Best TWAS P=4.24e-11 · Best GWAS P=2.03e-11 conditioned to 0.0256
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 | GTEx | Testis | KIAA1429 | 0.29 | 0.22 | enet | 21 | 0.22 | 3.3e-10 | -6.4 | 6.6 | 4.2e-11 | -0.82 | 0.02 | 0.98 | TRUE |
| 5 | METSIM | Adipose | RP11-267M23.4 | 0.04 | 0.04 | lasso | 2 | 0.02 | 1.1e-04 | -6.4 | -6.4 | 1.4e-10 | 0.84 | 0.02 | 0.98 | FALSE |
| 4 | METSIM | Adipose | KIAA1429 | 0.04 | 0.03 | lasso | 7 | 0.03 | 1.8e-05 | -6.4 | 6.4 | 1.8e-10 | -0.84 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | KIAA1429 | 0.16 | 0.13 | lasso | 2 | 0.11 | 9.5e-09 | -6.4 | 6.4 | 1.9e-10 | -0.84 | 0.02 | 0.98 | FALSE |
| 1 | CommonMind | Brain Pre-frontal Cortex | KIAA1429 | 0.10 | 0.10 | lasso | 8 | 0.09 | 1.8e-11 | -6.4 | 6.3 | 2.8e-10 | -0.84 | 0.02 | 0.98 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | KIAA1429 | 0.10 | 0.05 | blup | 57 | 0.08 | 4.1e-08 | -6.4 | 6.0 | 2.0e-09 | -0.74 | 0.02 | 0.98 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | RP11-267M23.4 | 0.08 | 0.04 | bslmm | 446 | 0.03 | 2.4e-05 | -6.4 | -5.3 | 1.1e-07 | 0.70 | 0.02 | 0.98 | FALSE |
| 6 | NTR | Blood | RAD54B | 0.03 | 0.02 | lasso | 3 | 0.02 | 3.7e-06 | -5.1 | -5.2 | 1.7e-07 | 0.64 | 0.64 | 0.35 | FALSE |