TWAS hub - METTL8

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0750	0.0250	1.4e-04	0.046	0.032	0.036	0.039	0.059	2.6e-06	7.9e-05	3.1e-05	1.4e-05	1.0e-07
2	GTEx	Colon Sigmoid	0.2310	0.0710	1.8e-04	0.299	NA	0.281	NA	0.289	3.6e-11	NA	1.7e-10	NA	8.9e-11
3	GTEx	Esophagus Muscularis	0.2830	0.0610	7.9e-11	0.268	NA	0.248	NA	0.269	1.7e-16	NA	3.1e-15	NA	1.5e-16
4	GTEx	Spleen	0.3900	0.1070	2.7e-04	0.336	NA	0.208	NA	0.287	2.0e-09	NA	4.8e-06	NA	4.4e-08
5	NTR	Blood	0.0322	0.0103	3.0e-06	0.023	0.016	0.024	0.019	0.024	3.5e-08	5.1e-06	2.7e-08	8.4e-07	1.7e-08
6	YFS	Blood	0.0432	0.0129	2.1e-08	0.034	0.025	0.032	0.028	0.033	2.9e-11	1.0e-08	9.7e-11	1.6e-09	4.4e-11
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0633	0.0318	7.8e-05	0.012	0.029	0.037	NA	0.013	1.5e-02	3.1e-04	4.4e-05	NA	1.0e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Trunk predicted mass	7.6	43.4	70.2	-7.5	-3.5	-4.6	-7.0	-8.4	-7.1	-6.6
Trunk fat-free mass	7.4	42.6	68.7	-7.5	-3.5	-4.5	-7.0	-8.3	-7.1	-6.5
Height	7.0	134.1	187.7	-13.3	-4.5	-6.2	-13.2	-13.6	-13.7	-12.5
Whole body water mass	6.9	39.5	66.1	-7.3	-3.1	-4.1	-6.8	-8.1	-6.9	-6.1
Whole body fat-free mass	6.8	38.6	64.8	-7.2	-3.0	-4.1	-6.8	-8.1	-6.8	-6.0
Leg predicted mass (right)	6.3	33.5	59.1	-6.9	-2.4	-3.4	-6.5	-7.7	-6.5	-5.2
Leg fat-free mass (right)	6.2	33.0	58.2	-6.8	-2.4	-3.4	-6.4	-7.6	-6.4	-5.2
Arm fat-free mass (left)	6.0	30.5	51.9	-6.3	-2.5	-3.4	-6.1	-7.2	-6.1	-5.5
Leg fat-free mass (left)	5.9	31.5	55.7	-6.7	-2.0	-3.0	-6.3	-7.5	-6.3	-5.2
Basal metabolic rate	5.9	32.9	56.0	-6.7	-2.5	-3.5	-6.3	-7.5	-6.3	-5.6
Arm predicted mass (left)	5.9	29.8	52.0	-6.3	-2.5	-3.4	-6.0	-7.2	-6.0	-5.3
Leg predicted mass (left)	5.8	30.8	54.8	-6.6	-2.1	-3.1	-6.2	-7.4	-6.2	-5.1
Standing height	5.8	58.0	83.5	-8.9	-3.3	-4.3	-8.4	-9.1	-8.7	-8.2
Arm fat-free mass (right)	5.8	29.7	50.4	-6.1	-2.6	-3.5	-6.0	-7.1	-5.9	-5.4
Arm predicted mass (right)	5.6	28.8	48.7	-6.0	-2.4	-3.3	-6.0	-7.0	-5.9	-5.4
Comparative height size at age 10	5.3	29.1	39.4	-5.7	-2.7	-3.4	-6.1	-6.1	-6.1	-6.3
Forced expiratory volume in 1-second (FEV1), predicted	4.5	9.4	11.9	-3.2	-2.9	-3.2	-2.8	-3.5	-2.9	-3.0
Sitting height	4.2	29.5	43.3	-6.0	-3.8	-4.4	-5.5	-6.6	-5.5	-5.6
Forced vital capacity (FVC)	4.2	16.1	26.4	-5.0	-2.2	-2.8	-4.0	-5.1	-4.6	-3.4
Medication: Lansoprazole	4.0	4.6	9.9	-2.0	-1.1	-1.3	-1.9	-2.9	-1.8	-3.1
Heart attack	3.9	5.0	10.1	2.3	0.5	1.0	2.9	2.6	3.2	1.8
Forced vital capacity (FVC), Best measure	3.9	14.4	22.3	-4.7	-2.4	-2.8	-3.7	-4.5	-4.3	-3.6
Impedance of leg (right)	3.6	17.2	29.9	4.8	3.1	3.9	4.2	5.5	4.3	2.5
Heart attack/myocardial infarction (self-reported)	3.6	4.7	9.7	2.3	0.3	0.8	2.8	2.5	3.1	1.7
Impedance of leg (left)	3.5	17.0	30.0	5.0	2.9	3.7	4.1	5.5	4.2	2.6
Hip circumference	3.1	13.5	24.9	-4.3	-1.0	-1.7	-4.3	-5.0	-4.1	-3.4
Coronary Artery Disease (CAD)	2.9	3.5	7.9	2.0	0.9	0.9	1.8	1.9	1.9	2.8
Other serious medical condition/disability diagnosed by doctor	2.9	3.7	6.7	-1.7	0.7	0.4	-2.6	-1.9	-2.4	-2.6
Lung FEV1/FVC ratio	2.7	13.8	17.7	3.8	3.6	4.2	3.6	4.1	4.1	2.0
Tinnitus: Yes, but not now, but have in the past	2.7	2.8	5.0	-1.7	0.6	0.4	-2.2	-1.7	-2.1	-2.0
Ever highly irritable/argumentative for 2 days	2.7	3.2	5.7	-2.2	0.2	-0.2	-2.4	-2.0	-2.4	-1.5
Pulse wave peak to peak time	2.7	3.2	5.0	-2.2	-0.6	-0.6	-1.8	-1.9	-2.1	-2.2
Reaction Time	2.6	5.0	8.3	1.6	2.7	2.9	2.0	2.0	1.9	2.3
Tinnitus: Yes, now most or all of the time	2.6	3.1	4.5	1.9	0.9	1.1	1.9	2.1	2.1	1.8
Fasting Glucose	2.5	3.0	7.2	-0.5	-2.4	-2.7	-1.9	-1.1	-1.7	0.3
Weight	2.5	12.1	20.9	-4.0	-1.1	-1.7	-4.1	-4.6	-3.8	-3.5
Number of live births	2.5	3.6	6.8	1.9	1.2	1.4	1.8	1.7	2.1	2.6
Noisy workplace	2.5	3.1	8.5	-1.6	-0.8	-1.1	-1.7	-1.7	-1.6	-2.9
Medication: Ibuprofen	2.5	2.9	6.0	1.9	0.4	0.6	1.6	2.4	1.7	2.3
Impedance of whole body	2.4	12.3	21.3	3.9	2.9	3.5	3.4	4.6	3.5	2.2
Qualifications: None of the above	2.3	5.0	9.2	3.0	-1.7	-1.4	2.4	2.4	2.9	1.0
Chronotype (morning person)	2.2	5.1	8.2	-2.5	-0.7	-1.2	-2.6	-2.9	-2.8	-2.2
Friendships satisfaction	2.2	2.8	4.1	-2.0	1.0	0.7	-1.8	-2.0	-2.0	-1.6
Qualifications: CSEs or equivalent	2.1	2.8	6.1	-1.7	0.5	0.5	-1.9	-2.0	-1.7	-2.5
Heel T-Score	2.0	16.1	25.5	5.0	1.1	1.8	4.4	5.0	4.8	3.9
Qualifications: A levels/AS levels or equivalent	2.0	4.3	7.3	-2.6	-0.2	-0.6	-2.6	-2.7	-2.7	-1.5
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.5	5.5	1.9	-0.2	0.1	1.6	2.4	1.7	1.7
Exposure to tobacco smoke at home	2.0	2.3	4.1	1.0	1.6	1.9	1.0	1.7	1.1	2.0
Eye problems/disorders: Glaucoma	2.0	2.3	3.1	1.6	1.4	1.5	1.4	1.5	1.5	1.8
Rheumatoid Arthritis	1.9	2.6	4.4	-2.1	1.3	1.1	-1.8	-1.9	-1.7	-1.2
Sensitivity / hurt feelings	1.9	3.2	4.8	-2.0	1.4	0.9	-2.1	-1.7	-2.2	-1.9
Stomach or abdominal pain in last month	1.9	2.3	4.4	-1.3	-0.8	-1.0	-2.1	-1.7	-1.8	-1.6
Mouth/teeth dental problems	1.9	3.0	6.3	-1.4	2.5	2.3	-1.7	-1.3	-1.6	0.4
Mouth/teeth dental problems: Dentures	1.9	3.3	4.9	1.7	-2.2	-2.0	1.9	1.7	2.0	-0.5
Mean time to correctly identify matches	1.9	3.7	4.1	1.7	1.8	2.0	2.0	2.0	2.0	1.9
Miserableness	1.9	3.3	5.8	-1.7	1.0	0.6	-2.3	-1.3	-2.4	-2.4
Commuting to job workplace: Cycle	1.9	2.3	5.5	-1.2	-1.7	-1.8	-0.8	-1.1	-1.0	-2.4
Crohns Disease (2012)	1.8	2.8	5.2	2.2	0.5	0.8	2.1	2.1	2.3	0.4
Blood clot in the leg (DVT)	1.8	2.3	4.2	-1.4	0.1	-0.5	-2.0	-1.9	-1.9	-1.4
Eye problems/disorders: Cataract	1.8	2.1	3.1	1.7	-0.1	0.2	1.7	1.8	1.7	1.6
Chronic bronchitis/emphysema (father)	1.7	2.0	6.1	-0.7	2.5	2.2	-1.0	-0.5	-0.8	-0.7
Hair/balding pattern: Pattern 2	1.7	2.1	4.8	2.2	-1.3	-1.0	0.8	2.2	1.0	1.0
Forced expiratory volume in 1-second (FEV1)	1.7	5.9	10.6	-3.1	-1.0	-1.3	-2.4	-3.3	-2.7	-2.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.4	8.2	-2.9	-1.3	-1.5	-2.2	-2.7	-2.5	-2.6
Number of children fathered	1.7	1.9	2.4	-1.6	-1.4	-1.4	-1.1	-1.5	-1.1	-1.5
Had major operations	1.7	2.0	4.6	-1.8	0.6	0.5	-2.1	-1.5	-1.7	-0.6
Irritability	1.7	2.8	7.8	-0.7	-1.7	-1.8	-1.5	-0.7	-1.6	-2.8
Supplements: Calcium	1.7	1.9	3.8	-1.7	0.1	0.2	-1.9	-1.5	-1.9	-1.0
Migraine (self-reported)	1.6	1.9	5.5	-1.0	-2.2	-2.3	-0.2	-0.9	-0.6	-1.0
Back pain experienced in last month	1.6	2.3	4.0	-1.5	-0.8	-1.1	-1.7	-2.0	-1.4	-1.9
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	4.6	-1.4	-0.8	-1.0	-1.3	-1.5	-1.2	-2.1
Medication: Omeprazole	1.5	1.8	4.3	-1.2	-1.1	-1.3	-1.2	-1.2	-1.1	-2.1
Leg fat percentage (left)	1.5	5.3	8.4	2.9	1.9	2.2	2.0	2.6	2.6	1.7
Ever had prostate specific antigen (PSA) test	1.5	1.8	2.6	-1.6	-1.0	-1.0	-1.5	-1.3	-1.6	-1.1
Respiratory disease	1.4	3.1	6.4	-1.2	0.6	0.4	-2.2	-2.2	-1.8	-2.5
Hair/balding pattern: Pattern 3	1.4	2.1	4.5	-0.8	-2.1	-2.1	-0.1	-1.1	-0.1	-2.0
Pulse wave Arterial Stiffness index	1.4	1.7	2.9	1.6	0.5	0.5	1.2	1.3	1.5	1.7
Leg fat percentage (right)	1.4	5.0	7.6	2.8	2.0	2.3	1.9	2.5	2.5	1.5
Leg pain on walking	1.4	1.7	3.5	-1.1	1.1	0.7	-1.9	-1.5	-1.6	-0.9
Average weekly red wine intake	1.4	2.0	3.1	-1.5	0.1	-0.3	-1.7	-1.7	-1.7	-1.8
Ever smoked	1.4	2.4	4.0	-1.8	-0.7	-0.9	-1.8	-2.0	-1.8	-1.5
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	3.2	-1.1	0.0	-0.4	-1.8	-1.7	-1.6	-1.3
Triglycerides	1.3	2.2	7.2	-0.1	-2.6	-2.7	-0.1	-0.4	-0.7	-0.4
Ulcerative Colitis	1.3	1.9	2.8	-1.7	-0.5	-0.8	-1.4	-1.6	-1.6	-1.6
Waist Hip Ratio (WHR)	1.3	6.0	11.6	2.9	1.5	2.0	2.8	3.4	2.7	0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.3	2.9	5.5	2.4	-0.2	0.2	1.7	2.4	2.1	1.4
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.2	3.8	-1.4	0.8	0.5	-2.0	-1.6	-1.7	-1.8
Pain type(s) experienced in last month: Hip pain	1.3	1.6	2.3	-1.2	-0.7	-1.0	-1.4	-1.5	-1.4	-1.4
Crohns Disease (2017)	1.2	2.6	3.5	1.7	-1.7	-1.4	1.9	1.8	1.6	-1.2
Age at First Birth	1.2	1.7	3.4	-1.9	-0.6	-0.8	-1.4	-1.6	-1.4	-1.1
Bipolar Disorder (2011)	1.2	1.2	1.9	-1.2	-0.1	-0.3	-1.2	-1.3	-1.4	-1.3
Mean Putamen Volume	1.2	1.4	2.5	1.2	1.4	1.6	0.6	1.5	1.1	0.4
Hand grip strength (right)	1.2	3.3	7.4	-2.6	-1.3	-1.6	-1.2	-2.7	-1.5	-1.2
Relative age voice broke	1.2	1.8	3.4	-0.8	-1.8	-1.8	-0.6	-0.8	-0.9	-1.9
Financial difficulties in last 2 years	1.2	1.6	5.5	0.3	2.3	2.4	-0.5	0.3	-0.1	-0.3
Impedance of arm (right)	1.2	5.4	9.2	2.3	2.2	2.7	2.1	3.0	2.0	1.6
Depression (self-reported)	1.2	1.4	4.2	-0.6	-1.9	-2.1	-0.2	-0.8	-0.7	-0.6
Length of working week for main job	1.2	1.3	2.8	-1.3	0.1	-0.3	-1.5	-1.7	-1.4	-0.8
Gout (self-reported)	1.2	1.6	3.9	-1.0	2.0	1.8	-1.1	-0.8	-0.9	-0.1
Number of full brothers	1.2	1.5	3.6	1.4	-0.2	-0.2	1.3	1.2	1.4	1.9
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	4.2	1.3	-2.0	-1.8	1.3	0.7	1.3	0.7
Osteoporosis (self-reported)	1.2	1.5	2.9	-1.7	0.1	-0.1	-1.5	-1.5	-1.5	-0.9
Medication: Lisinopril	1.2	1.5	2.7	-1.6	0.8	0.7	-1.4	-1.2	-1.4	-1.1
Fractured/broken bones in last 5 years	1.2	1.6	4.6	-0.7	-2.1	-2.1	-0.5	-0.8	-0.6	-0.7
Basal cell carcinoma (self-reported)	1.2	1.4	3.3	-1.8	-0.1	-0.4	-1.2	-1.5	-1.4	-0.6
Bipolar Disorder or Schizophrenia	1.1	2.7	5.5	-2.3	0.4	0.2	-1.5	-1.8	-1.9	-2.1
Alzheimer’s Disease (in mother)	1.1	1.3	1.9	1.2	1.4	1.3	1.1	0.8	0.9	1.0
Number of incorrect matches in round	1.1	1.9	3.7	-1.0	-0.4	-0.6	-1.9	-0.9	-1.9	-1.9
Past tobacco smoking	1.1	2.0	2.5	1.3	1.2	1.4	1.3	1.6	1.4	1.6
Father’s age at death	1.1	1.5	2.6	0.8	-1.3	-1.2	1.2	1.6	0.9	1.4
Pulse rate	1.1	1.8	3.4	1.5	-1.3	-1.0	1.8	1.4	1.5	0.3
Impedance of arm (left)	1.1	5.0	8.6	2.2	2.3	2.8	1.9	2.9	1.9	1.2
Health satisfaction	1.1	1.5	3.3	-0.6	1.4	1.2	-1.8	-0.8	-1.3	-0.9
Smoking status: Previous	1.1	1.7	4.1	-1.0	-1.1	-1.2	-1.1	-1.2	-1.1	-2.0
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.1	3.7	0.4	1.9	1.9	0.4	0.6	0.4	-0.2
Schizophrenia (2018)	1.0	2.1	4.5	-2.0	-0.3	-0.4	-1.1	-1.7	-1.5	-2.1
Major Depression (MDD)	1.0	1.2	3.3	-0.2	-1.8	-1.8	-0.6	-0.0	-0.6	-1.3
LDL Cholesterol	1.0	1.6	2.8	1.2	-1.2	-1.1	1.7	1.5	1.2	0.8
Tanning	1.0	11.7	22.4	3.6	1.1	1.4	3.8	3.8	3.8	4.7
Medication for hormone replacement therapy	1.0	1.1	2.0	-1.4	0.6	0.6	-1.1	-0.9	-1.1	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.4	5.3	2.3	0.2	0.5	1.4	2.1	1.8	1.1
Had menopause	1.0	1.3	2.8	1.3	0.4	0.6	1.2	1.7	1.4	0.6
Happiness	1.0	1.2	3.5	0.3	1.9	1.8	-0.1	0.4	0.2	1.1
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	3.4	1.5	-0.3	-0.1	1.6	1.8	1.5	1.3
Mouth/teeth dental problems: Loose teeth	1.0	1.1	2.1	1.1	-0.2	-0.0	1.3	1.2	1.3	1.5
Alcohol intake frequency.	1.0	2.2	4.1	1.8	-0.0	0.4	1.8	1.8	2.0	1.2
Ever had bowel cancer screening	1.0	1.2	2.3	-1.1	0.3	0.0	-1.5	-1.0	-1.5	-1.3
Commuting to job workplace: Walk	1.0	1.1	2.3	-1.2	0.7	0.5	-1.5	-1.1	-1.5	-0.4
Mother’s age at death	1.0	1.2	4.0	0.2	-2.0	-2.0	0.7	0.1	0.5	-0.2
Relative age of first facial hair	0.9	1.8	2.8	-1.6	0.4	0.2	-1.5	-1.7	-1.5	-1.7
Age when periods started (menarche)	0.9	2.1	4.8	-1.2	-2.0	-2.2	-0.2	-1.4	-0.8	-1.5
Asthma	0.9	1.9	3.6	-1.3	0.2	0.1	-1.5	-1.9	-1.3	-1.9
Birth weight of first child	0.9	1.6	3.4	-0.7	-1.6	-1.8	-1.0	-1.0	-1.1	-1.4
Body fat percentage	0.9	3.4	5.9	2.0	2.2	2.4	1.2	1.8	1.7	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.5	0.6	1.6	1.6	0.0	0.4	0.4	1.4
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.2	-1.3	-0.6	-0.7	-1.0	-1.5	-1.2	-0.2
Illnesses of siblings: Diabetes	0.9	1.0	3.1	-0.8	-0.1	-0.2	-1.1	-1.2	-0.9	-1.8
Ulcerative Colitis (UC)	0.8	1.4	2.1	-1.2	-1.3	-1.5	-0.6	-1.0	-1.0	-1.4
Breast Cancer	0.8	1.9	2.9	1.6	1.1	1.1	1.6	1.2	1.7	1.0
Lupus	0.8	1.2	3.3	0.9	-0.1	0.0	1.2	1.0	1.3	1.8
Ever had hysterectomy (womb removed)	0.8	0.9	3.0	0.2	1.7	1.6	-0.2	-0.1	0.1	0.7
Medication: Co-codamol	0.8	0.9	1.7	-0.7	-0.5	-0.6	-1.3	-0.9	-1.1	-1.2
Supplements: Glucosamine	0.8	1.1	1.8	-1.3	-0.5	-0.5	-1.3	-1.1	-1.2	-1.0
Medication: Ramipril	0.8	1.0	2.4	-1.3	-0.4	-0.6	-1.1	-1.6	-1.1	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	2.1	0.9	-0.1	-0.0	1.2	1.1	1.1	1.4
Hair/balding pattern: Pattern 4	0.8	1.8	5.4	0.2	2.3	2.3	-0.1	0.3	0.0	1.4
Medication: Seretide 50 evohaler	0.8	0.9	3.0	-0.4	0.1	-0.1	-1.2	-0.7	-1.1	-1.7
Alcohol drinker status: Never	0.8	0.9	2.8	-0.4	-1.7	-1.6	-0.1	-0.4	-0.1	-0.8
Prostate Cancer	0.7	0.9	1.8	1.3	0.6	0.6	0.8	1.0	0.8	1.4
Schizophrenia (2014)	0.7	1.6	2.8	-1.7	0.5	0.4	-1.1	-1.4	-1.4	-1.7
Allergy or Eczema	0.7	1.7	3.3	1.5	0.1	0.5	1.6	1.7	1.8	1.0
Cardiovascular Disease	0.7	2.4	3.2	-1.6	-1.1	-1.3	-1.7	-1.7	-1.8	-1.4
Hand grip strength (left)	0.7	1.9	3.1	-1.2	-1.7	-1.8	-0.6	-1.7	-0.9	-1.3
Average weekly spirits intake	0.7	0.8	1.5	1.0	1.0	0.9	0.9	1.2	0.6	0.7
Taking other prescription medications	0.7	1.1	2.4	-0.5	0.6	0.4	-1.6	-1.1	-1.0	-1.6
Bilateral oophorectomy (both ovaries removed)	0.7	0.9	1.6	1.0	-0.0	0.1	1.3	1.1	1.2	0.9
Hearing difficulty/problems with background noise	0.7	1.1	2.1	1.2	-1.5	-1.4	0.8	0.7	0.6	-1.1
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	3.2	0.1	-0.8	-0.9	-0.7	-0.4	-0.7	-1.8
Qualifications: O levels/GCSEs or equivalent	0.7	1.0	1.8	-1.2	1.0	1.0	-1.2	-0.5	-1.3	-0.7
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.5	-0.1	1.4	1.6	-0.5	-0.3	-0.2	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.1	0.2	-1.5	-1.4	1.2	0.1	0.8	-0.1
Wheeze or whistling in the chest in last year	0.7	1.3	3.9	-0.1	1.2	1.2	-1.1	-0.7	-0.8	-2.0
Eye problems/disorders: None of the above	0.7	0.8	1.4	-1.2	0.3	0.1	-1.1	-0.9	-1.2	-0.6
Angina (self-reported)	0.7	1.0	3.0	0.0	1.6	1.7	0.4	0.4	0.7	0.6
Overall health rating	0.7	1.6	4.8	0.4	2.2	2.1	-1.2	0.1	-0.4	-0.4
Family relationship satisfaction	0.7	0.9	2.9	-0.5	1.7	1.6	-0.6	-0.4	-0.6	-0.1
Knee pain experienced in last month	0.7	1.1	2.9	-1.0	-0.6	-0.6	-1.1	-1.1	-0.9	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	3.7	0.0	-1.1	-0.8	0.0	0.1	0.1	-1.9
Asthma (self-reported)	0.7	1.4	3.0	-1.1	0.2	0.1	-1.2	-1.7	-1.1	-1.7
Number of self-reported non-cancer illnesses	0.7	1.1	2.7	-0.9	0.1	-0.1	-1.6	-1.1	-1.4	-1.1
Age started oral contraceptive pill	0.7	0.9	2.0	1.0	0.2	0.4	1.2	1.4	1.0	0.9
Diastolic blood pressure, automated reading	0.7	2.0	3.2	-1.7	-1.4	-1.4	-1.3	-1.8	-1.3	-0.8
Bipolar Disorder (2018)	0.6	1.0	1.7	-1.3	1.0	0.8	-1.0	-0.8	-1.2	-0.7
Irritable Bowel Disease (IBD)	0.6	1.5	3.8	0.1	-1.9	-1.9	0.5	0.3	0.1	-1.8
Verbal and Numeric Reasoning (VNR)	0.6	1.4	2.5	-1.0	-1.6	-1.6	-0.5	-0.9	-0.9	-1.4
Primary Biliary Cirrhosis	0.6	0.8	1.7	-0.9	-1.0	-0.9	-0.3	-1.2	-0.2	-1.3
Neuroticism	0.6	1.4	4.8	-1.0	0.5	0.2	-1.4	-0.6	-1.4	-2.2
Angina	0.6	0.8	2.3	0.1	1.4	1.5	0.6	0.3	0.8	0.6
Medication: Cholesterol lowering	0.6	0.9	1.8	-1.0	0.7	0.5	-1.0	-1.3	-0.9	-0.8
Medication: Paracetamol	0.6	1.0	1.7	-1.2	1.3	1.1	-0.8	-0.9	-0.9	-0.8
Glaucoma (self-reported)	0.6	0.7	1.5	0.4	1.2	1.1	0.4	0.3	0.5	1.1
Exposure to tobacco smoke outside home	0.6	0.8	1.7	-1.3	0.1	0.0	-0.8	-1.1	-0.8	-1.2
Qualifications: College or University degree	0.6	2.0	4.7	-2.2	-0.1	-0.3	-1.2	-1.9	-1.7	-0.8
Age at last live birth	0.6	0.8	1.5	0.7	1.0	1.2	0.6	1.0	0.3	1.2
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.3	1.1	0.6	0.8	0.7	0.7	1.1	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.4	1.2	0.1	0.3	0.8	1.1	1.2	0.1
Long-standing illness, disability or infirmity	0.6	1.0	2.0	0.0	1.2	1.1	-1.2	-0.3	-0.8	-1.4
Diabetes diagnosed by doctor	0.6	0.9	2.0	-0.2	-1.4	-1.2	1.1	0.2	1.0	0.7
Mineral and other dietary supplements	0.6	0.8	1.6	0.7	1.2	1.2	0.6	0.6	0.7	0.9
Medication: Paracetamol	0.6	0.9	2.4	-1.0	1.6	1.4	-0.3	-0.7	-0.4	-0.5
Depression (Nagel 2018)	0.5	0.8	2.7	0.3	1.6	1.5	0.0	0.7	0.3	-0.1
Neuroticism (Nagel 2018)	0.5	1.2	5.3	-0.3	-0.0	-0.3	-1.2	-0.0	-1.2	-2.3
Blood Eosinophil Count	0.5	3.5	7.0	-2.6	0.2	-0.1	-1.9	-2.5	-2.0	-1.8
Lung FVC	0.5	2.8	4.2	-2.0	-1.6	-1.9	-1.4	-2.0	-1.8	0.0
Number of treatments/medications taken	0.5	1.0	1.6	-0.7	1.2	1.2	-0.9	-0.6	-0.7	-1.3
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.3	-0.5	-1.1	-1.0	0.6	-0.2	0.6	-0.8
Vitamin and mineral supplements	0.5	0.6	1.6	0.4	1.2	1.2	0.5	0.4	0.5	0.8
Severe depression (siblings)	0.5	0.5	0.9	-0.0	1.0	0.9	-0.8	-0.2	-0.7	-0.8
Alcohol usually taken with meals	0.5	0.8	1.6	-1.3	1.1	0.9	-0.8	-0.7	-0.8	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.6	-0.9	0.3	0.1	-0.7	-0.7	-0.7	-1.6
Diabetes (self-reported)	0.5	0.8	1.5	0.1	-1.2	-1.1	1.0	0.6	1.0	0.5
Time employed in main current job	0.5	0.5	2.3	-0.5	-0.8	-0.7	0.1	-0.1	-0.2	-1.5
Worrier / anxious feelings	0.5	1.0	2.2	1.4	-0.0	0.1	1.1	1.5	1.1	-0.6
Falls in the last year	0.5	0.7	2.6	-0.3	-0.7	-0.8	-0.9	-0.1	-0.6	-1.6
Prospective memory result	0.5	0.6	1.3	-0.7	-0.5	-0.6	-1.1	-0.7	-1.0	-0.5
Lung cancer (father)	0.5	0.6	1.8	0.2	1.4	1.2	0.0	0.4	0.0	0.6
Tense / ‘highly strung’	0.5	0.9	2.5	0.8	1.6	1.4	-0.2	0.8	-0.0	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.5	1.1	0.1	0.2	1.2	1.2	1.0	-0.0
Loud music exposure frequency	0.5	0.6	1.0	-0.9	-0.3	-0.4	-0.8	-1.0	-0.7	-0.9
Birth weight	0.5	1.1	3.1	-0.3	-1.8	-1.7	-0.2	-0.6	-0.1	-1.1
Number of full sisters	0.5	0.6	1.3	0.8	-0.1	0.1	0.7	1.0	1.1	0.8
Illnesses of father: Heart disease	0.5	0.7	1.6	1.2	-0.1	0.1	0.8	0.7	1.2	0.9
Qualifications: nursing, teaching	0.5	0.8	1.3	-1.1	-1.1	-1.0	-0.6	-0.7	-0.9	-0.6
Illnesses of father: None of the above (group 1)	0.5	0.6	1.3	-0.7	0.6	0.5	-1.0	-0.4	-1.1	-0.9
Wears glasses or contact lenses	0.5	0.6	1.1	-0.9	-0.5	-0.6	-0.6	-0.8	-0.7	-1.0
Risk taking	0.5	0.7	1.0	-0.8	-0.7	-0.9	-0.8	-0.9	-0.9	-1.0
Unable to work because of sickness or disability	0.5	0.6	1.6	-0.7	0.4	0.3	-1.0	-0.5	-0.8	-1.3
Alcohol drinker status: Previous	0.5	0.6	2.1	-0.1	-1.4	-1.3	0.5	0.3	0.3	-0.4
Worry (Nagel 2018)	0.4	0.9	5.3	-0.1	0.0	-0.1	-0.6	0.1	-0.6	-2.3
Alzheimer’s Disease (including proxy)	0.4	0.6	1.5	0.9	0.1	-0.0	1.2	0.4	1.0	1.0
Neuroticism (2016)	0.4	0.5	1.1	-0.3	0.2	-0.2	-1.1	-0.4	-1.1	-1.1
Hearing difficulty/problems: Yes	0.4	0.6	1.5	-0.3	-0.8	-0.8	-0.7	-0.3	-0.7	-1.2
Trunk fat percentage	0.4	1.7	4.3	1.2	1.9	2.1	0.4	1.0	1.0	0.2
Maternal smoking around birth	0.4	0.6	1.1	1.1	0.2	0.4	0.5	1.0	0.7	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.2	0.0	1.1	1.1	-0.4	0.3	-0.2	-1.1
Serious illness, injury or assault to yourself	0.4	0.5	2.2	-0.4	-0.2	-0.1	-0.6	-0.3	-0.6	-1.5
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.8	0.4	1.1	1.4	0.6	0.8	0.8	1.2
Waist circumference	0.4	1.4	3.0	-1.2	-0.1	-0.3	-1.4	-1.5	-1.1	-1.7
Pain all over the body in last month	0.4	0.4	0.7	0.9	-0.6	-0.5	0.5	0.4	0.6	0.9
Arm fat mass (right)	0.4	1.5	2.7	-1.3	0.8	0.6	-1.6	-1.6	-1.2	-1.2
Pulse wave reflection index	0.4	0.5	1.6	0.3	1.3	1.1	-0.2	0.2	0.2	0.7
Comparative body size at age 10	0.4	1.2	3.7	1.1	-0.1	-0.0	1.1	1.1	1.0	1.9
Age at first live birth	0.4	0.7	1.6	-0.8	1.3	1.2	-0.6	-0.3	-1.0	0.2
Neck or shoulder pain in last month	0.4	0.6	1.5	1.1	0.3	0.4	0.6	1.2	0.9	0.3
Medication: Blood pressure	0.4	0.7	1.1	-0.9	-0.1	-0.2	-0.9	-1.1	-1.0	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.4	-0.7	-0.2	-0.3	-0.6	-0.8	-0.7	-1.2
Arm fat percentage (left)	0.4	1.6	4.2	0.9	2.0	2.0	0.4	0.8	0.8	0.6
Loneliness, isolation	0.4	0.5	1.2	1.0	0.1	0.0	0.8	1.1	0.8	-0.2
Smoking status: Current	0.4	0.6	0.8	0.8	-0.7	-0.8	0.9	0.6	0.9	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.5	0.4	1.5	1.6	0.5	0.9	0.3	0.3
Arm fat mass (left)	0.4	1.6	2.9	-1.3	0.9	0.6	-1.7	-1.6	-1.3	-1.3
Hearing aid user	0.4	0.4	1.0	-0.3	-0.9	-1.0	-0.5	-0.3	-0.6	-0.6
Average weekly beer plus cider intake	0.4	0.5	1.2	0.7	0.1	0.5	0.9	1.1	0.9	0.1
Ever depressed for a whole week	0.4	0.5	2.2	0.5	-0.8	-0.8	-0.2	-0.0	-0.2	-1.5
Heart disease (siblings)	0.4	0.5	1.2	1.1	0.7	0.9	0.1	1.0	0.5	0.0
Pack years of smoking	0.4	0.6	1.8	-0.5	-1.2	-1.4	-0.3	-0.8	-0.2	-0.3
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.7	0.9	-1.2	-0.9	1.0	1.3	0.9	-0.1
Schizophrenia vs Biploar Disorder	0.3	0.4	0.9	0.5	-0.4	-0.2	0.9	0.7	0.6	0.6
Alzheimer’s Disease (in father)	0.3	0.3	0.9	0.3	-0.4	-0.3	0.9	0.2	0.7	-0.5
Ovarian Cancer	0.3	0.4	2.1	-0.5	-0.4	-0.4	0.0	-0.5	-0.2	-1.4
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.5	-0.4	0.7	0.7	-0.7	-0.4	-0.6	-0.5
Smoking Status	0.3	0.8	2.8	-0.3	-1.5	-1.7	0.2	-0.4	0.1	-0.4
Hypothyroidism (self reported)	0.3	0.7	1.5	0.9	-0.1	0.0	1.0	1.0	1.2	0.7
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.3	0.2	-0.2	0.0	1.2	0.6	1.1	1.0
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.0	0.7	-0.0	0.0	0.6	1.0	0.7	0.6
Medication: Metformin	0.3	0.4	1.3	-0.3	-1.1	-1.1	0.4	-0.2	0.4	0.4
Average weekly fortified wine intake	0.3	0.4	1.0	0.5	-1.0	-0.9	0.5	0.0	0.6	0.2
High blood pressure (mother)	0.3	0.4	0.6	-0.6	0.8	0.7	-0.6	-0.5	-0.7	0.3
Trunk fat mass	0.3	1.2	2.0	-0.9	0.9	0.7	-1.4	-1.2	-0.9	-1.3
Nervous feelings	0.3	0.6	1.8	0.7	-0.5	-0.4	0.6	1.0	0.6	-1.3
Fluid intelligence score	0.3	0.6	1.6	-0.8	-0.3	-0.3	-0.6	-0.5	-0.9	-1.3
Illnesses of siblings	0.3	0.4	0.9	0.4	-0.4	-0.3	1.0	0.7	0.7	0.7
Neuroticism score	0.3	0.7	4.0	-0.2	0.2	-0.0	-0.5	0.2	-0.6	-2.0
Arm fat percentage (right)	0.3	1.3	3.7	0.7	1.9	1.9	0.3	0.6	0.7	0.6
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.0	0.0	-0.5	-0.5	-0.8	-0.4	-0.8	-1.0
Worry too long after embarrassment	0.3	0.5	2.6	-0.7	-0.4	-0.5	-0.0	-0.3	-0.4	-1.6
Shortness of breath walking on level ground	0.3	0.4	1.0	0.5	1.0	1.0	-0.5	-0.2	-0.2	-0.1
Medication: Allopurinol	0.3	0.4	0.6	-0.8	0.7	0.7	-0.5	-0.7	-0.4	-0.7
Whole body fat mass	0.3	1.2	1.7	-0.8	1.2	1.0	-1.3	-1.2	-0.8	-1.2
Pulse rate, automated reading	0.3	1.0	1.4	0.9	-1.2	-0.9	1.2	0.9	1.1	-0.1
Chest pain or discomfort	0.3	0.4	2.2	0.6	0.1	0.2	-0.2	0.0	-0.0	-1.5
Hypertension (Self-reported)	0.3	0.9	1.3	-1.1	-0.6	-0.7	-1.1	-1.0	-1.0	-0.8
Average weekly champagne plus white wine intake	0.3	0.4	1.1	-1.0	-0.3	-0.6	-0.3	-1.0	-0.6	-0.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.0	-0.4	-0.8	-0.7	-0.6	-0.4	-0.6	-1.0
Illnesses of father: High blood pressure	0.3	0.3	1.0	0.2	0.8	0.7	-0.0	-0.2	0.1	1.0
Depressed Affect (Nagel 2018)	0.2	0.4	2.3	0.2	-0.0	-0.3	-0.6	0.4	-0.4	-1.5
HDL Cholesterol	0.2	0.3	0.8	-0.2	0.9	0.9	-0.4	-0.1	-0.1	-0.7
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.1	-0.2	1.1	0.8	-0.3	-0.1	-0.2	-0.5
Pack years adult smoking proportion	0.2	0.4	0.9	-0.4	-0.8	-1.0	-0.2	-0.8	-0.1	-0.3
Current tobacco smoking	0.2	0.3	0.7	0.4	-0.8	-0.9	0.6	0.2	0.6	0.3
Fed-up feelings	0.2	0.3	0.6	0.4	-0.7	-0.8	0.4	0.7	0.4	-0.2
High blood pressure	0.2	0.6	1.2	-1.0	-0.3	-0.4	-1.1	-0.8	-1.0	-0.5
Multivitamins +/- minerals	0.2	0.2	0.4	-0.4	-0.6	-0.7	-0.3	-0.3	-0.3	0.3
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.2	0.2	0.2	0.2	0.6	0.5	0.3	1.1
Had other major operations	0.2	0.3	0.9	0.4	1.0	0.8	0.1	0.5	0.1	0.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.8	-0.2	0.9	0.7	0.0	0.0	0.0	0.8
Alcohol intake versus 10 years previously	0.2	0.3	0.8	0.6	0.5	0.7	0.2	-0.1	0.5	0.9
Peak expiratory flow (PEF)	0.2	0.4	1.2	-0.7	-0.3	-0.4	-0.4	-1.1	-0.6	-0.7
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.5	-0.7	-0.4	-0.6	-0.1	-0.4	-0.3	-0.1
High blood pressure (siblings)	0.2	0.4	0.7	-0.6	0.4	0.1	-0.9	-0.8	-0.8	0.2
Emphysema/chronic bronchitis	0.2	0.2	0.7	0.4	0.5	0.5	-0.1	-0.2	-0.1	-0.8
Heart disease (mother)	0.2	0.2	0.4	-0.2	0.6	0.6	-0.5	0.3	-0.4	0.3
Leg fat mass (right)	0.2	0.6	1.6	-0.1	1.3	1.1	-0.7	-0.5	-0.2	-0.6
Suffer from ‘nerves’	0.2	0.3	1.4	0.2	0.2	0.0	0.7	0.3	0.5	-1.2
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.6	-0.4	0.1	0.0	-0.7	-0.4	-0.7	-0.1
Mood swings	0.2	0.4	0.8	0.5	-0.8	-0.9	-0.0	0.7	-0.1	-0.7
Breast cancer (self-reported)	0.2	0.2	0.5	0.5	-0.3	-0.4	0.1	0.7	-0.0	0.7
Medication: Gliclazide	0.2	0.2	0.7	-0.0	-0.5	-0.2	0.8	0.1	0.7	-0.4
Guilty feelings	0.2	0.3	0.7	0.6	0.1	0.1	0.8	0.8	0.6	0.4
Ever taken oral contraceptive pill	0.2	0.2	0.4	0.3	-0.7	-0.5	0.5	0.0	0.5	-0.5
Financial situation satisfaction	0.2	0.2	1.3	0.1	-0.4	-0.3	0.2	0.1	0.3	1.2
Commuting to job workplace: Public transport	0.2	0.3	0.6	-0.6	-0.2	-0.2	-0.6	-0.3	-0.8	0.6
Medication: Blood pressure	0.2	0.3	0.6	0.4	0.4	0.6	0.7	0.8	0.7	0.3
High cholesterol (Self-reported)	0.2	0.3	0.7	-0.0	-0.9	-0.8	-0.4	-0.4	-0.4	-0.2
Medication: Bendroflumethiazide	0.2	0.3	1.4	-0.4	0.1	0.2	-0.3	-0.4	-0.2	-1.2
Number of operations (self-reported)	0.2	0.4	0.8	-0.4	0.9	0.8	-0.9	-0.1	-0.6	0.1
Myopia	0.2	0.3	1.2	-0.2	0.9	1.1	0.1	0.1	0.0	0.1
Cholesterol lowering medication	0.2	0.3	0.4	0.6	-0.6	-0.5	0.4	0.5	0.5	0.3
Body Mass Index (BMI) (2010)	0.1	0.1	0.4	-0.1	-0.4	-0.6	0.1	-0.2	-0.0	-0.5
HbA1C	0.1	0.1	0.5	-0.1	-0.2	-0.4	0.7	0.2	0.0	-0.4
Blood Red Count	0.1	1.1	3.9	-1.0	-0.5	-0.5	-0.9	-0.6	-1.1	-2.0
Systolic Blood Pressure	0.1	0.3	0.7	0.0	-0.8	-0.5	0.8	0.6	0.5	-0.5
Supplements: Zinc	0.1	0.1	0.1	-0.3	0.3	0.2	-0.3	-0.3	-0.2	0.0
Diabetes (mother)	0.1	0.1	0.4	-0.2	-0.2	-0.5	-0.4	-0.6	-0.4	-0.2
Townsend deprivation index at recruitment	0.1	0.2	0.4	0.4	-0.1	0.1	0.5	0.6	0.6	0.6
Medication: Atenolol	0.1	0.1	0.2	0.0	-0.5	-0.4	0.1	0.1	0.2	-0.1
Allergy	0.1	0.3	0.8	0.1	-0.8	-0.9	0.3	0.3	0.1	0.4
Illnesses of mother	0.1	0.1	0.7	-0.0	-0.2	-0.4	0.2	-0.1	0.2	-0.8
Breastfed as a baby	0.1	0.2	0.7	-0.8	0.5	0.5	-0.1	-0.2	-0.3	-0.0
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.7	0.6	-0.4	-0.2	0.5	0.4	0.8	0.4
Medication: Amlodipine	0.1	0.1	0.5	-0.1	0.0	0.2	-0.1	0.3	-0.0	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	0.4	-0.5	-0.5	0.1	0.3	0.2	0.1
Medication for pain relief, constipation, heartburn	0.1	0.1	0.4	-0.2	-0.2	-0.2	-0.2	-0.2	-0.2	0.6
Medication: Aspirin	0.1	0.2	1.0	-0.1	-0.1	-0.3	-0.1	-0.4	-0.2	-1.0
Supplements: Vitamin C	0.1	0.2	0.3	-0.3	-0.6	-0.5	-0.4	-0.5	-0.1	-0.4
Medication for cholesterol	0.1	0.2	0.4	0.7	-0.5	-0.6	0.2	0.0	0.3	0.4
Osteoarthritis (self-reported)	0.1	0.1	0.2	-0.1	0.2	0.2	-0.3	-0.5	0.1	-0.4
Medication: Aspirin	0.1	0.1	0.2	0.3	0.4	0.2	0.4	-0.1	0.3	-0.4
Medication: Atorvastatin	0.1	0.1	0.2	0.3	-0.4	-0.3	0.4	0.2	0.5	-0.2
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.6	0.8	-0.1	-0.1	0.8	0.6	0.7	0.2
Pain experienced in last month	0.1	0.1	0.6	-0.2	-0.2	-0.1	0.3	-0.2	0.0	0.8
Leg fat mass (left)	0.1	0.4	1.1	-0.1	1.0	1.0	-0.6	-0.5	-0.1	-0.5
Blood Platelet Count	0.0	0.3	1.8	-0.3	-0.1	-0.2	-0.0	-0.2	-0.4	-1.3
Blood White Count	0.0	0.3	0.6	0.6	0.1	0.1	0.7	0.5	0.7	0.6
BMI	0.0	0.1	0.5	0.0	-0.1	-0.3	-0.3	-0.7	-0.0	-0.4
Hair Pigment	0.0	1.1	2.9	-1.7	1.1	0.7	-0.7	-1.2	-1.0	0.2
Systolic blood pressure, automated reading	0.0	0.1	0.4	-0.0	0.6	0.7	-0.2	0.2	-0.1	0.1
Diabetes (father)	0.0	0.1	0.1	-0.3	0.1	0.1	0.3	-0.4	0.1	-0.1
Medication: Levothyroxine sodium	0.0	0.0	0.1	0.3	-0.0	-0.0	-0.0	0.3	0.3	0.1
Body mass index (BMI)	0.0	0.1	0.2	0.1	0.3	0.2	-0.3	-0.4	0.2	0.2
Medication: Simvastatin	0.0	0.1	0.2	-0.4	-0.1	-0.1	-0.1	-0.5	-0.2	0.2
Headache pain in last month	0.0	0.0	0.1	-0.3	-0.1	-0.1	0.1	0.1	0.2	-0.3

Hub : Genes

METTL8

Models

Trait associations