[Hub]/) : Traits : Whole body fat-free mass :

chr1:182,298,784-184,739,300

Best TWAS P=7.65e-15 · Best GWAS P=9.57e-17 conditioned to 0.0121

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex TSEN15 0.23 0.18 lasso 9 0.18 4.7e-21 7.9 7.8 7.6e-15 0.90 0.02 0.98 TRUE
2 GTEx Adipose Subcutaneous RP11-181K3.4 0.09 0.11 enet 9 0.09 6.7e-08 5.7 5.7 1.1e-08 0.04 0.09 0.91 FALSE
3 GTEx Adipose Visceral Omentum RP11-181K3.4 0.13 0.06 lasso 3 0.14 8.3e-08 5.8 6.2 5.3e-10 0.04 0.04 0.95 TRUE
4 GTEx Artery Aorta RP11-181K3.4 0.17 0.01 enet 16 0.02 2.3e-02 5.7 5.5 3.9e-08 0.06 0.06 0.92 FALSE
5 GTEx Artery Tibial LAMC1 0.10 0.10 lasso 5 0.10 2.2e-08 5.7 -5.9 4.0e-09 -0.03 0.07 0.93 FALSE
6 GTEx Artery Tibial RP11-181K3.4 0.07 0.07 lasso 15 0.05 1.1e-04 5.7 5.9 3.4e-09 0.06 0.08 0.91 FALSE
7 GTEx Brain Cerebellar Hemisphere LAMC1 0.50 0.16 enet 13 0.13 3.8e-04 6.0 5.9 3.8e-09 0.04 0.05 0.94 FALSE
8 GTEx Brain Cerebellar Hemisphere TSEN15 0.38 0.08 lasso 13 0.16 5.3e-05 7.9 7.4 1.3e-13 0.83 0.01 0.96 FALSE
9 GTEx Brain Cerebellum LAMC1 0.27 0.36 enet 29 0.29 3.5e-09 6.0 5.8 4.8e-09 0.00 0.04 0.96 FALSE
10 GTEx Esophagus Muscularis LAMC1 0.11 0.08 enet 9 0.03 4.4e-03 5.8 -5.8 5.7e-09 -0.02 0.07 0.89 FALSE
11 GTEx Esophagus Muscularis RP11-181K3.4 0.05 0.09 lasso 1 0.07 3.9e-05 6.0 6.0 1.8e-09 0.03 0.04 0.95 FALSE
12 GTEx Lung LAMC1 0.18 0.20 enet 33 0.19 2.3e-14 6.0 -5.8 7.0e-09 -0.04 0.04 0.96 FALSE
13 GTEx Nerve Tibial LAMC1 0.07 0.08 enet 30 0.05 1.1e-04 6.0 5.8 5.6e-09 0.07 0.04 0.96 FALSE
14 GTEx Nerve Tibial RP11-181K3.4 0.18 0.24 enet 30 0.24 2.9e-17 6.0 5.9 3.6e-09 0.03 0.03 0.97 FALSE
15 GTEx Thyroid RP11-181K3.4 0.12 0.07 lasso 4 0.05 5.7e-05 5.7 5.8 7.8e-09 0.05 0.07 0.92 FALSE
16 GTEx Whole Blood LAMC1 0.08 0.05 enet 21 0.04 1.0e-04 5.8 5.3 1.1e-07 0.05 0.06 0.94 FALSE
17 METSIM Adipose TSEN15 0.06 0.02 enet 28 0.04 1.3e-06 7.9 7.2 7.7e-13 0.76 0.02 0.98 FALSE
18 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma GLT25D2 0.05 0.01 enet 10 0.04 6.3e-05 3.9 -7.3 2.0e-13 -0.69 0.01 0.94 FALSE
19 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma GLT25D2 0.11 0.02 blup 119 0.05 5.1e-06 -1.8 -5.7 1.4e-08 -0.50 0.14 0.31 FALSE
20 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma LAMC1 0.04 0.03 blup 108 0.04 1.2e-05 6.0 -5.8 9.1e-09 -0.04 0.04 0.95 FALSE
21 The Cancer Genome Atlas Brain Lower Grade Glioma TSEN15 0.11 0.08 blup 52 0.10 6.7e-12 7.9 6.9 4.1e-12 0.78 0.02 0.98 FALSE
22 The Cancer Genome Atlas Thyroid Carcinoma LAMC1 0.06 0.04 blup 109 0.05 1.3e-05 5.8 -5.6 2.5e-08 -0.07 0.04 0.96 FALSE