TWAS
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Usage
Models
Genes
Traits
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Traits
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Whole body fat-free mass
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chr1:180,186,713-181,614,143
Best TWAS P=1.18e-10 · Best GWAS P=3.62e-11 conditioned to 1
180.2M
180.4M
180.6M
180.8M
181M
181.2M
181.4M
181.6M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
CommonMind
Brain Pre-frontal Cortex
KIAA1614
0.19
0.17
lasso
7
0.18
2.9e-21
6.6
-6.4
1.2e-10
-0.97
0
1
TRUE
2
The Cancer Genome Atlas
Thyroid Carcinoma
KIAA1614
0.25
0.08
lasso
3
0.07
3.6e-07
6.6
-6.2
6.4e-10
-0.94
0
1
FALSE