Best TWAS P=7.63e-29 · Best GWAS P=2.48e-64 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DLEU7 | 0.05 | 0.00 | blup | 581 | 0.02 | 1.6e-03 | 1.50 | 7.3 | 3.2e-13 | -0.46 | 0.08 | 0.21 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | EBPL | 0.34 | 0.16 | bslmm | 399 | 0.33 | 2.5e-41 | 0.34 | -6.5 | 9.8e-11 | 0.04 | 1.00 | 0.00 | FALSE |
| 3 | CommonMind | Brain Pre-frontal Cortex | TRIM13 | 0.15 | 0.04 | lasso | 5 | 0.12 | 1.1e-14 | 8.43 | -6.3 | 3.8e-10 | 0.22 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Adipose Visceral Omentum | EBPL | 0.27 | 0.03 | enet | 17 | 0.20 | 1.4e-10 | 8.00 | -6.0 | 1.6e-09 | 0.09 | 0.88 | 0.01 | FALSE |
| 5 | GTEx | Artery Aorta | EBPL | 0.43 | 0.20 | enet | 78 | 0.28 | 8.1e-16 | 6.38 | -6.6 | 3.8e-11 | 0.14 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Artery Coronary | EBPL | 0.48 | 0.03 | enet | 99 | 0.12 | 9.7e-05 | 8.00 | -5.5 | 4.0e-08 | 0.04 | 0.29 | 0.04 | FALSE |
| 7 | GTEx | Artery Tibial | RCBTB2 | 0.14 | 0.01 | enet | 10 | 0.07 | 6.4e-06 | 1.59 | -5.2 | 1.7e-07 | -0.06 | 0.01 | 0.08 | TRUE |
| 8 | GTEx | Brain Caudate basal ganglia | EBPL | 0.41 | 0.06 | lasso | 7 | 0.12 | 2.1e-04 | 6.30 | -5.7 | 1.1e-08 | 0.02 | 0.11 | 0.17 | FALSE |
| 9 | GTEx | Brain Cerebellar Hemisphere | EBPL | 0.54 | 0.32 | enet | 17 | 0.34 | 1.2e-09 | 0.34 | -5.5 | 3.1e-08 | 0.08 | 0.65 | 0.02 | FALSE |
| 10 | GTEx | Brain Cerebellum | EBPL | 0.50 | 0.30 | enet | 23 | 0.36 | 1.8e-11 | 8.00 | -7.0 | 3.7e-12 | 0.05 | 0.86 | 0.01 | FALSE |
| 11 | GTEx | Brain Cortex | EBPL | 0.36 | 0.08 | enet | 24 | 0.14 | 1.5e-04 | 8.00 | -6.3 | 2.8e-10 | 0.14 | 0.18 | 0.15 | FALSE |
| 12 | GTEx | Brain Nucleus accumbens basal ganglia | EBPL | 0.25 | 0.11 | enet | 21 | 0.11 | 7.9e-04 | 6.41 | -5.8 | 4.8e-09 | 0.12 | 0.13 | 0.09 | FALSE |
| 13 | GTEx | Brain Putamen basal ganglia | EBPL | 0.31 | -0.01 | enet | 18 | 0.05 | 2.9e-02 | 6.41 | -5.7 | 1.1e-08 | 0.08 | 0.06 | 0.13 | FALSE |
| 14 | GTEx | Breast Mammary Tissue (Female) | SUCLA2 | 0.07 | 0.13 | lasso | 4 | 0.04 | 2.9e-02 | 5.16 | -5.3 | 1.2e-07 | -0.01 | 0.02 | 0.64 | TRUE |
| 15 | GTEx | Esophagus Gastroesophageal Junction | EBPL | 0.27 | 0.24 | enet | 14 | 0.26 | 4.6e-10 | 6.30 | -6.5 | 6.3e-11 | 0.02 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Esophagus Muscularis | EBPL | 0.39 | 0.16 | enet | 36 | 0.29 | 9.2e-18 | 6.38 | -6.1 | 9.8e-10 | 0.03 | 1.00 | 0.00 | FALSE |
| 17 | GTEx | Heart Atrial Appendage | EBPL | 0.17 | 0.04 | lasso | 5 | 0.05 | 2.2e-03 | 8.00 | -5.5 | 3.0e-08 | 0.07 | 0.26 | 0.03 | FALSE |
| 18 | GTEx | Nerve Tibial | DLEU2 | 0.11 | 0.05 | lasso | 3 | 0.02 | 7.8e-03 | 8.68 | 9.0 | 2.5e-19 | -0.11 | 0.51 | 0.02 | TRUE |
| 19 | GTEx | Pancreas | EBPL | 0.18 | 0.10 | enet | 5 | 0.09 | 1.6e-04 | 8.00 | -6.9 | 6.7e-12 | 0.07 | 0.38 | 0.04 | FALSE |
| 20 | GTEx | Pituitary | EBPL | 0.44 | 0.32 | enet | 29 | 0.37 | 3.1e-10 | 6.38 | -6.0 | 2.3e-09 | -0.02 | 0.92 | 0.01 | FALSE |
| 21 | GTEx | Skin Not Sun Exposed Suprapubic | EBPL | 0.34 | 0.26 | enet | 12 | 0.30 | 4.0e-17 | 6.38 | -5.9 | 3.3e-09 | 0.00 | 1.00 | 0.00 | FALSE |
| 22 | GTEx | Skin Sun Exposed Lower leg | EBPL | 0.28 | 0.21 | lasso | 5 | 0.20 | 2.5e-16 | 6.83 | -7.0 | 2.7e-12 | 0.02 | 1.00 | 0.00 | FALSE |
| 23 | GTEx | Spleen | RCBTB1 | 0.37 | 0.02 | lasso | 5 | 0.04 | 3.5e-02 | 0.66 | -6.2 | 4.9e-10 | 0.01 | 0.04 | 0.10 | FALSE |
| 24 | GTEx | Testis | EBPL | 0.33 | 0.17 | lasso | 6 | 0.24 | 8.4e-11 | 6.56 | -7.6 | 2.4e-14 | 0.03 | 1.00 | 0.00 | FALSE |
| 25 | GTEx | Thyroid | EBPL | 0.36 | 0.14 | enet | 33 | 0.30 | 5.1e-23 | 6.30 | -6.7 | 2.0e-11 | 0.08 | 1.00 | 0.00 | TRUE |
| 26 | METSIM | Adipose | EBPL | 0.32 | 0.12 | lasso | 7 | 0.27 | 1.4e-39 | 6.56 | -5.6 | 2.0e-08 | 0.03 | 1.00 | 0.00 | FALSE |
| 27 | NTR | Blood | DLEU7 | 0.07 | 0.02 | enet | 22 | 0.06 | 1.3e-19 | -7.28 | -11.1 | 7.6e-29 | 0.61 | 0.11 | 0.89 | TRUE |
| 28 | ROSMAP | Brain Pre-frontal Cortex | EBPL | 0.43 | 0.28 | lasso | 8 | 0.43 | 7.3e-60 | 6.30 | -5.9 | 3.5e-09 | 0.03 | 1.00 | 0.00 | FALSE |
| 29 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EBPL | 0.07 | 0.03 | enet | 11 | 0.06 | 2.1e-12 | 6.41 | -5.5 | 3.1e-08 | 0.04 | 0.06 | 0.94 | FALSE |
| 30 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DLEU2 | 0.08 | 0.02 | lasso | 2 | 0.01 | 1.6e-02 | -5.73 | 6.2 | 6.1e-10 | 0.02 | 0.13 | 0.25 | FALSE |
| 31 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | EBPL | 0.21 | 0.14 | enet | 15 | 0.19 | 3.6e-21 | -1.29 | -5.4 | 6.4e-08 | 0.08 | 1.00 | 0.00 | TRUE |
| 32 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | EBPL | 0.27 | 0.16 | blup | 59 | 0.22 | 1.0e-12 | -1.29 | -6.2 | 5.5e-10 | 0.06 | 0.29 | 0.71 | TRUE |
| 33 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | DLEU2 | 0.03 | 0.01 | blup | 61 | 0.02 | 2.4e-03 | 8.57 | 8.6 | 1.3e-17 | -0.10 | 0.01 | 0.96 | FALSE |
| 34 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | EBPL | 0.21 | 0.09 | enet | 10 | 0.13 | 4.9e-06 | 8.00 | -6.9 | 5.6e-12 | 0.07 | 0.00 | 1.00 | FALSE |
| 35 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | EBPL | 0.28 | 0.18 | blup | 59 | 0.19 | 4.3e-08 | 6.41 | -7.1 | 1.7e-12 | 0.06 | 0.01 | 0.98 | TRUE |
| 36 | The Cancer Genome Atlas | Prostate Adenocarcinoma | EBPL | 0.08 | 0.01 | blup | 59 | 0.04 | 6.4e-05 | 6.41 | -6.4 | 1.4e-10 | 0.04 | 0.01 | 0.89 | TRUE |
| 37 | The Cancer Genome Atlas | Stomach Adenocarcinoma | EBPL | 0.10 | 0.07 | enet | 7 | 0.08 | 2.8e-06 | 8.00 | -6.1 | 1.3e-09 | 0.12 | 0.00 | 1.00 | FALSE |
| 38 | The Cancer Genome Atlas | Thyroid Carcinoma | EBPL | 0.28 | 0.10 | enet | 17 | 0.26 | 7.7e-25 | -1.29 | -5.8 | 7.2e-09 | 0.02 | 0.24 | 0.76 | FALSE |
| 39 | The Cancer Genome Atlas | Thyroid Carcinoma | TRIM13 | 0.04 | 0.00 | blup | 26 | 0.02 | 8.5e-03 | 8.72 | -7.5 | 6.8e-14 | 0.06 | 0.00 | 0.46 | FALSE |