TWAS
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Traits
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Traits
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Whole body fat-free mass
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chr12:45,890,331-47,465,082
Best TWAS P=4.14e-20 · Best GWAS P=2.37e-23 conditioned to 0.00182
45.8M
46M
46.2M
46.4M
46.6M
46.8M
47M
47.2M
47.4M
0
5
10
15
20
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Kidney Renal Papillary Cell Carcinoma
SLC38A2
0.10
0.06
blup
30
0.05
8.3e-04
-9.9
9.2
4.1e-20
-0.86
0.01
0.91
TRUE
2
NTR
Blood
SLC38A1
0.12
0.07
lasso
6
0.08
8.4e-24
5.8
-5.8
5.1e-09
0.08
1.00
0.00
TRUE
4
The Cancer Genome Atlas
Soft Tissue Sarcoma
SLC38A2
0.06
0.01
blup
30
0.03
5.1e-03
-9.9
8.6
6.1e-18
-0.92
0.02
0.74
FALSE
1
METSIM
Adipose
SLC38A2
0.02
0.02
blup
341
0.01
5.8e-03
-9.3
8.5
1.8e-17
-0.90
0.06
0.90
FALSE