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chr7:2,032,803-3,581,391

Best TWAS P=6.94e-41 · Best GWAS P=3.16e-39 conditioned to 0.0161

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	AMZ1	0.19	0.12	enet	22	0.13	5.7e-16	6.7	8.3	7.5e-17	-0.43	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	GNA12	0.11	0.08	lasso	4	0.07	1.3e-06	-7.9	-8.8	9.9e-19	0.76	0.12	0.88	FALSE
3	GTEx	Artery Tibial	GNA12	0.24	0.13	enet	20	0.22	3.5e-17	-13.0	-11.2	6.3e-29	0.84	0.02	0.98	FALSE
4	GTEx	Cells EBV-transformed lymphocytes	GNA12	0.46	0.51	lasso	5	0.50	7.9e-19	-13.1	-13.0	8.7e-39	0.99	0.00	1.00	FALSE
5	GTEx	Cells Transformed fibroblasts	GNA12	0.21	0.11	lasso	11	0.15	1.7e-11	-13.0	-10.5	6.6e-26	0.86	0.02	0.98	FALSE
6	GTEx	Colon Sigmoid	GNA12	0.14	0.05	lasso	3	0.03	3.6e-02	-7.8	-10.7	6.4e-27	0.87	0.02	0.92	FALSE
7	GTEx	Colon Transverse	GNA12	0.19	0.08	lasso	4	0.10	2.3e-05	6.4	-7.4	1.5e-13	0.58	0.33	0.64	FALSE
8	GTEx	Esophagus Gastroesophageal Junction	GNA12	0.20	0.12	lasso	6	0.12	3.4e-05	-7.9	-10.8	2.8e-27	0.86	0.04	0.95	FALSE
9	GTEx	Esophagus Mucosa	GNA12	0.16	0.13	lasso	3	0.13	3.0e-09	-12.8	-11.7	1.4e-31	0.87	0.02	0.98	FALSE
10	GTEx	Esophagus Muscularis	GNA12	0.32	0.31	lasso	3	0.34	2.1e-21	-13.0	-12.6	1.4e-36	0.94	0.00	1.00	FALSE
11	GTEx	Lung	GNA12	0.16	0.08	enet	21	0.12	1.2e-09	-12.7	-10.4	3.3e-25	0.78	0.02	0.98	FALSE
12	GTEx	Nerve Tibial	GNA12	0.31	0.34	lasso	7	0.36	9.6e-27	-8.0	-10.5	8.7e-26	0.86	0.76	0.24	FALSE
13	GTEx	Skin Not Sun Exposed Suprapubic	GNA12	0.10	0.15	lasso	3	0.12	4.2e-07	5.8	-6.5	6.0e-11	0.54	0.32	0.66	FALSE
14	GTEx	Skin Sun Exposed Lower leg	GNA12	0.17	0.16	lasso	3	0.18	1.3e-14	-7.8	-10.5	9.7e-26	0.87	0.12	0.88	FALSE
15	GTEx	Small Intestine Terminal Ileum	GNA12	0.34	0.20	lasso	5	0.16	2.4e-04	-8.0	-8.7	5.3e-18	0.72	0.06	0.81	FALSE
16	GTEx	Stomach	GNA12	0.18	0.16	lasso	2	0.13	6.6e-07	-7.8	-7.9	3.0e-15	0.70	0.28	0.71	FALSE
17	GTEx	Whole Blood	GNA12	0.09	0.01	enet	4	0.00	3.3e-01	-12.7	-12.8	1.7e-37	0.94	0.02	0.92	FALSE
18	METSIM	Adipose	GNA12	0.07	0.05	lasso	3	0.05	3.3e-08	-8.0	-8.1	6.1e-16	0.72	0.24	0.76	FALSE
19	NTR	Blood	GNA12	0.07	0.03	bslmm	597	0.06	1.3e-17	-9.3	-9.2	2.2e-20	0.63	0.90	0.10	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	AMZ1	0.09	0.05	lasso	6	0.04	2.4e-06	-13.0	13.4	6.9e-41	-0.90	0.01	0.99	TRUE
21	YFS	Blood	GNA12	0.23	0.15	bslmm	570	0.25	4.5e-82	6.3	-8.5	1.7e-17	0.52	1.00	0.00	FALSE
22	The Cancer Genome Atlas	Esophageal Carcinoma	AMZ1	0.18	0.05	blup	69	0.05	1.4e-02	8.2	-11.4	2.5e-30	0.71	0.01	0.71	FALSE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GNA12	0.03	0.04	lasso	1	0.04	3.0e-05	-7.9	-7.9	2.4e-15	0.72	0.08	0.77	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	AMZ1	0.04	0.04	lasso	3	0.02	1.3e-03	8.2	9.4	4.7e-21	-0.60	0.03	0.91	FALSE
25	The Cancer Genome Atlas	Lung Adenocarcinoma	GNA12	0.03	0.01	enet	7	0.02	1.5e-03	5.2	-10.5	7.3e-26	0.78	0.06	0.74	FALSE
26	The Cancer Genome Atlas	Prostate Adenocarcinoma	AMZ1	0.08	0.01	blup	71	0.05	1.3e-05	-7.9	5.8	6.8e-09	-0.60	0.06	0.74	FALSE
27	The Cancer Genome Atlas	Thyroid Carcinoma	AMZ1	0.32	0.04	enet	19	0.20	3.3e-19	-9.3	5.5	3.7e-08	-0.52	0.17	0.83	FALSE