Hub : Genes

MASP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.099	0.0440	0.00530	0.061	NA	0.020	NA	0.034	1.1e-05	NA	7.9e-03	NA	8.8e-04
2	GTEx	Nerve Tibial	0.136	0.0456	0.00025	0.072	NA	0.074	NA	0.086	8.0e-06	NA	6.0e-06	NA	1.2e-06
3	TCGA	Liver Hepatocellular Carcinoma	0.055	0.0390	0.00440	0.030	0.039	0.003	NA	0.022	1.4e-02	0.006	2.3e-01	NA	3.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.0	0.1	0.1	-0.3	-0.3	0.0
Bipolar Disorder or Schizophrenia	0.9	2.1	3.2	-1.8	-1.7	0.7
Depressed Affect (Nagel 2018)	5.6	11.9	14.4	3.6	3.8	-2.9
Depression (Nagel 2018)	8.3	12.5	17.6	3.3	4.2	-3.0
Intelligence (Savage-Jansen 2018)	1.4	4.3	6.4	-1.8	-2.5	1.8
Neuroticism (Nagel 2018)	2.5	6.0	8.5	2.6	2.9	-1.6
Schizophrenia (2018)	1.4	2.9	4.3	-2.1	-1.9	0.9
Schizophrenia vs Biploar Disorder	0.1	0.1	0.1	-0.3	-0.3	-0.2
Worry (Nagel 2018)	0.3	0.7	1.4	0.8	1.2	-0.0
Alzheimer’s Disease (in mother)	0.1	0.2	0.3	0.4	0.3	-0.5
Alzheimer’s Disease (in father)	0.8	0.8	1.7	0.5	0.8	-1.3
Alzheimer’s Disease (including proxy)	1.5	2.2	3.2	1.2	1.4	-1.8
Crohns Disease (2017)	3.0	6.6	10.4	-3.2	-2.4	2.0
Irritable Bowel Disease (IBD)	1.5	3.7	5.7	-2.4	-2.0	1.1
Ulcerative Colitis (UC)	0.2	0.4	0.8	-0.7	-0.9	-0.0
Major Depression (MDD)	0.2	0.3	0.7	0.2	0.9	-0.1
Reaction Time	0.1	0.2	0.4	-0.3	-0.6	0.5
Verbal and Numeric Reasoning (VNR)	1.0	2.3	3.7	-1.4	-1.9	1.2
Breast Cancer	0.2	0.4	0.6	0.6	0.8	-0.6
Ovarian Cancer	0.1	0.1	0.2	0.1	0.1	-0.4
Prostate Cancer	0.1	0.1	0.2	0.4	0.3	0.0
Age at First Birth	0.4	0.6	1.0	-0.7	-0.6	1.0
Bipolar Disorder (2011)	0.1	0.1	0.2	0.0	0.0	0.5
Body Mass Index (BMI) (2010)	2.5	3.4	4.5	1.6	1.8	-2.1
Coronary Artery Disease (CAD)	0.3	0.3	0.4	-0.6	-0.5	0.5
Crohns Disease (2012)	1.9	3.0	6.1	-2.5	-1.5	0.9
Mean Putamen Volume	0.3	0.3	0.7	0.6	0.8	0.0
Fasting Glucose	0.7	0.8	1.2	-1.1	-0.8	0.8
HbA1C	0.1	0.1	0.2	-0.5	-0.1	0.2
HDL Cholesterol	0.3	0.6	1.2	0.4	1.1	-0.6
LDL Cholesterol	0.3	0.5	1.1	1.1	0.1	-0.6
Lupus	0.1	0.1	0.1	-0.3	-0.4	0.2
Neuroticism (2016)	0.4	0.6	1.7	-0.1	-0.1	1.3
Primary Biliary Cirrhosis	0.7	0.9	1.6	0.9	1.3	-0.6
Rheumatoid Arthritis	0.6	0.9	1.1	0.9	1.0	-0.9
Schizophrenia (2014)	1.0	2.2	3.5	-1.9	-1.6	0.5
Triglycerides	0.1	0.2	0.3	0.6	0.6	-0.2
Type 2 Diabetes (T2D) (2012)	3.4	4.0	5.5	-2.3	-1.9	1.6
Ulcerative Colitis	1.4	2.1	3.2	-1.8	-1.5	0.9
Blood Eosinophil Count	2.1	16.4	20.0	4.5	4.0	-3.6
Blood Platelet Count	0.1	1.4	1.7	-1.0	-1.3	1.1
Blood Red Count	0.5	5.2	7.8	-1.8	-2.1	2.8
Blood White Count	1.3	9.7	10.6	-3.3	-3.1	2.9
Heel T-Score	7.6	60.3	69.2	-7.8	-7.2	8.3
BMI	5.0	28.8	29.9	5.5	5.3	-5.3
Height	3.0	57.4	76.6	7.1	6.7	-8.8
Waist Hip Ratio (WHR)	3.4	15.2	16.6	-4.0	-4.1	3.5
Systolic Blood Pressure	1.2	5.8	6.7	-2.5	-2.1	2.6
Smoking Status	0.3	0.7	1.4	-0.8	-1.2	0.3
Allergy or Eczema	0.2	0.6	1.1	-0.8	-1.0	0.3
Cardiovascular Disease	0.1	0.2	0.6	-0.4	0.0	0.8
Hypothyroidism (self reported)	1.2	2.8	4.1	-1.7	-2.0	1.1
Respiratory disease	1.6	3.7	4.7	-2.0	-2.2	1.6
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.2	-0.4	-0.0	-0.4
Lung FEV1/FVC ratio	1.2	6.0	11.7	-2.1	-1.4	3.4
Lung FVC	0.3	1.5	2.1	-1.4	-1.4	0.6
Neuroticism	0.4	1.1	1.5	1.2	1.1	-0.6
Chronotype (morning person)	0.2	0.5	1.0	-0.6	-0.5	1.0
Hair Pigment	1.3	37.0	70.9	4.3	4.7	-8.4
Tanning	0.1	1.8	2.5	-1.0	-1.4	1.6
Hand grip strength (left)	0.2	0.5	0.7	-0.9	-0.9	0.1
Number of treatments/medications taken	0.2	0.4	0.8	-0.9	-0.4	0.5
Average weekly spirits intake	0.4	0.5	0.7	0.8	0.3	-0.8
Sensitivity / hurt feelings	0.8	1.3	2.8	-1.0	-0.5	1.7
Frequency of depressed mood in last 2 weeks	4.1	5.8	7.5	2.4	2.7	-2.0
Hearing difficulty/problems: Yes	0.7	1.1	1.6	-1.0	-0.8	1.3
Relative age of first facial hair	8.8	18.2	32.9	3.4	3.2	-5.7
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	0.8	-0.7	-0.8	0.9
Ever used hormone-replacement therapy (HRT)	1.1	1.4	1.7	1.3	1.0	-1.3
Ever had hysterectomy (womb removed)	1.4	1.6	2.7	0.7	1.2	-1.6
Systolic blood pressure, automated reading	0.2	0.4	0.7	-0.8	-0.6	0.6
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	0.9	0.5	1.0	-0.4
Angina	0.9	1.2	2.8	0.9	1.7	-0.1
Medication for hormone replacement therapy	1.8	2.0	3.1	1.8	1.4	-0.9
Vitamin and mineral supplements	0.5	0.6	0.9	0.6	0.9	0.8
Supplements: Zinc	2.8	3.0	4.0	-1.7	-2.0	1.4
Medication: Co-codamol	0.2	0.2	0.3	0.3	0.5	-0.6
Medication: Metformin	3.1	4.3	6.1	-2.2	-2.5	1.4
Diabetes (father)	0.6	0.7	1.3	0.9	1.1	-0.1
Diabetes (mother)	0.8	1.1	1.9	-1.4	-1.1	0.3
Severe depression (siblings)	0.7	0.8	1.2	-1.0	-1.1	0.2
Pack years adult smoking proportion	0.1	0.2	0.5	-0.2	0.7	0.2
Impedance of leg (right)	4.0	19.4	21.8	-4.1	-4.7	4.4
Leg fat-free mass (left)	7.1	37.7	44.9	5.9	5.8	-6.7
Trunk fat percentage	1.1	4.3	4.9	2.2	1.9	-2.0
Hand grip strength (right)	0.2	0.5	0.7	-0.8	-0.8	-0.1
Townsend deprivation index at recruitment	0.4	0.5	0.7	-0.8	-0.8	0.5
Current tobacco smoking	0.6	1.0	1.4	-1.2	-1.1	0.4
Average weekly fortified wine intake	1.9	2.3	4.5	-1.2	-2.1	0.9
Maternal smoking around birth	0.4	0.6	1.0	-1.0	-0.6	0.7
Fed-up feelings	5.8	10.5	12.7	3.6	3.4	-2.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	2.5	1.2	1.6	-0.7
Relative age voice broke	1.2	1.8	3.2	1.1	1.0	-1.8
Taking other prescription medications	0.6	1.0	1.7	-1.3	-1.0	0.4
Age when periods started (menarche)	0.3	0.7	1.0	-0.9	-1.0	0.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.6	0.2	0.8	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	2.7	6.2	7.5	-2.4	-2.3	2.7
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	0.3	-0.5	-0.2
Qualifications: CSEs or equivalent	0.3	0.4	0.9	0.4	1.0	0.4
Serious illness, injury or assault to yourself	1.0	1.2	2.5	1.0	1.6	-0.1
High blood pressure	0.1	0.3	0.7	0.6	0.8	-0.2
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.9	-0.7	-1.0	0.5
Multivitamins +/- minerals	0.6	0.8	1.2	-1.0	-1.1	-0.5
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.5	-0.4	0.1
Supplements: Glucosamine	0.3	0.5	0.8	0.5	0.6	-0.9
Diverticular disease/diverticulitis (self-reported)	3.5	4.1	4.7	-1.9	-2.0	2.2
Medication: Atenolol	0.1	0.1	0.3	0.1	0.3	0.5
Medication: Levothyroxine sodium	0.2	0.3	0.9	-0.3	-1.0	0.1
Sitting height	2.3	16.5	26.6	3.5	3.2	-5.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.1	0.3	0.2	-0.4
High blood pressure (mother)	0.2	0.2	0.4	0.6	0.6	0.1
Body mass index (BMI)	4.4	18.8	20.4	4.5	4.5	-4.0
Impedance of leg (left)	4.1	20.1	22.7	-4.2	-4.8	4.5
Leg predicted mass (left)	7.1	37.5	44.8	5.9	5.8	-6.7
Trunk fat mass	3.4	14.5	15.9	3.9	3.6	-4.0
Waist circumference	2.0	7.4	8.2	2.8	2.5	-2.9
Number of incorrect matches in round	1.8	3.0	4.5	-1.9	-2.1	1.1
Past tobacco smoking	0.1	0.1	0.4	-0.6	-0.2	-0.1
Alcohol usually taken with meals	1.2	2.0	2.3	-1.5	-1.1	1.5
Nervous feelings	0.3	0.5	1.1	0.6	1.0	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.9	0.8	1.0	0.1
Hearing difficulty/problems with background noise	2.3	3.7	4.5	-2.1	-1.9	1.8
Hair/balding pattern: Pattern 2	2.5	3.2	4.3	-1.7	-1.5	2.1
Had menopause	0.1	0.1	0.3	0.3	0.6	0.1
Had other major operations	0.4	0.5	0.8	0.7	0.9	-0.3
Forced vital capacity (FVC)	0.3	1.1	3.1	0.6	0.0	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.5	4.3	-1.9	-1.5	2.1
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	2.6	1.6	1.1	-1.5
Qualifications: None of the above	0.8	1.8	2.4	1.3	1.2	-1.5
Financial difficulties in last 2 years	0.6	0.9	1.2	-0.6	-1.0	1.1
Mouth/teeth dental problems	0.2	0.3	0.5	-0.3	-0.7	0.6
Heart attack	0.1	0.1	0.3	0.0	-0.0	0.5
Allergy	0.9	2.1	2.8	1.5	1.7	-1.0
Pain all over the body in last month	4.3	4.6	6.8	2.1	2.6	-1.6
Diabetes (self-reported)	0.4	0.6	0.9	-0.9	-0.9	0.0
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	-0.1	-0.4	0.4
Medication: Ramipril	0.1	0.1	0.3	-0.0	0.5	-0.4
Medication: Simvastatin	1.2	1.7	2.0	-1.4	-1.1	1.4
Fluid intelligence score	0.2	0.5	1.1	-0.5	-1.0	0.1
Illnesses of siblings	0.1	0.1	0.2	0.1	-0.5	0.3
Neuroticism score	1.0	2.2	3.2	1.7	1.8	-0.7
Weight	7.5	37.0	41.5	6.0	5.8	-6.4
Impedance of arm (right)	5.0	23.4	25.1	-4.7	-5.0	4.8
Arm fat percentage (right)	1.6	6.4	7.5	2.7	2.6	-2.3
Trunk fat-free mass	7.6	43.9	54.8	6.3	6.0	-7.4
Hip circumference	4.8	20.8	22.8	4.8	4.3	-4.6
Time employed in main current job	1.6	1.8	2.2	1.5	1.3	-1.3
Alcohol intake versus 10 years previously	0.2	0.3	0.6	0.1	0.3	-0.8
Father’s age at death	0.8	1.1	1.4	1.2	1.2	-0.7
Worrier / anxious feelings	0.2	0.4	1.0	-0.0	0.5	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	2.5	1.3	1.6	-0.4
Falls in the last year	0.3	0.4	0.7	0.7	0.8	0.1
Hair/balding pattern: Pattern 3	0.9	1.4	1.7	-1.2	-1.1	1.3
Number of live births	0.1	0.1	0.2	-0.0	0.5	-0.0
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.2	0.7	0.2	-1.1
Pulse rate	1.8	3.1	3.5	-1.9	-1.7	1.7
Happiness	5.2	6.4	8.3	2.9	2.6	-2.0
Noisy workplace	0.1	0.1	0.2	-0.0	0.4	0.3
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.6	-0.6	-1.2	0.2
Serious illness, injury or assault of a close relative in last 2 years	7.4	8.5	10.1	-3.2	-2.7	2.8
Mouth/teeth dental problems: Dentures	1.1	1.9	3.1	0.9	1.7	-1.3
Asthma	3.5	6.8	10.4	-2.7	-3.2	1.7
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.6	-1.3	-1.0	0.2
Medication: Cholesterol lowering	0.0	0.1	0.2	0.0	0.4	-0.0
Depression (self-reported)	0.0	0.0	0.0	-0.0	0.1	-0.1
Medication: Lansoprazole	0.1	0.2	0.4	-0.1	0.3	-0.6
Prospective memory result	0.1	0.1	0.2	-0.3	-0.4	0.2
Lung cancer (father)	0.3	0.4	0.6	-0.6	-0.8	0.4
Illnesses of mother	0.2	0.3	0.4	0.6	0.4	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	2.1	1.0	0.8	-1.5
Pulse wave Arterial Stiffness index	0.0	0.0	0.1	-0.0	-0.1	-0.3
Impedance of arm (left)	4.1	19.1	19.7	-4.3	-4.4	4.4
Arm fat mass (right)	4.3	17.8	18.6	4.3	4.2	-4.2
Trunk predicted mass	7.7	43.8	54.3	6.4	6.0	-7.4
Standing height	2.2	22.2	36.0	4.2	3.6	-6.0
Length of working week for main job	0.2	0.2	0.5	0.4	0.3	0.7
Exposure to tobacco smoke at home	0.1	0.1	0.1	0.2	0.3	-0.3
Breastfed as a baby	0.0	0.0	0.0	-0.0	-0.2	-0.2
Tense / ‘highly strung’	0.1	0.2	0.3	-0.5	-0.2	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.8	0.7	0.4	-0.9
Hair/balding pattern: Pattern 4	24.7	59.8	102.0	-6.2	-6.2	10.1
Birth weight of first child	0.1	0.1	0.3	0.1	0.5	-0.0
Peak expiratory flow (PEF)	0.6	1.3	2.6	-0.7	-1.6	1.0
Pulse wave reflection index	0.2	0.3	0.3	-0.6	-0.5	0.5
Ever highly irritable/argumentative for 2 days	1.1	1.4	1.8	1.2	1.3	-1.0
Loud music exposure frequency	0.1	0.1	0.2	0.0	0.4	0.0
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.1	0.1	-0.1	0.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	0.5	-0.1	-0.3
Blood clot in the leg (DVT)	0.6	0.8	0.9	0.9	1.0	-0.8
Medication: Paracetamol	0.0	0.0	0.1	-0.0	0.3	-0.1
Headache pain in last month	2.8	4.8	6.3	-2.0	-2.5	2.0
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.6	-0.2	-0.8	0.5
Glaucoma (self-reported)	0.0	0.0	0.1	-0.2	0.2	-0.2
Gout (self-reported)	0.2	0.3	0.4	-0.6	-0.6	0.3
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	3.8	-1.6	-1.9	0.8
Medication: Amlodipine	0.2	0.3	0.6	0.4	0.8	0.5
Medication: Ventolin 100micrograms inhaler	0.8	1.1	1.1	-1.0	-1.0	1.1
Birth weight	0.6	1.3	1.8	1.1	0.9	-1.3
Chronic bronchitis/emphysema (mother)	2.1	2.4	3.1	1.8	1.4	-1.5
High blood pressure (siblings)	0.1	0.1	0.3	-0.3	0.5	0.3
Forced vital capacity (FVC), Best measure	0.9	3.4	6.6	1.5	1.2	-2.6
Body fat percentage	1.5	6.0	7.1	2.7	2.3	-2.4
Leg fat percentage (right)	1.4	5.2	6.6	2.6	2.2	-2.1
Arm fat-free mass (right)	8.3	42.3	51.7	6.3	6.0	-7.2
Exposure to tobacco smoke outside home	0.1	0.1	0.2	0.1	0.5	0.1
Comparative body size at age 10	1.7	4.8	8.0	2.1	2.8	-1.4
Number of full brothers	0.5	0.6	1.0	0.8	1.0	-0.3
Worry too long after embarrassment	1.4	2.3	3.4	1.8	1.9	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.4	0.0	0.4	-0.6
Wheeze or whistling in the chest in last year	1.7	3.1	4.4	-2.1	-1.7	1.4
Number of children fathered	0.0	0.0	0.0	0.1	-0.0	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.0	0.5	0.7	-1.0
Age at first live birth	0.0	0.0	0.0	0.1	-0.1	0.1
Pulse wave peak to peak time	0.0	0.0	0.0	0.2	0.2	-0.0
Health satisfaction	0.0	0.0	0.0	-0.1	0.2	0.1
Shortness of breath walking on level ground	2.5	3.0	4.4	1.6	2.1	-1.4
Qualifications: College or University degree	0.1	0.2	0.4	0.2	-0.6	-0.2
Eye problems/disorders: None of the above	1.2	1.4	1.6	-1.0	-1.2	1.3
Mouth/teeth dental problems: Loose teeth	1.4	1.7	2.6	-1.6	-1.3	0.8
Emphysema/chronic bronchitis	2.5	2.8	3.0	-1.7	-1.7	1.6
Medication for pain relief, constipation, heartburn	0.1	0.2	0.5	0.1	-0.7	0.2
Neck or shoulder pain in last month	2.0	2.8	3.3	1.4	1.8	-1.8
Medication: Blood pressure	0.9	1.7	2.7	1.0	1.6	-1.1
Angina (self-reported)	1.1	1.5	3.4	1.0	1.8	-0.2
Migraine (self-reported)	0.6	0.7	1.2	-0.2	-0.9	1.1
Medication: Ibuprofen	0.2	0.2	0.5	-0.2	-0.3	-0.7
Medication: Allopurinol	0.1	0.1	0.2	0.1	0.2	-0.4
Medication: Omeprazole	1.5	1.8	3.1	0.8	1.8	-1.2
Medication: Seretide 50 evohaler	0.9	1.1	2.4	-0.9	-1.5	0.2
Mean time to correctly identify matches	0.2	0.5	0.7	-0.7	-0.8	0.5
Heart disease (mother)	1.3	1.6	1.7	-1.3	-1.3	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.5	4.1	4.8	-2.2	-1.9	2.0
Whole body fat mass	4.2	17.4	18.3	4.3	4.0	-4.3
Leg fat mass (right)	4.6	18.0	18.9	4.3	4.2	-4.2
Arm predicted mass (right)	7.9	40.5	48.4	6.1	6.0	-7.0
Pulse rate, automated reading	0.2	0.6	1.2	-0.6	-0.4	1.1
Alcohol intake frequency.	0.3	0.8	1.3	-0.9	-1.1	0.5
Comparative height size at age 10	4.8	26.6	36.7	4.9	4.4	-6.1
Number of full sisters	0.7	0.9	2.5	-0.3	-0.1	1.6
Suffer from ‘nerves’	0.1	0.1	0.3	0.1	0.3	0.6
Overall health rating	0.8	1.8	3.3	1.1	1.8	-0.9
Chest pain or discomfort	0.2	0.2	0.7	-0.1	-0.1	0.8
Had major operations	0.6	0.8	1.1	-1.0	-0.8	0.7
Age at last live birth	0.0	0.0	0.1	-0.2	-0.3	-0.2
Family relationship satisfaction	2.1	2.6	2.8	1.6	1.7	-1.5
Leg pain on walking	7.9	9.8	11.6	3.0	3.4	-2.9
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	3.2	-1.8	-1.2	1.6
Commuting to job workplace: Car/motor vehicle	2.0	2.3	3.0	1.7	1.1	-1.6
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.1	0.7	0.3	-1.1
Medication: Aspirin	0.4	0.6	1.5	-0.4	-0.2	1.2
Supplements: Vitamin C	0.2	0.2	0.7	0.1	-0.2	-0.8
Knee pain experienced in last month	0.1	0.1	0.2	-0.4	-0.3	0.4
Hypertension (Self-reported)	0.0	0.1	0.3	0.1	0.6	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	0.1	-0.0	-0.6
Illnesses of father: Heart disease	1.6	2.3	2.8	-1.4	-1.7	1.4
Illnesses of siblings: Diabetes	0.0	0.0	0.0	-0.0	0.1	-0.1
Smoking status: Previous	0.3	0.4	1.0	1.0	0.6	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	2.3	4.8	6.7	2.4	1.5	-2.6
Whole body fat-free mass	7.7	44.2	55.1	6.3	6.1	-7.4
Leg fat-free mass (right)	7.3	38.8	46.4	6.0	5.9	-6.8
Arm fat percentage (left)	1.9	7.5	8.5	2.9	2.8	-2.4
Average weekly red wine intake	0.4	0.5	0.6	-0.7	-0.7	0.8
Handedness (chirality/laterality): Left-handed	2.6	3.1	3.7	-1.9	-1.9	1.4
Mood swings	1.0	1.8	2.7	1.6	1.6	-0.3
Loneliness, isolation	1.2	1.7	2.2	1.5	1.5	-0.9
Long-standing illness, disability or infirmity	0.9	1.4	1.8	-1.3	-1.0	1.1
Ever had bowel cancer screening	0.1	0.1	0.2	-0.5	-0.4	0.3
Diabetes diagnosed by doctor	0.3	0.5	0.9	-0.9	-0.7	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.0	1.0	0.6	-0.1
Friendships satisfaction	6.0	7.5	10.5	3.2	2.8	-2.0
Qualifications: nursing, teaching	1.3	2.0	2.9	-1.2	-1.7	1.2
Commuting to job workplace: Walk	2.5	2.8	3.3	-1.8	-1.8	1.3
Eye problems/disorders: Cataract	0.8	0.9	1.5	-1.0	-1.2	0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.6	0.8	0.4	-0.6
Medication for cholesterol	0.2	0.4	0.8	0.3	0.5	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.8	0.6	0.9	-0.4
Back pain experienced in last month	0.9	1.3	1.8	1.3	1.3	-0.7
Mineral and other dietary supplements	0.4	0.5	0.8	-0.9	-0.7	0.6
Breast cancer (self-reported)	1.8	2.2	3.6	1.4	1.9	-1.1
Asthma (self-reported)	2.8	5.6	8.2	-2.4	-2.9	1.6
Osteoporosis (self-reported)	1.0	1.2	1.6	1.3	0.8	-1.2
Osteoarthritis (self-reported)	1.1	1.4	2.7	1.0	0.7	-1.6
Medication: Aspirin	0.6	0.8	1.7	-0.6	-0.5	1.3
Medication: Gliclazide	0.8	1.0	1.7	-1.3	-0.9	0.6
Illnesses of father: None of the above (group 1)	1.9	2.4	3.9	1.4	1.2	-2.0
Smoking status: Current	1.2	1.9	2.7	-1.6	-1.5	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.5	0.7	0.6	-0.6
Whole body water mass	7.7	44.1	55.1	6.3	6.1	-7.4
Leg predicted mass (right)	7.2	38.6	46.1	6.0	5.9	-6.8
Arm fat mass (left)	4.4	18.1	19.3	4.4	4.3	-4.1
Number of self-reported non-cancer illnesses	0.8	1.5	2.0	-1.3	-1.4	0.9
Average weekly champagne plus white wine intake	0.6	0.8	1.1	1.1	0.5	-1.0
Miserableness	0.8	1.3	1.8	0.8	1.3	-1.3
Guilty feelings	1.5	2.2	2.7	1.6	1.6	-1.1
Wears glasses or contact lenses	0.3	0.4	1.1	0.1	1.0	0.1
Ever taken oral contraceptive pill	0.6	0.7	1.0	-0.4	-1.0	0.9
Hearing aid user	4.8	5.5	7.7	-2.3	-1.8	2.8
Mother’s age at death	2.4	3.0	6.3	1.3	0.9	-2.5
Financial situation satisfaction	0.2	0.3	0.5	0.5	0.7	0.3
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.6	-0.2	-0.3	-0.8
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.0	0.2	0.5
Eye problems/disorders: Glaucoma	2.3	2.7	3.8	1.4	1.9	-1.6
Medication: Blood pressure	0.8	1.5	2.2	-1.2	-1.0	1.5
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.5	-0.9	-0.7	1.2
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	-0.4	-0.0	0.2
High cholesterol (Self-reported)	2.3	4.2	4.7	-1.9	-2.0	2.2
Medication: Bendroflumethiazide	0.9	1.3	1.8	1.4	1.3	-0.6
Medication: Paracetamol	0.2	0.3	0.5	0.4	0.7	-0.6
Medication: Lisinopril	0.1	0.1	0.3	-0.1	-0.1	0.5
Medication: Atorvastatin	0.7	0.9	1.5	1.2	1.1	-0.2
Illnesses of father: High blood pressure	0.2	0.3	0.7	-0.2	-0.2	0.8
Alcohol drinker status: Never	0.2	0.2	0.6	-0.3	-0.8	0.1
Ever smoked	0.0	0.1	0.2	0.4	0.1	0.1
Basal metabolic rate	7.8	43.4	52.7	6.4	6.1	-7.3
Leg fat percentage (left)	1.3	4.6	5.7	2.4	2.0	-2.0
Arm fat-free mass (left)	7.6	38.8	45.3	6.1	5.8	-6.7
Number of operations (self-reported)	0.9	1.4	1.5	1.1	1.2	-1.2
Average weekly beer plus cider intake	1.1	1.6	1.9	1.1	1.4	-1.2
Irritability	1.6	2.7	3.6	1.8	1.9	-1.0
Risk taking	1.0	1.4	2.0	1.4	0.8	-1.2
Ever had prostate specific antigen (PSA) test	7.3	8.4	8.6	2.9	2.9	-2.9
Fractured/broken bones in last 5 years	0.4	0.6	1.0	1.0	0.3	-0.8
Age started oral contraceptive pill	1.3	1.6	3.0	-0.9	-1.0	1.7
Diastolic blood pressure, automated reading	0.2	0.6	1.0	0.9	1.0	-0.3
Ever depressed for a whole week	1.8	2.2	2.6	1.6	1.5	-1.4
Unable to work because of sickness or disability	1.7	2.2	3.0	1.7	1.5	-1.1
Commuting to job workplace: Cycle	0.2	0.3	0.6	-0.4	-0.8	0.1
Myopia	0.0	0.1	0.1	-0.0	-0.3	-0.3
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.8	-0.9	-1.4	0.4
Cholesterol lowering medication	1.0	1.5	1.9	-1.2	-1.0	1.4
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.5	0.4	1.2	-0.9
Pain experienced in last month	0.2	0.3	0.4	0.6	0.4	-0.6
Supplements: Calcium	0.8	0.9	1.4	1.2	0.9	-0.7
Basal cell carcinoma (self-reported)	0.0	0.0	0.1	-0.2	0.2	-0.0
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.5	-0.2	-0.4	0.7
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	0.9	1.0	0.9	-0.8
Heart disease (siblings)	0.2	0.3	0.5	-0.7	-0.5	0.4
Alcohol drinker status: Previous	0.5	0.6	0.9	-0.8	-1.0	0.3
Pack years of smoking	0.1	0.2	0.5	-0.2	0.7	0.2
Impedance of whole body	4.8	24.4	25.8	-4.7	-5.0	5.1
Leg fat mass (left)	4.2	16.2	16.9	4.1	3.9	-4.1
Arm predicted mass (left)	7.9	39.9	48.0	6.2	5.8	-6.9