Hub : Genes

RCBTB2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.140 0.0587 0.00170 0.010 NA 0.067 NA 0.026 0.048 NA 6.4e-06 NA 0.0039
2 GTEx Nerve Tibial 0.138 0.0494 0.00063 -0.001 NA 0.036 NA 0.030 0.370 NA 1.3e-03 NA 0.0034
3 GTEx Thyroid 0.093 0.0410 0.00490 0.019 NA 0.067 NA 0.031 0.012 NA 7.2e-06 NA 0.0018

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.5 0.8 1.9 -1.4 -0.1 -0.7
Bipolar Disorder or Schizophrenia 0.6 1.4 3.2 -1.8 -0.7 0.7
Depressed Affect (Nagel 2018) 1.2 2.5 5.8 -0.9 1.0 -2.4
Depression (Nagel 2018) 0.5 0.7 1.7 -0.5 0.5 -1.3
Intelligence (Savage-Jansen 2018) 0.1 0.3 0.8 0.1 0.9 0.0
Neuroticism (Nagel 2018) 0.7 1.7 3.0 -0.9 1.0 -1.7
Schizophrenia (2018) 0.9 1.8 3.4 -1.9 -0.8 1.1
Schizophrenia vs Biploar Disorder 0.2 0.3 0.8 0.3 0.9 0.0
Worry (Nagel 2018) 0.2 0.5 0.7 -0.7 0.5 -0.8
Alzheimer’s Disease (in mother) 0.6 0.7 1.7 0.3 1.3 0.5
Alzheimer’s Disease (in father) 0.5 0.5 1.0 -1.0 -0.4 0.7
Alzheimer’s Disease (including proxy) 0.3 0.4 1.1 -1.1 0.1 0.2
Crohns Disease (2017) 1.8 3.9 5.6 -1.3 -2.4 -2.1
Irritable Bowel Disease (IBD) 2.9 6.9 14.6 -1.6 -3.8 -1.9
Ulcerative Colitis (UC) 1.9 3.5 8.3 -1.0 -2.9 -1.1
Major Depression (MDD) 1.0 1.2 2.2 -0.2 -1.5 -1.2
Reaction Time 1.0 1.8 2.8 0.8 1.4 1.7
Verbal and Numeric Reasoning (VNR) 0.2 0.4 0.8 0.3 0.6 -0.9
Breast Cancer 0.4 0.9 2.5 -1.6 0.4 -0.4
Ovarian Cancer 1.2 1.6 3.8 -2.0 -0.4 -0.9
Prostate Cancer 0.5 0.8 1.1 -1.1 0.4 -1.0
Age at First Birth 0.3 0.4 0.7 -0.3 -0.9 -0.6
Bipolar Disorder (2011) 0.6 0.6 1.0 -1.0 -0.9 -0.3
Body Mass Index (BMI) (2010) 0.5 0.6 1.2 0.2 0.8 1.1
Coronary Artery Disease (CAD) 0.4 0.5 0.8 0.8 0.9 0.3
Crohns Disease (2012) 0.5 0.8 1.6 -1.3 -0.8 -0.3
Mean Putamen Volume 0.1 0.1 0.1 -0.1 0.3 0.3
Fasting Glucose 1.0 1.1 3.2 0.5 0.1 1.8
HbA1C 0.1 0.1 0.2 -0.4 0.2 -0.4
HDL Cholesterol 1.7 2.9 5.7 1.1 2.4 1.3
LDL Cholesterol 0.3 0.4 1.0 -1.0 -0.1 -0.5
Lupus 0.2 0.3 0.7 -0.3 -0.8 0.3
Neuroticism (2016) 0.9 1.2 3.6 0.4 -0.0 -1.9
Primary Biliary Cirrhosis 1.4 2.0 3.7 -1.3 -1.9 -0.8
Rheumatoid Arthritis 0.9 1.2 2.0 -1.4 -0.1 -1.3
Schizophrenia (2014) 1.2 2.7 7.9 -2.8 -0.3 0.5
Triglycerides 0.3 0.4 1.2 0.1 -1.1 -0.3
Type 2 Diabetes (T2D) (2012) 1.0 1.2 2.5 -0.9 -1.6 -0.4
Ulcerative Colitis 1.4 2.1 4.8 -1.2 -2.2 -0.0
Blood Eosinophil Count 0.2 1.7 5.0 0.1 0.4 -2.2
Blood Platelet Count 0.2 2.9 5.0 1.7 2.2 0.9
Blood Red Count 0.7 6.9 10.3 0.8 3.2 3.1
Blood White Count 0.2 1.3 3.5 -1.9 -0.1 -0.6
Heel T-Score 0.2 1.5 2.1 1.2 1.4 1.0
BMI 0.8 4.9 9.2 -3.0 -2.0 -1.3
Height 0.5 9.3 20.1 -4.5 2.6 0.9
Waist Hip Ratio (WHR) 0.2 0.8 1.6 0.9 -0.2 1.2
Systolic Blood Pressure 0.7 3.4 6.2 2.5 1.6 1.2
Smoking Status 0.4 1.1 2.5 0.2 -0.8 -1.6
Allergy or Eczema 0.1 0.4 0.7 0.2 -0.6 -0.8
Cardiovascular Disease 0.2 0.8 2.1 1.5 0.3 0.4
Hypothyroidism (self reported) 0.2 0.5 1.4 1.2 0.0 0.1
Respiratory disease 0.7 1.6 3.2 -1.1 -1.8 -0.7
Type 2 Diabetes (T2D) (2018) 0.3 0.6 0.9 0.9 1.0 0.1
Lung FEV1/FVC ratio 0.5 2.4 3.9 0.4 2.0 1.8
Lung FVC 0.3 1.5 2.8 -1.3 0.4 -1.7
Neuroticism 0.6 1.5 2.8 -1.1 0.7 -1.7
Chronotype (morning person) 0.8 2.0 3.2 1.8 0.4 1.6
Hair Pigment 0.2 6.7 9.4 -3.1 -2.2 -2.4
Tanning 0.1 0.7 1.3 -0.3 -1.1 -0.8
Hand grip strength (left) 0.1 0.3 0.5 0.5 0.7 -0.2
Number of treatments/medications taken 0.3 0.6 1.3 -0.0 0.6 1.1
Average weekly spirits intake 1.8 2.2 3.4 -1.7 -0.4 -1.8
Sensitivity / hurt feelings 0.4 0.7 1.1 -1.1 -1.0 -0.0
Frequency of depressed mood in last 2 weeks 1.2 1.7 2.8 -1.2 -0.9 -1.7
Hearing difficulty/problems: Yes 1.0 1.5 3.8 -2.0 -0.7 0.2
Relative age of first facial hair 1.6 3.3 6.9 2.6 0.2 1.7
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.5 0.4 -1.2 -0.5
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.5 0.0 -0.7 -0.4
Ever had hysterectomy (womb removed) 0.6 0.6 1.8 -0.3 -0.2 -1.3
Systolic blood pressure, automated reading 0.2 0.7 1.0 1.0 1.0 -0.1
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.3 0.5 -0.1 0.3
Angina 0.2 0.3 0.6 0.4 -0.1 -0.8
Medication for hormone replacement therapy 1.9 2.1 5.4 0.8 0.6 2.3
Vitamin and mineral supplements 1.7 2.3 4.1 2.0 0.4 1.6
Supplements: Zinc 0.2 0.3 0.6 0.4 0.7 -0.3
Medication: Co-codamol 0.4 0.5 1.0 -0.6 -0.1 1.0
Medication: Metformin 0.2 0.3 0.4 0.6 0.6 0.4
Diabetes (father) 0.2 0.2 0.4 -0.6 -0.4 0.4
Diabetes (mother) 1.4 1.8 3.8 1.9 1.2 -0.0
Severe depression (siblings) 1.8 2.0 5.0 2.2 0.1 1.0
Pack years adult smoking proportion 2.8 4.3 5.2 -1.7 -2.3 -2.2
Impedance of leg (right) 1.2 5.6 12.5 3.5 1.9 1.0
Leg fat-free mass (left) 1.8 9.7 24.9 -5.0 -1.6 -1.3
Trunk fat percentage 0.4 1.5 4.1 -2.0 0.2 -0.7
Hand grip strength (right) 0.3 0.8 1.6 -0.7 0.5 -1.3
Townsend deprivation index at recruitment 0.3 0.4 0.9 -0.9 -0.6 -0.3
Current tobacco smoking 1.1 1.9 2.8 -0.3 -1.7 -1.6
Average weekly fortified wine intake 0.6 0.7 1.4 -0.5 -0.8 -1.2
Maternal smoking around birth 0.3 0.5 1.1 0.1 -1.1 -0.5
Fed-up feelings 1.0 1.8 3.8 -0.9 -1.0 -2.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.6 -0.0 -0.3 -0.8
Relative age voice broke 0.8 1.3 2.4 1.1 0.4 1.6
Taking other prescription medications 0.2 0.3 0.7 0.1 -0.5 0.8
Age when periods started (menarche) 0.1 0.2 0.4 0.0 -0.7 -0.2
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 1.5 0.2 1.2 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 2.2 -1.2 -0.7 -1.5
Tinnitus: Yes, but not now, but have in the past 3.5 3.7 7.1 -1.8 -0.9 -2.7
Qualifications: CSEs or equivalent 3.0 4.0 8.5 -2.9 -0.5 -1.8
Serious illness, injury or assault to yourself 1.8 2.1 4.6 1.0 2.1 0.9
High blood pressure 0.2 0.6 1.2 -0.0 -1.1 -0.7
Hayfever, allergic rhinitis or eczema 0.2 0.5 0.9 0.5 -0.6 -0.9
Multivitamins +/- minerals 2.2 2.8 5.9 -2.4 -1.4 -0.9
Stomach or abdominal pain in last month 0.2 0.2 0.4 0.6 0.2 -0.4
Supplements: Glucosamine 0.6 0.7 1.3 -1.1 0.9 0.2
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.1 0.3 -0.1 -0.3
Medication: Atenolol 0.2 0.3 0.7 0.8 0.1 -0.3
Medication: Levothyroxine sodium 0.4 0.7 0.9 0.7 -0.8 1.0
Sitting height 0.7 4.9 13.3 -3.6 -0.5 -1.1
Chronic bronchitis/emphysema (father) 1.1 1.3 2.5 -1.6 0.1 -1.1
High blood pressure (mother) 0.3 0.4 1.1 0.4 -1.1 -0.1
Body mass index (BMI) 0.9 3.6 8.5 -2.9 -0.9 -1.2
Impedance of leg (left) 1.3 6.4 11.9 3.5 2.4 1.3
Leg predicted mass (left) 1.9 10.0 25.5 -5.1 -1.7 -1.3
Trunk fat mass 1.0 4.1 10.5 -3.2 -0.3 -1.3
Waist circumference 0.8 3.1 7.3 -2.7 -1.4 -0.4
Number of incorrect matches in round 1.2 2.1 3.7 0.4 -1.5 -1.9
Past tobacco smoking 0.8 1.4 2.3 1.2 -1.5 0.8
Alcohol usually taken with meals 1.7 2.8 5.1 -0.1 2.2 1.8
Nervous feelings 0.1 0.1 0.2 -0.4 -0.3 -0.4
Frequency of tenseness / restlessness in last 2 weeks 1.6 2.5 4.5 -2.1 -0.2 -1.7
Hearing difficulty/problems with background noise 1.7 2.7 5.1 -0.2 -2.2 -1.7
Hair/balding pattern: Pattern 2 1.0 1.2 2.9 -1.7 -0.7 -0.6
Had menopause 0.9 1.1 2.9 1.7 0.4 0.3
Had other major operations 0.4 0.5 1.6 1.3 0.0 -0.0
Forced vital capacity (FVC) 0.2 0.9 2.6 -0.1 1.6 0.0
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.8 1.9 -1.3 -1.3 -1.4
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.8 0.3 -0.5 -1.4
Qualifications: None of the above 0.2 0.5 1.4 -0.0 0.0 -1.2
Financial difficulties in last 2 years 0.3 0.4 1.1 -0.3 0.1 1.1
Mouth/teeth dental problems 0.1 0.1 0.2 -0.4 -0.3 0.0
Heart attack 0.9 1.2 2.3 -1.1 0.3 -1.5
Allergy 0.4 1.0 2.3 0.8 0.3 1.5
Pain all over the body in last month 0.4 0.4 0.7 0.0 -0.8 -0.9
Diabetes (self-reported) 0.6 0.9 2.5 0.2 1.6 0.5
Hayfever/allergic rhinitis (self-reported) 1.8 2.4 4.8 -1.5 0.2 -2.2
Medication: Ramipril 0.4 0.6 1.3 0.5 -0.4 1.1
Medication: Simvastatin 0.4 0.6 1.5 0.3 -0.3 -1.2
Fluid intelligence score 0.1 0.2 0.5 -0.0 -0.0 -0.7
Illnesses of siblings 0.0 0.1 0.1 0.2 -0.1 0.4
Neuroticism score 0.6 1.3 2.8 -0.8 -0.8 -1.7
Weight 1.3 6.4 17.0 -4.1 -0.8 -1.3
Impedance of arm (right) 1.4 6.3 8.6 2.9 1.8 2.6
Arm fat percentage (right) 0.3 1.1 3.3 -1.8 0.0 -0.1
Trunk fat-free mass 1.7 9.7 25.2 -5.0 -1.1 -1.6
Hip circumference 0.8 3.2 9.5 -3.1 0.3 -0.4
Time employed in main current job 0.5 0.6 1.2 1.1 -0.6 0.4
Alcohol intake versus 10 years previously 1.1 1.6 2.8 -1.7 -1.3 -0.7
Father’s age at death 0.5 0.6 0.9 0.9 0.1 1.0
Worrier / anxious feelings 1.2 2.2 3.3 -1.4 -1.2 -1.8
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.2 -0.3 -0.2 -0.4
Falls in the last year 0.3 0.5 1.2 -1.1 0.4 0.1
Hair/balding pattern: Pattern 3 0.4 0.6 1.1 1.1 0.6 0.6
Number of live births 0.0 0.1 0.1 0.2 0.3 0.1
Forced expiratory volume in 1-second (FEV1) 0.8 2.6 6.1 0.4 2.5 1.2
Pulse rate 0.4 0.6 1.1 0.3 1.0 0.9
Happiness 2.3 2.8 6.1 -2.5 -0.9 -1.2
Noisy workplace 1.3 1.7 1.9 -1.4 -1.2 -1.2
Qualifications: A levels/AS levels or equivalent 0.7 1.6 3.1 0.7 1.2 1.8
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.6 -0.3 0.2 -0.8
Mouth/teeth dental problems: Dentures 0.4 0.6 1.3 0.1 -0.8 -1.1
Asthma 0.5 1.0 1.1 -1.0 -1.0 -1.0
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 3.0 -1.7 0.3 0.0
Medication: Cholesterol lowering 0.6 1.0 2.4 -0.6 -0.4 -1.6
Depression (self-reported) 0.7 0.8 1.4 1.0 -1.2 0.2
Medication: Lansoprazole 0.7 0.8 1.7 0.8 -1.3 0.4
Prospective memory result 1.5 1.9 3.8 1.9 -1.1 -0.8
Lung cancer (father) 0.2 0.2 0.5 -0.1 -0.7 -0.4
Illnesses of mother 0.0 0.1 0.1 -0.3 0.0 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.8 1.6 0.4 1.3 0.9
Pulse wave Arterial Stiffness index 0.2 0.2 0.4 0.6 -0.2 0.5
Impedance of arm (left) 0.8 3.7 4.8 2.2 1.4 2.1
Arm fat mass (right) 0.7 2.8 8.1 -2.8 -0.4 -0.5
Trunk predicted mass 1.6 9.4 24.5 -5.0 -1.0 -1.6
Standing height 0.3 3.4 10.0 -3.2 0.3 -0.2
Length of working week for main job 0.6 0.7 1.0 -0.3 1.0 1.0
Exposure to tobacco smoke at home 1.2 1.3 2.8 -0.4 1.1 1.7
Breastfed as a baby 1.7 2.1 2.4 -1.6 -1.3 -1.5
Tense / ‘highly strung’ 0.2 0.3 0.4 0.6 -0.3 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 1.4 0.6 -1.2 -1.0
Hair/balding pattern: Pattern 4 0.6 1.6 4.4 -0.3 0.5 -2.1
Birth weight of first child 0.9 1.7 2.3 -1.4 1.5 0.9
Peak expiratory flow (PEF) 0.1 0.3 0.7 -0.1 0.4 0.8
Pulse wave reflection index 0.4 0.5 1.5 -0.1 -1.2 0.4
Ever highly irritable/argumentative for 2 days 3.8 4.6 6.9 -1.3 -2.6 -2.3
Loud music exposure frequency 1.3 1.4 2.3 1.4 -1.5 0.2
Qualifications: O levels/GCSEs or equivalent 1.5 2.4 5.9 0.7 0.8 2.4
Mouth/teeth dental problems: Bleeding gums 1.2 1.5 2.2 -1.4 1.5 0.6
Blood clot in the leg (DVT) 0.5 0.7 1.1 -1.0 0.9 0.3
Medication: Paracetamol 0.7 1.2 1.8 -1.3 0.3 1.3
Headache pain in last month 0.5 0.8 1.6 -0.1 0.9 1.3
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.8 0.2 -0.1 0.9
Glaucoma (self-reported) 0.4 0.5 1.0 1.0 -0.6 -0.2
Gout (self-reported) 0.2 0.3 0.9 -0.9 -0.0 0.3
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.5 0.7 -0.2 0.6
Medication: Amlodipine 0.4 0.5 0.9 0.8 0.3 0.9
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.1 -0.2 -0.8 -1.0
Birth weight 0.6 1.3 2.7 -1.6 0.9 -0.7
Chronic bronchitis/emphysema (mother) 1.9 2.2 5.0 -1.1 -0.7 -2.2
High blood pressure (siblings) 0.4 0.6 1.3 0.6 -0.3 1.1
Forced vital capacity (FVC), Best measure 0.0 0.1 0.2 -0.2 0.4 -0.3
Body fat percentage 0.4 1.5 3.6 -1.9 -0.1 -1.0
Leg fat percentage (right) 0.2 0.6 1.0 -1.0 0.1 -1.0
Arm fat-free mass (right) 2.0 10.2 24.4 -4.9 -1.4 -2.1
Exposure to tobacco smoke outside home 0.6 0.9 2.4 -1.5 0.4 0.3
Comparative body size at age 10 0.3 0.9 2.4 -1.5 0.6 0.2
Number of full brothers 0.2 0.3 0.7 -0.1 0.8 -0.5
Worry too long after embarrassment 0.1 0.2 0.3 0.5 0.6 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.6 0.0 -0.8 -0.4
Wheeze or whistling in the chest in last year 2.9 5.2 8.2 -2.4 -1.2 -2.9
Number of children fathered 0.7 0.8 2.0 0.2 0.5 -1.4
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.4 -0.2 -0.2 0.7
Age at first live birth 0.5 0.9 1.9 1.4 -0.3 0.8
Pulse wave peak to peak time 0.3 0.3 0.5 -0.7 0.6 -0.5
Health satisfaction 1.2 1.6 3.8 -1.9 -0.6 -0.7
Shortness of breath walking on level ground 1.0 1.2 2.0 0.0 -1.2 -1.4
Qualifications: College or University degree 0.4 1.4 2.3 1.1 0.8 1.5
Eye problems/disorders: None of the above 3.2 3.6 8.5 -2.9 1.6 0.2
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.5 -0.5 0.7 -0.1
Emphysema/chronic bronchitis 3.2 3.6 7.9 -1.1 -1.2 -2.8
Medication for pain relief, constipation, heartburn 0.5 0.9 2.1 -0.0 -0.8 -1.4
Neck or shoulder pain in last month 0.9 1.3 3.0 0.3 -1.7 -0.9
Medication: Blood pressure 0.5 1.0 1.4 -1.2 0.4 -1.2
Angina (self-reported) 0.2 0.3 0.6 0.5 -0.1 -0.8
Migraine (self-reported) 0.8 0.9 1.4 -0.2 1.2 1.2
Medication: Ibuprofen 0.8 1.0 2.7 -1.6 0.3 -0.4
Medication: Allopurinol 0.4 0.5 0.7 -0.8 -0.9 0.5
Medication: Omeprazole 0.3 0.3 0.6 0.5 0.4 0.7
Medication: Seretide 50 evohaler 2.1 2.4 4.1 0.7 -2.0 -1.6
Mean time to correctly identify matches 0.1 0.2 0.3 0.3 0.5 0.6
Heart disease (mother) 0.3 0.4 0.7 -0.8 -0.6 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 3.3 0.7 1.8 0.4
Whole body fat mass 0.9 3.7 9.2 -3.0 -0.5 -1.3
Leg fat mass (right) 0.8 3.0 6.8 -2.6 -0.5 -1.4
Arm predicted mass (right) 1.9 9.6 24.0 -4.9 -1.1 -1.9
Pulse rate, automated reading 0.2 0.8 1.1 -0.6 1.1 0.9
Alcohol intake frequency. 0.2 0.4 0.7 -0.8 -0.4 0.5
Comparative height size at age 10 2.0 11.0 28.8 -5.4 0.3 -2.0
Number of full sisters 0.4 0.5 1.2 -0.5 0.0 -1.1
Suffer from ‘nerves’ 0.2 0.3 0.6 0.4 0.0 0.8
Overall health rating 0.3 0.6 1.3 -1.2 0.6 -0.0
Chest pain or discomfort 1.2 1.8 2.4 -0.9 -1.4 -1.5
Had major operations 0.3 0.4 0.7 0.5 0.9 0.4
Age at last live birth 0.3 0.4 0.5 0.7 -0.6 0.6
Family relationship satisfaction 1.2 1.5 3.9 -2.0 -0.6 -0.4
Leg pain on walking 1.8 2.2 2.8 -1.3 -1.7 -1.4
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 0.9 -0.9 -0.1 -1.0
Commuting to job workplace: Car/motor vehicle 0.7 0.8 1.8 -0.1 -1.3 -0.8
Illness, injury, bereavement, stress in last 2 years 1.5 1.8 4.8 -0.1 -2.2 -0.9
Medication: Aspirin 0.1 0.1 0.3 0.5 0.1 0.2
Supplements: Vitamin C 2.9 3.5 7.8 -1.4 -0.8 -2.8
Knee pain experienced in last month 1.9 3.0 3.8 -1.9 -1.5 -1.7
Hypertension (Self-reported) 0.1 0.4 1.0 0.4 -1.0 -0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.1 1.8 0.8 -1.3 -0.8
Illnesses of father: Heart disease 0.7 1.0 2.5 0.6 1.6 0.5
Illnesses of siblings: Diabetes 0.3 0.3 1.0 -1.0 0.1 -0.2
Smoking status: Previous 1.9 2.8 7.8 -0.8 2.8 0.1
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.5 3.0 -1.6 -1.3 -1.7
Whole body fat-free mass 1.9 10.9 27.8 -5.3 -1.4 -1.7
Leg fat-free mass (right) 1.8 9.4 25.3 -5.0 -1.4 -1.0
Arm fat percentage (left) 0.5 1.8 5.4 -2.3 -0.2 -0.4
Average weekly red wine intake 1.4 2.1 4.0 -1.3 2.0 -0.8
Handedness (chirality/laterality): Left-handed 0.3 0.3 0.7 -0.8 -0.3 0.5
Mood swings 0.8 1.4 3.4 -0.8 -0.0 -1.8
Loneliness, isolation 2.0 2.8 5.9 -1.3 -0.8 -2.4
Long-standing illness, disability or infirmity 0.4 0.7 1.2 1.1 -0.7 0.5
Ever had bowel cancer screening 0.9 1.0 3.0 -0.3 -0.1 -1.7
Diabetes diagnosed by doctor 0.2 0.4 0.9 -0.2 0.9 0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.8 -0.1 -0.9 -0.5
Friendships satisfaction 1.0 1.3 3.7 -0.2 -1.9 -0.1
Qualifications: nursing, teaching 2.9 4.4 7.7 1.7 1.7 2.8
Commuting to job workplace: Walk 0.2 0.2 0.4 0.4 0.7 0.0
Eye problems/disorders: Cataract 1.4 1.6 4.7 2.2 -0.1 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.9 1.5 3.7 1.9 0.3 0.8
Medication for cholesterol 0.6 0.8 1.6 -1.0 -0.1 -1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 0.6 0.8 0.3 0.3
Back pain experienced in last month 0.5 0.8 1.8 -0.4 -0.6 -1.4
Mineral and other dietary supplements 0.7 1.0 1.7 1.3 -0.1 1.2
Breast cancer (self-reported) 0.4 0.5 0.7 0.4 0.8 0.9
Asthma (self-reported) 0.3 0.5 0.6 -0.8 -0.8 -0.5
Osteoporosis (self-reported) 1.8 2.2 3.8 0.3 -2.0 -1.6
Osteoarthritis (self-reported) 0.4 0.5 0.6 -0.8 -0.6 -0.8
Medication: Aspirin 0.1 0.1 0.2 0.3 -0.5 0.1
Medication: Gliclazide 0.1 0.1 0.3 -0.1 0.1 0.6
Illnesses of father: None of the above (group 1) 0.5 0.6 1.1 1.1 -0.8 -0.3
Smoking status: Current 1.1 1.8 3.2 -0.3 -1.8 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.1 4.5 2.1 0.9 1.0
Whole body water mass 1.9 10.7 27.4 -5.2 -1.4 -1.6
Leg predicted mass (right) 1.8 9.8 25.6 -5.1 -1.5 -1.2
Arm fat mass (left) 0.8 3.3 9.5 -3.1 -0.2 -0.6
Number of self-reported non-cancer illnesses 0.1 0.2 0.5 -0.1 -0.4 -0.7
Average weekly champagne plus white wine intake 1.1 1.6 2.4 1.0 -1.1 1.6
Miserableness 0.4 0.6 1.0 -1.0 0.1 -0.9
Guilty feelings 0.3 0.4 0.8 0.9 0.7 -0.2
Wears glasses or contact lenses 0.4 0.4 0.6 -0.8 -0.5 -0.7
Ever taken oral contraceptive pill 1.2 1.4 2.9 -1.1 -1.7 -0.1
Hearing aid user 2.6 2.9 7.2 0.0 2.7 1.2
Mother’s age at death 1.6 2.0 4.3 0.6 2.1 -1.2
Financial situation satisfaction 1.6 2.0 4.1 -2.0 -0.8 -1.1
Tinnitus: Yes, now most or all of the time 0.6 0.7 0.9 1.0 -0.9 -0.5
Commuting to job workplace: Public transport 0.6 0.7 1.2 0.9 -1.1 0.2
Eye problems/disorders: Glaucoma 0.4 0.5 0.9 0.9 -0.6 0.6
Medication: Blood pressure 0.6 1.1 1.9 1.0 -1.4 0.5
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.5 0.6 0.2 -1.2
Supplements: Fish oil (including cod liver oil) 0.3 0.4 0.9 0.2 0.4 -0.9
High cholesterol (Self-reported) 0.3 0.6 0.8 0.8 0.9 -0.6
Medication: Bendroflumethiazide 0.2 0.4 0.5 0.7 -0.7 0.3
Medication: Paracetamol 0.9 1.4 2.8 -1.7 0.7 1.0
Medication: Lisinopril 0.6 0.8 2.0 -0.4 -0.6 -1.4
Medication: Atorvastatin 0.6 0.8 1.6 -0.8 1.3 0.2
Illnesses of father: High blood pressure 0.9 1.1 1.5 1.2 -1.0 -0.9
Alcohol drinker status: Never 2.2 2.7 4.8 2.2 1.6 0.8
Ever smoked 1.0 1.7 3.1 -1.8 0.2 -1.4
Basal metabolic rate 1.7 9.4 24.5 -5.0 -1.2 -1.4
Leg fat percentage (left) 0.2 0.8 1.4 -1.2 0.4 -0.9
Arm fat-free mass (left) 1.4 6.9 18.4 -4.3 -0.8 -1.3
Number of operations (self-reported) 0.2 0.3 0.3 0.5 0.6 0.4
Average weekly beer plus cider intake 0.3 0.5 1.3 -0.2 -1.1 -0.1
Irritability 2.5 4.2 7.2 -2.0 -1.1 -2.7
Risk taking 0.7 1.1 2.7 0.4 0.6 1.7
Ever had prostate specific antigen (PSA) test 0.9 1.0 1.7 0.1 1.2 -1.3
Fractured/broken bones in last 5 years 3.2 4.1 6.7 2.6 2.1 1.1
Age started oral contraceptive pill 0.3 0.3 0.9 -0.3 -1.0 -0.1
Diastolic blood pressure, automated reading 0.4 1.3 2.5 -1.1 1.6 0.5
Ever depressed for a whole week 0.3 0.3 0.8 0.4 0.2 -0.9
Unable to work because of sickness or disability 0.5 0.6 1.0 -0.1 -1.0 0.9
Commuting to job workplace: Cycle 0.3 0.3 0.9 -0.2 -0.1 -0.9
Myopia 0.3 0.5 1.3 1.1 0.4 0.1
Vascular/heart problems diagnosed by doctor 0.3 0.7 1.2 -0.3 1.1 1.0
Cholesterol lowering medication 0.7 1.1 3.2 0.1 1.8 0.1
Medication: Omeprazole (e.g. Zanprol) 0.0 0.0 0.0 -0.1 -0.1 -0.1
Pain experienced in last month 0.4 0.7 1.6 -0.4 1.2 0.5
Supplements: Calcium 0.3 0.3 0.7 -0.4 -0.4 -0.8
Basal cell carcinoma (self-reported) 1.9 2.3 6.4 -0.4 2.5 -0.5
Heart attack/myocardial infarction (self-reported) 0.8 1.0 1.8 -1.4 0.3 -1.1
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 0.7 -0.8 0.8 0.5
Heart disease (siblings) 0.0 0.0 0.0 0.0 -0.2 0.2
Alcohol drinker status: Previous 0.4 0.5 0.6 0.4 -0.8 0.8
Pack years of smoking 4.1 6.0 7.2 -2.0 -2.6 -2.7
Impedance of whole body 1.1 5.6 10.1 3.2 2.0 1.7
Leg fat mass (left) 0.8 3.0 7.3 -2.7 -0.3 -1.2
Arm predicted mass (left) 1.4 6.9 17.7 -4.2 -0.8 -1.5