco smoking	1.2	1.9	4.7	-0.6	-0.8	-2.2
Average weekly fortified wine intake	0.6	0.7	2.0	0.3	-1.4	0.1
Maternal smoking around birth	0.4	0.6	1.1	0.7	0.3	-1.1
Fed-up feelings	0.2	0.3	0.9	-0.2	-0.2	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.4	-1.2	0.1	0.2
Relative age voice broke	1.3	2.0	4.5	-0.2	-2.1	1.2
Taking other prescription medications	1.3	2.0	5.6	0.2	-2.4	-0.6
Age when periods started (menarche)	0.4	1.1	3.1	1.8	0.2	0.0
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	4.3	2.1	-0.6	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.0	8.1	0.1	2.9	0.9
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	3.8	1.0	0.8	1.9
Qualifications: CSEs or equivalent	0.6	0.8	1.9	0.0	1.4	-0.8
Serious illness, injury or assault to yourself	1.0	1.3	3.0	0.9	-1.7	0.0
High blood pressure	0.2	0.6	1.8	0.0	-1.3	0.4
Hayfever, allergic rhinitis or eczema	1.1	2.5	4.3	0.4	1.7	2.1
Multivitamins +/- minerals	0.3	0.3	0.8	0.4	-0.1	0.9
Stomach or abdominal pain in last month	1.1	1.3	2.7	1.1	1.6	-0.2
Supplements: Glucosamine	4.4	5.8	13.2	-2.0	-3.6	0.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.6	0.5	-0.8	-0.3
Medication: Atenolol	1.0	1.3	3.6	0.3	-1.9	0.3
Medication: Levothyroxine sodium	0.5	0.9	1.5	1.2	-1.1	-0.0
Sitting height	2.0	14.0	30.5	1.3	5.5	3.1
Chronic bronchitis/emphysema (father)	2.3	2.7	6.7	-1.2	-2.6	0.2
High blood pressure (mother)	0.3	0.5	0.6	-0.6	-0.6	-0.8
Body mass index (BMI)	0.2	0.8	2.2	0.0	1.5	-0.4
Impedance of leg (left)	0.3	1.5	3.8	0.3	-1.9	0.7
Leg predicted mass (left)	1.5	7.9	22.7	-0.3	4.8	1.0
Trunk fat mass	0.2	0.9	2.5	0.4	1.6	0.2
Waist circumference	0.7	2.7	7.8	-0.5	2.8	-0.0
Number of incorrect matches in round	0.3	0.6	0.8	-0.8	0.4	-0.9
Past tobacco smoking	0.6	1.0	1.4	0.7	1.2	1.1
Alcohol usually taken with meals	1.5	2.4	6.8	-0.0	0.7	2.6
Nervous feelings	0.1	0.2	0.3	-0.5	-0.3	0.5
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	4.2	-2.0	-0.4	0.7
Hearing difficulty/problems with background noise	1.3	2.0	4.5	0.7	-1.0	-2.1
Hair/balding pattern: Pattern 2	0.8	1.0	2.2	-0.8	1.5	-0.0
Had menopause	1.6	2.0	3.1	-1.8	-1.7	-0.2
Had other major operations	0.9	1.2	1.9	-0.6	-1.1	1.4
Forced vital capacity (FVC)	2.3	8.8	15.3	-0.2	3.9	3.3
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	7.6	-0.4	2.8	0.8
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.8	-1.4	-0.5	0.8
Qualifications: None of the above	2.5	5.4	14.7	-0.4	-1.2	-3.8
Financial difficulties in last 2 years	0.6	0.8	1.5	-1.2	0.8	0.2
Mouth/teeth dental problems	0.9	1.4	2.1	1.1	1.5	1.0
Heart attack	1.4	1.7	4.5	2.1	-0.8	0.2
Allergy	0.7	1.6	4.4	0.2	-0.7	-2.1
Pain all over the body in last month	0.6	0.7	1.2	-0.8	-1.1	-0.4
Diabetes (self-reported)	0.7	1.2	2.1	1.1	-0.5	-1.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.3	0.5	1.1	0.1
Medication: Ramipril	0.7	0.8	2.4	0.3	-0.1	-1.6
Medication: Simvastatin	0.5	0.7	1.0	-0.6	-0.9	-1.0
Fluid intelligence score	0.3	0.7	1.3	0.5	0.6	1.1
Illnesses of siblings	0.8	1.1	2.3	-1.5	0.2	0.9
Neuroticism score	0.3	0.6	1.0	-1.0	-0.5	-0.7
Weight	1.1	5.6	15.8	-0.1	4.0	0.9
Impedance of arm (right)	1.1	5.1	15.2	-0.4	-3.9	0.0
Arm fat percentage (right)	0.1	0.3	0.6	0.4	-0.2	-0.8
Trunk fat-free mass	2.5	14.6	39.8	-0.5	6.3	1.9
Hip circumference	0.8	3.6	10.3	0.2	3.2	0.7
Time employed in main current job	0.3	0.3	0.9	-0.1	0.9	0.2
Alcohol intake versus 10 years previously	0.7	1.0	1.8	0.6	1.4	1.0
Father’s age at death	0.1	0.1	0.3	-0.6	-0.1	0.3
Worrier / anxious feelings	0.0	0.1	0.1	0.2	0.2	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	1.4	-1.1	-1.2	0.2
Falls in the last year	2.7	3.6	9.5	0.8	-0.8	-3.1
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	-0.3	-0.2	0.9
Number of live births	1.0	1.4	3.2	-0.1	-1.0	-1.8
Forced expiratory volume in 1-second (FEV1)	2.7	9.2	16.2	-0.3	4.0	3.4
Pulse rate	1.7	2.8	4.2	-1.8	-1.0	2.0
Happiness	0.6	0.8	1.5	-0.1	-0.9	1.2
Noisy workplace	2.8	3.5	5.9	-1.7	-1.4	-2.4
Qualifications: A levels/AS levels or equivalent	1.3	2.8	8.2	0.5	0.0	2.9
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.7	0.2	1.3	0.2
Mouth/teeth dental problems: Dentures	0.6	1.1	2.2	-0.9	-1.5	-0.6
Asthma	0.1	0.1	0.3	-0.4	-0.5	-0.0
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	3.8	-2.0	-0.7	0.7
Medication: Cholesterol lowering	1.0	1.6	3.8	0.8	-1.9	0.4
Depression (self-reported)	1.1	1.4	3.4	-1.8	0.8	0.2
Medication: Lansoprazole	0.6	0.7	1.3	0.5	-0.7	-1.2
Prospective memory result	0.8	0.9	2.0	0.4	-0.8	-1.4
Lung cancer (father)	1.3	1.5	2.7	1.2	0.6	-1.6
Illnesses of mother	0.9	1.2	1.8	1.4	1.3	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	2.5	8.0	14.1	0.2	3.8	3.1
Pulse wave Arterial Stiffness index	1.0	1.1	2.4	-1.5	-1.0	0.1
Impedance of arm (left)	1.2	5.5	16.2	0.4	-4.0	0.2
Arm fat mass (right)	0.4	1.6	4.8	0.2	2.2	-0.1
Trunk predicted mass	2.6	14.6	39.4	-0.6	6.3	2.0
Standing height	1.5	14.6	32.3	-0.5	5.7	3.4
Length of working week for main job	0.1	0.1	0.2	0.2	0.4	0.2
Exposure to tobacco smoke at home	0.6	0.7	2.0	-1.4	0.1	0.4
Breastfed as a baby	0.1	0.2	0.3	0.6	0.4	0.0
Tense / ‘highly strung’	0.5	0.8	1.6	-1.3	-0.9	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	3.5	-1.2	-1.9	-0.4
Hair/balding pattern: Pattern 4	1.8	4.4	11.2	1.0	-3.4	-1.0
Birth weight of first child	0.5	0.9	1.9	0.3	1.4	0.8
Peak expiratory flow (PEF)	2.0	4.6	9.5	-0.9	1.9	3.1
Pulse wave reflection index	0.3	0.4	0.9	-0.3	-0.9	-0.5
Ever highly irritable/argumentative for 2 days	1.7	2.0	3.6	-1.3	0.9	1.9
Loud music exposure frequency	0.5	0.6	1.4	-1.2	-0.2	-0.5
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	6.5	0.4	-0.3	2.6
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	4.7	-2.2	-0.7	-0.5
Blood clot in the leg (DVT)	0.2	0.3	0.8	0.9	-0.2	-0.0
Medication: Paracetamol	0.3	0.5	1.2	-0.3	-0.4	1.1
Headache pain in last month	0.3	0.5	0.7	-0.9	0.4	0.8
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	3.5	-1.2	1.9	0.0
Glaucoma (self-reported)	0.2	0.2	0.3	0.6	0.5	-0.3
Gout (self-reported)	1.9	2.6	5.1	-1.7	0.1	2.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.5	1.2	-0.3	0.5
Medication: Amlodipine	0.5	0.7	1.5	-0.7	-1.2	0.2
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.3	-0.4	-0.2	0.6
Birth weight	0.4	0.8	1.3	1.0	1.1	0.4
Chronic bronchitis/emphysema (mother)	1.1	1.2	2.8	1.7	-0.0	-1.0
High blood pressure (siblings)	0.1	0.2	0.3	0.4	0.6	-0.2
Forced vital capacity (FVC), Best measure	1.8	6.5	9.9	-0.2	3.1	3.1
Body fat percentage	0.1	0.2	0.4	0.6	-0.1	-0.6
Leg fat percentage (right)	0.1	0.2	0.4	0.5	0.2	-0.6
Arm fat-free mass (right)	2.6	13.5	36.7	-0.3	6.1	1.9
Exposure to tobacco smoke outside home	0.3	0.4	1.0	0.1	-1.0	-0.3
Comparative body size at age 10	1.1	3.0	8.8	-0.1	3.0	-0.2
Number of full brothers	1.3	1.7	4.9	0.4	0.3	-2.2
Worry too long after embarrassment	0.6	1.0	2.6	-0.6	0.0	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	3.2	4.1	5.5	-1.9	-1.8	-2.3
Wheeze or whistling in the chest in last year	0.2	0.4	0.7	-0.8	-0.1	0.7
Number of children fathered	0.2	0.2	0.5	-0.7	-0.3	0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	2.4	-1.0	1.3	1.6
Age at first live birth	0.5	1.0	2.0	0.9	0.4	1.4
Pulse wave peak to peak time	1.1	1.3	2.6	1.6	1.1	0.3
Health satisfaction	0.3	0.4	0.9	-0.5	-0.9	0.2
Shortness of breath walking on level ground	0.3	0.3	0.4	0.6	-0.6	0.4
Qualifications: College or University degree	0.9	2.9	4.0	1.1	2.0	1.9
Eye problems/disorders: None of the above	0.6	0.7	1.2	1.1	-0.6	-0.7
Mouth/teeth dental problems: Loose teeth	0.8	0.9	1.4	-0.8	-1.2	-0.8
Emphysema/chronic bronchitis	0.2	0.2	0.4	-0.4	-0.3	0.6
Medication for pain relief, constipation, heartburn	0.1	0.2	0.3	0.2	0.4	-0.5
Neck or shoulder pain in last month	0.8	1.2	1.8	-0.2	-1.3	1.3
Medication: Blood pressure	1.6	2.8	6.0	1.5	-2.5	-0.4
Angina (self-reported)	0.6	0.7	0.9	0.9	0.7	0.9
Migraine (self-reported)	0.2	0.2	0.5	0.7	0.3	0.0
Medication: Ibuprofen	1.9	2.2	4.9	-2.2	0.1	1.3
Medication: Allopurinol	0.3	0.4	0.7	-0.9	-0.1	0.7
Medication: Omeprazole	0.6	0.8	1.1	0.7	-1.0	0.8
Medication: Seretide 50 evohaler	0.9	1.1	1.3	-1.1	0.9	-1.1
Mean time to correctly identify matches	0.8	1.5	2.9	-0.2	1.3	-1.7
Heart disease (mother)	0.5	0.6	1.0	-1.0	0.4	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	1.7	1.3	0.9	-1.1
Whole body fat mass	0.3	1.3	3.7	0.5	1.9	0.1
Leg fat mass (right)	0.4	1.5	4.5	0.4	2.1	0.1
Arm predicted mass (right)	2.8	14.2	38.7	-0.2	6.2	1.9
Pulse rate, automated reading	0.4	1.2	2.6	-1.6	0.1	1.0
Alcohol intake frequency.	0.5	1.2	3.5	1.9	0.3	-0.2
Comparative height size at age 10	1.2	6.7	18.4	-1.2	4.3	0.6
Number of full sisters	0.8	0.9	1.6	-1.3	0.3	-1.1
Suffer from ‘nerves’	0.8	1.2	2.3	-0.6	-1.5	-1.0
Overall health rating	1.7	3.7	9.5	-0.1	-1.2	-3.1
Chest pain or discomfort	0.7	1.0	1.9	-1.1	0.1	1.4
Had major operations	0.9	1.0	2.7	0.6	-1.6	0.1
Age at last live birth	0.2	0.3	0.4	0.6	0.1	0.6
Family relationship satisfaction	1.7	2.1	3.4	1.2	1.2	1.8
Leg pain on walking	0.2	0.3	0.5	-0.2	-0.5	-0.7
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.0	1.1	0.6	-1.4
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.0	-1.4	0.1	-0.9
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.2	-0.5	0.3	0.4
Medication: Aspirin	0.2	0.2	0.7	0.8	-0.1	-0.2
Supplements: Vitamin C	3.3	3.9	9.4	-1.4	-3.1	0.6
Knee pain experienced in last month	0.5	0.8	1.8	0.6	0.4	-1.3
Hypertension (Self-reported)	0.3	1.0	2.7	0.3	-1.7	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.7	0.1	-0.9	-0.0
Illnesses of father: Heart disease	0.4	0.5	0.9	-0.7	-0.2	0.9
Illnesses of siblings: Diabetes	2.5	3.0	4.0	2.0	-1.7	-1.5
Smoking status: Previous	0.5	0.8	2.0	-0.0	-1.4	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	2.4	5.0	13.2	-0.5	3.6	1.3
Whole body fat-free mass	2.3	13.0	35.6	-0.6	6.0	1.7
Leg fat-free mass (right)	1.5	8.1	23.6	-0.4	4.9	0.7
Arm fat percentage (left)	0.1	0.4	0.6	0.7	-0.3	-0.8
Average weekly red wine intake	0.3	0.4	0.8	0.9	0.5	0.3
Handedness (chirality/laterality): Left-handed	0.5	0.5	1.2	-0.6	-1.1	-0.2
Mood swings	0.0	0.0	0.1	0.0	0.3	-0.2
Loneliness, isolation	0.4	0.5	1.1	0.1	-0.7	-1.0
Long-standing illness, disability or infirmity	2.5	3.8	6.9	1.8	-2.6	-1.1
Ever had bowel cancer screening	0.5	0.6	0.7	-0.7	0.7	0.8
Diabetes diagnosed by doctor	1.2	2.0	4.3	1.1	-0.8	-2.1
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.2	4.8	0.2	-1.3	-2.2
Friendships satisfaction	0.8	0.9	1.5	-0.3	1.1	1.2
Qualifications: nursing, teaching	1.1	1.7	3.4	1.1	0.8	1.8
Commuting to job workplace: Walk	0.6	0.6	1.8	-1.4	-0.3	-0.1
Eye problems/disorders: Cataract	0.7	0.8	1.3	-1.1	-0.6	0.9
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	3.0	0.1	-1.7	-0.6
Medication for cholesterol	0.3	0.4	0.7	0.6	0.3	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.2	1.1	0.3	0.0
Back pain experienced in last month	1.7	2.5	6.0	-1.1	0.7	2.4
Mineral and other dietary supplements	1.0	1.4	3.1	0.5	1.8	-0.9
Breast cancer (self-reported)	0.4	0.5	0.9	-0.1	-0.8	0.9
Asthma (self-reported)	0.1	0.3	0.8	-0.1	-0.9	-0.2
Osteoporosis (self-reported)	2.0	2.4	6.4	0.7	-2.5	0.6
Osteoarthritis (self-reported)	1.4	1.8	4.6	-0.6	-2.1	0.7
Medication: Aspirin	0.2	0.2	0.6	0.8	-0.1	0.2
Medication: Gliclazide	1.1	1.2	3.3	0.3	-0.5	-1.8
Illnesses of father: None of the above (group 1)	0.2	0.3	0.5	0.3	0.7	0.4
Smoking status: Current	0.8	1.3	2.7	-1.0	-0.5	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	3.2	1.0	0.9	1.8
Whole body water mass	2.2	12.3	34.5	-0.4	5.9	1.5
Leg predicted mass (right)	1.5	8.2	24.0	-0.4	4.9	0.7
Arm fat mass (left)	0.3	1.4	4.0	0.3	2.0	0.0
Number of self-reported non-cancer illnesses	2.7	4.7	10.3	-0.3	-3.2	-2.0
Average weekly champagne plus white wine intake	4.3	6.0	9.5	-2.9	0.2	3.1
Miserableness	0.6	1.0	1.6	-1.1	0.3	-1.3
Guilty feelings	0.0	0.0	0.1	0.0	-0.3	0.2
Wears glasses or contact lenses	0.5	0.6	1.3	-0.8	-0.1	-1.1
Ever taken oral contraceptive pill	0.1	0.1	0.3	-0.1	0.6	0.3
Hearing aid user	0.3	0.3	0.4	0.6	0.6	0.4
Mother’s age at death	0.2	0.2	0.7	-0.2	-0.8	-0.0
Financial situation satisfaction	0.2	0.2	0.6	-0.8	0.0	0.3
Tinnitus: Yes, now most or all of the time	1.3	1.5	3.6	-1.9	-0.1	-0.9
Commuting to job workplace: Public transport	0.9	1.1	1.6	1.3	-1.1	0.7
Eye problems/disorders: Glaucoma	0.1	0.2	0.3	0.3	0.6	0.1
Medication: Blood pressure	0.4	0.8	2.1	-0.5	0.1	-1.5
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.4	-0.6	-0.5	0.4
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.7	-0.3	-0.8	0.8
High cholesterol (Self-reported)	0.2	0.3	0.6	-0.6	-0.8	0.2
Medication: Bendroflumethiazide	1.1	1.7	4.5	-0.1	-2.1	-0.7
Medication: Paracetamol	0.7	1.2	3.1	-0.5	-0.1	1.8
Medication: Lisinopril	0.7	0.9	1.9	0.5	-1.4	-0.7
Medication: Atorvastatin	0.8	1.0	1.6	0.0	-1.2	1.3
Illnesses of father: High blood pressure	0.4	0.5	1.0	-0.4	1.0	-0.7
Alcohol drinker status: Never	0.1	0.1	0.3	0.1	0.5	0.3
Ever smoked	0.3	0.6	1.2	-0.6	-0.3	-1.1
Basal metabolic rate	2.1	11.4	32.0	-0.3	5.7	1.4
Leg fat percentage (left)	0.1	0.5	1.1	0.6	0.2	-1.0
Arm fat-free mass (left)	2.7	13.6	38.4	-0.5	6.2	1.4
Number of operations (self-reported)	1.1	1.6	4.3	-0.0	-2.1	0.7
Average weekly beer plus cider intake	3.7	5.4	10.7	-0.9	-2.1	-3.3
Irritability	0.4	0.7	1.8	0.4	-1.3	-0.2
Risk taking	0.5	0.7	1.0	0.8	-1.0	-0.6
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	0.6	-0.1	-0.4
Fractured/broken bones in last 5 years	3.8	4.9	13.7	-0.0	-3.7	-0.9
Age started oral contraceptive pill	1.2	1.4	3.5	0.7	-1.9	-0.6
Diastolic blood pressure, automated reading	0.2	0.6	1.2	-0.6	-1.1	0.4
Ever depressed for a whole week	0.1	0.1	0.2	-0.4	0.2	0.4
Unable to work because of sickness or disability	1.2	1.5	4.2	-0.6	-0.2	-2.0
Commuting to job workplace: Cycle	1.5	1.9	4.8	2.2	-0.9	0.3
Myopia	0.7	1.0	3.0	-1.7	0.1	0.1
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.4	-0.3	1.5	0.3
Cholesterol lowering medication	0.4	0.6	0.8	-0.9	-0.7	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	0.7	-0.9	0.5
Pain experienced in last month	0.3	0.5	0.7	0.8	-0.3	-0.8
Supplements: Calcium	2.5	2.8	8.3	0.2	-2.9	0.1
Basal cell carcinoma (self-reported)	0.3	0.3	0.7	0.6	-0.8	-0.1
Heart attack/myocardial infarction (self-reported)	1.4	1.8	4.3	2.1	-0.9	0.3
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.6	0.7	-0.2	0.0
Heart disease (siblings)	0.1	0.1	0.3	-0.5	0.1	-0.2
Alcohol drinker status: Previous	0.5	0.6	1.0	0.3	-0.8	1.0
Pack years of smoking	2.8	4.0	7.3	1.2	-1.8	-2.7
Impedance of whole body	0.8	4.3	12.4	0.1	-3.5	0.6
Leg fat mass (left)	0.4	1.6	4.6	0.5	2.1	-0.2
Arm predicted mass (left)	2.4	12.4	34.9	-0.4	5.9	1.4