TWAS hub - MNAT1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Liver	0.2080	0.0870	0.0031	0	NA	-0.010	NA	-0.007	0.32	NA	0.840	NA	0.54
2	TCGA	Prostate Adenocarcinoma	0.0922	0.0498	0.0060	0	0.004	0.005	NA	0.003	0.29	0.12	0.088	NA	0.16

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Height	6.6	127.0	252.8	-15.9	1.1
Chronotype (morning person)	6.5	15.1	28.2	-5.3	1.4
High blood pressure (siblings)	6.4	9.2	11.6	2.6	3.4
Standing height	5.8	57.5	114.5	-10.7	0.7
Arm predicted mass (left)	5.7	29.1	53.9	-7.3	2.1
Trunk fat-free mass	5.4	30.8	59.0	-7.7	1.6
Trunk predicted mass	5.4	30.9	59.1	-7.7	1.6
Arm fat-free mass (left)	5.3	27.1	48.5	-7.0	2.4
Whole body water mass	5.1	28.9	53.7	-7.3	2.0
Nervous feelings	5.0	9.4	17.0	4.1	1.3
Whole body fat-free mass	5.0	28.8	53.4	-7.3	2.1
Eye problems/disorders: Glaucoma	4.8	5.7	11.4	-3.4	-0.2
Arm fat-free mass (right)	4.6	23.5	42.6	-6.5	2.1
Basal metabolic rate	4.6	25.6	46.7	-6.8	2.1
Arm predicted mass (right)	4.5	23.0	42.2	-6.5	1.9
Glaucoma (self-reported)	4.3	5.1	8.5	-2.9	1.3
Supplements: Fish oil (including cod liver oil)	4.2	5.4	10.8	-0.1	3.3
Leg predicted mass (right)	3.9	20.7	36.1	-6.0	2.3
Hair/balding pattern: Pattern 2	3.8	4.9	9.5	-3.1	-0.4
Leg fat-free mass (right)	3.8	20.6	35.9	-6.0	2.3
Leg fat-free mass (left)	3.7	19.8	35.2	-5.9	2.1
Leg predicted mass (left)	3.7	19.4	34.4	-5.9	2.1
Tense / ‘highly strung’	3.7	6.1	6.2	2.5	2.4
Age when periods started (menarche)	3.5	8.4	12.7	-3.6	2.0
Illnesses of siblings: Diabetes	3.4	4.2	7.2	-1.1	-2.7
Ever had prostate specific antigen (PSA) test	3.3	3.8	7.2	-0.5	2.7
Sitting height	3.2	23.0	40.4	-6.4	2.4
Weight	3.1	15.3	22.7	-4.8	2.8
Osteoporosis (self-reported)	3.1	3.9	7.4	2.7	-0.6
Had major operations	3.0	3.5	6.0	-2.4	1.0
Alcohol intake versus 10 years previously	2.9	4.4	8.7	3.0	0.1
Friendships satisfaction	2.9	3.6	5.9	2.4	-1.1
Hearing difficulty/problems: Yes	2.8	4.2	8.4	2.9	0.1
Worry too long after embarrassment	2.7	4.6	9.1	3.0	0.3
Alcohol drinker status: Previous	2.7	3.1	6.2	-0.2	2.5
Comparative height size at age 10	2.4	13.5	26.6	-5.2	0.6
Illnesses of father: Heart disease	2.4	3.3	6.2	-0.6	2.5
Forced expiratory volume in 1-second (FEV1), predicted	2.4	5.0	10.0	-3.2	0.0
Worry (Nagel 2018)	2.3	4.9	9.3	3.0	-0.8
Crohns Disease (2012)	2.3	3.7	6.9	2.6	0.7
Rheumatoid Arthritis	2.3	3.2	5.8	2.4	0.7
Hip circumference	2.2	9.7	14.4	-3.8	2.2
Breastfed as a baby	2.2	2.8	5.3	-2.3	-0.5
Body Mass Index (BMI) (2010)	2.1	2.9	5.8	2.4	0.0
Ulcerative Colitis	2.1	3.1	4.8	-1.2	-2.2
Medication for hormone replacement therapy	2.1	2.3	4.6	-2.2	0.0
Medication: Lansoprazole	2.1	2.4	3.7	1.1	-1.9
Eye problems/disorders: None of the above	2.1	2.4	4.5	2.1	-0.6
Medication: Blood pressure	2.1	3.7	4.5	1.7	2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.5	4.5	0.7	2.1
Crohns Disease (2017)	2.0	4.3	8.6	2.9	0.2
Waist Hip Ratio (WHR)	2.0	9.0	16.1	4.0	-1.4
Lung FVC	2.0	9.9	16.5	4.1	1.8
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.6	2.6	1.6	1.6
Number of children fathered	2.0	2.2	2.9	-1.2	1.7
Commuting to job workplace: Car/motor vehicle	2.0	2.3	3.7	-1.9	-1.0
Neuroticism (Nagel 2018)	1.9	4.4	8.3	2.9	-0.7
Neuroticism	1.9	4.5	8.9	3.0	0.2
Systolic blood pressure, automated reading	1.9	5.6	10.0	1.1	3.2
Diabetes (self-reported)	1.9	2.9	5.1	-0.9	2.3
Medication: Ibuprofen	1.9	2.2	2.9	1.3	1.7
Diastolic blood pressure, automated reading	1.9	5.9	8.4	2.9	1.9
Average weekly fortified wine intake	1.8	2.1	3.6	1.9	0.7
Hearing difficulty/problems with background noise	1.8	2.8	4.8	2.2	0.9
Illnesses of siblings	1.8	2.5	4.1	-2.0	-0.9
Worrier / anxious feelings	1.8	3.3	6.6	2.6	-0.2
Medication: Omeprazole (e.g. Zanprol)	1.8	2.1	2.6	-1.3	-1.6
Schizophrenia vs Biploar Disorder	1.7	2.2	2.6	1.3	1.6
Illnesses of father: None of the above (group 1)	1.7	2.1	4.2	-0.1	-2.0
Cholesterol lowering medication	1.7	2.5	4.6	-2.1	0.7
Supplements: Calcium	1.7	1.9	3.6	1.9	0.4
Hand grip strength (left)	1.6	4.2	7.7	-2.8	0.9
Ever used hormone-replacement therapy (HRT)	1.6	2.1	3.3	-1.8	0.9
Townsend deprivation index at recruitment	1.6	2.2	2.2	1.5	-1.5
Number of full brothers	1.6	2.0	2.4	-1.6	-1.2
Medication: Omeprazole	1.6	1.9	2.1	-1.5	-1.3
Hearing aid user	1.6	1.8	3.5	0.4	1.9
Commuting to job workplace: Public transport	1.6	1.9	3.4	-0.6	1.8
Depression (Nagel 2018)	1.5	2.2	3.7	-0.8	-1.9
Systolic Blood Pressure	1.5	7.7	14.2	1.1	3.8
Fed-up feelings	1.5	2.7	5.3	2.3	-0.3
Serious illness, injury or assault to yourself	1.5	1.8	3.5	0.2	1.9
Medication: Seretide 50 evohaler	1.5	1.7	3.1	1.8	-0.6
Medication for cholesterol	1.5	2.2	2.7	1.6	-1.3
Mother’s age at death	1.5	1.9	3.8	-0.1	2.0
Blood Eosinophil Count	1.4	10.9	12.3	-3.1	-3.5
Mouth/teeth dental problems	1.4	2.2	2.8	-1.7	1.3
Number of live births	1.4	2.0	3.6	-1.9	-0.6
Pulse rate	1.4	2.4	4.5	2.1	-0.6
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	4.3	-2.1	-0.2
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	3.3	-1.2	-1.8
Hypertension (Self-reported)	1.4	4.0	5.4	2.3	1.6
Number of operations (self-reported)	1.4	2.1	2.6	-1.6	1.3
Vascular/heart problems diagnosed by doctor	1.4	3.8	5.3	-2.3	-1.5
Reaction Time	1.3	2.5	4.2	2.1	-0.9
High blood pressure	1.3	3.5	4.5	2.1	1.6
Medication: Atenolol	1.3	1.6	3.1	0.2	1.8
Trunk fat mass	1.3	5.7	6.8	-2.2	2.6
Arm fat mass (right)	1.3	5.3	7.9	-1.6	2.8
Exposure to tobacco smoke at home	1.3	1.4	1.9	1.0	-1.4
Medication: Aspirin	1.3	1.7	2.7	0.9	1.6
Guilty feelings	1.3	1.9	3.8	1.9	-0.2
Illnesses of father: High blood pressure	1.3	1.6	2.0	1.1	1.4
Pack years of smoking	1.3	2.0	3.2	-1.8	0.9
Lupus	1.2	1.8	3.5	1.9	-0.2
Hand grip strength (right)	1.2	3.2	5.4	-2.3	1.0
Emphysema/chronic bronchitis	1.2	1.3	2.6	0.2	-1.6
Number of full sisters	1.2	1.5	1.7	-1.1	-1.3
Arm fat mass (left)	1.2	5.1	8.1	-1.4	2.9
Myopia	1.2	1.7	2.7	-1.7	-0.8
BMI	1.1	6.4	12.7	-0.2	3.6
Average weekly spirits intake	1.1	1.4	2.6	1.6	-0.3
Impedance of leg (right)	1.1	5.5	7.8	1.8	-2.8
Relative age voice broke	1.1	1.7	2.7	0.8	-1.7
Medication: Cholesterol lowering	1.1	1.7	3.3	0.1	1.8
Depression (self-reported)	1.1	1.3	2.4	-1.5	0.5
Pulse rate, automated reading	1.1	3.6	6.9	2.6	-0.5
Overall health rating	1.1	2.3	4.5	2.1	0.4
Supplements: Vitamin C	1.1	1.3	1.5	-1.2	-1.0
Long-standing illness, disability or infirmity	1.1	1.6	2.4	-1.5	0.9
Smoking status: Current	1.1	1.8	3.1	0.7	-1.8
Depressed Affect (Nagel 2018)	1.0	2.2	4.1	2.0	-0.4
Bipolar Disorder (2011)	1.0	1.0	1.9	1.4	0.0
Neuroticism (2016)	1.0	1.5	3.0	1.7	0.0
Smoking Status	1.0	2.5	3.9	1.0	-2.0
Hypothyroidism (self reported)	1.0	2.4	4.5	-0.5	2.1
Hayfever, allergic rhinitis or eczema	1.0	2.1	4.1	2.0	-0.2
Supplements: Glucosamine	1.0	1.3	1.9	-1.4	0.8
Arm fat percentage (right)	1.0	3.8	7.2	0.6	2.7
Prospective memory result	1.0	1.3	1.6	1.0	1.3
Length of working week for main job	1.0	1.1	2.0	-1.4	-0.4
Loud music exposure frequency	1.0	1.1	2.2	1.5	0.1
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.5	1.6	-0.3
Pulse wave peak to peak time	1.0	1.2	1.8	-1.4	0.8
Mean time to correctly identify matches	1.0	1.8	2.7	1.6	-1.0
Whole body fat mass	1.0	4.3	6.4	-1.5	2.5
Family relationship satisfaction	1.0	1.3	2.0	0.8	-1.4
Arm fat percentage (left)	1.0	4.0	6.7	1.2	2.6
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	2.6	0.8	1.6
Fractured/broken bones in last 5 years	1.0	1.3	1.9	1.4	0.8
Pain experienced in last month	1.0	1.6	2.8	-0.7	1.7
HDL Cholesterol	0.9	1.5	3.0	-1.7	0.0
Current tobacco smoking	0.9	1.4	2.7	0.3	-1.6
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	1.6	-1.3	0.5
Impedance of leg (left)	0.9	4.1	5.2	1.8	-2.3
Had menopause	0.9	1.1	2.2	1.5	0.3
Qualifications: None of the above	0.9	1.8	3.5	1.9	0.5
Neuroticism score	0.9	2.0	3.9	2.0	0.3
Happiness	0.9	1.1	1.9	0.6	-1.4
Mouth/teeth dental problems: Dentures	0.9	1.5	2.2	0.9	-1.5
Asthma	0.9	1.7	3.3	-0.3	-1.8
Exposure to tobacco smoke outside home	0.9	1.1	2.1	1.5	0.4
Mouth/teeth dental problems: Loose teeth	0.9	1.0	1.4	0.8	-1.2
Qualifications: nursing, teaching	0.9	1.4	2.7	-1.6	-0.2
Osteoarthritis (self-reported)	0.9	1.2	1.9	-0.6	-1.4
Miserableness	0.9	1.6	2.2	1.5	1.0
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.2	1.5	0.2
Average weekly beer plus cider intake	0.9	1.3	1.7	0.9	-1.3
Ever depressed for a whole week	0.9	1.1	2.1	-0.1	-1.5
Leg fat mass (left)	0.9	3.5	5.5	-1.2	2.3
HbA1C	0.8	0.8	1.2	0.7	-1.1
Heel T-Score	0.8	6.0	11.0	-3.3	-1.0
Number of treatments/medications taken	0.8	1.5	2.0	-1.0	1.4
Relative age of first facial hair	0.8	1.6	2.2	1.5	-1.0
Body mass index (BMI)	0.8	3.5	7.0	0.1	2.6
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.0	0.7	-1.4
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.6	1.3	-0.6
Time employed in main current job	0.8	0.9	1.2	-1.1	0.7
Peak expiratory flow (PEF)	0.8	2.0	3.6	-0.6	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	1.5	-0.6	-1.2
Loneliness, isolation	0.8	1.1	2.0	1.4	-0.4
Eye problems/disorders: Cataract	0.8	0.9	1.7	-1.3	0.2
Mineral and other dietary supplements	0.8	1.0	2.0	0.2	-1.4
Asthma (self-reported)	0.8	1.5	3.1	-0.1	-1.8
Financial situation satisfaction	0.8	0.9	1.0	0.9	-1.0
Leg fat percentage (left)	0.8	2.8	4.0	1.3	2.0
Impedance of whole body	0.8	4.0	4.1	2.0	-2.0
Bipolar Disorder (2018)	0.7	1.1	1.5	1.2	-0.9
Alzheimer’s Disease (in father)	0.7	0.8	1.0	-0.8	-1.0
Irritable Bowel Disease (IBD)	0.7	1.8	2.0	1.4	-1.2
Ovarian Cancer	0.7	0.9	1.8	-0.1	-1.3
Cardiovascular Disease	0.7	2.2	2.4	1.6	1.4
Hair Pigment	0.7	21.3	42.6	-6.5	0.1
Pack years adult smoking proportion	0.7	1.1	2.0	-1.4	0.3
Multivitamins +/- minerals	0.7	0.9	1.8	0.1	1.3
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.7	1.3	-0.4
Birth weight of first child	0.7	1.3	2.6	0.1	1.6
Birth weight	0.7	1.5	2.8	1.7	0.4
Qualifications: College or University degree	0.7	2.1	3.2	-1.8	-1.0
Leg fat mass (right)	0.7	2.8	4.1	-1.2	2.0
High cholesterol (Self-reported)	0.7	1.2	2.1	-1.4	0.5
Alcohol drinker status: Never	0.7	0.9	1.1	-0.8	-1.0
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.7	1.3	0.5
Intelligence (Savage-Jansen 2018)	0.6	1.9	3.4	-1.8	-0.6
Alzheimer’s Disease (including proxy)	0.6	0.9	1.1	0.8	-1.1
Ulcerative Colitis (UC)	0.6	1.2	2.2	-0.5	-1.5
Major Depression (MDD)	0.6	0.7	1.4	1.2	-0.2
Fasting Glucose	0.6	0.7	1.5	-1.2	0.2
Allergy or Eczema	0.6	1.5	3.0	1.7	-0.1
Respiratory disease	0.6	1.3	2.3	-0.6	-1.5
Angina	0.6	0.8	1.6	1.3	0.0
Trunk fat percentage	0.6	2.4	4.7	-0.3	2.2
Maternal smoking around birth	0.6	0.9	1.8	-1.3	-0.1
Chronic bronchitis/emphysema (father)	0.6	0.7	1.3	-1.1	0.2
Waist circumference	0.6	2.1	3.7	-0.7	1.9
Number of incorrect matches in round	0.6	0.9	1.6	1.3	0.5
Pulse wave Arterial Stiffness index	0.6	0.7	0.8	0.9	-0.7
Impedance of arm (left)	0.6	2.9	3.0	1.7	-1.7
Body fat percentage	0.6	2.4	4.5	0.5	2.1
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.3	0.2	-1.1
Angina (self-reported)	0.6	0.8	1.6	1.3	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.0	-0.7	1.0
Medication: Aspirin	0.6	0.8	1.2	0.7	1.1
Average weekly red wine intake	0.6	1.0	1.9	1.4	0.2
Mood swings	0.6	1.1	2.3	1.5	-0.1
Diabetes diagnosed by doctor	0.6	0.9	1.7	-0.4	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.4	1.5	0.1
Heart disease (siblings)	0.6	0.7	1.0	1.0	-0.6
Alzheimer’s Disease (in mother)	0.5	0.6	1.1	1.1	0.3
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.0	-0.1	-1.0
Supplements: Zinc	0.5	0.6	1.1	-0.2	1.1
Taking other prescription medications	0.5	0.7	1.4	-1.2	-0.1
Medication: Levothyroxine sodium	0.5	0.9	1.4	-1.2	0.6
Alcohol usually taken with meals	0.5	0.8	1.4	-1.2	0.4
Financial difficulties in last 2 years	0.5	0.7	0.9	0.9	-0.7
Heart attack	0.5	0.6	1.2	1.1	0.0
Falls in the last year	0.5	0.7	1.4	1.2	0.1
Ever highly irritable/argumentative for 2 days	0.5	0.6	0.8	-0.6	-0.9
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.1	-1.1	0.8
Leg fat percentage (right)	0.5	2.0	2.4	1.2	1.5
Shortness of breath walking on level ground	0.5	0.6	0.9	0.6	-1.0
Medication for pain relief, constipation, heartburn	0.5	0.9	1.1	-1.1	-0.8
Leg pain on walking	0.5	0.6	1.0	1.0	0.3
Ever had bowel cancer screening	0.5	0.6	1.2	-1.1	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	0.9	0.4	-0.9
Breast cancer (self-reported)	0.5	0.6	0.9	0.6	-1.0
Risk taking	0.5	0.8	1.4	-1.2	0.5
Age started oral contraceptive pill	0.5	0.6	1.0	-1.0	0.4
Bipolar Disorder or Schizophrenia	0.4	1.1	2.0	1.4	-0.3
Mean Putamen Volume	0.4	0.4	0.9	0.1	-0.9
LDL Cholesterol	0.4	0.6	1.2	-1.1	0.0
Schizophrenia (2014)	0.4	1.0	1.9	1.4	0.0
Blood Red Count	0.4	4.1	7.5	-2.7	-0.9
Sensitivity / hurt feelings	0.4	0.7	1.0	-0.6	1.0
Vitamin and mineral supplements	0.4	0.6	1.2	-0.1	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.8	-1.4	-0.1
Impedance of arm (right)	0.4	2.0	2.8	1.1	-1.7
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.1	1.1	0.3
Medication: Paracetamol	0.4	0.7	1.0	1.0	-0.6
Medication: Amlodipine	0.4	0.5	0.7	0.6	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	0.8	-0.6	0.9
Medication: Allopurinol	0.4	0.6	0.6	-0.7	-0.8
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.9	-0.9	0.4
Medication: Blood pressure	0.4	0.7	1.4	-0.2	1.2
Medication: Paracetamol	0.4	0.6	0.9	0.5	-1.0
Medication: Atorvastatin	0.4	0.5	0.5	-0.7	0.7
Ever smoked	0.4	0.8	1.5	1.2	0.1
Unable to work because of sickness or disability	0.4	0.5	1.0	-1.0	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.6	-0.8	0.7
Medication: Metformin	0.3	0.5	0.5	0.7	0.7
Diabetes (father)	0.3	0.3	0.7	0.1	0.8
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.6	0.2	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.1	-1.1	0.2
Qualifications: CSEs or equivalent	0.3	0.4	0.8	-0.9	0.2
High blood pressure (mother)	0.3	0.5	0.7	0.8	0.5
Allergy	0.3	0.7	1.0	-0.6	1.0
Medication: Simvastatin	0.3	0.4	0.5	-0.7	0.6
Fluid intelligence score	0.3	0.6	0.9	-0.9	-0.6
Father’s age at death	0.3	0.4	0.4	-0.5	0.7
Noisy workplace	0.3	0.4	0.7	0.3	-0.8
Lung cancer (father)	0.3	0.3	0.4	0.4	0.7
Forced vital capacity (FVC), Best measure	0.3	1.0	1.7	-1.3	0.5
Age at first live birth	0.3	0.5	0.9	-0.4	-0.9
Health satisfaction	0.3	0.3	0.7	0.1	-0.8
Suffer from ‘nerves’	0.3	0.4	0.9	0.9	-0.1
Medication: Gliclazide	0.3	0.3	0.3	-0.6	0.6
Number of self-reported non-cancer illnesses	0.3	0.5	1.0	0.0	1.0
Average weekly champagne plus white wine intake	0.3	0.4	0.7	-0.8	-0.1
Basal cell carcinoma (self-reported)	0.3	0.3	0.6	-0.8	0.2
Schizophrenia (2018)	0.2	0.4	0.7	0.8	0.0
Breast Cancer	0.2	0.4	0.7	-0.8	-0.1
Coronary Artery Disease (CAD)	0.2	0.2	0.4	-0.6	0.0
Primary Biliary Cirrhosis	0.2	0.3	0.5	0.7	0.2
Blood Platelet Count	0.2	2.5	4.2	2.0	1.0
Tanning	0.2	2.3	2.8	1.4	-1.7
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.6	0.0	-0.8
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	-0.2	0.6
Medication: Co-codamol	0.2	0.2	0.5	-0.7	0.1
Diabetes (mother)	0.2	0.2	0.5	0.7	-0.0
Severe depression (siblings)	0.2	0.3	0.4	0.4	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.4	-0.5	-0.6
Past tobacco smoking	0.2	0.4	0.7	-0.8	0.1
Medication: Ramipril	0.2	0.2	0.3	0.5	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.5	-0.2	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.5	-0.2	0.7
Blood clot in the leg (DVT)	0.2	0.3	0.4	-0.7	0.4
Migraine (self-reported)	0.2	0.2	0.5	-0.7	0.2
Chest pain or discomfort	0.2	0.3	0.3	-0.6	0.5
Age at last live birth	0.2	0.2	0.4	0.3	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.3	-0.5	-0.4
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	-0.7	-0.2
Commuting to job workplace: Walk	0.2	0.2	0.3	0.3	-0.6
Ever taken oral contraceptive pill	0.2	0.2	0.3	-0.2	-0.5
Medication: Bendroflumethiazide	0.2	0.3	0.5	0.4	0.7
Irritability	0.2	0.3	0.5	0.7	0.3
Blood White Count	0.1	0.4	0.7	0.4	0.8
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.3	0.1	0.6
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.2	-0.5
Had other major operations	0.1	0.1	0.1	-0.3	0.3
Forced vital capacity (FVC)	0.1	0.3	0.6	-0.7	0.3
Pain all over the body in last month	0.1	0.1	0.1	-0.3	-0.2
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	0.3	-0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.5	-0.4	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.5	-0.7	-0.1
Hair/balding pattern: Pattern 4	0.1	0.3	0.4	-0.5	0.6
Gout (self-reported)	0.1	0.1	0.2	-0.4	-0.2
Comparative body size at age 10	0.1	0.2	0.3	0.5	0.5
Alcohol intake frequency.	0.1	0.1	0.3	-0.5	0.1
Smoking status: Previous	0.1	0.1	0.2	0.5	-0.0
Wears glasses or contact lenses	0.1	0.1	0.2	-0.4	-0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.0	-0.5
Commuting to job workplace: Cycle	0.1	0.1	0.3	0.1	-0.5
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.1	-0.1	-0.3
Prostate Cancer	0.0	0.1	0.1	-0.1	-0.3
Age at First Birth	0.0	0.0	0.0	0.2	0.0
Triglycerides	0.0	0.0	0.0	-0.1	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.1	0.0
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.1	0.2	0.1
Lung FEV1/FVC ratio	0.0	0.0	0.1	-0.3	-0.1
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.0	-0.2	0.1
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.1	-0.3	-0.2
Illnesses of mother	0.0	0.0	0.1	-0.0	0.3
Pulse wave reflection index	0.0	0.0	0.1	0.1	0.3
Headache pain in last month	0.0	0.1	0.2	-0.1	0.4
Medication: Ventolin 100micrograms inhaler	0.0	0.1	0.1	-0.2	-0.3
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.0	0.0	-0.1
Wheeze or whistling in the chest in last year	0.0	0.0	0.0	-0.2	-0.2
Neck or shoulder pain in last month	0.0	0.0	0.0	-0.2	-0.1
Heart disease (mother)	0.0	0.0	0.1	-0.3	0.0
Knee pain experienced in last month	0.0	0.0	0.1	-0.2	0.1
Back pain experienced in last month	0.0	0.0	0.0	-0.2	-0.1
Medication: Lisinopril	0.0	0.0	0.0	0.1	0.1

Hub : Genes

MNAT1

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Trait associations