[Hub]/) : Traits : Whole body fat-free mass :

chr1:10,391,536-12,013,869

Best TWAS P=2.25e-20 · Best GWAS P=4.55e-18 conditioned to 0.22

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex EXOSC10 0.06 0.08 lasso 2 0.07 6.8e-09 8.7 8.7 2.3e-18 0.99 0.01 0.99 FALSE
2 CommonMind Brain Pre-frontal Cortex MTOR 0.13 0.15 lasso 4 0.15 5.6e-18 8.4 8.2 2.1e-16 0.88 0.05 0.95 FALSE
3 GTEx Adipose Subcutaneous MASP2 0.10 0.06 lasso 2 0.03 8.8e-04 6.3 6.3 2.4e-10 0.69 0.51 0.27 FALSE
4 GTEx Adipose Subcutaneous EXOSC10 0.17 0.00 lasso 3 0.00 1.8e-01 8.5 8.0 1.1e-15 0.94 0.02 0.56 FALSE
5 GTEx Adipose Visceral Omentum RP4-635E18.7 0.19 0.08 lasso 6 0.05 9.0e-04 8.7 8.2 3.2e-16 0.96 0.02 0.96 FALSE
6 GTEx Brain Cerebellar Hemisphere EXOSC10 0.23 0.10 lasso 3 0.12 6.4e-04 8.0 8.2 1.7e-16 0.90 0.05 0.73 FALSE
7 GTEx Brain Cerebellum EXOSC10 0.33 0.16 lasso 6 0.18 3.8e-06 8.6 8.7 5.4e-18 0.94 0.02 0.97 FALSE
8 GTEx Brain Cerebellum RP4-635E18.7 0.17 0.17 lasso 5 0.09 1.3e-03 8.6 8.5 1.3e-17 0.96 0.02 0.94 FALSE
9 GTEx Brain Cortex RP4-635E18.7 0.17 0.05 lasso 4 0.07 6.4e-03 8.4 8.4 3.2e-17 0.91 0.04 0.77 FALSE
10 GTEx Lung EXOSC10 0.11 0.07 lasso 4 0.05 1.2e-04 8.6 8.5 2.5e-17 0.97 0.01 0.98 FALSE
11 GTEx Nerve Tibial MASP2 0.14 0.07 lasso 5 0.09 1.2e-06 6.3 6.1 1.0e-09 0.68 0.35 0.56 FALSE
12 GTEx Thyroid RP4-635E18.7 0.07 0.02 lasso 2 0.01 5.5e-02 8.6 9.0 3.3e-19 0.93 0.02 0.91 FALSE
13 GTEx Whole Blood MTOR 0.16 0.06 enet 18 0.07 5.1e-07 7.7 6.4 1.4e-10 0.66 0.79 0.20 FALSE
14 METSIM Adipose EXOSC10 0.05 0.06 lasso 1 0.05 3.5e-08 7.0 7.0 2.7e-12 0.85 0.02 0.98 FALSE
15 METSIM Adipose MTOR 0.04 0.02 bslmm 434 0.02 1.5e-04 8.4 8.5 1.7e-17 0.89 0.03 0.97 FALSE
16 ROSMAP Brain Pre-frontal Cortex EXOSC10 0.06 0.06 lasso 2 0.06 4.9e-08 8.7 8.6 6.5e-18 1.00 0.01 0.99 FALSE
17 ROSMAP Brain Pre-frontal Cortex MTOR 0.07 0.05 bslmm 423 0.04 2.0e-06 8.4 9.2 2.3e-20 0.87 0.08 0.92 TRUE
18 ROSMAP Brain Pre-frontal Cortex RP4-635E18.7 0.23 0.09 enet 24 0.24 3.8e-30 6.3 6.5 1.1e-10 0.71 0.02 0.98 FALSE
19 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MTOR 0.02 0.02 blup 54 0.02 5.4e-03 8.3 8.4 3.3e-17 0.91 0.07 0.65 FALSE
20 The Cancer Genome Atlas Brain Lower Grade Glioma MTOR 0.03 0.01 blup 54 0.02 5.9e-03 8.3 8.2 2.4e-16 0.88 0.03 0.74 FALSE
21 The Cancer Genome Atlas Liver Hepatocellular Carcinoma MASP2 0.05 0.03 blup 30 0.04 6.0e-03 2.8 -7.4 1.2e-13 -0.84 0.02 0.58 FALSE