Best TWAS P=4.24e-25 · Best GWAS P=3.32e-43 conditioned to 0.00333
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | C14orf39 | 0.08 | 0.05 | lasso | 8 | 0.06 | 2.1e-05 | 7.04 | -7.0 | 2.0e-12 | -0.41 | 0.92 | 0.02 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | RP11-193F5.4 | 0.06 | 0.00 | enet | 16 | 0.01 | 6.5e-02 | 6.85 | 5.2 | 1.8e-07 | 0.33 | 0.11 | 0.11 | FALSE |
| 3 | GTEx | Esophagus Muscularis | C14orf39 | 0.10 | 0.02 | enet | 9 | 0.02 | 2.9e-02 | -0.29 | -5.7 | 1.2e-08 | -0.41 | 0.11 | 0.18 | TRUE |
| 4 | GTEx | Liver | MNAT1 | 0.21 | 0.00 | lasso | 4 | -0.01 | 5.4e-01 | 0.36 | -7.3 | 2.3e-13 | -0.44 | 0.08 | 0.20 | TRUE |
| 5 | GTEx | Muscle Skeletal | C14orf39 | 0.06 | 0.05 | lasso | 3 | 0.05 | 2.7e-05 | 7.04 | -10.3 | 4.2e-25 | -0.67 | 0.13 | 0.86 | TRUE |
| 6 | GTEx | Pituitary | C14orf39 | 0.39 | 0.38 | enet | 20 | 0.35 | 1.0e-09 | 7.04 | -5.8 | 7.1e-09 | -0.34 | 0.98 | 0.00 | FALSE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | PCNXL4 | 0.15 | 0.05 | enet | 15 | 0.12 | 6.2e-07 | 3.02 | -9.8 | 6.9e-23 | -0.61 | 0.76 | 0.09 | TRUE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | C14orf39 | 0.02 | 0.02 | blup | 37 | 0.02 | 4.2e-03 | 6.80 | -9.2 | 2.8e-20 | -0.55 | 0.06 | 0.44 | FALSE |
| 9 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C14orf39 | 0.08 | 0.05 | blup | 37 | 0.05 | 4.2e-03 | 6.42 | -8.7 | 3.3e-18 | -0.51 | 0.09 | 0.36 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C14orf39 | 0.08 | 0.09 | blup | 37 | 0.11 | 1.8e-11 | 6.85 | -8.6 | 8.9e-18 | -0.51 | 0.99 | 0.01 | FALSE |