Hub : Genes

SLC38A1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.1173	0.0234	3.2e-15	0.070	0.067	0.071	0.075	0.078	1.5e-21	8.8e-21	5.4e-22	3.9e-23	8.4e-24
2	YFS	Blood	0.2237	0.0369	0.0e+00	0.131	0.173	0.184	0.184	0.185	1.7e-40	3.8e-54	4.6e-58	6.5e-58	3.0e-58
3	TCGA	Prostate Adenocarcinoma	0.0772	0.0307	3.1e-04	0.043	0.036	0.023	NA	0.041	2.4e-05	1.1e-04	1.6e-03	NA	3.5e-05
4	TCGA	Thyroid Carcinoma	0.0410	0.0200	6.9e-03	0.025	0.014	0.000	NA	0.005	1.5e-03	1.4e-02	3.6e-01	NA	9.3e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.2	0.3	0.7	-0.3	-0.8	-0.2	-0.7
Bipolar Disorder or Schizophrenia	0.6	1.5	3.9	2.0	0.9	-0.9	-0.8
Depressed Affect (Nagel 2018)	0.5	1.0	2.1	0.3	1.2	0.7	1.5
Depression (Nagel 2018)	2.8	4.2	12.2	-0.0	1.4	3.5	1.6
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.4	0.7	0.7	0.3	-1.6
Neuroticism (Nagel 2018)	0.5	1.1	2.4	1.2	0.8	-0.0	1.5
Schizophrenia (2018)	1.4	3.0	7.7	2.8	1.8	-1.0	-0.4
Schizophrenia vs Biploar Disorder	1.9	2.5	4.3	2.1	1.4	-1.3	-1.4
Worry (Nagel 2018)	0.4	0.9	1.8	1.3	0.5	-1.2	0.5
Alzheimer’s Disease (in mother)	0.6	0.8	1.7	-1.3	-0.9	-0.1	-0.8
Alzheimer’s Disease (in father)	1.2	1.3	4.1	0.6	0.9	-2.0	-0.2
Alzheimer’s Disease (including proxy)	0.6	0.8	1.6	-0.6	-0.3	-1.1	-1.3
Crohns Disease (2017)	0.1	0.1	0.3	0.4	-0.2	-0.5	-0.3
Irritable Bowel Disease (IBD)	0.3	0.7	2.2	1.5	0.6	-0.0	-0.2
Ulcerative Colitis (UC)	1.4	2.6	6.1	2.5	1.7	1.0	-0.4
Major Depression (MDD)	0.1	0.1	0.2	0.3	0.5	0.4	0.0
Reaction Time	3.0	5.8	14.5	-1.1	-2.2	-3.8	-1.6
Verbal and Numeric Reasoning (VNR)	0.6	1.5	3.1	1.1	0.8	1.1	-1.8
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.1	0.1	0.2	-0.3	0.3	-0.5	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	4.0	5.9	8.6	2.2	2.3	-2.2	-2.9
Bipolar Disorder (2011)	0.5	0.5	1.1	-1.1	-1.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.1	1.5	3.8	0.1	0.9	1.9	1.2
Coronary Artery Disease (CAD)	1.4	1.7	3.9	0.9	0.3	2.0	-1.4
Crohns Disease (2012)	0.2	0.3	0.8	-0.3	-0.4	-0.9	-0.3
Mean Putamen Volume	0.3	0.4	1.3	0.5	0.0	-1.1	0.1
Fasting Glucose	0.2	0.3	0.5	-0.5	-0.7	-0.4	0.2
HbA1C	0.2	0.2	0.7	0.4	0.9	-0.2	-0.2
HDL Cholesterol	0.5	0.9	2.0	-0.2	-0.4	-1.2	-1.4
LDL Cholesterol	0.5	0.7	1.6	-0.7	-1.3	-0.1	0.9
Lupus	0.4	0.6	1.3	-0.7	-0.6	-1.1	-0.3
Neuroticism (2016)	0.2	0.2	0.4	-0.5	-0.6	-0.6	0.2
Primary Biliary Cirrhosis	0.8	1.1	2.2	0.7	1.4	0.0	-1.5
Rheumatoid Arthritis	2.2	3.0	5.9	2.4	2.1	-1.3	0.4
Schizophrenia (2014)	1.4	3.1	6.5	2.6	1.2	-1.4	-1.6
Triglycerides	2.0	3.3	8.5	-1.8	-1.2	2.9	0.5
Type 2 Diabetes (T2D) (2012)	2.4	2.7	5.0	1.1	0.6	2.2	-2.1
Ulcerative Colitis	0.4	0.6	1.9	1.4	0.7	-0.0	-0.3
Blood Eosinophil Count	1.0	7.7	22.8	0.9	-2.1	-4.8	-1.7
Blood Platelet Count	0.5	5.9	11.8	2.5	-1.2	2.0	-3.4
Blood Red Count	0.4	4.1	11.0	-1.9	-0.1	-1.3	3.3
Blood White Count	0.3	2.1	5.7	-0.3	1.0	-2.4	1.2
Heel T-Score	0.3	2.2	8.1	0.4	2.9	0.2	-0.7
BMI	0.8	4.7	9.9	-1.9	0.4	3.1	2.2
Height	0.8	15.5	32.2	-5.7	0.8	0.3	5.4
Waist Hip Ratio (WHR)	0.2	0.8	2.6	0.5	-1.6	-0.1	-0.5
Systolic Blood Pressure	0.8	4.1	7.6	2.7	0.3	-1.2	-2.8
Smoking Status	1.0	2.4	5.9	-0.2	0.6	-1.8	2.4
Allergy or Eczema	1.6	4.3	9.2	2.7	0.3	0.8	-3.0
Cardiovascular Disease	0.3	0.9	1.8	-1.4	-1.1	0.6	0.6
Hypothyroidism (self reported)	1.0	2.2	6.8	1.3	2.6	-0.1	-0.6
Respiratory disease	0.4	1.0	3.4	0.7	0.1	-1.9	0.1
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.4	-0.8	-1.2	-1.1	-0.1
Lung FEV1/FVC ratio	0.3	1.3	4.6	-0.9	-0.1	0.0	2.1
Lung FVC	0.7	3.6	12.8	-0.7	1.0	-0.1	3.6
Neuroticism	0.8	1.9	3.1	1.4	1.8	-0.7	1.4
Chronotype (morning person)	0.6	1.5	2.1	-1.4	-1.3	-1.5	0.4
Hair Pigment	0.2	6.8	19.8	-0.7	-4.5	0.4	-2.6
Tanning	0.3	3.8	9.7	2.1	3.1	0.6	0.9
Hand grip strength (left)	1.1	2.8	4.3	-1.3	1.5	2.1	1.8
Number of treatments/medications taken	1.1	1.9	3.4	-1.1	-1.4	-1.8	1.0
Average weekly spirits intake	3.8	4.7	8.4	1.5	2.8	2.9	-0.4
Sensitivity / hurt feelings	0.7	1.2	2.2	0.4	-0.0	-1.5	1.5
Frequency of depressed mood in last 2 weeks	1.3	1.8	2.3	0.5	1.5	1.5	1.5
Hearing difficulty/problems: Yes	0.0	0.0	0.0	-0.2	-0.2	-0.1	0.2
Relative age of first facial hair	0.7	1.4	2.4	-1.4	-1.1	-1.6	0.1
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	3.1	0.5	0.9	1.8	-0.4
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.8	-0.0	0.3	0.0	0.9
Ever had hysterectomy (womb removed)	0.5	0.6	1.7	0.1	1.3	0.7	-0.0
Systolic blood pressure, automated reading	0.8	2.4	5.0	2.2	1.1	0.6	-1.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.9	-0.2	0.4	-0.3	1.0
Angina	2.2	2.9	5.6	-2.4	-0.8	-1.4	1.8
Medication for hormone replacement therapy	0.8	0.9	2.3	-0.6	-0.3	-1.0	1.5
Vitamin and mineral supplements	0.3	0.4	1.0	-0.2	1.0	0.3	0.7
Supplements: Zinc	0.4	0.5	1.1	0.9	0.0	0.2	1.0
Medication: Co-codamol	0.4	0.4	1.4	-0.1	0.4	0.4	1.2
Medication: Metformin	0.8	1.1	2.5	-1.6	-1.2	-0.1	-0.7
Diabetes (father)	0.9	1.1	1.5	-1.2	-1.0	-0.9	1.1
Diabetes (mother)	1.3	1.6	2.7	-0.0	-1.3	-1.4	-1.6
Severe depression (siblings)	1.1	1.2	1.8	-1.1	-1.2	-1.4	0.7
Pack years adult smoking proportion	0.2	0.3	0.4	-0.5	-0.7	-0.5	-0.5
Impedance of leg (right)	1.0	5.0	8.1	2.3	-2.8	-1.6	-2.0
Leg fat-free mass (left)	2.0	10.5	28.8	-5.4	-0.3	1.9	3.1
Trunk fat percentage	0.4	1.6	3.1	-0.5	-1.4	1.8	1.0
Hand grip strength (right)	0.7	1.8	4.2	-1.2	0.9	2.0	0.9
Townsend deprivation index at recruitment	1.9	2.6	7.8	1.0	1.2	-2.8	-0.6
Current tobacco smoking	0.8	1.4	4.0	-0.0	0.9	-2.0	0.9
Average weekly fortified wine intake	0.7	0.8	2.6	-0.2	-0.3	-0.6	-1.6
Maternal smoking around birth	1.1	1.6	4.5	-0.8	-1.1	0.1	2.1
Fed-up feelings	0.8	1.5	4.7	-0.4	0.2	1.1	2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	2.7	0.3	1.5	1.0	1.6
Relative age voice broke	0.7	1.0	2.4	-0.3	-0.6	-1.5	-1.1
Taking other prescription medications	0.7	1.0	3.8	0.2	-0.3	-1.9	-0.5
Age when periods started (menarche)	0.4	0.9	1.9	0.4	0.1	-1.2	-1.4
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.8	0.2	0.2	0.9	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.7	0.3	0.5	-0.1	-0.8
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	2.0	0.9	1.4	0.4	0.0
Qualifications: CSEs or equivalent	0.5	0.7	2.1	-0.2	0.2	1.5	0.6
Serious illness, injury or assault to yourself	0.3	0.3	0.8	-0.1	-0.0	-0.9	0.8
High blood pressure	0.1	0.2	0.3	0.1	-0.6	0.2	-0.6
Hayfever, allergic rhinitis or eczema	1.1	2.5	5.9	2.4	0.9	-0.3	-1.7
Multivitamins +/- minerals	0.3	0.4	0.8	0.1	-0.9	-0.1	-0.9
Stomach or abdominal pain in last month	0.1	0.1	0.3	0.4	0.1	-0.2	-0.5
Supplements: Glucosamine	0.5	0.6	1.4	-0.3	-0.6	-0.7	1.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.5	0.2	0.7	0.7	-0.7
Medication: Atenolol	2.3	2.9	6.0	1.9	1.3	-0.5	-2.4
Medication: Levothyroxine sodium	0.5	0.9	2.7	-0.5	0.6	-1.6	-0.4
Sitting height	1.4	10.2	21.3	-4.6	1.2	0.1	4.2
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	-0.4	-0.6	-0.4	-0.4
High blood pressure (mother)	0.2	0.3	0.7	0.8	-0.2	-0.6	-0.5
Body mass index (BMI)	1.0	4.1	7.6	-1.9	0.1	2.7	2.3
Impedance of leg (left)	1.2	6.0	7.9	2.8	-2.3	-2.4	-2.2
Leg predicted mass (left)	2.0	10.5	29.3	-5.4	-0.3	1.9	3.0
Trunk fat mass	0.7	3.1	4.2	-2.0	-1.2	1.9	1.8
Waist circumference	0.8	3.0	5.2	-2.2	-0.8	1.2	2.3
Number of incorrect matches in round	3.1	5.1	8.7	3.0	1.0	-1.7	-2.8
Past tobacco smoking	0.5	0.9	2.0	0.4	0.6	1.0	-1.4
Alcohol usually taken with meals	1.3	2.1	5.1	-1.5	-2.3	0.6	-0.6
Nervous feelings	0.3	0.6	1.8	1.3	0.6	-0.1	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.0	1.4	1.4	0.3	0.7
Hearing difficulty/problems with background noise	0.3	0.4	0.8	-0.7	-0.2	0.9	0.6
Hair/balding pattern: Pattern 2	0.1	0.1	0.4	-0.6	-0.2	0.3	-0.1
Had menopause	0.4	0.5	0.9	0.3	0.8	0.7	0.9
Had other major operations	0.7	0.9	2.5	0.4	0.6	1.6	0.7
Forced vital capacity (FVC)	1.4	5.4	12.5	-2.6	-0.2	1.5	3.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.5	0.3	0.5	0.7	-0.6
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.0	0.0	-1.0	-0.9	0.6
Qualifications: None of the above	1.4	2.9	5.2	2.1	2.3	-1.5	-0.2
Financial difficulties in last 2 years	1.6	2.1	4.8	1.0	1.5	2.2	0.7
Mouth/teeth dental problems	0.4	0.6	0.9	0.3	-0.9	0.8	-0.9
Heart attack	2.1	2.6	4.6	-1.9	-0.2	-1.4	2.1
Allergy	1.5	3.4	6.7	-2.6	-1.1	2.0	1.4
Pain all over the body in last month	0.4	0.4	0.8	0.5	0.9	-0.8	0.0
Diabetes (self-reported)	0.9	1.4	3.3	-1.0	-1.8	-1.0	-0.3
Hayfever/allergic rhinitis (self-reported)	2.2	2.9	8.2	-0.6	-1.5	-2.9	-0.8
Medication: Ramipril	0.3	0.4	1.5	0.0	0.3	-1.2	0.4
Medication: Simvastatin	1.3	1.9	2.9	-1.2	0.6	1.7	1.7
Fluid intelligence score	0.6	1.3	2.8	0.6	0.4	1.4	-1.7
Illnesses of siblings	0.4	0.6	0.9	1.0	0.9	-0.3	0.7
Neuroticism score	0.5	1.1	2.0	1.4	1.2	-0.3	1.0
Weight	1.8	8.7	17.4	-4.2	-0.5	2.4	3.4
Impedance of arm (right)	0.9	4.4	9.0	3.0	-1.8	-0.1	-2.3
Arm fat percentage (right)	0.7	2.8	6.5	-0.9	-0.9	2.6	1.8
Trunk fat-free mass	2.1	12.0	31.9	-5.7	0.5	1.6	3.6
Hip circumference	1.5	6.3	11.1	-3.3	-0.3	2.3	3.0
Time employed in main current job	2.8	3.2	5.7	2.3	2.4	-0.9	-1.0
Alcohol intake versus 10 years previously	1.7	2.5	3.7	-1.9	-1.6	-1.9	0.5
Father’s age at death	0.8	1.0	2.0	-0.5	-0.6	1.4	1.2
Worrier / anxious feelings	0.9	1.7	4.8	2.2	0.5	-0.9	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.1	0.4	1.1	-0.8	-0.4
Falls in the last year	1.8	2.4	5.7	2.4	1.8	-0.7	-0.5
Hair/balding pattern: Pattern 3	1.0	1.4	4.0	1.2	0.2	0.4	2.0
Number of live births	0.8	1.1	3.5	0.7	1.9	-0.5	0.6
Forced expiratory volume in 1-second (FEV1)	1.4	4.6	10.1	-2.2	0.1	1.8	3.2
Pulse rate	0.0	0.1	0.2	-0.1	-0.5	-0.2	0.0
Happiness	1.4	1.7	3.7	1.9	1.5	-0.2	-1.0
Noisy workplace	0.1	0.2	0.6	-0.7	-0.0	0.4	0.2
Qualifications: A levels/AS levels or equivalent	1.2	2.6	8.1	0.9	-1.1	0.4	-2.8
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	0.2	-0.1	0.4	0.4
Mouth/teeth dental problems: Dentures	0.9	1.5	3.0	-1.7	-0.5	-1.5	0.6
Asthma	0.7	1.3	4.4	-0.1	-0.9	-2.1	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.9	0.1	0.6	-0.9	0.1
Medication: Cholesterol lowering	0.9	1.4	2.8	-1.6	-0.2	0.3	1.7
Depression (self-reported)	0.3	0.4	1.5	0.3	-0.0	-0.0	1.2
Medication: Lansoprazole	0.7	0.8	2.3	-1.5	-0.8	0.5	0.3
Prospective memory result	1.8	2.2	5.2	-2.3	-1.4	-0.7	1.2
Lung cancer (father)	1.1	1.3	2.6	-1.5	-0.5	-0.1	1.6
Illnesses of mother	0.5	0.6	2.1	-1.4	0.2	0.1	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.7	7.6	-2.4	-0.4	1.1	2.8
Pulse wave Arterial Stiffness index	1.7	2.0	5.2	-1.1	0.7	1.0	2.3
Impedance of arm (left)	1.1	5.2	10.7	3.3	-1.9	-0.2	-2.5
Arm fat mass (right)	1.1	4.4	7.3	-2.2	-0.5	2.7	2.3
Trunk predicted mass	2.1	11.9	32.2	-5.7	0.4	1.6	3.6
Standing height	0.9	9.2	27.4	-5.2	-1.2	-0.0	2.8
Length of working week for main job	0.9	1.0	2.3	-0.3	0.2	1.2	1.5
Exposure to tobacco smoke at home	0.6	0.7	1.8	0.2	-0.9	-0.5	-1.4
Breastfed as a baby	0.8	1.0	2.5	0.6	1.0	1.6	0.6
Tense / ‘highly strung’	0.7	1.2	2.7	0.1	0.6	-1.3	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	5.9	0.0	-0.6	0.1	2.4
Hair/balding pattern: Pattern 4	0.3	0.8	2.9	-1.7	0.2	-0.1	0.4
Birth weight of first child	3.2	5.9	10.0	-2.8	-1.5	3.2	1.9
Peak expiratory flow (PEF)	0.9	2.1	5.9	-1.2	0.3	2.4	1.0
Pulse wave reflection index	1.1	1.3	4.2	-0.2	0.9	0.3	2.0
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.7	0.8	0.6	-0.7	-0.7
Loud music exposure frequency	1.4	1.6	4.4	1.3	0.5	2.1	-0.2
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	4.6	-1.5	-2.2	0.3	-1.1
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	5.2	-0.3	1.0	-0.7	2.3
Blood clot in the leg (DVT)	0.2	0.3	0.9	0.3	1.0	0.1	-0.2
Medication: Paracetamol	0.9	1.5	4.5	-0.9	-0.2	-0.8	2.1
Headache pain in last month	0.6	1.0	2.0	-0.4	0.7	-1.4	1.1
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.2	0.3	-0.0	1.1	-0.7
Glaucoma (self-reported)	0.4	0.5	1.5	-1.2	-0.4	0.3	0.3
Gout (self-reported)	1.3	1.7	3.6	0.9	1.5	-1.9	-0.5
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	3.4	0.9	1.9	-0.3	-0.9
Medication: Amlodipine	1.4	2.0	6.7	0.6	0.8	-2.6	-0.3
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.2	1.1	-0.2	-1.1	-0.4
Birth weight	2.6	5.7	14.7	-3.8	-1.5	1.0	2.2
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.7	0.2	-0.6	0.5	-0.9
High blood pressure (siblings)	0.7	0.9	2.2	-0.9	-1.5	0.9	-0.1
Forced vital capacity (FVC), Best measure	1.2	4.2	7.8	-2.8	-0.9	0.7	2.8
Body fat percentage	0.5	1.8	3.6	-0.6	-1.2	1.9	1.3
Leg fat percentage (right)	0.4	1.6	2.3	-0.7	-1.2	1.4	1.5
Arm fat-free mass (right)	2.0	10.3	30.2	-5.5	0.1	0.8	3.2
Exposure to tobacco smoke outside home	3.5	4.7	9.7	3.1	1.8	-1.1	-2.1
Comparative body size at age 10	0.5	1.5	4.6	-0.6	-0.7	2.1	-0.6
Number of full brothers	2.2	2.7	5.5	0.3	0.7	-2.3	2.2
Worry too long after embarrassment	0.3	0.5	1.6	0.5	-0.6	-1.3	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.9	0.4	-1.0	-0.5	0.6
Wheeze or whistling in the chest in last year	0.9	1.5	4.1	-0.0	0.7	-2.0	1.2
Number of children fathered	0.4	0.5	1.3	-0.7	0.3	0.1	1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	4.3	0.1	0.4	-2.1	0.6
Age at first live birth	0.3	0.5	1.6	0.1	0.2	-1.2	-0.6
Pulse wave peak to peak time	1.5	1.7	4.7	1.0	-0.5	-1.0	-2.2
Health satisfaction	1.2	1.5	5.6	-0.2	0.2	-2.4	0.6
Shortness of breath walking on level ground	0.8	1.0	2.6	-0.8	0.4	-1.6	0.7
Qualifications: College or University degree	0.4	1.4	3.8	0.6	-1.0	0.7	-1.9
Eye problems/disorders: None of the above	0.2	0.2	0.4	0.5	0.6	-0.4	0.0
Mouth/teeth dental problems: Loose teeth	1.4	1.6	6.3	-0.3	-0.2	-2.5	-0.2
Emphysema/chronic bronchitis	1.0	1.1	1.7	1.3	1.1	-0.9	-0.9
Medication for pain relief, constipation, heartburn	1.2	2.0	3.7	-0.0	-1.1	1.7	-1.9
Neck or shoulder pain in last month	1.1	1.6	4.2	1.0	2.0	0.1	1.1
Medication: Blood pressure	1.3	2.3	6.8	0.9	0.5	-2.6	-1.3
Angina (self-reported)	2.4	3.1	5.7	-2.4	-0.8	-1.6	1.9
Migraine (self-reported)	0.8	1.0	2.3	-0.7	-1.5	-0.8	-0.7
Medication: Ibuprofen	0.5	0.5	1.7	0.2	0.6	-1.3	-0.3
Medication: Allopurinol	0.8	1.0	1.9	0.7	1.4	-1.1	-0.7
Medication: Omeprazole	0.6	0.8	1.9	0.8	1.4	-0.7	0.0
Medication: Seretide 50 evohaler	0.3	0.3	0.6	-0.6	-0.8	0.6	-0.3
Mean time to correctly identify matches	3.0	5.8	19.1	-0.3	-1.2	-4.4	-1.6
Heart disease (mother)	0.2	0.2	0.4	-0.3	-0.7	-0.2	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	0.9	-0.4	-0.9	0.4	0.7
Whole body fat mass	0.9	3.8	4.9	-2.1	-1.1	2.2	2.1
Leg fat mass (right)	1.1	4.4	7.2	-2.7	-1.4	1.7	2.3
Arm predicted mass (right)	2.1	10.6	29.7	-5.4	0.2	1.2	3.4
Pulse rate, automated reading	0.0	0.1	0.1	-0.1	0.4	0.1	0.3
Alcohol intake frequency.	0.6	1.3	2.5	-1.6	-1.5	0.7	0.0
Comparative height size at age 10	0.7	4.0	11.6	-3.4	-1.1	0.3	1.7
Number of full sisters	0.1	0.1	0.2	-0.5	-0.2	0.5	0.1
Suffer from ‘nerves’	1.3	2.1	4.7	2.2	0.7	-1.4	-1.1
Overall health rating	0.9	1.9	2.9	-1.5	0.0	-1.6	1.7
Chest pain or discomfort	1.5	2.1	3.6	1.1	1.9	-1.8	-0.6
Had major operations	0.3	0.3	0.4	0.6	-0.6	0.7	-0.4
Age at last live birth	0.1	0.1	0.1	-0.2	-0.3	-0.4	-0.4
Family relationship satisfaction	0.2	0.3	0.7	0.1	-0.4	0.8	-0.4
Leg pain on walking	0.8	1.0	3.4	-0.1	0.7	-0.0	1.8
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	2.9	-0.9	-0.0	1.2	1.7
Commuting to job workplace: Car/motor vehicle	2.2	2.5	6.5	-0.9	-0.6	-2.6	1.5
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.4	-0.4	-0.5	0.9	-1.2
Medication: Aspirin	0.6	0.8	1.3	-1.0	-0.6	-1.1	0.8
Supplements: Vitamin C	0.7	0.9	2.3	-0.8	0.0	0.8	1.5
Knee pain experienced in last month	0.5	0.8	0.9	0.7	0.9	-0.9	0.9
Hypertension (Self-reported)	0.1	0.2	0.4	0.3	-0.4	0.3	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.1	-0.2	0.9	-1.1	0.8
Illnesses of father: Heart disease	0.1	0.1	0.4	0.0	0.2	0.1	0.6
Illnesses of siblings: Diabetes	1.0	1.2	2.3	0.7	0.4	1.4	-1.5
Smoking status: Previous	0.6	0.9	3.2	-0.4	-0.3	-0.0	1.8
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.8	7.6	-2.8	-1.6	-0.6	0.7
Whole body fat-free mass	2.1	12.1	34.1	-5.8	0.2	1.5	3.5
Leg fat-free mass (right)	1.7	9.3	27.1	-5.2	0.1	1.6	2.8
Arm fat percentage (left)	0.6	2.5	6.7	-0.7	-0.8	2.6	1.4
Average weekly red wine intake	0.4	0.6	0.7	0.8	0.8	0.8	0.6
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.5	0.2	-0.1	-1.2	0.2
Mood swings	0.4	0.7	2.0	0.1	0.5	0.6	1.4
Loneliness, isolation	0.7	1.0	2.5	1.2	1.6	0.6	-0.1
Long-standing illness, disability or infirmity	0.5	0.7	2.7	-0.5	-1.6	-0.1	0.0
Ever had bowel cancer screening	0.7	0.9	2.4	0.8	0.4	1.6	-0.5
Diabetes diagnosed by doctor	0.7	1.2	2.9	-1.1	-1.7	-0.7	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.4	0.1	0.3	-1.5	0.8
Friendships satisfaction	0.2	0.3	1.0	0.5	1.0	0.0	0.1
Qualifications: nursing, teaching	0.4	0.7	2.4	-0.1	-0.5	-0.3	-1.6
Commuting to job workplace: Walk	2.6	2.8	6.3	-1.5	-1.3	2.5	1.1
Eye problems/disorders: Cataract	0.8	0.9	2.6	-0.1	-0.5	1.6	0.9
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.1	-0.3	-0.7	1.1	-0.0
Medication for cholesterol	0.5	0.7	2.0	0.6	0.7	-0.3	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.1	-0.3	1.3	0.8	1.4
Back pain experienced in last month	1.2	1.7	2.8	-1.0	1.7	-1.2	1.3
Mineral and other dietary supplements	0.3	0.4	1.0	-1.0	-0.2	-0.6	-0.1
Breast cancer (self-reported)	0.7	0.8	2.0	0.7	0.8	-1.4	0.5
Asthma (self-reported)	1.0	2.0	6.7	-0.3	-1.0	-2.6	0.2
Osteoporosis (self-reported)	1.6	1.9	3.7	1.8	0.8	0.1	-1.9
Osteoarthritis (self-reported)	1.1	1.4	4.6	-1.0	-0.4	-0.3	2.1
Medication: Aspirin	0.8	1.0	1.7	-1.3	-1.0	-0.7	0.8
Medication: Gliclazide	0.4	0.5	0.7	-0.7	-0.8	0.7	-0.3
Illnesses of father: None of the above (group 1)	1.1	1.4	3.2	1.2	1.8	-0.0	-1.0
Smoking status: Current	0.7	1.2	4.0	0.0	0.6	-2.0	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.6	3.0	0.2	1.7	-0.6	1.7
Whole body water mass	2.1	11.9	33.2	-5.8	0.2	1.5	3.5
Leg predicted mass (right)	1.7	9.1	26.6	-5.2	0.1	1.5	2.8
Arm fat mass (left)	1.0	4.3	8.3	-2.0	-0.4	2.9	2.1
Number of self-reported non-cancer illnesses	0.8	1.3	2.0	-1.1	-1.0	-1.4	1.0
Average weekly champagne plus white wine intake	1.0	1.4	3.1	0.7	-1.4	-0.1	-1.8
Miserableness	0.6	1.0	2.1	-0.8	0.2	-1.1	1.5
Guilty feelings	1.8	2.7	6.0	2.5	1.9	0.0	1.0
Wears glasses or contact lenses	2.9	3.4	6.9	2.6	2.6	-0.1	-0.1
Ever taken oral contraceptive pill	0.6	0.7	1.5	0.0	0.3	-1.1	1.2
Hearing aid user	0.2	0.2	0.5	-0.7	-0.5	-0.2	0.1
Mother’s age at death	1.5	1.9	3.0	1.7	1.4	-1.1	-1.2
Financial situation satisfaction	0.4	0.5	0.9	0.5	0.9	0.9	-0.2
Tinnitus: Yes, now most or all of the time	1.1	1.3	3.9	2.0	1.1	0.5	-0.3
Commuting to job workplace: Public transport	2.1	2.6	4.8	-2.2	-1.9	0.7	-1.1
Eye problems/disorders: Glaucoma	0.4	0.4	1.1	-1.1	-0.1	0.7	-0.3
Medication: Blood pressure	0.4	0.8	1.6	-0.4	-1.3	-1.0	-0.5
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.3	-0.2	0.5	-0.2	0.3
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.4	0.7	-0.6	0.3	-0.2
High cholesterol (Self-reported)	0.5	1.0	2.7	-0.3	0.2	1.6	1.0
Medication: Bendroflumethiazide	0.2	0.3	1.1	0.1	-0.3	1.0	-0.2
Medication: Paracetamol	0.4	0.6	1.3	0.2	0.6	-0.9	1.1
Medication: Lisinopril	2.3	3.0	6.5	-2.6	-2.3	0.5	0.2
Medication: Atorvastatin	0.1	0.2	0.4	0.3	-0.6	-0.4	0.2
Illnesses of father: High blood pressure	0.4	0.4	0.8	-0.4	-0.9	-0.7	-0.6
Alcohol drinker status: Never	0.6	0.7	2.4	-0.7	0.4	-1.5	0.1
Ever smoked	0.7	1.3	3.1	0.1	0.0	-1.8	1.4
Basal metabolic rate	2.1	11.7	31.2	-5.6	-0.1	1.8	3.5
Leg fat percentage (left)	0.2	0.9	1.9	-0.3	-0.6	1.1	1.4
Arm fat-free mass (left)	1.9	9.8	26.6	-5.2	0.3	1.4	3.2
Number of operations (self-reported)	1.2	1.7	3.5	1.0	1.6	1.9	-0.0
Average weekly beer plus cider intake	0.4	0.5	0.9	0.6	0.8	-1.0	0.5
Irritability	1.1	1.9	3.4	1.7	0.5	1.8	1.0
Risk taking	0.5	0.7	0.9	-0.8	-0.9	-0.7	0.9
Ever had prostate specific antigen (PSA) test	1.8	2.1	4.5	1.8	2.1	0.8	-0.6
Fractured/broken bones in last 5 years	1.7	2.1	4.3	2.1	1.4	1.4	-0.4
Age started oral contraceptive pill	1.7	2.2	3.5	1.6	1.9	1.5	-0.6
Diastolic blood pressure, automated reading	0.3	1.0	2.0	1.2	0.8	1.4	-0.2
Ever depressed for a whole week	0.1	0.1	0.3	0.5	-0.1	-0.3	0.3
Unable to work because of sickness or disability	0.2	0.2	0.4	0.4	0.6	-0.2	0.6
Commuting to job workplace: Cycle	1.3	1.5	3.0	-1.7	-1.6	0.7	-0.0
Myopia	2.2	3.1	9.5	-0.4	-0.4	-3.1	1.6
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.0	1.0	1.0	-0.3	-0.3
Cholesterol lowering medication	1.3	1.9	3.3	-1.2	-1.2	1.2	1.8
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	2.8	1.2	1.7	-1.1	-1.0
Pain experienced in last month	1.1	1.9	5.5	-0.3	-1.4	2.3	-0.2
Supplements: Calcium	1.0	1.1	2.1	1.5	0.5	0.2	-1.4
Basal cell carcinoma (self-reported)	0.2	0.2	0.6	0.1	0.2	0.8	-0.5
Heart attack/myocardial infarction (self-reported)	1.9	2.4	4.4	-1.8	-0.1	-1.5	2.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.8	0.2	0.9	0.1	0.1
Heart disease (siblings)	2.7	3.3	5.9	-2.4	-2.3	-1.2	0.8
Alcohol drinker status: Previous	0.2	0.2	0.3	0.5	-0.1	0.5	0.6
Pack years of smoking	0.2	0.3	0.6	-0.5	-0.5	-0.4	-0.8
Impedance of whole body	1.1	5.8	10.2	3.2	-2.4	-1.2	-2.4
Leg fat mass (left)	0.9	3.4	5.6	-2.4	-0.9	1.5	2.2
Arm predicted mass (left)	1.8	9.3	24.6	-5.0	0.7	1.4	3.2