Best TWAS P=2.31e-21 · Best GWAS P=1.56e-18 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NOSTRIN | 0.14 | 0.13 | lasso | 4 | 0.12 | 1.9e-14 | -8.8 | 9.5 | 2.3e-21 | -0.97 | 0.00 | 1.00 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | NOSTRIN | 0.11 | 0.03 | lasso | 4 | 0.04 | 1.6e-04 | -6.7 | 5.5 | 3.2e-08 | -0.22 | 0.27 | 0.66 | FALSE |
| 3 | GTEx | Adrenal Gland | NOSTRIN | 0.21 | 0.09 | lasso | 4 | 0.09 | 4.1e-04 | 7.0 | 7.1 | 1.0e-12 | -0.40 | 0.36 | 0.34 | FALSE |
| 4 | GTEx | Lung | NOSTRIN | 0.09 | 0.06 | lasso | 4 | 0.07 | 7.1e-06 | 8.3 | 7.6 | 2.5e-14 | -0.39 | 0.08 | 0.90 | FALSE |
| 5 | GTEx | Pancreas | NOSTRIN | 0.30 | 0.12 | enet | 17 | 0.08 | 3.3e-04 | -6.7 | 6.6 | 3.4e-11 | -0.47 | 0.19 | 0.75 | FALSE |
| 6 | GTEx | Stomach | NOSTRIN | 0.15 | 0.04 | enet | 9 | 0.09 | 6.8e-05 | 8.3 | 8.8 | 1.0e-18 | -0.58 | 0.10 | 0.87 | FALSE |
| 7 | GTEx | Testis | NOSTRIN | 0.43 | 0.17 | enet | 17 | 0.32 | 1.0e-14 | -6.2 | 7.6 | 2.2e-14 | -0.68 | 0.08 | 0.92 | FALSE |
| 8 | METSIM | Adipose | NOSTRIN | 0.07 | 0.09 | lasso | 6 | 0.08 | 1.6e-12 | 8.3 | 8.2 | 1.5e-16 | -0.59 | 0.09 | 0.91 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NOSTRIN | 0.03 | 0.01 | blup | 55 | 0.02 | 9.5e-05 | -6.4 | 7.2 | 6.4e-13 | -0.37 | 0.03 | 0.94 | FALSE |
| 10 | The Cancer Genome Atlas | Colon Adenocarcinoma | G6PC2 | 0.32 | 0.07 | blup | 29 | 0.06 | 3.8e-04 | -6.1 | -7.7 | 9.8e-15 | 0.79 | 0.02 | 0.77 | FALSE |
| 11 | The Cancer Genome Atlas | Glioblastoma Multiforme | NOSTRIN | 0.25 | 0.01 | blup | 55 | 0.08 | 2.0e-03 | -6.4 | 5.8 | 6.4e-09 | -0.25 | 0.02 | 0.58 | FALSE |
| 12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NOSTRIN | 0.09 | 0.03 | enet | 5 | 0.09 | 1.7e-10 | 6.4 | 5.6 | 1.7e-08 | -0.19 | 0.04 | 0.96 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | G6PC2 | 0.47 | 0.23 | enet | 8 | 0.28 | 4.4e-32 | -6.1 | -7.0 | 1.9e-12 | 0.79 | 0.34 | 0.66 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NOSTRIN | 0.12 | 0.13 | lasso | 7 | 0.14 | 4.5e-15 | -6.4 | 7.5 | 6.8e-14 | -0.43 | 0.13 | 0.87 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | G6PC2 | 0.56 | 0.13 | blup | 29 | 0.16 | 2.1e-09 | -6.1 | -7.4 | 1.2e-13 | 0.75 | 0.05 | 0.95 | FALSE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NOSTRIN | 0.08 | 0.01 | enet | 6 | 0.04 | 2.1e-05 | 6.8 | 7.4 | 1.1e-13 | -0.32 | 0.01 | 0.98 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Adenocarcinoma | NOSTRIN | 0.04 | 0.00 | blup | 55 | 0.01 | 1.6e-02 | 7.0 | 5.3 | 1.1e-07 | -0.23 | 0.00 | 0.99 | FALSE |
| 18 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | NOSTRIN | 0.05 | 0.00 | blup | 55 | 0.01 | 1.1e-02 | -6.4 | 7.0 | 3.5e-12 | -0.38 | 0.01 | 0.74 | FALSE |
| 19 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | NOSTRIN | 0.17 | 0.07 | lasso | 2 | 0.08 | 4.3e-04 | 6.4 | 7.0 | 3.6e-12 | -0.44 | 0.01 | 0.96 | FALSE |
| 20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NOSTRIN | 0.06 | 0.01 | blup | 55 | 0.01 | 2.9e-02 | -5.6 | 5.6 | 2.4e-08 | -0.23 | 0.11 | 0.72 | FALSE |
| 21 | The Cancer Genome Atlas | Stomach Adenocarcinoma | G6PC2 | 0.22 | 0.01 | enet | 4 | 0.08 | 3.1e-06 | -6.1 | -5.8 | 6.4e-09 | 0.71 | 0.08 | 0.52 | FALSE |
| 22 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | NOSTRIN | 0.27 | 0.04 | lasso | 3 | 0.08 | 2.8e-03 | 7.0 | 6.6 | 4.1e-11 | -0.44 | 0.00 | 0.65 | FALSE |