TWAS
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Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Basal metabolic rate
:
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chr7:5,753,101-7,191,181
Best TWAS P=5.08e-10 · Best GWAS P=1.5e-10 conditioned to 1
5.8M
6M
6.2M
6.4M
6.6M
6.8M
7M
7.2M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
ROSMAP
Brain Pre-frontal Cortex
DAGLB
0.09
0.06
lasso
5
0.06
4.8e-08
6.3
-6.2
5.1e-10
-0.98
0.00
1.00
TRUE
4
The Cancer Genome Atlas
Thyroid Carcinoma
DAGLB
0.06
0.02
blup
71
0.03
7.4e-04
4.6
-5.8
7.4e-09
-0.72
0.01
0.75
FALSE
3
The Cancer Genome Atlas
Breast Invasive Carcinoma
RAC1
0.03
0.02
enet
7
0.02
6.8e-05
4.2
5.5
3.7e-08
0.62
0.16
0.70
FALSE
1
ROSMAP
Brain Pre-frontal Cortex
KDELR2
0.07
0.05
lasso
2
0.05
1.4e-06
-4.6
5.2
2.7e-07
0.42
0.81
0.10
FALSE