[Hub]/) : Traits : Whole body water mass :

chr19:1,127,720-5,153,606

Best TWAS P=8.64e-17 · Best GWAS P=1.6e-17 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex REXO1 0.07 0.01 bslmm 391 0.01 1.7e-02 -2.05 6.3 2.2e-10 0.16 0.28 0.03 TRUE
2 CommonMind Brain Pre-frontal Cortex UBXN6 0.27 0.25 enet 28 0.29 4.6e-36 5.22 -6.4 1.4e-10 0.11 0.03 0.97 FALSE
3 GTEx Adipose Subcutaneous AMH 0.18 0.05 lasso 8 0.06 1.9e-05 -3.80 5.3 9.5e-08 0.46 0.91 0.02 FALSE
4 GTEx Adipose Subcutaneous CTB-50L17.9 0.29 0.30 lasso 2 0.30 2.3e-24 5.40 -5.4 7.5e-08 0.09 0.14 0.86 FALSE
5 GTEx Adipose Visceral Omentum NFIC 0.20 0.00 lasso 5 0.02 2.2e-02 5.54 -5.6 1.9e-08 -0.04 0.07 0.20 FALSE
6 GTEx Adipose Visceral Omentum CHAF1A 0.24 0.26 lasso 3 0.26 6.2e-14 5.75 -5.6 2.0e-08 0.09 0.00 1.00 FALSE
7 GTEx Adipose Visceral Omentum CTB-50L17.9 0.30 0.23 lasso 4 0.22 2.1e-11 5.40 -5.4 5.6e-08 0.10 0.08 0.92 FALSE
8 GTEx Adrenal Gland CHAF1A 0.22 0.18 lasso 3 0.17 1.1e-06 5.21 -5.5 3.4e-08 0.10 0.01 0.98 FALSE
9 GTEx Adrenal Gland CTB-50L17.9 0.38 0.35 lasso 3 0.34 5.8e-13 5.40 -5.4 7.1e-08 0.09 0.12 0.88 FALSE
10 GTEx Artery Aorta MPND 0.14 0.06 lasso 2 0.03 6.7e-03 5.18 5.2 2.0e-07 -0.10 0.06 0.76 FALSE
11 GTEx Artery Aorta CHAF1A 0.29 0.33 lasso 3 0.34 2.4e-19 5.75 -5.4 7.5e-08 0.09 0.01 0.99 FALSE
12 GTEx Artery Aorta UBXN6 0.13 0.02 lasso 5 0.03 5.7e-03 -5.36 -6.7 2.6e-11 0.09 0.02 0.96 FALSE
13 GTEx Artery Aorta CTB-50L17.5 0.16 0.15 lasso 7 0.15 1.0e-08 6.05 -5.9 3.0e-09 0.09 0.01 0.99 FALSE
14 GTEx Artery Aorta CTB-50L17.9 0.32 0.31 lasso 4 0.30 2.9e-17 5.40 -5.5 4.0e-08 0.09 0.13 0.87 FALSE
15 GTEx Artery Coronary CTB-50L17.9 0.43 0.14 lasso 6 0.12 6.5e-05 5.40 -5.6 1.7e-08 0.07 0.04 0.81 FALSE
16 GTEx Artery Tibial DOT1L 0.09 0.06 lasso 5 0.05 7.3e-05 7.96 7.4 1.2e-13 0.78 0.05 0.93 TRUE
17 GTEx Artery Tibial NFIC 0.14 0.13 enet 11 0.12 7.6e-10 5.54 -5.8 6.3e-09 -0.02 0.51 0.49 TRUE
18 GTEx Artery Tibial CHAF1A 0.39 0.37 lasso 7 0.39 1.2e-32 5.75 -5.2 1.6e-07 0.09 0.02 0.98 FALSE
19 GTEx Artery Tibial UBXN6 0.18 0.07 lasso 3 0.14 6.3e-11 6.16 -6.8 1.1e-11 0.11 0.00 1.00 FALSE
20 GTEx Artery Tibial CTB-50L17.5 0.23 0.13 lasso 4 0.11 4.1e-09 6.05 -5.3 1.3e-07 0.08 0.00 1.00 FALSE
21 GTEx Artery Tibial AC005306.3 0.25 0.12 enet 59 0.11 3.9e-09 -3.01 -5.5 3.3e-08 -0.11 1.00 0.00 TRUE
22 GTEx Artery Tibial CTB-50L17.9 0.27 0.31 lasso 3 0.31 2.2e-24 5.40 -5.5 4.9e-08 0.09 0.15 0.85 FALSE
23 GTEx Brain Caudate basal ganglia CTB-50L17.9 0.27 0.25 lasso 2 0.24 1.8e-07 6.05 -6.0 1.6e-09 0.09 0.01 0.98 FALSE
24 GTEx Brain Cerebellar Hemisphere CHAF1A 0.62 0.40 lasso 8 0.36 3.5e-10 6.05 -6.0 2.3e-09 0.09 0.01 0.99 FALSE
25 GTEx Brain Cerebellar Hemisphere CTB-50L17.9 0.61 0.45 lasso 2 0.50 1.2e-14 5.40 -5.5 4.8e-08 0.09 0.02 0.98 FALSE
26 GTEx Brain Cerebellum CHAF1A 0.51 0.35 lasso 4 0.34 9.7e-11 6.05 -5.9 3.2e-09 0.09 0.01 0.99 FALSE
27 GTEx Brain Cerebellum CTB-50L17.5 0.33 0.22 lasso 4 0.20 1.8e-06 5.40 -5.4 5.9e-08 0.09 0.02 0.98 FALSE
28 GTEx Brain Cerebellum CTB-50L17.9 0.53 0.41 lasso 2 0.50 3.6e-17 5.40 -6.0 1.5e-09 0.10 0.01 0.99 FALSE
29 GTEx Brain Cortex CTB-50L17.9 0.28 0.25 lasso 2 0.25 1.7e-07 5.40 -5.4 5.5e-08 0.09 0.03 0.96 FALSE
30 GTEx Brain Frontal Cortex BA9 UBXN6 0.31 0.06 enet 5 0.12 3.5e-04 5.40 -5.7 1.2e-08 0.11 0.01 0.93 FALSE
31 GTEx Brain Frontal Cortex BA9 CTB-50L17.9 0.27 0.21 lasso 3 0.19 7.9e-06 5.40 -5.9 2.8e-09 0.10 0.02 0.97 FALSE
32 GTEx Brain Frontal Cortex BA9 AC007292.6 0.35 0.01 lasso 6 0.12 3.6e-04 -0.17 -5.5 4.4e-08 0.07 0.03 0.61 FALSE
33 GTEx Brain Hypothalamus CTB-50L17.9 0.44 0.26 lasso 4 0.24 2.8e-06 5.40 -5.3 1.4e-07 0.09 0.03 0.85 FALSE
34 GTEx Brain Nucleus accumbens basal ganglia CHAF1A 0.31 0.28 lasso 2 0.24 4.0e-07 5.75 -5.7 1.0e-08 0.09 0.01 0.98 FALSE
35 GTEx Brain Nucleus accumbens basal ganglia CTB-50L17.9 0.45 0.25 lasso 8 0.23 8.6e-07 6.05 -6.9 6.9e-12 0.09 0.01 0.98 FALSE
36 GTEx Brain Putamen basal ganglia CHAF1A 0.40 0.34 lasso 4 0.37 1.2e-09 6.05 -5.5 3.6e-08 0.09 0.01 0.99 FALSE
37 GTEx Brain Putamen basal ganglia CTB-50L17.9 0.33 0.32 lasso 1 0.33 1.2e-08 5.40 -5.4 6.7e-08 0.09 0.01 0.98 FALSE
38 GTEx Breast Mammary Tissue CTB-50L17.9 0.42 0.33 lasso 9 0.32 3.0e-17 5.40 -5.5 3.5e-08 0.09 0.10 0.90 FALSE
39 GTEx Breast Mammary Tissue (Male) CHAF1A 0.20 -0.01 lasso 12 0.00 4.2e-01 5.22 -5.2 1.6e-07 0.09 0.03 0.66 FALSE
40 GTEx Breast Mammary Tissue (Male) CTB-50L17.9 0.30 0.18 lasso 4 0.10 2.3e-03 5.40 -5.4 8.3e-08 0.10 0.03 0.58 FALSE
41 GTEx Breast Mammary Tissue (Female) CHAF1A 0.33 0.14 lasso 6 0.09 1.6e-03 5.75 -5.5 3.8e-08 0.09 0.02 0.95 FALSE
42 GTEx Breast Mammary Tissue (Female) CTB-50L17.9 0.45 0.25 lasso 7 0.26 1.6e-08 5.52 -5.3 1.3e-07 0.07 0.03 0.96 FALSE
43 GTEx Cells EBV-transformed lymphocytes CTB-50L17.9 0.31 0.27 lasso 1 0.23 3.6e-08 5.40 -5.4 6.7e-08 0.09 0.08 0.92 FALSE
44 GTEx Cells Transformed fibroblasts UBXN6 0.09 0.10 lasso 1 0.08 1.5e-06 -5.36 -5.4 8.5e-08 0.05 0.14 0.84 FALSE
45 GTEx Cells Transformed fibroblasts CTB-50L17.9 0.17 0.16 lasso 4 0.16 7.4e-12 5.40 -5.2 2.3e-07 0.09 0.12 0.88 FALSE
46 GTEx Colon Sigmoid CHAF1A 0.33 0.08 lasso 5 0.12 7.5e-05 5.75 -5.5 4.0e-08 0.08 0.01 0.98 FALSE
47 GTEx Colon Sigmoid UBXN6 0.34 0.15 lasso 6 0.14 1.7e-05 5.40 -6.1 1.1e-09 0.09 0.02 0.97 FALSE
48 GTEx Colon Sigmoid CTB-50L17.9 0.42 0.38 lasso 5 0.37 4.4e-14 5.40 -5.4 5.4e-08 0.09 0.03 0.97 FALSE
49 GTEx Colon Transverse AC007292.6 0.32 0.05 lasso 6 0.20 1.2e-09 5.21 -5.3 9.9e-08 0.05 0.01 0.99 FALSE
50 GTEx Esophagus Gastroesophageal Junction CTB-50L17.9 0.22 0.18 lasso 2 0.19 1.7e-07 5.40 -5.5 4.6e-08 0.09 0.03 0.97 FALSE
51 GTEx Esophagus Mucosa CTB-50L17.9 0.20 0.23 lasso 4 0.22 8.2e-15 5.40 -5.4 6.0e-08 0.09 0.12 0.88 FALSE
52 GTEx Esophagus Muscularis UBXN6 0.35 0.24 enet 20 0.29 3.7e-18 5.40 -5.9 4.9e-09 0.09 0.01 0.99 FALSE
53 GTEx Esophagus Muscularis CTB-50L17.5 0.28 0.17 lasso 3 0.19 6.7e-12 6.16 -5.3 1.0e-07 0.10 0.00 1.00 FALSE
54 GTEx Esophagus Muscularis CTB-50L17.9 0.37 0.36 lasso 5 0.35 3.8e-22 5.40 -5.4 6.9e-08 0.09 0.11 0.89 FALSE
55 GTEx Esophagus Muscularis AC007292.6 0.13 0.08 lasso 2 0.05 4.9e-04 5.22 -5.3 1.2e-07 0.10 0.08 0.86 FALSE
56 GTEx Heart Atrial Appendage UBXN6 0.34 0.12 lasso 6 0.21 6.5e-10 6.05 -6.5 8.5e-11 0.09 0.02 0.98 FALSE
57 GTEx Heart Atrial Appendage CTB-50L17.9 0.32 0.34 lasso 3 0.34 3.8e-16 5.40 -5.6 2.1e-08 0.09 0.12 0.88 FALSE
58 GTEx Heart Left Ventricle CHAF1A 0.17 0.12 lasso 2 0.11 1.9e-06 6.05 -6.1 1.3e-09 0.09 0.00 1.00 FALSE
59 GTEx Heart Left Ventricle UBXN6 0.21 0.14 lasso 6 0.16 5.6e-09 -5.43 -6.3 3.0e-10 0.08 0.07 0.93 FALSE
60 GTEx Lung CTB-50L17.9 0.23 0.32 lasso 2 0.32 2.4e-25 5.52 -5.5 4.1e-08 0.09 0.11 0.89 FALSE
61 GTEx Muscle Skeletal MPND 0.10 0.07 lasso 3 0.05 6.3e-06 5.22 5.2 1.9e-07 -0.10 0.11 0.89 FALSE
62 GTEx Muscle Skeletal CHAF1A 0.18 0.21 lasso 2 0.20 9.7e-20 6.05 -6.0 2.0e-09 0.09 0.01 0.99 FALSE
63 GTEx Muscle Skeletal UBXN6 0.19 0.14 lasso 5 0.18 4.1e-17 -5.44 -6.7 1.9e-11 0.08 0.12 0.88 FALSE
64 GTEx Muscle Skeletal CTB-50L17.9 0.23 0.23 lasso 5 0.21 2.0e-20 5.40 -5.5 4.5e-08 0.09 0.12 0.88 FALSE
65 GTEx Nerve Tibial UBXN6 0.17 0.08 enet 20 0.09 4.4e-07 5.52 -6.0 1.7e-09 0.13 0.02 0.98 FALSE
66 GTEx Nerve Tibial CTB-50L17.5 0.11 0.08 enet 4 0.08 1.6e-06 5.75 -5.9 4.1e-09 0.09 0.01 0.99 FALSE
67 GTEx Nerve Tibial CTB-50L17.9 0.35 0.41 lasso 1 0.40 2.1e-30 5.40 -5.4 6.7e-08 0.09 0.15 0.85 FALSE
68 GTEx Ovary CTB-50L17.9 0.29 0.24 lasso 2 0.21 6.5e-06 5.52 -5.5 3.7e-08 0.09 0.03 0.94 FALSE
69 GTEx Pancreas CHAF1A 0.23 0.10 enet 14 0.10 6.6e-05 6.16 -5.4 8.1e-08 0.09 0.01 0.99 FALSE
70 GTEx Pancreas CTB-50L17.9 0.24 0.15 lasso 4 0.07 1.0e-03 5.40 -5.4 8.1e-08 0.09 0.08 0.88 FALSE
71 GTEx Prostate UBXN6 0.27 0.15 enet 19 0.14 2.4e-04 5.40 -5.6 1.8e-08 0.08 0.04 0.70 FALSE
72 GTEx Skin Not Sun Exposed Suprapubic CHAF1A 0.27 0.22 lasso 5 0.24 2.8e-13 5.40 -5.1 3.1e-07 0.09 0.02 0.98 FALSE
73 GTEx Skin Not Sun Exposed Suprapubic CTB-50L17.9 0.43 0.52 lasso 2 0.51 3.3e-32 5.40 -5.4 6.1e-08 0.09 0.13 0.87 FALSE
74 GTEx Skin Not Sun Exposed Suprapubic AC007292.6 0.11 0.08 lasso 6 0.07 7.8e-05 6.16 -5.8 5.7e-09 0.10 0.01 0.98 FALSE
75 GTEx Skin Sun Exposed Lower leg CHAF1A 0.19 0.18 lasso 1 0.17 5.1e-14 5.75 -5.7 9.2e-09 0.09 0.01 0.99 FALSE
76 GTEx Skin Sun Exposed Lower leg CTB-50L17.9 0.39 0.48 lasso 3 0.47 7.7e-44 5.40 -5.4 6.2e-08 0.09 0.15 0.85 FALSE
77 GTEx Small Intestine Terminal Ileum CTB-50L17.9 0.46 0.34 lasso 4 0.36 7.2e-09 5.40 -5.2 1.8e-07 0.09 0.03 0.96 FALSE
78 GTEx Stomach CTB-50L17.9 0.28 0.31 lasso 1 0.31 3.6e-15 5.40 -5.4 6.7e-08 0.09 0.12 0.88 FALSE
79 GTEx Stomach AC007292.4 0.27 0.09 lasso 5 0.04 4.0e-03 -5.77 6.0 2.7e-09 -0.05 0.03 0.83 FALSE
80 GTEx Testis CHAF1A 0.18 0.09 lasso 2 0.07 4.0e-04 6.05 -5.7 9.1e-09 0.08 0.01 0.94 FALSE
81 GTEx Testis UBXN6 0.20 0.10 lasso 3 0.10 2.9e-05 5.40 -5.5 3.0e-08 0.09 0.02 0.98 FALSE
82 GTEx Testis CTB-50L17.9 0.39 0.30 enet 36 0.34 9.4e-16 5.40 -6.2 4.4e-10 0.08 0.05 0.95 FALSE
83 GTEx Thyroid UBXN6 0.25 0.19 lasso 5 0.23 8.8e-18 6.16 -6.0 1.5e-09 0.11 0.00 1.00 FALSE
84 GTEx Thyroid CTB-50L17.9 0.35 0.42 lasso 2 0.42 2.2e-34 5.40 -5.4 6.7e-08 0.09 0.15 0.85 FALSE
85 GTEx Vagina CTB-50L17.9 0.38 0.26 lasso 5 0.23 5.7e-06 6.05 -6.0 1.6e-09 0.11 0.01 0.97 FALSE
86 GTEx Whole Blood CTB-50L17.9 0.21 0.17 lasso 3 0.18 9.6e-17 5.40 -5.4 8.6e-08 0.09 0.02 0.98 FALSE
87 NTR Blood C19orf35 0.03 0.01 enet 9 0.02 3.7e-07 -2.72 -6.1 1.4e-09 -0.46 0.97 0.02 FALSE
88 ROSMAP Brain Pre-frontal Cortex KLF16 0.12 0.08 bslmm 372 0.08 1.0e-10 -4.40 -5.2 1.6e-07 -0.01 1.00 0.00 TRUE
89 The Cancer Genome Atlas Breast Invasive Carcinoma UBXN6 0.03 0.03 lasso 3 0.03 2.3e-06 -5.36 -5.7 1.3e-08 0.06 0.04 0.96 FALSE
90 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma UBXN6 0.05 0.01 blup 57 0.04 6.6e-05 6.05 -7.6 3.2e-14 0.10 0.00 0.98 TRUE
91 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CHAF1A 0.12 0.11 lasso 3 0.12 7.9e-13 5.75 -6.1 1.2e-09 0.10 0.01 0.99 FALSE
92 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma DOT1L 0.08 0.12 enet 8 0.10 2.5e-11 7.96 8.3 8.6e-17 0.84 0.01 0.99 TRUE
93 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MPND 0.05 0.03 lasso 3 0.02 5.3e-03 5.67 5.6 2.5e-08 -0.09 0.03 0.72 FALSE
94 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma UBXN6 0.18 0.17 enet 18 0.18 9.9e-20 6.05 -5.8 6.2e-09 0.09 0.00 1.00 FALSE
95 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma CHAF1A 0.15 0.12 lasso 2 0.12 3.2e-07 5.75 -5.8 7.1e-09 0.09 0.03 0.97 FALSE
96 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma JSRP1 0.07 0.04 blup 33 0.03 7.8e-03 -3.86 5.4 6.9e-08 0.44 0.01 0.11 FALSE
97 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma UBXN6 0.15 0.10 lasso 1 0.10 2.8e-06 5.40 -5.4 6.7e-08 0.09 0.02 0.96 FALSE
98 The Cancer Genome Atlas Liver Hepatocellular Carcinoma DOT1L 0.09 0.08 blup 60 0.07 4.1e-04 -6.70 7.6 2.7e-14 0.68 0.06 0.88 TRUE
99 The Cancer Genome Atlas Lung Adenocarcinoma CHAF1A 0.05 0.04 lasso 4 0.03 2.3e-04 6.05 -5.7 1.4e-08 0.09 0.01 0.98 FALSE
100 The Cancer Genome Atlas Lung Squamous Cell Carcinoma JSRP1 0.03 0.00 blup 33 0.02 2.1e-03 -3.63 -6.2 5.7e-10 -0.52 0.01 0.25 TRUE
101 The Cancer Genome Atlas Lung Squamous Cell Carcinoma UBXN6 0.04 0.03 lasso 2 0.02 1.6e-03 5.40 -5.9 4.5e-09 0.09 0.00 0.92 FALSE
102 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma CHAF1A 0.20 0.11 lasso 2 0.11 5.6e-05 6.16 -6.3 2.8e-10 0.11 0.00 0.99 FALSE
103 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma UBXN6 0.23 0.11 lasso 5 0.12 2.5e-05 5.40 -6.4 1.4e-10 0.12 0.02 0.77 FALSE
104 The Cancer Genome Atlas Prostate Adenocarcinoma CHAF1A 0.13 0.09 lasso 6 0.10 3.5e-10 6.05 -5.3 1.5e-07 0.09 0.00 1.00 FALSE
105 The Cancer Genome Atlas Prostate Adenocarcinoma UBXN6 0.13 0.10 lasso 2 0.10 1.3e-10 6.05 -6.4 1.7e-10 0.09 0.00 1.00 FALSE
106 The Cancer Genome Atlas Testicular Germ Cell Tumors DOT1L 0.40 -0.01 enet 20 0.03 3.6e-02 -3.98 6.0 1.5e-09 0.50 0.01 0.22 FALSE
107 The Cancer Genome Atlas Thyroid Carcinoma CHAF1A 0.22 0.19 lasso 3 0.20 5.4e-19 5.75 -5.2 1.9e-07 0.09 0.01 0.99 FALSE
108 The Cancer Genome Atlas Thyroid Carcinoma UBXN6 0.16 0.12 lasso 2 0.12 5.4e-12 6.05 -6.3 3.7e-10 0.09 0.00 1.00 FALSE