Hub : Genes

PCNXL4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cortex	0.2190	0.0990	1.5e-04	0.105	NA	0.102	NA	0.051	8.0e-04	NA	9.6e-04	NA	1.6e-02
2	GTEx	Brain Frontal Cortex BA9	0.1368	0.0589	1.7e-03	0.104	NA	0.086	NA	0.108	1.1e-03	NA	2.7e-03	NA	8.5e-04
3	GTEx	Muscle Skeletal	0.0698	0.0242	5.4e-08	0.075	NA	0.062	NA	0.068	7.9e-08	NA	1.0e-06	NA	3.1e-07
4	GTEx	Skin Not Sun Exposed Suprapubic	0.1540	0.0540	2.1e-06	0.051	NA	0.117	NA	0.107	8.9e-04	NA	6.2e-07	NA	1.8e-06
5	GTEx	Skin Sun Exposed Lower leg	0.1020	0.0380	7.1e-09	0.107	NA	0.123	NA	0.119	3.5e-09	NA	2.4e-10	NA	4.5e-10
6	GTEx	Thyroid	0.0980	0.0370	6.4e-07	0.086	NA	0.059	NA	0.080	4.0e-07	NA	2.5e-05	NA	1.1e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.3	0.4	1.3	-1.1	-0.0	0.0	-1.2	0.2	0.0
Bipolar Disorder or Schizophrenia	0.1	0.4	0.6	-0.8	0.6	-0.5	-0.8	0.3	0.5
Depressed Affect (Nagel 2018)	1.2	2.5	5.8	1.2	1.6	-1.4	2.4	1.5	1.1
Depression (Nagel 2018)	5.9	8.9	11.6	2.0	3.3	-3.2	2.9	3.4	3.0
Intelligence (Savage-Jansen 2018)	0.7	2.2	8.9	2.0	-0.2	0.4	-3.0	-0.7	-0.0
Neuroticism (Nagel 2018)	0.3	0.7	1.7	0.9	0.8	-0.4	1.3	0.9	0.4
Schizophrenia (2018)	0.1	0.2	0.5	-0.1	0.7	-0.7	-0.1	0.3	0.6
Schizophrenia vs Biploar Disorder	2.8	3.7	7.0	2.7	1.8	-1.5	1.5	2.1	1.7
Worry (Nagel 2018)	0.3	0.6	1.9	-0.4	0.7	-0.4	1.4	0.8	0.4
Alzheimer’s Disease (in mother)	2.6	3.1	4.1	-1.2	-1.9	1.9	-1.4	-2.0	-2.0
Alzheimer’s Disease (in father)	1.2	1.3	4.2	-2.1	-1.1	1.0	-0.7	-0.8	-0.8
Alzheimer’s Disease (including proxy)	1.0	1.5	2.1	-1.5	-1.2	1.2	-0.6	-1.3	-1.3
Crohns Disease (2017)	0.0	0.0	0.0	-0.1	0.2	0.1	0.2	-0.2	-0.0
Irritable Bowel Disease (IBD)	0.4	1.1	1.8	-1.3	-0.9	1.1	-0.1	-1.1	-1.1
Ulcerative Colitis (UC)	1.0	2.0	3.7	-1.9	-1.5	1.5	-0.2	-1.1	-1.5
Major Depression (MDD)	2.2	2.6	7.3	2.7	1.4	-1.2	0.3	1.5	1.6
Reaction Time	1.0	2.0	4.6	-2.1	-1.2	1.4	-0.9	-1.1	-1.3
Verbal and Numeric Reasoning (VNR)	0.7	1.6	4.2	2.0	0.9	-0.6	-1.6	0.7	1.1
Breast Cancer	0.6	1.4	2.7	1.2	1.0	-0.6	1.6	1.5	0.9
Ovarian Cancer	0.2	0.3	0.4	-0.4	-0.6	0.6	-0.5	-0.4	-0.6
Prostate Cancer	0.8	1.1	4.2	-2.0	-0.6	0.5	1.0	-0.5	-0.6
Age at First Birth	0.2	0.2	0.7	0.3	-0.3	0.3	-0.8	-0.6	-0.4
Bipolar Disorder (2011)	0.7	0.7	1.1	-0.5	1.1	-1.0	-0.0	0.9	1.0
Body Mass Index (BMI) (2010)	1.0	1.4	2.7	-0.9	1.5	-1.6	0.2	1.0	1.4
Coronary Artery Disease (CAD)	1.3	1.6	2.7	-0.5	-1.1	1.3	-1.2	-1.6	-1.5
Crohns Disease (2012)	0.1	0.2	0.5	0.2	-0.2	0.4	0.1	-0.7	-0.5
Mean Putamen Volume	0.4	0.5	1.7	-0.4	-0.6	0.7	1.3	-0.4	-0.5
Fasting Glucose	0.2	0.2	0.7	-0.1	-0.4	0.4	-0.8	-0.3	-0.1
HbA1C	0.3	0.3	1.7	0.4	-0.3	0.2	1.3	0.0	-0.3
HDL Cholesterol	0.5	0.9	3.1	1.8	0.2	-0.2	-1.5	-0.1	0.2
LDL Cholesterol	0.3	0.5	1.1	-0.4	-1.0	1.0	-0.3	-0.5	-0.7
Lupus	2.6	4.0	5.9	-2.4	-1.6	1.7	-2.4	-1.9	-1.7
Neuroticism (2016)	0.2	0.3	0.8	0.5	0.9	-0.4	0.5	0.6	0.4
Primary Biliary Cirrhosis	0.3	0.4	2.0	1.4	0.3	-0.2	-0.3	0.5	0.3
Rheumatoid Arthritis	0.3	0.3	0.5	0.5	0.5	-0.6	0.7	0.6	0.6
Schizophrenia (2014)	0.2	0.4	0.6	-0.2	0.7	-0.6	0.5	0.8	0.6
Triglycerides	1.1	1.8	3.5	-1.9	-1.4	1.1	-0.2	-1.6	-1.2
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.7	-1.0	-1.0	0.9	-0.3	-1.0	-1.3
Ulcerative Colitis	4.0	5.8	8.1	-2.9	-2.4	2.3	-1.4	-2.6	-2.5
Blood Eosinophil Count	0.2	1.8	9.6	-1.0	0.1	-0.5	3.1	-0.1	-0.1
Blood Platelet Count	0.4	4.6	6.7	-1.2	-2.4	2.6	-1.8	-2.3	-2.3
Blood Red Count	0.0	0.3	0.6	-0.8	-0.7	0.5	0.1	-0.3	-0.6
Blood White Count	0.5	3.7	4.6	-1.3	-2.1	2.1	-1.9	-2.2	-2.0
Heel T-Score	1.2	9.9	30.1	-2.0	-2.4	2.2	-5.5	-2.6	-2.8
BMI	0.2	1.4	4.9	-1.0	-0.7	0.4	-2.2	-1.1	-0.9
Height	2.6	50.2	228.0	0.7	-4.2	4.6	-15.1	-3.8	-4.3
Waist Hip Ratio (WHR)	1.2	5.5	13.8	-2.0	-2.0	2.2	3.7	-1.3	-2.1
Systolic Blood Pressure	1.5	7.6	16.3	-0.4	-2.6	3.1	-4.0	-2.2	-2.8
Smoking Status	2.6	6.3	8.9	1.4	2.9	-2.9	2.0	2.6	3.0
Allergy or Eczema	0.1	0.2	0.4	-0.5	-0.3	0.3	-0.1	-0.6	-0.5
Cardiovascular Disease	0.7	2.2	3.9	-0.5	-1.4	1.8	-2.0	-1.2	-1.6
Hypothyroidism (self reported)	0.3	0.8	1.2	0.7	0.9	-0.9	1.1	0.7	1.0
Respiratory disease	0.4	1.0	1.9	1.4	0.9	-0.9	1.0	0.7	0.8
Type 2 Diabetes (T2D) (2018)	0.7	1.4	3.9	-0.3	1.1	-1.1	2.0	1.0	0.8
Lung FEV1/FVC ratio	0.3	1.5	7.0	-0.4	0.5	-1.0	2.7	0.2	0.7
Lung FVC	0.1	0.4	1.0	0.4	-0.4	0.8	-1.0	-0.1	-0.5
Neuroticism	0.4	0.9	2.7	-0.2	1.0	-0.7	1.6	1.1	0.5
Chronotype (morning person)	2.9	6.6	11.2	-2.0	-2.6	2.7	-3.3	-2.1	-2.6
Hair Pigment	0.2	5.4	11.8	-3.4	-2.3	2.2	1.4	-1.8	-2.4
Tanning	0.0	0.5	2.0	-0.1	-0.5	0.2	-1.4	-0.6	-0.2
Hand grip strength (left)	0.5	1.3	1.7	1.2	1.1	-1.0	-1.2	1.3	1.0
Number of treatments/medications taken	0.6	1.1	1.9	-0.1	-1.0	1.2	-1.1	-0.8	-1.4
Average weekly spirits intake	0.1	0.2	0.8	0.9	-0.1	0.1	0.4	0.2	-0.0
Sensitivity / hurt feelings	1.3	2.2	6.2	1.0	-1.1	1.3	-2.5	-1.0	-1.4
Frequency of depressed mood in last 2 weeks	5.5	7.6	10.0	1.9	3.1	-3.0	2.2	3.2	3.0
Hearing difficulty/problems: Yes	0.2	0.3	0.7	0.8	-0.0	0.4	0.8	0.3	-0.1
Relative age of first facial hair	0.4	0.8	1.6	-0.2	0.8	-0.6	1.2	1.2	0.7
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.2	-0.7	-0.8	1.1	-1.5	-0.6	-0.7
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.7	0.5	-0.7	0.8	-1.3	-0.4	-0.6
Ever had hysterectomy (womb removed)	0.4	0.5	2.6	0.0	-0.3	0.3	-1.6	-0.2	0.0
Systolic blood pressure, automated reading	1.9	5.5	16.4	0.4	-1.9	2.0	-4.1	-2.0	-2.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.7	0.7	0.8	-0.7	0.3	0.6	0.7
Angina	0.1	0.1	0.4	-0.2	0.1	0.2	0.6	0.6	0.1
Medication for hormone replacement therapy	0.3	0.4	1.3	0.2	-0.5	0.5	-1.1	-0.4	-0.5
Vitamin and mineral supplements	0.5	0.7	3.4	0.5	-0.2	0.4	1.8	0.4	-0.2
Supplements: Zinc	0.8	0.9	1.5	0.3	1.2	-1.2	-0.0	1.1	1.1
Medication: Co-codamol	0.5	0.6	1.0	-1.0	-0.7	0.6	0.5	-1.0	-0.6
Medication: Metformin	0.3	0.4	1.0	0.3	0.6	-0.6	1.0	0.7	0.4
Diabetes (father)	0.4	0.5	2.3	-1.5	-0.1	-0.2	0.6	-0.4	0.2
Diabetes (mother)	0.5	0.7	1.3	-0.4	0.9	-1.0	1.1	0.5	0.7
Severe depression (siblings)	3.3	3.6	5.4	2.1	2.1	-2.3	0.2	1.4	2.3
Pack years adult smoking proportion	0.8	1.2	1.6	1.1	1.1	-1.0	1.3	0.8	1.1
Impedance of leg (right)	2.3	11.2	41.3	1.5	2.2	-1.8	6.4	3.3	2.2
Leg fat-free mass (left)	3.2	17.1	76.9	-1.6	-2.3	2.1	-8.8	-2.9	-2.3
Trunk fat percentage	0.1	0.3	1.2	-0.5	-0.0	-0.1	-1.1	-0.3	-0.1
Hand grip strength (right)	0.4	1.2	6.5	0.3	0.3	-0.1	-2.6	0.6	0.4
Townsend deprivation index at recruitment	1.2	1.7	2.6	1.0	1.4	-1.4	1.6	1.0	1.4
Current tobacco smoking	2.7	4.5	6.9	0.5	2.5	-2.6	1.7	2.0	2.6
Average weekly fortified wine intake	1.0	1.2	2.0	-0.8	-1.4	1.1	-0.3	-1.3	-1.1
Maternal smoking around birth	0.3	0.4	0.8	-0.6	0.6	-0.6	0.4	0.7	0.9
Fed-up feelings	1.4	2.6	3.1	1.5	1.7	-1.6	1.8	1.6	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	3.9	5.2	6.5	1.4	2.5	-2.4	2.2	2.6	2.4
Relative age voice broke	1.0	1.5	3.7	0.1	1.4	-1.1	0.1	1.9	1.3
Taking other prescription medications	0.6	0.9	1.4	-0.8	-1.0	1.2	0.3	-0.9	-1.1
Age when periods started (menarche)	1.3	3.1	15.3	0.9	0.5	-0.5	-3.9	1.2	0.6
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.9	0.8	0.9	-0.7	0.0	1.4	1.1
Heel bone mineral density (BMD) T-score, automated (left)	3.5	7.8	18.2	-1.5	-2.4	2.4	-4.3	-3.0	-2.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.1	1.1	-0.4	0.5	-0.1	0.0	-0.5
Qualifications: CSEs or equivalent	1.5	1.9	2.8	-1.0	-1.6	1.6	-0.3	-1.5	-1.7
Serious illness, injury or assault to yourself	0.4	0.5	1.7	0.7	0.5	-0.5	1.3	0.5	0.5
High blood pressure	0.7	2.0	3.1	-0.0	-1.5	1.5	-1.8	-1.4	-1.7
Hayfever, allergic rhinitis or eczema	0.2	0.3	0.7	-0.6	-0.5	0.5	0.1	-0.8	-0.6
Multivitamins +/- minerals	0.8	1.0	1.8	0.3	1.1	-1.3	-1.1	0.7	1.1
Stomach or abdominal pain in last month	0.0	0.0	0.2	-0.1	0.1	-0.1	0.4	0.2	0.2
Supplements: Glucosamine	3.2	4.2	10.7	-1.3	-1.8	1.8	-3.3	-1.8	-1.8
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.0	0.8	0.2	-0.2	-1.0	0.0	0.2
Medication: Atenolol	1.5	1.9	5.0	-0.0	-1.2	1.3	-2.2	-1.2	-1.3
Medication: Levothyroxine sodium	1.2	2.0	2.6	1.6	1.4	-1.4	0.9	1.6	1.6
Sitting height	3.3	23.2	96.5	1.0	-3.1	3.5	-9.8	-3.0	-3.3
Chronic bronchitis/emphysema (father)	1.7	2.0	3.6	0.2	1.6	-1.8	0.5	1.4	1.9
High blood pressure (mother)	1.2	1.6	2.3	-0.6	-1.2	1.2	-1.5	-1.5	-1.4
Body mass index (BMI)	0.3	1.2	5.4	-0.8	-0.4	0.0	-2.3	-1.1	-0.4
Impedance of leg (left)	2.2	10.8	35.4	2.0	2.3	-1.9	6.0	3.3	2.3
Leg predicted mass (left)	3.2	16.8	75.5	-1.6	-2.3	2.0	-8.7	-2.9	-2.3
Trunk fat mass	0.6	2.7	12.8	-0.8	-0.7	0.6	-3.6	-1.0	-0.8
Waist circumference	0.8	2.8	6.0	-1.4	-1.4	1.2	-2.5	-1.7	-1.5
Number of incorrect matches in round	0.4	0.6	0.9	-0.9	-0.7	0.6	-1.0	-0.6	-0.7
Past tobacco smoking	0.6	1.2	3.1	-1.8	-1.1	0.9	-0.1	-0.8	-1.1
Alcohol usually taken with meals	0.0	0.1	0.1	0.2	-0.2	0.1	0.3	-0.3	-0.2
Nervous feelings	0.3	0.5	0.6	0.4	0.8	-0.7	0.7	0.8	0.8
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	3.1	0.6	1.5	-1.4	1.0	1.8	1.7
Hearing difficulty/problems with background noise	1.5	2.4	3.3	1.6	1.6	-1.4	1.3	1.8	1.6
Hair/balding pattern: Pattern 2	1.6	2.0	2.6	-1.2	-1.4	1.3	-1.3	-1.6	-1.5
Had menopause	0.5	0.7	0.9	0.9	0.8	-0.9	0.1	1.0	0.9
Had other major operations	1.0	1.2	2.5	-0.7	-0.9	1.0	-1.6	-1.2	-1.1
Forced vital capacity (FVC)	1.4	5.3	20.9	0.4	-1.6	2.0	-4.6	-1.2	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	2.4	5.5	12.5	-2.0	-1.8	1.8	-3.5	-2.4	-2.0
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.3	1.5	0.7	-0.5	1.5	0.9	0.6
Qualifications: None of the above	1.4	2.9	10.7	-0.5	1.2	-1.5	3.3	1.1	1.2
Financial difficulties in last 2 years	0.4	0.6	1.6	-0.4	0.7	-0.7	1.3	0.5	0.7
Mouth/teeth dental problems	1.3	2.0	6.3	-0.9	-1.0	1.1	-2.5	-1.1	-1.1
Heart attack	0.3	0.4	1.5	0.3	0.6	-0.3	1.2	0.5	0.2
Allergy	0.0	0.1	0.5	0.1	-0.3	0.3	-0.7	0.2	0.0
Pain all over the body in last month	0.1	0.1	0.2	0.2	0.2	-0.4	0.4	0.1	0.3
Diabetes (self-reported)	0.0	0.1	0.2	0.0	0.3	-0.4	0.4	0.1	0.1
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.3	0.4	0.4	-0.3	0.5	0.2	0.1
Medication: Ramipril	1.7	2.2	3.3	-1.4	-1.5	1.6	-0.9	-1.4	-1.8
Medication: Simvastatin	0.3	0.4	1.4	-0.3	-0.5	0.6	-1.2	-0.1	-0.5
Fluid intelligence score	0.3	0.6	2.4	1.5	0.0	0.2	-1.0	0.1	0.1
Illnesses of siblings	0.2	0.2	1.0	-1.0	-0.0	-0.2	0.4	-0.1	0.2
Neuroticism score	0.0	0.0	0.0	0.1	0.2	0.0	0.1	0.2	-0.2
Weight	2.0	9.6	46.4	-0.8	-1.5	1.3	-6.8	-2.0	-1.6
Impedance of arm (right)	0.6	2.8	10.6	1.3	1.0	-0.7	3.2	1.4	1.1
Arm fat percentage (right)	0.1	0.5	1.4	-0.5	-0.3	0.1	-1.2	-0.9	-0.4
Trunk fat-free mass	3.8	21.9	99.6	-1.1	-2.7	2.7	-10.0	-2.9	-2.8
Hip circumference	1.3	5.7	30.0	-0.3	-0.9	0.7	-5.5	-1.5	-0.9
Time employed in main current job	0.3	0.3	0.8	-0.9	-0.4	0.4	-0.5	-0.5	-0.4
Alcohol intake versus 10 years previously	0.3	0.4	1.3	-1.2	-0.3	0.4	0.4	-0.5	-0.5
Father’s age at death	0.7	0.9	1.8	-0.4	-1.3	1.2	0.0	-0.9	-1.1
Worrier / anxious feelings	0.7	1.2	2.1	-0.4	-1.2	1.4	-0.9	-1.1	-1.5
Frequency of tiredness / lethargy in last 2 weeks	3.0	5.0	6.2	2.2	2.5	-2.3	1.0	2.5	2.5
Falls in the last year	0.6	0.8	1.5	-0.4	-1.0	0.8	-1.0	-1.2	-0.9
Hair/balding pattern: Pattern 3	2.2	3.3	5.3	1.1	2.2	-2.0	0.8	2.3	2.0
Number of live births	0.2	0.3	0.6	-0.8	0.4	-0.7	0.3	0.1	0.4
Forced expiratory volume in 1-second (FEV1)	0.7	2.2	9.3	0.4	-1.0	1.2	-3.1	-0.7	-1.0
Pulse rate	0.7	1.1	2.2	-0.6	-1.0	1.0	1.5	-0.9	-1.1
Happiness	0.3	0.4	0.6	0.7	0.7	-0.8	-0.2	0.2	0.7
Noisy workplace	0.3	0.3	1.0	-1.0	-0.1	-0.1	1.0	-0.1	0.0
Qualifications: A levels/AS levels or equivalent	0.8	1.7	5.2	-0.4	-1.1	1.1	-2.3	-1.2	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	0.7	-0.4	0.5	-0.3	-0.4	-0.3
Mouth/teeth dental problems: Dentures	4.1	6.9	11.9	2.3	2.5	-2.3	3.5	2.8	2.3
Asthma	0.3	0.5	1.7	1.1	0.4	-0.4	1.3	0.3	0.1
Medication: Ibuprofen (e.g. Nurofen)	2.9	3.6	4.9	-1.7	-2.0	2.2	-1.2	-2.0	-2.1
Medication: Cholesterol lowering	0.2	0.3	0.8	-0.9	-0.4	0.6	-0.6	-0.4	-0.6
Depression (self-reported)	0.9	1.1	3.9	0.1	-0.9	0.8	-2.0	-1.1	-0.4
Medication: Lansoprazole	0.8	0.9	1.8	0.0	1.0	-1.0	1.4	0.9	1.0
Prospective memory result	0.2	0.2	0.6	-0.7	0.2	-0.1	-0.8	0.5	0.2
Lung cancer (father)	0.1	0.1	0.2	0.4	-0.3	0.3	0.0	-0.5	-0.2
Illnesses of mother	2.8	3.5	5.4	1.3	1.8	-2.1	1.6	2.0	2.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	5.9	1.3	-0.4	0.5	-2.4	-0.3	-0.2
Pulse wave Arterial Stiffness index	0.3	0.4	1.0	-1.0	0.5	-0.4	0.5	0.8	0.3
Impedance of arm (left)	1.1	5.1	15.4	1.3	1.8	-1.6	3.9	2.0	1.9
Arm fat mass (right)	0.9	3.8	17.6	-0.8	-1.0	0.7	-4.2	-1.5	-1.0
Trunk predicted mass	3.8	21.5	98.6	-1.1	-2.7	2.6	-9.9	-2.8	-2.8
Standing height	2.5	24.5	114.9	-0.4	-2.8	3.2	-10.7	-2.4	-2.9
Length of working week for main job	0.7	0.8	1.3	-0.0	1.0	-1.1	0.2	1.1	0.9
Exposure to tobacco smoke at home	0.2	0.2	1.2	-1.1	0.0	-0.2	-0.2	-0.1	0.1
Breastfed as a baby	0.1	0.1	0.4	0.3	-0.1	0.2	-0.6	-0.0	-0.4
Tense / ‘highly strung’	0.1	0.2	0.6	0.8	0.2	-0.1	0.3	0.3	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	4.5	2.1	0.6	-0.4	0.5	0.5	0.7
Hair/balding pattern: Pattern 4	0.1	0.2	1.0	-1.0	0.0	-0.3	-0.4	0.1	0.3
Birth weight of first child	1.3	2.4	3.1	1.3	1.8	-1.7	0.9	1.7	1.6
Peak expiratory flow (PEF)	0.3	0.7	1.1	-0.5	-0.9	0.9	-1.1	-0.9	-0.8
Pulse wave reflection index	0.3	0.4	2.1	-1.4	0.1	-0.1	-0.2	0.7	0.1
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.8	0.9	0.4	-0.5	0.0	0.4	0.5
Loud music exposure frequency	0.1	0.2	0.8	0.1	-0.1	0.2	-0.9	-0.2	0.1
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	3.0	1.5	0.2	-0.1	-1.7	-0.0	0.2
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.3	0.5	0.4	-0.5	0.4	0.4	0.6
Blood clot in the leg (DVT)	0.1	0.1	0.3	-0.2	0.4	-0.5	0.4	-0.2	0.2
Medication: Paracetamol	1.9	3.1	6.5	1.4	1.6	-1.4	2.6	1.8	1.5
Headache pain in last month	0.5	0.8	1.1	0.2	1.0	-1.0	0.8	1.0	1.0
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.3	-0.4	0.2	-0.5	0.6	0.2	0.5
Glaucoma (self-reported)	2.3	2.7	13.4	-0.1	-0.8	0.9	-3.7	-0.6	-0.9
Gout (self-reported)	0.5	0.7	1.2	-0.4	-0.6	0.7	-1.1	-1.1	-0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	0.8	0.3	0.7	-0.7	0.5	0.7	0.9
Medication: Amlodipine	0.5	0.7	2.0	0.4	0.6	-0.8	1.4	0.7	0.6
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.4	1.5	1.1	-1.1	1.2	1.0	0.9
Birth weight	0.6	1.3	2.3	1.1	1.2	-1.5	0.4	0.9	1.3
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.5	0.7	0.4	-0.3	-0.1	0.3	0.2
High blood pressure (siblings)	1.2	1.7	3.3	1.5	-1.1	1.3	-1.8	-0.8	-1.1
Forced vital capacity (FVC), Best measure	1.1	4.0	18.2	1.4	-0.9	1.3	-4.3	-0.8	-0.9
Body fat percentage	0.0	0.1	0.2	-0.3	0.3	-0.4	-0.4	-0.1	0.1
Leg fat percentage (right)	0.2	0.6	1.6	-0.1	0.8	-0.9	1.3	0.6	0.6
Arm fat-free mass (right)	3.0	15.5	72.6	-1.2	-2.1	2.0	-8.5	-2.4	-2.2
Exposure to tobacco smoke outside home	0.0	0.1	0.3	-0.1	-0.0	0.0	-0.5	-0.1	-0.1
Comparative body size at age 10	0.4	1.1	4.5	0.9	0.6	-0.8	-2.1	-0.0	0.5
Number of full brothers	0.0	0.0	0.1	0.3	0.1	-0.2	0.1	0.1	0.1
Worry too long after embarrassment	0.2	0.4	1.0	0.9	-0.2	0.4	-1.0	-0.2	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.7	1.3	0.5	-0.5	-0.3	0.2	0.5
Wheeze or whistling in the chest in last year	0.8	1.4	2.0	0.9	1.3	-1.4	1.2	0.9	1.2
Number of children fathered	0.7	0.8	1.2	-0.1	1.1	-1.1	-0.1	1.1	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.6	0.5	0.6	-0.6	-1.6	0.3	0.6
Age at first live birth	1.3	2.2	5.3	-0.3	-1.2	1.4	-2.3	-1.4	-1.6
Pulse wave peak to peak time	0.5	0.6	1.2	1.0	-0.5	0.5	-1.1	-0.9	-0.4
Health satisfaction	2.2	2.9	3.7	-1.6	-1.7	1.8	-1.3	-1.8	-1.9
Shortness of breath walking on level ground	1.9	2.3	3.1	-1.5	-1.6	1.6	-0.5	-1.7	-1.8
Qualifications: College or University degree	1.1	3.4	15.2	0.9	-1.1	1.3	-3.9	-0.8	-0.7
Eye problems/disorders: None of the above	1.0	1.2	2.5	-0.6	1.0	-1.0	1.6	0.8	1.3
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.5	0.3	0.2	-0.2	0.7	-0.4	-0.1
Emphysema/chronic bronchitis	3.1	3.5	5.1	0.8	2.3	-2.2	1.3	1.9	2.2
Medication for pain relief, constipation, heartburn	0.6	1.0	1.8	-0.2	1.1	-1.3	-0.7	1.0	1.3
Neck or shoulder pain in last month	0.1	0.1	0.3	-0.1	0.3	-0.2	-0.5	0.5	0.4
Medication: Blood pressure	0.3	0.5	1.2	0.6	-0.5	0.7	-1.1	-0.4	-0.8
Angina (self-reported)	0.2	0.2	0.6	-0.4	0.2	0.1	0.8	0.7	0.2
Migraine (self-reported)	0.4	0.5	0.9	0.1	-0.9	1.0	0.6	-0.4	-0.7
Medication: Ibuprofen	1.6	1.9	3.0	-1.0	-1.5	1.7	-0.8	-1.4	-1.7
Medication: Allopurinol	0.5	0.6	1.2	-1.1	-0.6	0.7	-0.6	-0.8	-0.8
Medication: Omeprazole	0.6	0.7	2.1	0.8	-0.6	0.6	1.5	-0.4	-0.6
Medication: Seretide 50 evohaler	0.2	0.2	0.6	0.6	0.3	-0.3	0.8	0.2	-0.0
Mean time to correctly identify matches	0.5	1.0	2.0	-1.4	-0.7	1.0	-1.1	-0.6	-1.1
Heart disease (mother)	4.2	5.1	6.9	-0.4	-2.3	2.6	-2.6	-2.2	-2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	-0.3	-0.1	0.1	0.1	-0.2	-0.2
Whole body fat mass	0.6	2.4	11.4	-1.0	-0.6	0.4	-3.4	-1.0	-0.7
Leg fat mass (right)	0.3	1.3	5.9	-0.9	-0.4	0.1	-2.4	-0.8	-0.5
Arm predicted mass (right)	3.1	15.9	73.9	-1.4	-2.2	2.0	-8.6	-2.4	-2.2
Pulse rate, automated reading	0.1	0.2	1.0	-0.2	-0.2	0.2	1.0	-0.2	-0.1
Alcohol intake frequency.	0.4	0.8	3.2	-0.2	0.6	-0.9	1.8	0.4	0.5
Comparative height size at age 10	1.2	6.7	27.4	-0.8	-1.7	1.9	-5.2	-1.3	-1.9
Number of full sisters	1.4	1.7	3.1	0.9	1.5	-1.8	-0.9	0.8	1.6
Suffer from ‘nerves’	0.1	0.1	0.5	-0.2	-0.0	0.2	0.7	0.4	-0.0
Overall health rating	0.5	1.1	5.2	-2.3	-0.4	0.1	-0.3	-0.8	-0.4
Chest pain or discomfort	0.4	0.5	0.7	0.8	0.8	-0.8	-0.0	0.8	0.8
Had major operations	1.9	2.3	5.4	-0.4	-1.2	1.4	-2.3	-1.6	-1.4
Age at last live birth	0.9	1.3	5.2	-0.1	-0.6	0.8	-2.3	-0.9	-1.0
Family relationship satisfaction	0.2	0.3	0.5	0.5	-0.5	0.4	0.7	-0.5	-0.6
Leg pain on walking	0.5	0.6	1.2	-0.8	1.0	-1.1	0.4	0.5	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.6	-0.8	-0.6	0.5	1.2	-0.5	-0.6
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.8	-1.2	-0.1	0.1	-1.7	-0.2	-0.1
Illness, injury, bereavement, stress in last 2 years	2.3	2.9	6.3	-0.9	-1.5	1.5	-2.5	-1.6	-1.7
Medication: Aspirin	1.3	1.7	2.9	-0.7	-1.5	1.7	0.8	-1.1	-1.7
Supplements: Vitamin C	0.2	0.3	0.9	-1.0	-0.2	0.1	-0.8	-0.2	-0.3
Knee pain experienced in last month	1.0	1.5	3.5	-1.6	-0.8	1.0	-1.9	-0.7	-1.0
Hypertension (Self-reported)	0.7	2.1	3.5	-0.0	-1.5	1.5	-1.9	-1.3	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.2	1.1	0.2	-0.1	1.1	0.4	0.1
Illnesses of father: Heart disease	1.5	2.1	4.2	-1.1	-1.3	1.3	-2.1	-1.4	-1.5
Illnesses of siblings: Diabetes	1.4	1.7	4.5	1.0	1.2	-1.2	2.1	0.8	1.0
Smoking status: Previous	0.7	1.0	2.0	1.4	1.1	-1.0	0.3	0.7	1.1
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.6	14.0	-0.0	-2.0	1.9	-3.7	-1.8	-1.7
Whole body fat-free mass	3.6	20.7	96.0	-1.2	-2.5	2.4	-9.8	-2.9	-2.5
Leg fat-free mass (right)	3.4	18.3	85.3	-1.3	-2.3	2.0	-9.2	-2.9	-2.3
Arm fat percentage (left)	0.0	0.2	0.7	-0.3	0.1	-0.3	-0.8	-0.5	-0.0
Average weekly red wine intake	0.6	0.9	1.6	0.3	0.9	-0.8	1.1	1.3	1.1
Handedness (chirality/laterality): Left-handed	1.6	1.9	8.0	1.5	-0.5	0.7	-2.8	-0.4	-0.7
Mood swings	0.6	1.1	2.3	-0.3	-1.1	1.2	0.1	-1.2	-1.5
Loneliness, isolation	1.0	1.4	5.0	0.2	1.0	-1.1	2.2	0.6	0.8
Long-standing illness, disability or infirmity	0.1	0.2	0.7	0.8	-0.0	0.1	-0.4	-0.3	-0.2
Ever had bowel cancer screening	1.7	2.0	3.3	1.1	1.6	-1.8	-0.1	1.4	1.7
Diabetes diagnosed by doctor	0.1	0.2	0.8	0.3	0.4	-0.3	0.9	0.2	0.1
Ever had stillbirth, spontaneous miscarriage or termination	2.3	2.5	6.0	1.8	1.1	-1.0	2.4	1.5	1.0
Friendships satisfaction	0.3	0.4	1.0	-0.3	0.7	-0.5	1.0	0.5	0.5
Qualifications: nursing, teaching	0.4	0.6	2.8	0.4	0.4	-0.4	-1.7	0.1	0.7
Commuting to job workplace: Walk	0.8	0.9	1.3	1.2	0.9	-0.9	0.9	0.7	1.1
Eye problems/disorders: Cataract	0.8	0.9	1.4	-0.6	-1.1	0.9	0.2	-1.2	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.8	0.9	0.4	-0.4	0.5	0.6	0.6
Medication for cholesterol	0.5	0.8	1.2	-0.0	1.0	-1.1	1.1	0.6	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	3.2	1.1	1.7	-1.6	0.6	1.8	1.6
Back pain experienced in last month	0.4	0.6	1.0	0.5	1.0	-0.9	0.5	0.7	1.0
Mineral and other dietary supplements	1.7	2.2	4.7	1.7	1.1	-0.9	2.2	1.4	1.3
Breast cancer (self-reported)	0.5	0.7	1.6	-1.3	-0.9	0.6	-0.5	-0.8	-0.6
Asthma (self-reported)	0.2	0.4	1.6	0.8	0.2	-0.2	1.3	0.0	-0.1
Osteoporosis (self-reported)	0.7	0.9	3.8	0.3	0.5	-0.4	1.9	0.9	0.5
Osteoarthritis (self-reported)	0.1	0.1	0.3	0.3	0.3	-0.3	-0.5	-0.1	0.3
Medication: Aspirin	1.1	1.4	2.7	-0.2	-1.3	1.7	0.8	-0.8	-1.6
Medication: Gliclazide	0.4	0.5	0.8	-0.3	-0.7	0.8	-0.9	-0.3	-0.8
Illnesses of father: None of the above (group 1)	2.7	3.3	9.8	1.4	1.4	-1.3	3.1	1.6	1.4
Smoking status: Current	2.4	3.9	5.8	0.8	2.2	-2.4	1.7	1.8	2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.8	0.2	-0.5	0.7	-0.9	-0.4	-0.5
Whole body water mass	3.8	21.6	97.0	-1.4	-2.7	2.6	-9.8	-3.1	-2.8
Leg predicted mass (right)	3.5	18.7	85.4	-1.4	-2.4	2.1	-9.2	-3.0	-2.4
Arm fat mass (left)	0.9	3.5	15.2	-0.9	-1.0	0.7	-3.9	-1.5	-1.0
Number of self-reported non-cancer illnesses	1.1	1.9	3.1	0.1	-1.3	1.4	-1.8	-1.5	-1.4
Average weekly champagne plus white wine intake	0.6	0.8	2.3	0.4	-0.8	0.5	-1.5	-0.8	-0.8
Miserableness	0.1	0.2	0.5	0.7	-0.2	0.3	-0.5	-0.3	-0.2
Guilty feelings	0.9	1.3	2.2	1.4	1.3	-0.9	0.1	1.5	1.0
Wears glasses or contact lenses	0.1	0.1	0.3	-0.2	-0.2	0.2	0.3	-0.5	-0.2
Ever taken oral contraceptive pill	0.8	0.9	2.2	1.5	0.6	-0.4	1.3	0.9	0.6
Hearing aid user	0.5	0.6	1.0	-0.2	-0.7	0.7	-1.0	-0.7	-1.0
Mother’s age at death	3.8	4.8	6.7	-1.2	-2.4	2.5	-1.9	-2.2	-2.6
Financial situation satisfaction	0.8	1.0	1.7	-1.3	-0.9	0.8	-0.5	-1.2	-1.0
Tinnitus: Yes, now most or all of the time	0.5	0.5	1.0	0.2	0.6	-0.6	0.9	1.0	0.8
Commuting to job workplace: Public transport	1.2	1.4	2.4	0.4	-1.4	1.5	-0.2	-1.2	-1.5
Eye problems/disorders: Glaucoma	0.8	0.9	4.8	0.1	0.2	-0.1	-2.2	0.7	0.2
Medication: Blood pressure	0.6	1.1	1.6	-0.2	-1.2	1.3	-1.0	-0.9	-1.3
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.2	-0.4	0.4	0.2	-0.2	-0.2
Supplements: Fish oil (including cod liver oil)	1.1	1.5	4.8	-1.2	-0.8	0.6	-2.2	-1.0	-0.9
High cholesterol (Self-reported)	0.1	0.2	0.8	-0.9	0.2	-0.1	0.6	0.1	-0.1
Medication: Bendroflumethiazide	0.5	0.7	2.2	1.5	-0.6	0.7	-0.6	-0.5	-0.8
Medication: Paracetamol	2.4	3.7	7.2	1.6	1.8	-1.6	2.7	2.0	1.6
Medication: Lisinopril	0.0	0.1	0.3	0.6	0.0	-0.1	-0.0	-0.1	0.0
Medication: Atorvastatin	0.4	0.5	1.6	1.0	0.3	-0.2	1.3	0.5	0.1
Illnesses of father: High blood pressure	0.5	0.6	2.4	0.8	-0.5	0.5	-1.6	-0.3	-0.4
Alcohol drinker status: Never	2.6	3.1	9.2	0.9	1.4	-1.4	3.0	1.7	1.2
Ever smoked	0.2	0.4	1.3	1.2	0.5	-0.3	-0.8	0.3	0.5
Basal metabolic rate	3.4	19.0	86.7	-1.3	-2.5	2.3	-9.3	-2.9	-2.5
Leg fat percentage (left)	0.1	0.4	0.8	0.2	0.7	-0.9	0.9	0.4	0.6
Arm fat-free mass (left)	4.1	20.8	88.9	-1.4	-2.9	2.8	-9.4	-3.1	-2.9
Number of operations (self-reported)	0.3	0.4	2.5	-0.1	-0.1	0.2	-1.6	-0.3	-0.1
Average weekly beer plus cider intake	3.8	5.4	7.3	-2.7	-2.2	2.4	-2.1	-2.1	-2.4
Irritability	0.1	0.1	0.4	0.7	0.1	0.2	-0.4	-0.0	-0.1
Risk taking	3.3	4.9	7.9	1.5	2.5	-2.8	0.9	2.1	2.8
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.8	-0.9	-0.2	0.4	0.1	-0.3	-0.4
Fractured/broken bones in last 5 years	1.7	2.2	3.6	1.2	1.3	-1.6	1.9	1.2	1.6
Age started oral contraceptive pill	0.2	0.3	1.4	0.1	-0.2	0.2	-1.2	0.1	-0.1
Diastolic blood pressure, automated reading	1.0	3.0	10.3	0.3	-1.4	1.4	-3.2	-1.2	-1.5
Ever depressed for a whole week	0.2	0.2	0.7	0.8	-0.2	0.5	0.4	-0.1	-0.3
Unable to work because of sickness or disability	0.2	0.3	1.3	-0.0	0.4	-0.5	1.1	0.2	0.3
Commuting to job workplace: Cycle	1.6	1.9	4.4	-2.1	-1.3	1.3	-0.1	-1.5	-1.2
Myopia	1.4	2.1	8.7	-0.6	-0.9	0.7	-3.0	-1.3	-0.6
Vascular/heart problems diagnosed by doctor	0.5	1.3	1.9	-0.4	1.2	-1.3	1.4	1.1	1.3
Cholesterol lowering medication	0.5	0.8	1.6	1.3	0.8	-0.8	0.6	1.0	0.8
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.7	1.3	0.0	-0.0	1.3	0.1	0.1
Pain experienced in last month	0.3	0.5	0.7	0.6	-0.7	0.5	-0.8	-0.8	-0.6
Supplements: Calcium	0.3	0.3	0.5	0.6	0.7	-0.7	-0.2	0.5	0.7
Basal cell carcinoma (self-reported)	1.0	1.2	3.1	0.1	-1.2	1.1	-1.8	-0.7	-0.8
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.9	0.0	0.2	0.1	0.9	0.2	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	-0.4	-0.0	-0.1	0.0	-0.5	-0.2
Heart disease (siblings)	0.8	1.0	2.9	1.7	0.9	-0.7	0.6	0.9	0.7
Alcohol drinker status: Previous	0.4	0.5	1.2	0.6	0.7	-0.6	-1.1	0.1	0.7
Pack years of smoking	0.5	0.8	1.1	1.0	0.9	-0.8	1.0	0.6	0.9
Impedance of whole body	1.6	8.3	28.4	1.7	2.0	-1.6	5.3	2.8	2.1
Leg fat mass (left)	0.4	1.4	7.1	-0.7	-0.3	0.1	-2.7	-0.8	-0.4
Arm predicted mass (left)	3.7	18.8	81.8	-1.2	-2.7	2.6	-9.0	-2.9	-2.8