Best TWAS P=2.64e-25 · Best GWAS P=2.64e-46 conditioned to 2.07e-23
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | RP11-446E9.1 | 0.07 | 0.00 | lasso | 6 | 0.00 | 6.6e-01 | -6.6 | 7.8 | 8.9e-15 | -0.71 | 0.04 | 0.54 | FALSE |
| 2 | GTEx | Brain Cerebellum | RPS20 | 0.26 | 0.07 | enet | 17 | 0.10 | 5.4e-04 | -9.1 | -8.1 | 7.1e-16 | 0.64 | 0.11 | 0.73 | FALSE |
| 3 | GTEx | Brain Cerebellum | RP11-446E9.1 | 0.15 | 0.05 | lasso | 3 | 0.03 | 3.7e-02 | -6.0 | 5.8 | 7.5e-09 | -0.54 | 0.06 | 0.43 | FALSE |
| 4 | GTEx | Brain Nucleus accumbens basal ganglia | RPS20 | 0.41 | 0.05 | lasso | 8 | 0.13 | 3.1e-04 | -6.5 | -6.2 | 4.7e-10 | 0.54 | 0.04 | 0.46 | FALSE |
| 5 | GTEx | Esophagus Muscularis | RPS20 | 0.12 | 0.04 | lasso | 6 | 0.05 | 7.2e-04 | -9.2 | -9.0 | 2.4e-19 | 0.81 | 0.19 | 0.69 | FALSE |
| 6 | GTEx | Muscle Skeletal | RPS20 | 0.07 | 0.09 | lasso | 1 | 0.07 | 1.5e-07 | -5.9 | -5.9 | 4.6e-09 | 0.52 | 0.90 | 0.10 | FALSE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | RPS20 | 0.18 | 0.03 | enet | 12 | 0.07 | 1.5e-04 | -8.8 | -10.4 | 2.6e-25 | 0.80 | 0.18 | 0.38 | TRUE |
| 8 | GTEx | Stomach | RP11-446E9.1 | 0.12 | 0.08 | lasso | 4 | 0.03 | 1.7e-02 | -5.5 | 5.4 | 8.1e-08 | -0.51 | 0.25 | 0.24 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | RPS20 | 0.24 | 0.20 | lasso | 6 | 0.23 | 3.4e-29 | -7.4 | -6.6 | 4.1e-11 | 0.55 | 1.00 | 0.00 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | RP11-446E9.1 | 0.23 | 0.32 | lasso | 7 | 0.34 | 2.0e-45 | -5.9 | 6.8 | 1.3e-11 | -0.56 | 1.00 | 0.00 | FALSE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RPS20 | 0.04 | 0.02 | blup | 29 | 0.03 | 4.8e-04 | -7.3 | -6.7 | 3.0e-11 | 0.51 | 0.03 | 0.03 | FALSE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RPS20 | 0.33 | 0.07 | enet | 8 | 0.07 | 1.7e-08 | -7.4 | -8.6 | 1.1e-17 | 0.52 | 0.96 | 0.03 | FALSE |
| 13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RPS20 | 0.04 | 0.03 | lasso | 3 | 0.04 | 1.3e-04 | -7.4 | -7.4 | 1.2e-13 | 0.60 | 0.15 | 0.05 | FALSE |
| 14 | The Cancer Genome Atlas | Thyroid Carcinoma | LYN | 0.09 | 0.12 | lasso | 2 | 0.12 | 8.4e-12 | -5.5 | 5.5 | 3.3e-08 | -0.53 | 1.00 | 0.00 | FALSE |