Hub : Genes

RCBTB2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.140	0.0587	0.00170	0.010	NA	0.067	NA	0.026	0.048	NA	6.4e-06	NA	0.0039
2	GTEx	Nerve Tibial	0.138	0.0494	0.00063	-0.001	NA	0.036	NA	0.030	0.370	NA	1.3e-03	NA	0.0034
3	GTEx	Thyroid	0.093	0.0410	0.00490	0.019	NA	0.067	NA	0.031	0.012	NA	7.2e-06	NA	0.0018

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.5	0.8	1.9	-1.4	-0.1	-0.7
Bipolar Disorder or Schizophrenia	0.6	1.4	3.2	-1.8	-0.7	0.7
Depressed Affect (Nagel 2018)	1.2	2.5	5.8	-0.9	1.0	-2.4
Depression (Nagel 2018)	0.5	0.7	1.7	-0.5	0.5	-1.3
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.8	0.1	0.9	0.0
Neuroticism (Nagel 2018)	0.7	1.7	3.0	-0.9	1.0	-1.7
Schizophrenia (2018)	0.9	1.8	3.4	-1.9	-0.8	1.1
Schizophrenia vs Biploar Disorder	0.2	0.3	0.8	0.3	0.9	0.0
Worry (Nagel 2018)	0.2	0.5	0.7	-0.7	0.5	-0.8
Alzheimer’s Disease (in mother)	0.6	0.7	1.7	0.3	1.3	0.5
Alzheimer’s Disease (in father)	0.5	0.5	1.0	-1.0	-0.4	0.7
Alzheimer’s Disease (including proxy)	0.3	0.4	1.1	-1.1	0.1	0.2
Crohns Disease (2017)	1.8	3.9	5.6	-1.3	-2.4	-2.1
Irritable Bowel Disease (IBD)	2.9	6.9	14.6	-1.6	-3.8	-1.9
Ulcerative Colitis (UC)	1.9	3.5	8.3	-1.0	-2.9	-1.1
Major Depression (MDD)	1.0	1.2	2.2	-0.2	-1.5	-1.2
Reaction Time	1.0	1.8	2.8	0.8	1.4	1.7
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.8	0.3	0.6	-0.9
Breast Cancer	0.4	0.9	2.5	-1.6	0.4	-0.4
Ovarian Cancer	1.2	1.6	3.8	-2.0	-0.4	-0.9
Prostate Cancer	0.5	0.8	1.1	-1.1	0.4	-1.0
Age at First Birth	0.3	0.4	0.7	-0.3	-0.9	-0.6
Bipolar Disorder (2011)	0.6	0.6	1.0	-1.0	-0.9	-0.3
Body Mass Index (BMI) (2010)	0.5	0.6	1.2	0.2	0.8	1.1
Coronary Artery Disease (CAD)	0.4	0.5	0.8	0.8	0.9	0.3
Crohns Disease (2012)	0.5	0.8	1.6	-1.3	-0.8	-0.3
Mean Putamen Volume	0.1	0.1	0.1	-0.1	0.3	0.3
Fasting Glucose	1.0	1.1	3.2	0.5	0.1	1.8
HbA1C	0.1	0.1	0.2	-0.4	0.2	-0.4
HDL Cholesterol	1.7	2.9	5.7	1.1	2.4	1.3
LDL Cholesterol	0.3	0.4	1.0	-1.0	-0.1	-0.5
Lupus	0.2	0.3	0.7	-0.3	-0.8	0.3
Neuroticism (2016)	0.9	1.2	3.6	0.4	-0.0	-1.9
Primary Biliary Cirrhosis	1.4	2.0	3.7	-1.3	-1.9	-0.8
Rheumatoid Arthritis	0.9	1.2	2.0	-1.4	-0.1	-1.3
Schizophrenia (2014)	1.2	2.7	7.9	-2.8	-0.3	0.5
Triglycerides	0.3	0.4	1.2	0.1	-1.1	-0.3
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.5	-0.9	-1.6	-0.4
Ulcerative Colitis	1.4	2.1	4.8	-1.2	-2.2	-0.0
Blood Eosinophil Count	0.2	1.7	5.0	0.1	0.4	-2.2
Blood Platelet Count	0.2	2.9	5.0	1.7	2.2	0.9
Blood Red Count	0.7	6.9	10.3	0.8	3.2	3.1
Blood White Count	0.2	1.3	3.5	-1.9	-0.1	-0.6
Heel T-Score	0.2	1.5	2.1	1.2	1.4	1.0
BMI	0.8	4.9	9.2	-3.0	-2.0	-1.3
Height	0.5	9.3	20.1	-4.5	2.6	0.9
Waist Hip Ratio (WHR)	0.2	0.8	1.6	0.9	-0.2	1.2
Systolic Blood Pressure	0.7	3.4	6.2	2.5	1.6	1.2
Smoking Status	0.4	1.1	2.5	0.2	-0.8	-1.6
Allergy or Eczema	0.1	0.4	0.7	0.2	-0.6	-0.8
Cardiovascular Disease	0.2	0.8	2.1	1.5	0.3	0.4
Hypothyroidism (self reported)	0.2	0.5	1.4	1.2	0.0	0.1
Respiratory disease	0.7	1.6	3.2	-1.1	-1.8	-0.7
Type 2 Diabetes (T2D) (2018)	0.3	0.6	0.9	0.9	1.0	0.1
Lung FEV1/FVC ratio	0.5	2.4	3.9	0.4	2.0	1.8
Lung FVC	0.3	1.5	2.8	-1.3	0.4	-1.7
Neuroticism	0.6	1.5	2.8	-1.1	0.7	-1.7
Chronotype (morning person)	0.8	2.0	3.2	1.8	0.4	1.6
Hair Pigment	0.2	6.7	9.4	-3.1	-2.2	-2.4
Tanning	0.1	0.7	1.3	-0.3	-1.1	-0.8
Hand grip strength (left)	0.1	0.3	0.5	0.5	0.7	-0.2
Number of treatments/medications taken	0.3	0.6	1.3	-0.0	0.6	1.1
Average weekly spirits intake	1.8	2.2	3.4	-1.7	-0.4	-1.8
Sensitivity / hurt feelings	0.4	0.7	1.1	-1.1	-1.0	-0.0
Frequency of depressed mood in last 2 weeks	1.2	1.7	2.8	-1.2	-0.9	-1.7
Hearing difficulty/problems: Yes	1.0	1.5	3.8	-2.0	-0.7	0.2
Relative age of first facial hair	1.6	3.3	6.9	2.6	0.2	1.7
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.5	0.4	-1.2	-0.5
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.5	0.0	-0.7	-0.4
Ever had hysterectomy (womb removed)	0.6	0.6	1.8	-0.3	-0.2	-1.3
Systolic blood pressure, automated reading	0.2	0.7	1.0	1.0	1.0	-0.1
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	0.5	-0.1	0.3
Angina	0.2	0.3	0.6	0.4	-0.1	-0.8
Medication for hormone replacement therapy	1.9	2.1	5.4	0.8	0.6	2.3
Vitamin and mineral supplements	1.7	2.3	4.1	2.0	0.4	1.6
Supplements: Zinc	0.2	0.3	0.6	0.4	0.7	-0.3
Medication: Co-codamol	0.4	0.5	1.0	-0.6	-0.1	1.0
Medication: Metformin	0.2	0.3	0.4	0.6	0.6	0.4
Diabetes (father)	0.2	0.2	0.4	-0.6	-0.4	0.4
Diabetes (mother)	1.4	1.8	3.8	1.9	1.2	-0.0
Severe depression (siblings)	1.8	2.0	5.0	2.2	0.1	1.0
Pack years adult smoking proportion	2.8	4.3	5.2	-1.7	-2.3	-2.2
Impedance of leg (right)	1.2	5.6	12.5	3.5	1.9	1.0
Leg fat-free mass (left)	1.8	9.7	24.9	-5.0	-1.6	-1.3
Trunk fat percentage	0.4	1.5	4.1	-2.0	0.2	-0.7
Hand grip strength (right)	0.3	0.8	1.6	-0.7	0.5	-1.3
Townsend deprivation index at recruitment	0.3	0.4	0.9	-0.9	-0.6	-0.3
Current tobacco smoking	1.1	1.9	2.8	-0.3	-1.7	-1.6
Average weekly fortified wine intake	0.6	0.7	1.4	-0.5	-0.8	-1.2
Maternal smoking around birth	0.3	0.5	1.1	0.1	-1.1	-0.5
Fed-up feelings	1.0	1.8	3.8	-0.9	-1.0	-2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.6	-0.0	-0.3	-0.8
Relative age voice broke	0.8	1.3	2.4	1.1	0.4	1.6
Taking other prescription medications	0.2	0.3	0.7	0.1	-0.5	0.8
Age when periods started (menarche)	0.1	0.2	0.4	0.0	-0.7	-0.2
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.5	0.2	1.2	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	2.2	-1.2	-0.7	-1.5
Tinnitus: Yes, but not now, but have in the past	3.5	3.7	7.1	-1.8	-0.9	-2.7
Qualifications: CSEs or equivalent	3.0	4.0	8.5	-2.9	-0.5	-1.8
Serious illness, injury or assault to yourself	1.8	2.1	4.6	1.0	2.1	0.9
High blood pressure	0.2	0.6	1.2	-0.0	-1.1	-0.7
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.9	0.5	-0.6	-0.9
Multivitamins +/- minerals	2.2	2.8	5.9	-2.4	-1.4	-0.9
Stomach or abdominal pain in last month	0.2	0.2	0.4	0.6	0.2	-0.4
Supplements: Glucosamine	0.6	0.7	1.3	-1.1	0.9	0.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	0.3	-0.1	-0.3
Medication: Atenolol	0.2	0.3	0.7	0.8	0.1	-0.3
Medication: Levothyroxine sodium	0.4	0.7	0.9	0.7	-0.8	1.0
Sitting height	0.7	4.9	13.3	-3.6	-0.5	-1.1
Chronic bronchitis/emphysema (father)	1.1	1.3	2.5	-1.6	0.1	-1.1
High blood pressure (mother)	0.3	0.4	1.1	0.4	-1.1	-0.1
Body mass index (BMI)	0.9	3.6	8.5	-2.9	-0.9	-1.2
Impedance of leg (left)	1.3	6.4	11.9	3.5	2.4	1.3
Leg predicted mass (left)	1.9	10.0	25.5	-5.1	-1.7	-1.3
Trunk fat mass	1.0	4.1	10.5	-3.2	-0.3	-1.3
Waist circumference	0.8	3.1	7.3	-2.7	-1.4	-0.4
Number of incorrect matches in round	1.2	2.1	3.7	0.4	-1.5	-1.9
Past tobacco smoking	0.8	1.4	2.3	1.2	-1.5	0.8
Alcohol usually taken with meals	1.7	2.8	5.1	-0.1	2.2	1.8
Nervous feelings	0.1	0.1	0.2	-0.4	-0.3	-0.4
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	4.5	-2.1	-0.2	-1.7
Hearing difficulty/problems with background noise	1.7	2.7	5.1	-0.2	-2.2	-1.7
Hair/balding pattern: Pattern 2	1.0	1.2	2.9	-1.7	-0.7	-0.6
Had menopause	0.9	1.1	2.9	1.7	0.4	0.3
Had other major operations	0.4	0.5	1.6	1.3	0.0	-0.0
Forced vital capacity (FVC)	0.2	0.9	2.6	-0.1	1.6	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	1.9	-1.3	-1.3	-1.4
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.8	0.3	-0.5	-1.4
Qualifications: None of the above	0.2	0.5	1.4	-0.0	0.0	-1.2
Financial difficulties in last 2 years	0.3	0.4	1.1	-0.3	0.1	1.1
Mouth/teeth dental problems	0.1	0.1	0.2	-0.4	-0.3	0.0
Heart attack	0.9	1.2	2.3	-1.1	0.3	-1.5
Allergy	0.4	1.0	2.3	0.8	0.3	1.5
Pain all over the body in last month	0.4	0.4	0.7	0.0	-0.8	-0.9
Diabetes (self-reported)	0.6	0.9	2.5	0.2	1.6	0.5
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	4.8	-1.5	0.2	-2.2
Medication: Ramipril	0.4	0.6	1.3	0.5	-0.4	1.1
Medication: Simvastatin	0.4	0.6	1.5	0.3	-0.3	-1.2
Fluid intelligence score	0.1	0.2	0.5	-0.0	-0.0	-0.7
Illnesses of siblings	0.0	0.1	0.1	0.2	-0.1	0.4
Neuroticism score	0.6	1.3	2.8	-0.8	-0.8	-1.7
Weight	1.3	6.4	17.0	-4.1	-0.8	-1.3
Impedance of arm (right)	1.4	6.3	8.6	2.9	1.8	2.6
Arm fat percentage (right)	0.3	1.1	3.3	-1.8	0.0	-0.1
Trunk fat-free mass	1.7	9.7	25.2	-5.0	-1.1	-1.6
Hip circumference	0.8	3.2	9.5	-3.1	0.3	-0.4
Time employed in main current job	0.5	0.6	1.2	1.1	-0.6	0.4
Alcohol intake versus 10 years previously	1.1	1.6	2.8	-1.7	-1.3	-0.7
Father’s age at death	0.5	0.6	0.9	0.9	0.1	1.0
Worrier / anxious feelings	1.2	2.2	3.3	-1.4	-1.2	-1.8
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	-0.3	-0.2	-0.4
Falls in the last year	0.3	0.5	1.2	-1.1	0.4	0.1
Hair/balding pattern: Pattern 3	0.4	0.6	1.1	1.1	0.6	0.6
Number of live births	0.0	0.1	0.1	0.2	0.3	0.1
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	6.1	0.4	2.5	1.2
Pulse rate	0.4	0.6	1.1	0.3	1.0	0.9
Happiness	2.3	2.8	6.1	-2.5	-0.9	-1.2
Noisy workplace	1.3	1.7	1.9	-1.4	-1.2	-1.2
Qualifications: A levels/AS levels or equivalent	0.7	1.6	3.1	0.7	1.2	1.8
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	-0.3	0.2	-0.8
Mouth/teeth dental problems: Dentures	0.4	0.6	1.3	0.1	-0.8	-1.1
Asthma	0.5	1.0	1.1	-1.0	-1.0	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	3.0	-1.7	0.3	0.0
Medication: Cholesterol lowering	0.6	1.0	2.4	-0.6	-0.4	-1.6
Depression (self-reported)	0.7	0.8	1.4	1.0	-1.2	0.2
Medication: Lansoprazole	0.7	0.8	1.7	0.8	-1.3	0.4
Prospective memory result	1.5	1.9	3.8	1.9	-1.1	-0.8
Lung cancer (father)	0.2	0.2	0.5	-0.1	-0.7	-0.4
Illnesses of mother	0.0	0.1	0.1	-0.3	0.0	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	1.6	0.4	1.3	0.9
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	0.6	-0.2	0.5
Impedance of arm (left)	0.8	3.7	4.8	2.2	1.4	2.1
Arm fat mass (right)	0.7	2.8	8.1	-2.8	-0.4	-0.5
Trunk predicted mass	1.6	9.4	24.5	-5.0	-1.0	-1.6
Standing height	0.3	3.4	10.0	-3.2	0.3	-0.2
Length of working week for main job	0.6	0.7	1.0	-0.3	1.0	1.0
Exposure to tobacco smoke at home	1.2	1.3	2.8	-0.4	1.1	1.7
Breastfed as a baby	1.7	2.1	2.4	-1.6	-1.3	-1.5
Tense / ‘highly strung’	0.2	0.3	0.4	0.6	-0.3	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.4	0.6	-1.2	-1.0
Hair/balding pattern: Pattern 4	0.6	1.6	4.4	-0.3	0.5	-2.1
Birth weight of first child	0.9	1.7	2.3	-1.4	1.5	0.9
Peak expiratory flow (PEF)	0.1	0.3	0.7	-0.1	0.4	0.8
Pulse wave reflection index	0.4	0.5	1.5	-0.1	-1.2	0.4
Ever highly irritable/argumentative for 2 days	3.8	4.6	6.9	-1.3	-2.6	-2.3
Loud music exposure frequency	1.3	1.4	2.3	1.4	-1.5	0.2
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	5.9	0.7	0.8	2.4
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	2.2	-1.4	1.5	0.6
Blood clot in the leg (DVT)	0.5	0.7	1.1	-1.0	0.9	0.3
Medication: Paracetamol	0.7	1.2	1.8	-1.3	0.3	1.3
Headache pain in last month	0.5	0.8	1.6	-0.1	0.9	1.3
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.8	0.2	-0.1	0.9
Glaucoma (self-reported)	0.4	0.5	1.0	1.0	-0.6	-0.2
Gout (self-reported)	0.2	0.3	0.9	-0.9	-0.0	0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.5	0.7	-0.2	0.6
Medication: Amlodipine	0.4	0.5	0.9	0.8	0.3	0.9
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.1	-0.2	-0.8	-1.0
Birth weight	0.6	1.3	2.7	-1.6	0.9	-0.7
Chronic bronchitis/emphysema (mother)	1.9	2.2	5.0	-1.1	-0.7	-2.2
High blood pressure (siblings)	0.4	0.6	1.3	0.6	-0.3	1.1
Forced vital capacity (FVC), Best measure	0.0	0.1	0.2	-0.2	0.4	-0.3
Body fat percentage	0.4	1.5	3.6	-1.9	-0.1	-1.0
Leg fat percentage (right)	0.2	0.6	1.0	-1.0	0.1	-1.0
Arm fat-free mass (right)	2.0	10.2	24.4	-4.9	-1.4	-2.1
Exposure to tobacco smoke outside home	0.6	0.9	2.4	-1.5	0.4	0.3
Comparative body size at age 10	0.3	0.9	2.4	-1.5	0.6	0.2
Number of full brothers	0.2	0.3	0.7	-0.1	0.8	-0.5
Worry too long after embarrassment	0.1	0.2	0.3	0.5	0.6	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.0	-0.8	-0.4
Wheeze or whistling in the chest in last year	2.9	5.2	8.2	-2.4	-1.2	-2.9
Number of children fathered	0.7	0.8	2.0	0.2	0.5	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	-0.2	-0.2	0.7
Age at first live birth	0.5	0.9	1.9	1.4	-0.3	0.8
Pulse wave peak to peak time	0.3	0.3	0.5	-0.7	0.6	-0.5
Health satisfaction	1.2	1.6	3.8	-1.9	-0.6	-0.7
Shortness of breath walking on level ground	1.0	1.2	2.0	0.0	-1.2	-1.4
Qualifications: College or University degree	0.4	1.4	2.3	1.1	0.8	1.5
Eye problems/disorders: None of the above	3.2	3.6	8.5	-2.9	1.6	0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.5	-0.5	0.7	-0.1
Emphysema/chronic bronchitis	3.2	3.6	7.9	-1.1	-1.2	-2.8
Medication for pain relief, constipation, heartburn	0.5	0.9	2.1	-0.0	-0.8	-1.4
Neck or shoulder pain in last month	0.9	1.3	3.0	0.3	-1.7	-0.9
Medication: Blood pressure	0.5	1.0	1.4	-1.2	0.4	-1.2
Angina (self-reported)	0.2	0.3	0.6	0.5	-0.1	-0.8
Migraine (self-reported)	0.8	0.9	1.4	-0.2	1.2	1.2
Medication: Ibuprofen	0.8	1.0	2.7	-1.6	0.3	-0.4
Medication: Allopurinol	0.4	0.5	0.7	-0.8	-0.9	0.5
Medication: Omeprazole	0.3	0.3	0.6	0.5	0.4	0.7
Medication: Seretide 50 evohaler	2.1	2.4	4.1	0.7	-2.0	-1.6
Mean time to correctly identify matches	0.1	0.2	0.3	0.3	0.5	0.6
Heart disease (mother)	0.3	0.4	0.7	-0.8	-0.6	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.3	0.7	1.8	0.4
Whole body fat mass	0.9	3.7	9.2	-3.0	-0.5	-1.3
Leg fat mass (right)	0.8	3.0	6.8	-2.6	-0.5	-1.4
Arm predicted mass (right)	1.9	9.6	24.0	-4.9	-1.1	-1.9
Pulse rate, automated reading	0.2	0.8	1.1	-0.6	1.1	0.9
Alcohol intake frequency.	0.2	0.4	0.7	-0.8	-0.4	0.5
Comparative height size at age 10	2.0	11.0	28.8	-5.4	0.3	-2.0
Number of full sisters	0.4	0.5	1.2	-0.5	0.0	-1.1
Suffer from ‘nerves’	0.2	0.3	0.6	0.4	0.0	0.8
Overall health rating	0.3	0.6	1.3	-1.2	0.6	-0.0
Chest pain or discomfort	1.2	1.8	2.4	-0.9	-1.4	-1.5
Had major operations	0.3	0.4	0.7	0.5	0.9	0.4
Age at last live birth	0.3	0.4	0.5	0.7	-0.6	0.6
Family relationship satisfaction	1.2	1.5	3.9	-2.0	-0.6	-0.4
Leg pain on walking	1.8	2.2	2.8	-1.3	-1.7	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	0.9	-0.9	-0.1	-1.0
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.8	-0.1	-1.3	-0.8
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	4.8	-0.1	-2.2	-0.9
Medication: Aspirin	0.1	0.1	0.3	0.5	0.1	0.2
Supplements: Vitamin C	2.9	3.5	7.8	-1.4	-0.8	-2.8
Knee pain experienced in last month	1.9	3.0	3.8	-1.9	-1.5	-1.7
Hypertension (Self-reported)	0.1	0.4	1.0	0.4	-1.0	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	1.8	0.8	-1.3	-0.8
Illnesses of father: Heart disease	0.7	1.0	2.5	0.6	1.6	0.5
Illnesses of siblings: Diabetes	0.3	0.3	1.0	-1.0	0.1	-0.2
Smoking status: Previous	1.9	2.8	7.8	-0.8	2.8	0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	3.0	-1.6	-1.3	-1.7
Whole body fat-free mass	1.9	10.9	27.8	-5.3	-1.4	-1.7
Leg fat-free mass (right)	1.8	9.4	25.3	-5.0	-1.4	-1.0
Arm fat percentage (left)	0.5	1.8	5.4	-2.3	-0.2	-0.4
Average weekly red wine intake	1.4	2.1	4.0	-1.3	2.0	-0.8
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.7	-0.8	-0.3	0.5
Mood swings	0.8	1.4	3.4	-0.8	-0.0	-1.8
Loneliness, isolation	2.0	2.8	5.9	-1.3	-0.8	-2.4
Long-standing illness, disability or infirmity	0.4	0.7	1.2	1.1	-0.7	0.5
Ever had bowel cancer screening	0.9	1.0	3.0	-0.3	-0.1	-1.7
Diabetes diagnosed by doctor	0.2	0.4	0.9	-0.2	0.9	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.8	-0.1	-0.9	-0.5
Friendships satisfaction	1.0	1.3	3.7	-0.2	-1.9	-0.1
Qualifications: nursing, teaching	2.9	4.4	7.7	1.7	1.7	2.8
Commuting to job workplace: Walk	0.2	0.2	0.4	0.4	0.7	0.0
Eye problems/disorders: Cataract	1.4	1.6	4.7	2.2	-0.1	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	3.7	1.9	0.3	0.8
Medication for cholesterol	0.6	0.8	1.6	-1.0	-0.1	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.6	0.8	0.3	0.3
Back pain experienced in last month	0.5	0.8	1.8	-0.4	-0.6	-1.4
Mineral and other dietary supplements	0.7	1.0	1.7	1.3	-0.1	1.2
Breast cancer (self-reported)	0.4	0.5	0.7	0.4	0.8	0.9
Asthma (self-reported)	0.3	0.5	0.6	-0.8	-0.8	-0.5
Osteoporosis (self-reported)	1.8	2.2	3.8	0.3	-2.0	-1.6
Osteoarthritis (self-reported)	0.4	0.5	0.6	-0.8	-0.6	-0.8
Medication: Aspirin	0.1	0.1	0.2	0.3	-0.5	0.1
Medication: Gliclazide	0.1	0.1	0.3	-0.1	0.1	0.6
Illnesses of father: None of the above (group 1)	0.5	0.6	1.1	1.1	-0.8	-0.3
Smoking status: Current	1.1	1.8	3.2	-0.3	-1.8	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	4.5	2.1	0.9	1.0
Whole body water mass	1.9	10.7	27.4	-5.2	-1.4	-1.6
Leg predicted mass (right)	1.8	9.8	25.6	-5.1	-1.5	-1.2
Arm fat mass (left)	0.8	3.3	9.5	-3.1	-0.2	-0.6
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	-0.1	-0.4	-0.7
Average weekly champagne plus white wine intake	1.1	1.6	2.4	1.0	-1.1	1.6
Miserableness	0.4	0.6	1.0	-1.0	0.1	-0.9
Guilty feelings	0.3	0.4	0.8	0.9	0.7	-0.2
Wears glasses or contact lenses	0.4	0.4	0.6	-0.8	-0.5	-0.7
Ever taken oral contraceptive pill	1.2	1.4	2.9	-1.1	-1.7	-0.1
Hearing aid user	2.6	2.9	7.2	0.0	2.7	1.2
Mother’s age at death	1.6	2.0	4.3	0.6	2.1	-1.2
Financial situation satisfaction	1.6	2.0	4.1	-2.0	-0.8	-1.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	0.9	1.0	-0.9	-0.5
Commuting to job workplace: Public transport	0.6	0.7	1.2	0.9	-1.1	0.2
Eye problems/disorders: Glaucoma	0.4	0.5	0.9	0.9	-0.6	0.6
Medication: Blood pressure	0.6	1.1	1.9	1.0	-1.4	0.5
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.5	0.6	0.2	-1.2
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.9	0.2	0.4	-0.9
High cholesterol (Self-reported)	0.3	0.6	0.8	0.8	0.9	-0.6
Medication: Bendroflumethiazide	0.2	0.4	0.5	0.7	-0.7	0.3
Medication: Paracetamol	0.9	1.4	2.8	-1.7	0.7	1.0
Medication: Lisinopril	0.6	0.8	2.0	-0.4	-0.6	-1.4
Medication: Atorvastatin	0.6	0.8	1.6	-0.8	1.3	0.2
Illnesses of father: High blood pressure	0.9	1.1	1.5	1.2	-1.0	-0.9
Alcohol drinker status: Never	2.2	2.7	4.8	2.2	1.6	0.8
Ever smoked	1.0	1.7	3.1	-1.8	0.2	-1.4
Basal metabolic rate	1.7	9.4	24.5	-5.0	-1.2	-1.4
Leg fat percentage (left)	0.2	0.8	1.4	-1.2	0.4	-0.9
Arm fat-free mass (left)	1.4	6.9	18.4	-4.3	-0.8	-1.3
Number of operations (self-reported)	0.2	0.3	0.3	0.5	0.6	0.4
Average weekly beer plus cider intake	0.3	0.5	1.3	-0.2	-1.1	-0.1
Irritability	2.5	4.2	7.2	-2.0	-1.1	-2.7
Risk taking	0.7	1.1	2.7	0.4	0.6	1.7
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.7	0.1	1.2	-1.3
Fractured/broken bones in last 5 years	3.2	4.1	6.7	2.6	2.1	1.1
Age started oral contraceptive pill	0.3	0.3	0.9	-0.3	-1.0	-0.1
Diastolic blood pressure, automated reading	0.4	1.3	2.5	-1.1	1.6	0.5
Ever depressed for a whole week	0.3	0.3	0.8	0.4	0.2	-0.9
Unable to work because of sickness or disability	0.5	0.6	1.0	-0.1	-1.0	0.9
Commuting to job workplace: Cycle	0.3	0.3	0.9	-0.2	-0.1	-0.9
Myopia	0.3	0.5	1.3	1.1	0.4	0.1
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.2	-0.3	1.1	1.0
Cholesterol lowering medication	0.7	1.1	3.2	0.1	1.8	0.1
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.0	-0.1	-0.1	-0.1
Pain experienced in last month	0.4	0.7	1.6	-0.4	1.2	0.5
Supplements: Calcium	0.3	0.3	0.7	-0.4	-0.4	-0.8
Basal cell carcinoma (self-reported)	1.9	2.3	6.4	-0.4	2.5	-0.5
Heart attack/myocardial infarction (self-reported)	0.8	1.0	1.8	-1.4	0.3	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.7	-0.8	0.8	0.5
Heart disease (siblings)	0.0	0.0	0.0	0.0	-0.2	0.2
Alcohol drinker status: Previous	0.4	0.5	0.6	0.4	-0.8	0.8
Pack years of smoking	4.1	6.0	7.2	-2.0	-2.6	-2.7
Impedance of whole body	1.1	5.6	10.1	3.2	2.0	1.7
Leg fat mass (left)	0.8	3.0	7.3	-2.7	-0.3	-1.2
Arm predicted mass (left)	1.4	6.9	17.7	-4.2	-0.8	-1.5