[Hub]/) : Traits : Whole body water mass :

chr2:171,478,402-173,555,880

Best TWAS P=9.29e-33 · Best GWAS P=1.86e-36 conditioned to 0.00486

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CYBRD1 0.33 0.18 lasso 7 0.27 5.2e-33 5.9 9.8 1.2e-22 -0.69 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex METTL8 0.07 0.05 lasso 4 0.06 1.0e-07 6.5 -7.3 2.9e-13 0.29 0.99 0.00 FALSE
3 GTEx Adipose Subcutaneous CYBRD1 0.35 0.19 lasso 6 0.24 7.3e-20 -9.2 10.2 2.3e-24 -0.77 0.00 1.00 FALSE
4 GTEx Adipose Subcutaneous DYNC1I2 0.13 0.11 enet 13 0.11 4.1e-09 -6.2 6.4 1.7e-10 -0.29 1.00 0.00 FALSE
5 GTEx Adipose Visceral Omentum CYBRD1 0.33 0.10 lasso 10 0.26 4.6e-14 -7.7 10.9 1.2e-27 -0.71 0.03 0.97 FALSE
6 GTEx Artery Aorta CYBRD1 0.52 0.30 lasso 10 0.41 6.0e-24 5.9 9.7 3.3e-22 -0.66 0.96 0.04 FALSE
7 GTEx Artery Aorta SLC25A12 0.13 0.03 lasso 16 0.01 1.2e-01 -6.2 -5.8 7.9e-09 0.27 0.57 0.02 FALSE
8 GTEx Artery Coronary CYBRD1 0.29 0.01 enet 44 0.11 2.0e-04 -7.7 11.2 5.9e-29 -0.68 0.05 0.61 FALSE
9 GTEx Artery Tibial CYBRD1 0.37 0.08 lasso 9 0.21 3.0e-16 -8.3 10.3 9.9e-25 -0.75 0.00 1.00 FALSE
10 GTEx Artery Tibial DYNC1I2 0.10 0.06 enet 17 0.06 2.2e-05 -6.8 5.8 6.1e-09 -0.23 0.94 0.01 FALSE
11 GTEx Artery Tibial SLC25A12 0.11 0.09 lasso 8 0.06 8.4e-06 -6.1 -6.3 3.8e-10 0.28 1.00 0.00 FALSE
12 GTEx Brain Cerebellar Hemisphere DYNC1I2 0.32 0.24 lasso 7 0.26 2.0e-07 -5.1 5.5 5.0e-08 -0.27 0.90 0.01 FALSE
13 GTEx Brain Cerebellum SLC25A12 0.24 0.22 lasso 7 0.17 1.3e-05 -6.5 -5.9 4.0e-09 0.28 0.90 0.01 FALSE
14 GTEx Breast Mammary Tissue CYBRD1 0.32 0.21 enet 16 0.27 2.0e-14 -9.2 10.9 1.5e-27 -0.74 0.00 1.00 FALSE
15 GTEx Breast Mammary Tissue (Male) CYBRD1 0.35 0.24 lasso 6 0.20 2.4e-05 -9.2 10.0 1.1e-23 -0.72 0.00 0.98 FALSE
16 GTEx Breast Mammary Tissue (Female) CYBRD1 0.20 0.07 lasso 2 0.14 4.5e-05 -9.2 10.3 5.3e-25 -0.78 0.00 0.98 FALSE
17 GTEx Cells Transformed fibroblasts CYBRD1 0.34 0.16 enet 27 0.26 6.3e-20 -7.8 9.5 2.9e-21 -0.57 0.99 0.01 FALSE
18 GTEx Cells Transformed fibroblasts DYNC1I2 0.12 0.14 lasso 3 0.14 1.4e-10 -6.6 6.7 2.7e-11 -0.29 1.00 0.00 FALSE
19 GTEx Esophagus Muscularis CYBRD1 0.33 0.07 lasso 9 0.22 1.3e-13 -8.3 11.4 3.5e-30 -0.75 0.06 0.94 FALSE
20 GTEx Lung CYBRD1 0.14 0.05 enet 8 0.10 5.6e-08 4.9 8.2 3.2e-16 -0.45 0.98 0.01 FALSE
21 GTEx Muscle Skeletal CYBRD1 0.10 0.00 enet 9 0.01 1.5e-02 -9.2 9.4 5.0e-21 -0.71 0.00 0.99 FALSE
22 GTEx Muscle Skeletal DYNC1I2 0.11 0.12 lasso 2 0.12 6.5e-12 -6.8 6.9 6.0e-12 -0.30 1.00 0.00 FALSE
23 GTEx Nerve Tibial CYBRD1 0.36 0.07 lasso 10 0.20 2.3e-14 -9.2 10.3 4.6e-25 -0.73 0.00 1.00 FALSE
24 GTEx Skin Sun Exposed Lower leg DYNC1I2 0.11 0.16 lasso 1 0.15 8.9e-13 -6.6 6.6 3.1e-11 -0.29 1.00 0.00 FALSE
25 GTEx Spleen METTL8 0.39 0.34 lasso 2 0.29 4.4e-08 6.8 -6.8 9.5e-12 0.25 0.89 0.01 FALSE
26 GTEx Testis DYNC1I2 0.13 0.02 lasso 4 0.01 1.1e-01 -6.7 6.6 4.8e-11 -0.29 0.17 0.09 FALSE
27 GTEx Thyroid CYBRD1 0.26 0.08 enet 26 0.12 1.4e-09 -9.2 9.1 7.0e-20 -0.72 0.00 1.00 FALSE
28 GTEx Uterus CYBRD1 0.54 0.04 lasso 6 0.19 1.1e-04 7.5 8.3 7.4e-17 -0.49 0.05 0.44 FALSE
29 GTEx Whole Blood CYBRD1 0.25 0.14 enet 19 0.15 1.4e-13 5.3 7.3 3.4e-13 -0.52 1.00 0.00 FALSE
30 METSIM Adipose CYBRD1 0.08 0.06 lasso 6 0.06 8.0e-09 5.9 7.8 5.0e-15 -0.48 0.92 0.08 FALSE
31 METSIM Adipose SLC25A12 0.05 0.03 blup 544 0.04 8.2e-07 -6.8 -6.5 1.1e-10 0.33 1.00 0.00 FALSE
32 NTR Blood METTL8 0.03 0.02 lasso 7 0.02 1.7e-08 6.5 -8.1 4.2e-16 0.37 1.00 0.00 FALSE
33 ROSMAP Brain Pre-frontal Cortex CYBRD1 0.37 0.16 lasso 9 0.30 3.0e-39 -7.6 10.5 6.8e-26 -0.77 0.30 0.70 FALSE
34 ROSMAP Brain Pre-frontal Cortex SLC25A12 0.13 0.08 lasso 6 0.11 1.8e-13 -6.6 -6.2 7.0e-10 0.28 1.00 0.00 FALSE
35 ROSMAP Brain Pre-frontal Cortex AC068039.4 0.43 0.64 enet 35 0.65 1.6e-110 -6.6 -6.7 2.1e-11 0.29 1.00 0.00 FALSE
36 YFS Blood METTL8 0.04 0.03 lasso 9 0.03 4.4e-11 6.8 -6.9 6.3e-12 0.27 1.00 0.00 FALSE
37 YFS Blood SLC25A12 0.09 0.15 lasso 7 0.15 1.3e-45 -6.6 -6.6 3.9e-11 0.29 1.00 0.00 FALSE
38 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma CYBRD1 0.14 0.04 enet 12 0.09 2.2e-05 -12.6 -11.0 5.0e-28 0.78 0.00 0.96 FALSE
39 The Cancer Genome Atlas Colon Adenocarcinoma CYBRD1 0.14 0.06 blup 69 0.05 6.4e-04 5.7 -6.1 1.1e-09 0.52 0.16 0.48 FALSE
40 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma DYNC1I2 0.05 0.06 lasso 4 0.05 6.3e-06 -6.8 6.6 3.5e-11 -0.26 0.02 0.98 FALSE
41 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma METTL8 0.06 0.01 enet 15 0.04 4.4e-05 7.1 -6.1 1.1e-09 0.17 0.25 0.55 TRUE
42 The Cancer Genome Atlas Brain Lower Grade Glioma CYBRD1 0.03 0.02 lasso 3 0.03 4.5e-04 5.9 7.3 2.7e-13 -0.46 0.18 0.21 FALSE
43 The Cancer Genome Atlas Prostate Adenocarcinoma CYBRD1 0.08 0.06 blup 68 0.08 1.5e-08 -7.6 7.0 2.9e-12 -0.51 0.94 0.06 FALSE
44 The Cancer Genome Atlas Thyroid Carcinoma CYBRD1 0.10 0.06 lasso 4 0.06 6.2e-07 -9.2 11.9 9.3e-33 -0.86 0.00 1.00 TRUE