TWAS
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Traits
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Traits
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Whole body fat-free mass
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chr12:49,569,311-51,256,065
Best TWAS P=1.3e-17 · Best GWAS P=7.53e-26 conditioned to 0.000285
49.6M
49.8M
50M
50.2M
50.4M
50.6M
50.8M
51M
51.2M
0
5
10
15
20
25
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
GTEx
Testis
FAIM2
0.27
0.09
lasso
5
0.06
0.00093
9.01
-8.5
1.3e-17
-0.77
0.05
0.84
TRUE
4
The Cancer Genome Atlas
Breast Invasive Carcinoma
FAIM2
0.02
0.00
blup
71
0.01
0.00853
0.50
-5.6
1.9e-08
-0.36
0.16
0.12
TRUE
2
GTEx
Breast Mammary Tissue (Female)
CERS5
0.09
0.03
lasso
3
0.05
0.01750
0.65
-6.5
5.9e-11
-0.53
0.05
0.22
FALSE
1
CommonMind
Brain Pre-frontal Cortex
FAIM2
0.09
0.00
bslmm
336
0.03
0.00037
0.50
5.6
2.1e-08
0.52
0.06
0.79
FALSE