TWAS hub - DLEU7

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0530	0.0230	9.9e-03	-0.001	0.020	0.005	0.018	0.003	4.3e-01	1.6e-03	7.5e-02	2.3e-03	1.1e-01
2	NTR	Blood	0.0741	0.0163	5.1e-12	0.016	0.051	0.063	0.058	0.062	6.1e-06	4.0e-16	1.3e-19	5.3e-18	2.8e-19
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.1128	0.0532	5.2e-03	0.003	0.013	0.031	NA	0.002	1.4e-01	1.2e-02	1.8e-04	NA	2.0e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Trunk fat-free mass	11.2	64.3	132.2	7.4	-11.5	-2.3
Trunk predicted mass	11.1	63.3	130.0	7.3	-11.4	-2.4
Whole body fat-free mass	10.8	61.7	125.4	7.3	-11.2	-2.5
Whole body water mass	10.7	60.8	123.2	7.3	-11.1	-2.5
Leg fat-free mass (right)	10.0	53.4	108.2	6.8	-10.4	-2.3
Leg predicted mass (right)	10.0	53.1	108.3	6.8	-10.4	-2.2
Arm fat-free mass (right)	9.9	50.8	111.4	6.2	-10.6	-1.8
Leg fat-free mass (left)	9.5	50.1	99.2	6.7	-10.0	-2.5
Arm predicted mass (right)	9.5	48.7	110.2	5.7	-10.5	-1.8
Basal metabolic rate	9.4	52.1	110.2	6.3	-10.5	-2.4
Leg predicted mass (left)	9.3	49.3	96.5	6.7	-9.8	-2.4
Arm fat-free mass (left)	9.1	46.3	97.3	6.0	-9.9	-2.3
Arm predicted mass (left)	9.1	46.5	98.1	6.1	-9.9	-2.2
Height	7.5	144.6	282.2	10.3	-16.8	-6.8
Sitting height	7.5	53.3	104.7	5.9	-10.2	-4.5
Hand grip strength (left)	7.3	19.3	30.0	5.5	-5.1	-1.3
Standing height	7.3	72.1	134.9	7.8	-11.6	-4.6
Hand grip strength (right)	7.0	19.1	27.9	5.2	-5.3	-1.6
Pulse rate	5.6	9.4	19.4	-4.4	3.0	0.2
Impedance of leg (left)	5.3	25.7	42.7	-5.9	6.5	0.2
Impedance of leg (right)	5.0	24.4	45.2	-5.3	6.7	0.0
Impedance of whole body	4.7	23.9	46.7	-4.9	6.8	-0.7
Weight	4.5	22.2	51.6	3.2	-7.2	-2.1
Medication: Lansoprazole	4.5	5.1	7.2	-2.7	2.2	1.8
Heel T-Score	4.3	33.8	86.3	-2.8	9.3	2.7
Emphysema/chronic bronchitis	4.0	4.5	12.0	1.0	-3.5	-0.7
Comparative height size at age 10	4.0	22.2	40.5	4.3	-6.4	-2.7
Leg pain on walking	3.7	4.6	7.9	0.8	-2.8	-2.3
Stomach or abdominal pain in last month	3.6	4.4	11.0	0.5	-3.3	1.4
Impedance of arm (left)	3.5	16.2	33.9	-3.6	5.8	-1.2
Prostate Cancer	3.4	4.8	8.2	-2.2	2.9	1.1
Impedance of arm (right)	3.4	15.9	35.9	-3.1	6.0	-1.4
Medication: Allopurinol	3.3	4.5	5.8	-2.2	1.6	2.4
Forced expiratory volume in 1-second (FEV1), predicted	3.1	6.4	11.1	2.7	-3.3	-1.0
Hearing aid user	3.1	3.5	9.6	-3.1	0.8	-0.2
Osteoporosis (self-reported)	2.9	3.5	5.6	-2.1	-0.8	2.4
Noisy workplace	2.8	3.4	9.8	-3.1	-0.7	-0.1
Average weekly spirits intake	2.7	3.4	6.5	-2.5	0.5	1.9
Ever had hysterectomy (womb removed)	2.6	2.9	3.8	-2.0	1.6	1.5
Migraine (self-reported)	2.6	3.3	5.4	2.3	-1.3	-1.6
Eye problems/disorders: Diabetes related eye disease	2.5	2.7	6.8	-2.6	-1.2	0.2
Hypothyroidism/myxoedema (self-reported)	2.5	4.9	13.4	0.2	-3.7	-1.1
Number of full brothers	2.5	3.1	3.9	-1.6	2.0	1.7
Body Mass Index (BMI) (2010)	2.4	3.3	8.9	0.8	-3.0	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	2.4	2.8	3.6	1.9	-1.5	-1.6
Pulse rate, automated reading	2.4	7.8	12.0	-3.5	3.2	1.2
Tinnitus: Yes, now most or all of the time	2.4	2.8	5.9	-2.4	0.8	1.3
Pain all over the body in last month	2.3	2.5	5.7	0.6	-1.2	-2.4
Birth weight	2.3	4.9	9.0	3.0	-1.5	-1.9
Bipolar Disorder (2018)	2.2	3.4	6.1	0.7	-1.9	-2.5
Blood White Count	2.2	16.4	33.1	-1.6	3.7	5.8
Peak expiratory flow (PEF)	2.2	5.1	7.3	2.2	-2.7	-1.8
Mouth/teeth dental problems: Loose teeth	2.2	2.6	4.7	-1.7	-0.2	-2.2
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	6.0	1.2	-0.9	2.5
Supplements: Fish oil (including cod liver oil)	2.1	2.7	5.9	1.5	0.1	-2.4
Hypothyroidism (self reported)	2.0	4.6	13.3	-0.5	-3.6	-0.6
Systolic blood pressure, automated reading	2.0	5.8	15.7	-1.0	4.0	0.8
Serious illness, injury or assault to yourself	2.0	2.5	5.0	-2.2	-1.3	-0.9
Medication: Levothyroxine sodium	2.0	3.3	9.9	0.2	-3.1	-0.0
Wheeze or whistling in the chest in last year	2.0	3.5	9.1	1.0	-3.0	-0.6
Commuting to job workplace: Walk	2.0	2.2	3.6	-0.2	1.9	-1.7
Lung FVC	1.9	9.6	18.0	-3.1	4.2	0.9
Supplements: Zinc	1.9	2.0	3.8	1.3	-1.9	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.5	5.6	1.0	-2.4	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.3	4.4	-2.1	0.8	1.4
Commuting to job workplace: Car/motor vehicle	1.9	2.1	4.4	1.4	-2.1	0.3
Diabetes (self-reported)	1.8	2.8	6.7	-2.6	-1.0	-0.7
Hair/balding pattern: Pattern 4	1.8	4.4	7.8	2.8	-1.4	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	3.8	-1.4	0.8	1.9
Medication: Paracetamol	1.8	2.7	5.9	-2.4	0.8	1.3
Primary Biliary Cirrhosis	1.7	2.4	5.2	-0.8	-2.3	-1.2
Severe depression (siblings)	1.7	1.9	2.5	1.3	-1.6	-1.2
Mouth/teeth dental problems	1.7	2.6	4.1	2.0	-1.8	-0.7
Lung cancer (father)	1.7	2.0	4.5	-2.1	1.2	-0.0
Health satisfaction	1.7	2.2	5.4	-0.6	-2.3	-1.0
Neck or shoulder pain in last month	1.7	2.5	3.7	0.3	-1.9	-1.9
Diastolic blood pressure, automated reading	1.7	5.2	14.5	-0.9	3.8	0.5
Myopia	1.7	2.4	4.4	2.1	-1.3	-1.0
Coronary Artery Disease (CAD)	1.6	1.9	4.2	-0.8	-2.0	0.9
Tinnitus: Yes, but not now, but have in the past	1.6	1.8	3.8	0.4	-1.2	2.0
Hip circumference	1.6	6.9	12.5	1.6	-3.5	-2.4
Number of children fathered	1.6	1.8	4.8	2.2	-0.7	0.2
Back pain experienced in last month	1.6	2.3	3.3	0.6	-1.8	1.8
Taking other prescription medications	1.5	2.3	4.0	-2.0	-1.7	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.5	6.2	-0.5	2.0	2.5
Loud music exposure frequency	1.5	1.7	3.2	-1.8	-0.1	1.4
Medication: Paracetamol	1.5	2.5	3.6	-1.9	0.6	1.9
Medication: Seretide 50 evohaler	1.5	1.7	3.1	-1.2	-1.8	0.8
Diabetes diagnosed by doctor	1.5	2.5	5.1	-2.2	-1.5	-0.4
Pain experienced in last month	1.5	2.4	4.7	-1.5	2.2	0.7
Reaction Time	1.4	2.7	4.4	-1.7	2.1	0.8
Type 2 Diabetes (T2D) (2012)	1.4	1.6	2.4	-1.1	-1.1	-1.6
Ulcerative Colitis	1.4	2.1	6.2	-2.5	-0.2	-0.1
Type 2 Diabetes (T2D) (2018)	1.4	2.5	6.4	-2.5	-1.1	-0.2
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	3.5	0.2	1.2	-1.9
Medication: Cholesterol lowering	1.4	2.1	6.1	-2.5	-0.1	-0.5
Pulse wave Arterial Stiffness index	1.4	1.7	2.9	-1.3	-1.7	-0.7
Medication for pain relief, constipation, heartburn	1.4	2.5	4.2	2.0	-1.1	-1.4
Overall health rating	1.4	2.9	7.4	-2.7	-1.0	0.6
Number of treatments/medications taken	1.3	2.4	5.9	-2.4	-1.0	0.5
Average weekly fortified wine intake	1.3	1.5	3.6	-0.8	-1.9	-0.6
High blood pressure (mother)	1.3	1.8	3.3	1.2	1.8	-0.7
Allergy	1.3	3.0	6.8	-0.4	2.6	1.5
Leg fat percentage (right)	1.3	4.7	10.3	-3.2	1.8	-0.5
Mood swings	1.3	2.4	3.7	1.8	-1.9	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.3	4.0	2.0	0.2	0.1
Leg fat percentage (left)	1.3	4.8	12.2	-3.5	1.5	-0.2
Ovarian Cancer	1.2	1.6	3.1	0.2	-1.8	-1.3
Illnesses of mother	1.2	1.5	3.2	-0.0	-1.8	-1.2
Supplements: Vitamin C	1.2	1.4	3.1	0.1	1.0	-1.8
Handedness (chirality/laterality): Left-handed	1.2	1.5	4.1	-0.4	0.2	2.0
Medication: Aspirin	1.2	1.5	4.2	-2.0	0.3	0.5
Average weekly beer plus cider intake	1.2	1.7	2.7	-1.4	0.6	1.6
Ever had prostate specific antigen (PSA) test	1.2	1.4	3.2	0.0	1.0	-1.8
Ever depressed for a whole week	1.2	1.5	4.0	-0.3	-0.8	2.0
Bipolar Disorder or Schizophrenia	1.1	2.7	4.2	2.1	-1.1	-1.6
Schizophrenia vs Biploar Disorder	1.1	1.5	2.2	1.5	0.2	1.5
Age at First Birth	1.1	1.6	2.7	1.6	1.4	0.4
Respiratory disease	1.1	2.5	5.6	0.8	-2.4	-1.2
Medication for hormone replacement therapy	1.1	1.2	2.4	1.0	0.3	1.6
Medication: Co-codamol	1.1	1.2	2.9	-0.7	-1.7	0.6
Waist circumference	1.1	3.8	10.5	-0.1	-3.2	-1.0
Pulse wave reflection index	1.1	1.3	2.1	0.8	-1.5	-1.1
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	4.2	2.1	-0.5	0.9
High blood pressure (siblings)	1.1	1.6	3.3	1.2	0.2	-1.8
Mean time to correctly identify matches	1.1	2.2	3.6	-1.9	1.7	0.1
Breast cancer (self-reported)	1.1	1.3	2.9	-1.7	0.8	-0.7
Ever taken oral contraceptive pill	1.1	1.2	2.2	1.1	-1.5	-0.6
Verbal and Numeric Reasoning (VNR)	1.0	2.5	3.6	1.9	1.5	1.2
Systolic Blood Pressure	1.0	5.0	14.5	-0.6	3.8	0.0
Relative age of first facial hair	1.0	2.0	5.8	-0.4	2.4	0.4
Supplements: Glucosamine	1.0	1.2	3.3	0.6	-0.3	-1.8
Trunk fat mass	1.0	4.3	7.4	-0.6	-2.7	-2.3
Medication: Simvastatin	1.0	1.5	4.3	-2.1	-0.4	0.0
Depression (self-reported)	1.0	1.2	2.9	-0.8	-1.7	-0.3
Birth weight of first child	1.0	1.7	5.0	0.4	2.2	-0.3
Medication: Amlodipine	1.0	1.4	2.1	1.4	-0.1	-1.5
Exposure to tobacco smoke outside home	1.0	1.3	3.0	-1.7	-0.3	0.9
Pulse wave peak to peak time	1.0	1.2	3.0	1.7	0.7	0.4
Whole body fat mass	1.0	4.0	8.5	-0.4	-2.9	-1.9
Average weekly red wine intake	1.0	1.5	4.1	2.0	0.2	-0.7
Number of self-reported non-cancer illnesses	1.0	1.7	2.8	-0.3	-1.5	-1.7
Wears glasses or contact lenses	1.0	1.1	2.8	-1.7	-0.6	0.6
Medication: Atorvastatin	1.0	1.2	2.3	0.1	-1.1	-1.5
Age started oral contraceptive pill	1.0	1.3	2.5	0.7	1.6	1.0
Alzheimer’s Disease (in father)	0.9	1.0	2.7	-0.4	-0.2	-1.6
Crohns Disease (2017)	0.9	1.9	5.4	0.6	-2.3	0.0
Fasting Glucose	0.9	1.0	1.9	0.7	-0.9	1.4
Waist Hip Ratio (WHR)	0.9	4.1	9.5	-3.1	-0.0	1.6
Alcohol usually taken with meals	0.9	1.5	2.9	1.2	0.3	-1.7
Forced vital capacity (FVC)	0.9	3.4	6.0	1.9	-2.5	-0.7
Alcohol intake versus 10 years previously	0.9	1.4	2.4	0.4	-1.2	1.6
Father’s age at death	0.9	1.2	2.0	0.3	1.2	-1.4
Arm fat mass (right)	0.9	3.6	9.4	0.0	-3.1	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.0	1.4	-1.4	-0.6
Body fat percentage	0.9	3.6	8.3	-2.9	0.9	-1.3
Comparative body size at age 10	0.9	2.5	3.7	1.9	-1.1	1.7
Angina (self-reported)	0.9	1.1	2.1	-1.5	-0.6	0.9
Illnesses of siblings: Diabetes	0.9	1.1	2.7	-0.8	-1.6	-0.2
Loneliness, isolation	0.9	1.2	2.6	0.7	-1.6	-0.8
Eye problems/disorders: Cataract	0.9	1.0	1.5	1.2	-1.1	0.6
Mineral and other dietary supplements	0.9	1.3	3.7	-0.3	-0.2	1.9
Arm fat mass (left)	0.9	3.6	9.1	-0.4	-3.0	-1.2
High cholesterol (Self-reported)	0.9	1.5	2.0	-0.9	-1.4	-1.4
Basal cell carcinoma (self-reported)	0.9	1.0	2.2	0.8	0.3	-1.5
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.1	-1.5	-0.3	1.2
Heart disease (siblings)	0.9	1.2	1.6	-1.3	1.1	0.8
Alcohol drinker status: Previous	0.9	1.1	2.8	-1.7	-0.1	0.7
Depressed Affect (Nagel 2018)	0.8	1.6	2.2	1.4	-0.8	-1.5
Rheumatoid Arthritis	0.8	1.1	2.7	-1.6	0.3	0.7
Lung FEV1/FVC ratio	0.8	4.2	11.3	-1.1	3.4	-0.2
Angina	0.8	1.0	1.9	-1.4	-0.4	1.0
Diabetes (father)	0.8	0.9	2.2	-1.5	-0.1	0.8
Trunk fat percentage	0.8	3.1	5.8	-2.4	0.3	-1.9
Qualifications: CSEs or equivalent	0.8	1.0	2.3	-0.3	-1.5	0.8
Hearing difficulty/problems with background noise	0.8	1.3	2.9	-0.9	0.2	1.7
Had menopause	0.8	0.9	2.6	-0.4	1.6	0.2
Worrier / anxious feelings	0.8	1.5	3.2	-1.1	1.8	0.4
Worry too long after embarrassment	0.8	1.3	2.5	-1.1	0.5	-1.6
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	2.1	-0.4	0.9	-1.4
Illnesses of father: Heart disease	0.8	1.1	2.3	-0.7	1.5	0.7
Long-standing illness, disability or infirmity	0.8	1.3	2.1	-0.8	-1.0	1.5
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	2.8	-0.7	0.5	1.7
Medication: Gliclazide	0.8	0.9	1.7	-1.0	0.0	1.3
Average weekly champagne plus white wine intake	0.8	1.0	2.5	-1.6	0.6	-0.4
Mother’s age at death	0.8	0.9	2.0	0.2	1.4	-0.9
Medication: Blood pressure	0.8	1.6	2.5	1.6	-1.0	-1.1
Neuroticism (Nagel 2018)	0.7	1.7	3.1	1.4	0.2	-1.8
Schizophrenia (2018)	0.7	1.5	4.4	2.1	0.1	-0.3
Lupus	0.7	1.0	1.6	0.1	-1.3	1.2
Schizophrenia (2014)	0.7	1.6	4.2	2.1	-0.7	-0.2
Blood Platelet Count	0.7	8.1	18.1	0.6	2.4	4.2
Hearing difficulty/problems: Yes	0.7	1.0	1.4	-1.2	0.5	1.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.6	-1.2	-0.7	-0.9
Diabetes (mother)	0.7	0.9	1.6	1.1	-0.2	-1.2
Townsend deprivation index at recruitment	0.7	1.0	3.1	-1.7	0.2	0.1
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.2	-1.1	1.1	-0.1
Hair/balding pattern: Pattern 2	0.7	0.9	2.3	-0.6	-1.5	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	3.0	-0.1	1.3	1.7
Medication: Ramipril	0.7	0.9	2.1	0.3	-0.7	-1.4
Falls in the last year	0.7	1.0	1.5	-0.3	-1.2	1.2
Hair/balding pattern: Pattern 3	0.7	1.0	2.3	-0.3	0.8	1.5
Exposure to tobacco smoke at home	0.7	0.8	1.5	-0.9	-1.2	-0.2
Glaucoma (self-reported)	0.7	0.9	2.2	-0.5	-1.5	0.3
Medication: Aspirin	0.7	0.9	2.2	-1.5	-0.0	0.7
Arm fat percentage (left)	0.7	2.7	7.3	-2.7	0.6	-0.8
Pain type(s) experienced in last month: Hip pain	0.7	0.8	2.1	-0.5	-1.5	-0.4
Unable to work because of sickness or disability	0.7	0.9	1.8	-0.5	-1.3	0.7
Pack years of smoking	0.7	1.0	2.2	-1.5	-0.8	-0.3
Worry (Nagel 2018)	0.6	1.2	2.9	1.7	0.7	-0.2
Major Depression (MDD)	0.6	0.8	1.5	1.2	0.1	-0.9
Bipolar Disorder (2011)	0.6	0.6	1.3	0.1	-0.8	1.1
Allergy or Eczema	0.6	1.5	2.9	0.9	-1.7	-1.0
Chronotype (morning person)	0.6	1.4	2.5	1.2	0.5	1.6
Hayfever, allergic rhinitis or eczema	0.6	1.4	2.9	0.8	-1.7	-0.8
Multivitamins +/- minerals	0.6	0.8	1.6	1.3	0.9	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.4	1.2	-1.1	-0.7
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.3	0.2	-0.8	1.2
Heart attack	0.6	0.8	1.5	-1.2	-0.5	0.8
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.1	-1.5	0.5	0.4
Asthma	0.6	1.2	2.1	-0.7	-1.4	-1.0
Prospective memory result	0.6	0.7	1.4	0.8	-0.4	-1.2
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.7	-0.0	-0.7	-1.3
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.4	1.5	-0.8	-0.3
Medication: Blood pressure	0.6	1.0	1.5	-0.5	1.1	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.2	-1.1	-0.9	-0.3
Asthma (self-reported)	0.6	1.3	2.2	-0.9	-1.5	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	3.6	-0.5	1.9	0.3
Risk taking	0.6	0.8	2.0	1.4	-0.7	-0.2
Cholesterol lowering medication	0.6	0.9	2.2	-0.2	-1.5	-0.8
Leg fat mass (left)	0.6	2.3	5.4	-0.9	-2.3	-0.7
Mean Putamen Volume	0.5	0.5	1.4	-1.2	0.4	0.1
Medication: Metformin	0.5	0.8	1.3	-0.9	-1.1	-0.4
Pack years adult smoking proportion	0.5	0.8	1.4	-1.2	-0.9	-0.3
Maternal smoking around birth	0.5	0.7	0.8	-0.9	-0.7	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.0	0.3	-0.9	1.0
Relative age voice broke	0.5	0.7	1.6	0.2	1.3	0.7
Number of incorrect matches in round	0.5	0.8	1.7	1.3	-0.2	0.8
Had other major operations	0.5	0.6	0.9	1.0	-0.5	-0.8
Arm fat percentage (right)	0.5	1.9	4.3	-2.1	0.5	-1.1
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	3.2	1.8	-1.2	-0.7
Length of working week for main job	0.5	0.5	1.2	-0.2	-0.5	-1.1
Tense / ‘highly strung’	0.5	0.9	2.3	1.5	0.2	-0.6
Gout (self-reported)	0.5	0.6	1.2	-0.6	0.5	1.1
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.4	-0.2	-1.2	0.7
Forced vital capacity (FVC), Best measure	0.5	1.7	2.5	1.6	-1.6	0.3
Leg fat mass (right)	0.5	2.0	4.7	-0.7	-2.2	-0.9
Family relationship satisfaction	0.5	0.6	1.0	0.9	-1.0	-0.3
Smoking status: Previous	0.5	0.7	1.1	-0.9	-0.4	1.1
Ever had bowel cancer screening	0.5	0.6	1.0	-1.0	0.1	-1.0
Medication for cholesterol	0.5	0.8	2.0	-1.4	0.5	0.2
Financial situation satisfaction	0.5	0.7	1.3	-0.4	1.1	-0.8
Irritable Bowel Disease (IBD)	0.4	0.9	2.0	-0.5	-1.4	0.6
HDL Cholesterol	0.4	0.6	1.0	1.0	0.9	-0.1
LDL Cholesterol	0.4	0.7	1.3	0.8	0.2	1.2
Smoking Status	0.4	0.8	1.5	-1.0	0.1	1.2
Neuroticism	0.4	0.9	2.4	0.0	-0.6	-1.6
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	0.7	0.5	0.8	-0.5
Chronic bronchitis/emphysema (father)	0.4	0.5	0.7	0.6	-0.8	0.7
Body mass index (BMI)	0.4	1.7	5.2	-0.2	-2.3	-0.1
Nervous feelings	0.4	0.7	1.2	1.1	0.4	0.9
Fluid intelligence score	0.4	0.8	2.3	0.4	0.2	1.5
Time employed in main current job	0.4	0.4	1.2	0.1	1.1	0.3
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.3	1.0	-0.2	-1.2
Mouth/teeth dental problems: Dentures	0.4	0.7	1.2	-0.7	1.1	-0.6
Age at first live birth	0.4	0.6	1.2	1.1	-0.8	0.0
Eye problems/disorders: None of the above	0.4	0.5	1.1	1.0	0.2	0.7
Alcohol intake frequency.	0.4	1.0	2.8	-1.7	-0.1	0.5
Age at last live birth	0.4	0.5	0.8	0.8	-0.9	-0.3
Qualifications: nursing, teaching	0.4	0.6	1.5	1.2	0.1	0.3
Smoking status: Current	0.4	0.6	1.1	-0.8	1.0	0.2
Alzheimer’s Disease (in mother)	0.3	0.3	0.5	-0.2	0.7	0.7
Ulcerative Colitis (UC)	0.3	0.6	1.3	-1.1	0.1	0.8
Breast Cancer	0.3	0.8	2.0	-1.4	-0.5	-0.5
Triglycerides	0.3	0.4	0.8	0.9	0.7	-0.2
Blood Red Count	0.3	3.3	7.6	-1.4	-0.7	-2.8
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.3	0.1	-0.1	1.1
Vitamin and mineral supplements	0.3	0.4	0.9	-1.0	-0.5	-0.2
Age when periods started (menarche)	0.3	0.7	1.2	0.1	0.9	1.1
High blood pressure	0.3	0.9	1.1	1.0	0.8	-1.0
Past tobacco smoking	0.3	0.6	1.4	1.2	-0.0	-0.6
Breastfed as a baby	0.3	0.4	1.2	-0.1	0.1	-1.1
Headache pain in last month	0.3	0.5	0.8	0.4	-0.8	0.9
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.1	-0.1	-0.0	1.1
Number of full sisters	0.3	0.4	0.7	-0.6	0.8	-0.3
Had major operations	0.3	0.3	0.6	-0.5	0.8	-0.1
Knee pain experienced in last month	0.3	0.5	1.2	0.4	-1.1	-0.4
Hypertension (Self-reported)	0.3	1.0	1.7	0.9	0.6	-1.3
Guilty feelings	0.3	0.5	1.3	-0.3	-0.3	-1.2
Commuting to job workplace: Public transport	0.3	0.4	0.9	-0.4	1.0	-0.3
Alcohol drinker status: Never	0.3	0.4	1.1	-0.2	1.1	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.9	0.3	-0.1	-1.0
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.4	1.2	0.8	0.0
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	-0.0	0.3	-0.9
Crohns Disease (2012)	0.2	0.4	1.1	-0.0	-1.1	-0.0
Neuroticism (2016)	0.2	0.2	0.5	0.4	-0.2	-0.7
Blood Eosinophil Count	0.2	1.2	2.8	0.9	0.2	1.7
BMI	0.2	1.2	2.1	-0.1	-1.4	1.2
Sensitivity / hurt feelings	0.2	0.4	0.7	-0.3	0.8	-0.7
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.3	-0.6	-0.2	0.5
Current tobacco smoking	0.2	0.3	0.4	-0.5	0.7	0.4
Medication: Atenolol	0.2	0.2	0.4	0.3	0.5	0.7
Financial difficulties in last 2 years	0.2	0.2	0.4	-0.0	-0.5	-0.6
Neuroticism score	0.2	0.4	1.0	0.4	-0.2	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.7	-0.1	-0.5	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.5	1.2	-0.3	-0.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.5	-0.6	-0.7	-0.3
Qualifications: College or University degree	0.2	0.5	1.1	1.0	-0.2	0.6
Medication: Ibuprofen	0.2	0.3	0.7	-0.4	0.8	-0.1
Medication: Omeprazole	0.2	0.2	0.4	0.4	-0.6	0.5
Chest pain or discomfort	0.2	0.3	0.6	-0.8	-0.5	-0.1
Friendships satisfaction	0.2	0.2	0.3	0.4	0.4	0.6
Osteoarthritis (self-reported)	0.2	0.3	0.6	0.5	0.0	-0.8
Illnesses of father: None of the above (group 1)	0.2	0.2	0.5	-0.0	-0.7	-0.4
Eye problems/disorders: Glaucoma	0.2	0.3	0.6	-0.7	-0.5	0.1
Medication: Lisinopril	0.2	0.2	0.6	0.8	-0.3	0.3
Irritability	0.2	0.3	0.4	0.6	-0.6	-0.4
Fractured/broken bones in last 5 years	0.2	0.2	0.4	-0.7	0.4	-0.4
Commuting to job workplace: Cycle	0.2	0.2	0.6	0.1	-0.3	0.8
Depression (Nagel 2018)	0.1	0.1	0.2	0.0	-0.4	0.3
Tanning	0.1	0.7	1.1	-0.5	1.1	-0.9
Fed-up feelings	0.1	0.2	0.5	0.1	-0.7	-0.1
Qualifications: None of the above	0.1	0.2	0.4	-0.3	-0.5	0.6
Illnesses of siblings	0.1	0.2	0.5	0.1	0.0	0.7
Number of live births	0.1	0.1	0.4	0.0	0.0	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.4	0.3	0.6	0.0
Blood clot in the leg (DVT)	0.1	0.2	0.3	0.4	0.2	-0.5
Shortness of breath walking on level ground	0.1	0.1	0.1	-0.2	-0.4	-0.2
Miserableness	0.1	0.1	0.3	0.4	0.5	-0.1
Illnesses of father: High blood pressure	0.1	0.1	0.1	0.4	-0.3	-0.2
Number of operations (self-reported)	0.1	0.1	0.2	-0.5	0.3	-0.1
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.7	-0.3	-0.8	0.7
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	0.5	-0.2	0.4
Supplements: Calcium	0.1	0.1	0.3	-0.6	0.2	-0.2
HbA1C	0.0	0.1	0.1	0.2	-0.2	0.3
Cardiovascular Disease	0.0	0.0	0.1	-0.1	0.2	0.1
Hair Pigment	0.0	0.8	1.8	-0.3	1.3	0.7
Happiness	0.0	0.0	0.0	-0.1	0.1	0.2
Heart disease (mother)	0.0	0.0	0.1	0.0	0.1	0.4
Suffer from ‘nerves’	0.0	0.1	0.1	-0.2	0.3	0.0
Medication: Bendroflumethiazide	0.0	0.0	0.0	-0.2	-0.0	0.1
Ever smoked	0.0	0.0	0.1	-0.1	-0.1	-0.3

Hub : Genes

DLEU7

Models

Trait associations