TWAS hub - KIAA1429

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1000	0.0290	1.1e-07	0.097	0.073	0.068	0.088	0.094	7.8e-12	2.9e-09	9.8e-09	7.6e-11	1.8e-11
2	GTEx	Cells Transformed fibroblasts	0.1590	0.0500	5.5e-05	0.130	NA	0.088	NA	0.112	5.4e-10	NA	3.8e-07	NA	9.5e-09
3	GTEx	Testis	0.2920	0.0670	5.8e-08	0.219	NA	0.222	NA	0.215	4.6e-10	NA	3.3e-10	NA	6.3e-10
4	METSIM	Adipose	0.0364	0.0153	1.0e-03	0.035	0.024	0.026	0.025	0.031	5.3e-06	1.4e-04	6.6e-05	1.0e-04	1.8e-05
5	TCGA	Breast Invasive Carcinoma	0.0304	0.0175	1.7e-03	0.013	0.002	0.012	NA	0.007	6.9e-04	1.0e-01	1.5e-03	NA	1.3e-02
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0964	0.0443	7.2e-06	0.048	0.048	0.053	NA	0.049	4.1e-06	3.8e-06	1.2e-06	NA	3.5e-06
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.1280	0.0564	7.6e-06	0.030	0.047	0.039	NA	0.028	2.2e-04	4.5e-06	3.1e-05	NA	4.0e-04
8	TCGA	Brain Lower Grade Glioma	0.0837	0.0360	3.7e-06	0.016	0.023	0.043	NA	0.036	5.6e-03	1.1e-03	1.0e-05	NA	5.7e-05
9	TCGA	Liver Hepatocellular Carcinoma	0.1280	0.0670	7.0e-04	0.085	0.070	0.068	NA	0.066	8.2e-05	3.5e-04	4.1e-04	NA	5.1e-04
10	TCGA	Lung Adenocarcinoma	0.0964	0.0618	4.5e-04	0.007	0.035	0.026	NA	0.028	4.8e-02	5.7e-05	4.2e-04	NA	2.8e-04
11	TCGA	Lung Squamous Cell Carcinoma	0.0929	0.0398	2.0e-06	0.040	0.041	0.046	NA	0.043	2.4e-05	1.8e-05	5.6e-06	NA	9.9e-06
12	TCGA	Prostate Adenocarcinoma	0.0717	0.0362	1.3e-04	0.000	0.017	0.019	NA	0.015	2.9e-01	6.0e-03	4.2e-03	NA	1.0e-02
13	TCGA	Thyroid Carcinoma	0.1040	0.0470	1.7e-08	0.045	0.079	0.051	NA	0.054	2.9e-05	4.1e-08	9.9e-06	NA	5.1e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Impedance of arm (left)	6.2	28.7	68.4	-7.4	-7.6	-7.6	-7.6	-1.2	-1.9	-0.7	-2.1	-6.1	-1.2	-2.3	-4.8	-8.3
Impedance of arm (right)	6.1	28.3	56.2	-7.3	-7.4	-7.3	-7.4	-2.1	-2.6	-1.6	-2.8	-6.3	-1.8	-2.9	-5.0	-7.5
Pack years adult smoking proportion	5.7	8.8	19.9	4.4	4.5	4.3	4.4	0.5	1.1	0.3	1.1	3.1	0.3	1.2	2.0	4.3
Arm fat-free mass (right)	5.1	26.4	52.6	7.0	7.0	7.3	7.1	2.4	3.3	1.8	3.6	5.8	2.2	3.2	4.7	6.2
Arm predicted mass (right)	5.1	25.9	52.1	7.0	7.0	7.2	7.1	2.2	3.1	1.7	3.4	5.8	2.0	3.1	4.5	6.3
Pain type(s) experienced in last month: Hip pain	5.1	6.4	9.1	2.8	3.0	3.0	3.0	1.4	2.8	2.2	2.7	3.0	1.8	2.6	2.4	1.4
Pack years of smoking	5.1	7.6	16.9	4.0	4.1	4.0	4.1	0.5	1.1	0.1	1.0	2.8	0.5	1.2	2.1	4.0
Impedance of whole body	4.8	24.7	58.0	-6.9	-7.0	-6.8	-7.1	-1.0	-2.0	-0.7	-2.1	-5.7	-1.4	-2.3	-4.5	-7.6
Back pain experienced in last month	4.6	6.8	14.2	3.6	3.8	3.6	3.7	1.5	1.7	0.9	1.7	2.9	1.0	1.5	2.0	3.2
Arm fat-free mass (left)	4.5	22.9	47.2	6.5	6.6	6.9	6.6	2.0	2.9	1.4	3.0	5.4	2.1	2.7	4.4	6.2
Arm predicted mass (left)	4.4	22.3	47.1	6.4	6.5	6.9	6.5	1.9	2.7	1.2	2.8	5.3	2.0	2.5	4.4	6.3
Leg fat mass (left)	4.3	17.0	37.8	5.3	5.4	6.1	5.5	1.6	2.7	0.8	2.3	4.6	2.5	2.2	4.3	5.4
Relative age of first facial hair	4.1	8.4	19.0	-4.0	-4.2	-4.4	-4.3	-0.9	-1.5	-0.8	-1.7	-3.1	-0.8	-1.5	-2.4	-3.7
Body mass index (BMI)	4.1	17.7	37.7	5.4	5.6	6.1	5.6	1.5	2.5	0.7	1.9	4.7	2.5	2.0	4.5	6.0
Hip circumference	4.1	17.8	39.9	5.9	6.0	6.3	6.0	0.6	2.4	0.1	2.3	4.3	1.9	2.1	3.8	5.7
Leg fat mass (right)	4.1	15.7	36.0	5.0	5.1	6.0	5.2	1.7	2.7	0.7	2.2	4.4	2.6	2.0	4.3	5.1
BMI	3.9	22.4	46.3	6.5	6.7	6.8	6.7	1.4	2.5	1.2	2.5	5.4	1.7	2.6	4.1	6.5
Waist circumference	3.9	14.2	29.3	4.7	4.9	5.4	5.0	2.1	2.6	0.9	2.1	4.2	2.6	1.9	4.2	4.8
Number of live births	3.9	5.5	12.6	0.4	0.5	1.2	0.7	3.3	2.9	2.8	2.7	2.4	3.3	2.4	3.5	-0.3
Trunk predicted mass	3.8	21.5	44.8	6.4	6.4	6.7	6.4	1.8	2.8	1.4	2.9	5.3	1.9	2.6	4.1	6.0
Tinnitus: Yes, but not now, but have in the past	3.7	4.0	7.7	2.1	1.9	1.6	1.9	1.4	1.9	2.4	2.3	2.8	1.3	2.2	2.3	1.0
Trunk fat-free mass	3.7	21.4	44.5	6.4	6.4	6.7	6.4	1.8	2.8	1.5	3.0	5.3	1.9	2.7	4.1	5.9
Whole body water mass	3.7	21.2	43.2	6.4	6.5	6.6	6.5	1.5	2.6	1.2	2.9	5.1	1.7	2.6	3.9	6.0
Basal metabolic rate	3.7	20.6	43.6	6.3	6.4	6.6	6.4	1.4	2.6	1.1	2.7	5.0	1.8	2.5	3.9	6.0
Weight	3.6	17.5	39.1	5.7	5.8	6.3	5.8	1.2	2.6	0.7	2.4	4.5	2.1	2.2	3.9	5.5
Whole body fat-free mass	3.6	20.7	42.5	6.4	6.4	6.5	6.4	1.5	2.6	1.2	2.8	5.1	1.7	2.6	3.9	6.0
Hearing difficulty/problems with background noise	3.5	5.6	9.7	-2.9	-2.8	-2.5	-2.7	-1.5	-2.3	-2.1	-3.1	-2.7	-1.1	-2.9	-1.7	-1.0
Current tobacco smoking	3.4	5.6	14.7	3.5	3.4	3.4	3.4	-0.0	0.7	0.3	0.5	2.7	-0.1	0.6	1.5	3.8
Smoking status: Current	3.4	5.4	14.8	3.4	3.4	3.5	3.4	-0.3	0.4	0.0	0.4	2.5	-0.4	0.5	1.3	3.9
Neuroticism (2016)	3.3	4.8	14.8	-1.0	-1.2	-1.5	-1.3	-3.9	-2.3	-2.8	-2.1	-3.0	-1.7	-1.9	-2.8	-0.6
Worry too long after embarrassment	3.3	5.5	9.7	-3.1	-3.1	-3.0	-3.1	-2.0	-1.9	-1.5	-2.0	-2.6	-1.4	-1.7	-1.9	-2.3
Primary Biliary Cirrhosis	3.2	4.6	9.6	0.8	0.8	0.2	0.7	2.4	2.8	2.8	3.1	2.0	2.7	3.0	2.4	-0.8
Medication: Atenolol	3.2	4.0	8.0	2.2	2.5	2.8	2.5	0.8	2.1	1.2	2.2	2.2	1.3	1.9	1.9	1.1
Nervous feelings	3.2	6.0	15.2	-3.7	-3.7	-3.9	-3.7	-0.1	-0.9	-0.4	-1.1	-2.5	0.2	-1.0	-1.1	-3.4
Loneliness, isolation	3.2	4.4	9.7	3.1	3.1	2.7	3.1	0.5	1.4	0.2	1.6	1.8	1.3	1.6	2.0	2.3
Leg fat-free mass (left)	3.0	15.7	32.2	5.6	5.7	5.7	5.6	1.1	2.3	0.8	2.5	4.3	1.6	2.3	3.3	5.2
Leg predicted mass (left)	3.0	15.9	32.1	5.5	5.7	5.7	5.6	1.2	2.4	0.9	2.6	4.4	1.6	2.4	3.4	5.1
Leg predicted mass (right)	3.0	15.9	34.1	5.7	5.8	5.6	5.8	0.9	2.2	0.9	2.5	4.3	1.2	2.4	3.0	5.3
Leg fat-free mass (right)	2.9	15.8	33.6	5.7	5.8	5.6	5.7	0.8	2.1	0.9	2.5	4.3	1.2	2.4	3.0	5.3
Chronic bronchitis/emphysema (father)	2.8	3.2	9.4	1.6	1.8	2.0	1.8	-2.0	-1.4	-1.9	-1.9	0.2	-1.6	-1.8	-0.5	3.1
Smoking Status	2.7	6.4	14.2	3.8	3.6	3.8	3.6	-0.3	1.5	0.3	1.4	2.7	0.5	1.4	1.9	3.2
Friendships satisfaction	2.7	3.4	9.2	-3.0	-3.0	-2.3	-2.9	-0.2	-0.8	-0.2	-1.0	-1.7	0.1	-1.0	-0.7	-2.4
Medication: Co-codamol	2.6	3.1	8.5	2.9	2.9	2.0	2.8	-1.6	0.0	-0.7	0.8	1.1	-0.8	1.1	-0.1	2.1
Alcohol intake versus 10 years previously	2.6	3.9	12.4	2.5	2.4	2.4	2.4	-0.9	-1.7	-1.6	-1.3	1.0	-2.2	-1.4	-0.3	3.5
Arm fat mass (left)	2.6	10.7	23.3	4.1	4.3	4.8	4.3	1.3	2.3	0.6	1.7	3.5	2.4	1.7	3.6	4.3
Leg fat percentage (left)	2.6	9.5	23.4	3.8	3.9	4.8	4.0	1.0	1.7	0.0	1.0	3.3	1.9	1.1	3.4	4.5
Average weekly beer plus cider intake	2.6	3.7	11.2	2.6	2.6	2.9	2.6	0.4	0.4	-0.0	0.4	2.2	0.3	0.2	1.7	3.4
Arm fat mass (right)	2.5	10.3	22.9	4.0	4.2	4.8	4.2	1.2	2.2	0.5	1.6	3.5	2.3	1.6	3.5	4.3
Whole body fat mass	2.5	10.5	23.9	4.1	4.3	4.9	4.3	1.2	2.3	0.6	1.9	3.5	2.2	1.8	3.4	4.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	2.9	6.1	-1.0	-1.2	-1.0	-1.2	-2.3	-2.2	-2.5	-2.0	-1.8	-1.9	-1.4	-1.8	-0.1
Bilateral oophorectomy (both ovaries removed)	2.4	2.8	3.8	1.9	1.8	2.0	1.9	1.3	1.8	1.3	1.9	1.9	1.2	1.6	1.7	1.1
Exposure to tobacco smoke outside home	2.4	3.2	4.5	1.9	2.1	1.8	2.1	1.1	2.0	1.9	2.1	2.1	1.2	2.0	1.5	0.8
Emphysema/chronic bronchitis	2.4	2.7	5.2	-2.0	-2.0	-2.0	-2.0	-0.8	-1.2	-1.2	-1.5	-2.3	-0.7	-1.4	-1.8	-1.5
Wears glasses or contact lenses	2.4	2.7	5.9	-2.4	-2.2	-2.0	-2.2	-0.7	-0.9	-1.3	-1.7	-2.2	0.3	-1.5	-1.0	-1.4
Lupus	2.3	3.5	8.9	-0.7	-0.6	-1.3	-0.8	-2.8	-2.1	-1.9	-2.0	-2.1	-2.4	-1.7	-3.0	-0.2
Impedance of leg (right)	2.3	11.4	28.4	-4.9	-5.1	-4.3	-5.0	-0.0	-1.1	-0.3	-1.4	-3.6	-0.6	-1.7	-2.5	-5.3
Hair/balding pattern: Pattern 2	2.3	3.0	5.1	1.7	2.0	1.9	2.0	2.0	1.7	1.0	1.7	1.6	1.8	1.4	2.3	1.0
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.6	4.1	-1.9	-1.7	-2.0	-1.8	-1.5	-1.9	-1.2	-1.4	-1.7	-1.7	-1.0	-1.9	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.8	5.6	1.9	2.1	1.8	2.0	-2.0	-1.2	-2.0	-1.1	0.1	-1.7	-1.1	-0.7	2.4
Leg fat percentage (right)	2.1	7.6	19.8	3.2	3.3	4.5	3.5	1.1	1.7	-0.0	0.8	3.0	2.0	0.8	3.4	4.0
Worry (Nagel 2018)	2.0	4.2	10.1	-2.9	-2.9	-3.2	-2.9	-0.5	-0.9	-0.7	-1.2	-2.5	0.1	-1.1	-1.2	-2.8
Coronary Artery Disease (CAD)	2.0	2.4	5.5	-2.1	-2.3	-1.6	-2.3	-1.4	-0.5	-0.3	-0.7	-1.7	-0.3	-0.9	-1.4	-2.2
Impedance of leg (left)	2.0	9.8	24.4	-4.4	-4.5	-4.0	-4.5	-0.3	-1.3	-0.3	-1.2	-3.4	-1.0	-1.5	-2.7	-4.9
Qualifications: College or University degree	2.0	6.3	18.4	-3.5	-3.5	-4.3	-3.7	0.1	-0.4	0.6	-0.0	-2.4	0.4	0.4	-1.4	-4.1
Age at last live birth	2.0	2.9	4.5	-2.0	-1.9	-1.6	-1.9	-1.6	-1.5	-1.6	-1.6	-2.1	-1.2	-1.6	-1.7	-1.6
Allergy	1.9	4.4	10.1	3.0	3.1	2.1	2.9	-2.2	-1.2	-1.5	-0.4	0.5	-2.1	0.0	-1.2	3.2
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.0	4.2	2.0	1.9	2.1	1.9	0.6	1.0	0.7	1.1	1.7	0.5	0.9	1.1	1.5
Sensitivity / hurt feelings	1.8	3.1	7.8	-2.4	-2.4	-2.8	-2.5	-1.1	-1.1	-0.7	-1.2	-2.1	-0.1	-0.7	-1.3	-1.9
Severe depression (siblings)	1.8	2.0	5.8	-2.2	-2.0	-2.0	-2.0	0.4	0.6	0.6	0.2	-1.0	1.1	-0.0	-0.1	-2.4
Age started oral contraceptive pill	1.8	2.3	4.9	-1.8	-1.9	-2.2	-2.0	-1.1	-1.3	-1.2	-1.4	-1.9	-0.5	-1.0	-1.2	-1.3
Unable to work because of sickness or disability	1.8	2.3	7.0	2.2	2.3	2.6	2.4	-0.2	0.1	-0.4	0.2	1.1	-0.1	0.1	0.8	2.3
Heart disease (siblings)	1.8	2.2	4.4	-1.5	-1.4	-0.6	-1.3	2.1	1.6	2.1	1.2	0.6	1.8	1.1	1.2	-1.8
Hayfever, allergic rhinitis or eczema	1.7	3.7	10.2	-2.8	-2.9	-2.2	-2.7	1.7	1.0	1.1	0.6	-0.8	1.9	0.1	0.9	-3.2
Qualifications: A levels/AS levels or equivalent	1.7	3.8	9.3	-2.8	-2.9	-3.0	-2.9	0.3	-1.0	-0.1	-0.8	-2.0	-0.4	-0.8	-1.3	-2.6
Illnesses of father: Heart disease	1.7	2.4	5.7	-2.4	-2.2	-2.2	-2.2	-0.5	-0.4	-0.5	-0.5	-1.9	0.3	-0.1	-0.9	-2.4
Bipolar Disorder (2011)	1.6	1.6	3.3	-1.8	-1.7	-1.6	-1.7	-1.1	-0.8	-0.1	-0.9	-1.0	-0.8	-0.9	-1.2	-1.4
Neuroticism	1.6	3.9	6.8	-2.3	-2.3	-2.6	-2.3	-1.8	-1.4	-1.2	-1.6	-2.6	-1.0	-1.4	-2.3	-2.1
Ever had hysterectomy (womb removed)	1.6	1.8	5.6	2.0	2.1	1.3	2.0	-0.1	-0.5	-0.4	-0.4	1.0	-1.3	-0.3	-0.3	2.4
Prospective memory result	1.6	2.0	5.4	1.9	2.3	1.8	2.3	1.0	1.0	1.0	1.0	1.4	0.2	0.6	0.5	1.4
Lung cancer (father)	1.6	1.8	4.3	0.2	-0.0	-0.1	-0.1	-1.6	-1.9	-2.1	-1.5	-1.5	-1.8	-1.5	-1.7	0.5
Birth weight of first child	1.6	2.9	4.4	-1.1	-1.4	-1.4	-1.4	-2.1	-2.1	-2.1	-1.8	-2.1	-1.8	-1.5	-2.1	-0.6
Illnesses of siblings: Diabetes	1.6	2.0	4.8	0.6	0.7	0.1	0.7	1.3	2.1	1.7	2.2	0.8	2.1	2.0	1.2	-0.7
Long-standing illness, disability or infirmity	1.6	2.5	6.8	2.3	2.6	2.3	2.5	-0.5	0.7	0.5	0.7	1.6	-0.0	0.9	0.7	1.9
Body Mass Index (BMI) (2010)	1.5	2.1	5.4	2.2	2.2	1.9	2.2	0.6	0.4	0.1	0.4	1.4	0.1	0.5	0.5	2.3
Ulcerative Colitis	1.5	2.2	4.3	0.9	0.9	1.1	0.9	1.0	2.1	1.8	1.8	1.9	1.8	1.6	1.9	0.2
Trunk fat mass	1.5	6.6	16.2	3.3	3.5	4.0	3.5	0.7	1.7	0.1	1.2	2.5	1.8	1.2	2.6	3.4
Medication: Amlodipine	1.5	2.1	6.2	2.4	2.5	1.7	2.4	-0.7	-0.2	-0.7	0.2	0.7	-0.6	0.3	-0.2	2.2
Osteoarthritis (self-reported)	1.5	2.0	7.1	1.8	1.9	1.2	1.8	-0.7	-1.2	-0.9	-1.0	0.7	-1.4	-0.6	-0.2	2.7
Average weekly champagne plus white wine intake	1.5	2.1	5.0	-1.9	-1.9	-2.2	-1.9	-1.5	-0.4	0.0	-0.3	-1.4	-0.4	-0.1	-1.4	-2.2
Commuting to job workplace: Cycle	1.5	1.8	3.5	-1.6	-1.5	-1.7	-1.6	-1.1	-1.0	-0.6	-1.0	-1.6	-0.9	-1.0	-1.9	-1.4
Depression (Nagel 2018)	1.4	2.2	6.0	1.2	1.3	1.4	1.3	-1.7	-1.3	-2.5	-1.6	-0.3	-1.1	-1.5	-0.1	2.1
Ulcerative Colitis (UC)	1.4	2.6	4.1	1.7	1.7	1.4	1.8	0.5	1.8	1.4	1.9	2.0	1.6	1.7	2.0	0.9
Allergy or Eczema	1.3	3.3	9.1	-3.0	-3.0	-2.1	-2.9	1.0	0.3	0.1	-0.4	-1.2	1.4	-0.6	0.6	-2.7
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.0	6.2	1.4	1.6	1.8	1.7	-1.7	-1.8	-2.5	-1.6	-0.1	-2.0	-1.6	-0.5	2.5
Ever highly irritable/argumentative for 2 days	1.3	1.5	3.9	0.9	0.9	0.5	0.9	0.7	1.1	2.0	1.4	1.8	0.9	1.8	1.4	0.5
Suffer from ‘nerves’	1.3	2.1	4.6	-2.1	-2.1	-1.8	-2.1	-0.4	-0.8	-1.0	-1.2	-1.7	-0.0	-1.3	-0.7	-1.6
Medication: Gliclazide	1.3	1.4	4.4	-0.8	-0.7	-0.0	-0.6	1.5	1.7	2.1	1.2	0.9	1.5	0.7	1.1	-1.2
Illnesses of father: High blood pressure	1.3	1.6	2.5	1.3	1.0	1.5	1.0	1.1	1.3	1.4	1.3	1.6	1.1	1.4	1.3	0.8
LDL Cholesterol	1.2	1.9	4.8	-2.2	-2.1	-1.6	-2.2	-1.0	-0.2	0.5	-0.7	-0.9	-0.4	-0.4	-1.0	-2.1
Blood Red Count	1.2	11.8	20.6	4.5	4.4	4.5	4.4	2.4	2.5	2.5	2.6	4.3	1.4	2.3	2.9	3.7
Relative age voice broke	1.2	1.8	4.9	-2.2	-2.2	-1.5	-2.2	0.0	0.0	0.4	-0.4	-0.9	0.0	-0.4	-0.7	-2.2
High blood pressure (mother)	1.2	1.6	3.0	0.8	0.7	0.9	0.8	1.7	1.5	1.6	1.6	1.4	1.3	1.6	1.4	0.1
Worrier / anxious feelings	1.2	2.3	6.2	-2.0	-1.9	-2.5	-2.0	-0.9	-0.9	-0.8	-0.7	-1.8	-0.4	-0.6	-1.1	-2.0
Hair/balding pattern: Pattern 3	1.2	1.7	3.2	-0.5	-0.5	-0.8	-0.5	-1.4	-1.8	-1.5	-1.8	-1.2	-1.7	-1.7	-1.7	0.6
Wheeze or whistling in the chest in last year	1.2	2.1	3.8	1.1	1.2	1.5	1.2	0.9	1.9	1.6	1.6	1.8	1.4	1.6	1.8	0.1
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	2.8	0.9	0.8	1.2	0.8	0.8	1.5	1.3	1.7	1.5	1.1	1.6	1.6	0.1
Smoking status: Previous	1.2	1.8	5.1	-0.1	-0.2	0.4	-0.1	1.0	2.2	1.1	1.8	0.8	2.3	1.7	1.8	-1.2
Guilty feelings	1.2	1.8	3.3	-1.3	-1.3	-1.4	-1.3	-1.5	-1.2	-1.5	-1.6	-1.8	-0.8	-1.4	-1.4	-0.8
Medication: Blood pressure	1.2	2.3	4.3	-0.9	-0.8	-0.8	-0.9	-1.8	-2.0	-1.9	-2.0	-1.8	-1.5	-1.8	-2.1	0.3
Alcohol drinker status: Never	1.2	1.4	3.7	1.6	1.9	1.5	1.9	1.0	0.4	0.8	0.7	1.4	-0.4	0.5	0.3	1.4
Townsend deprivation index at recruitment	1.1	1.6	4.8	2.0	2.2	1.6	2.1	0.0	0.1	-0.4	0.5	0.5	0.1	0.5	0.4	1.8
Number of incorrect matches in round	1.1	1.8	4.1	-0.8	-0.8	-0.9	-0.9	-1.2	-2.0	-1.0	-2.0	-1.1	-1.9	-1.6	-1.7	0.1
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	5.8	-1.5	-1.5	-0.8	-1.4	1.0	1.3	0.9	1.0	-0.2	1.2	0.4	0.7	-2.4
Mouth/teeth dental problems: Dentures	1.1	1.9	5.4	1.5	1.6	2.3	1.7	0.7	1.5	1.0	0.7	1.7	0.8	0.6	1.4	1.3
Pulse wave peak to peak time	1.1	1.3	4.1	1.3	0.9	1.1	1.1	2.0	0.9	0.9	1.3	1.1	0.8	0.8	1.1	0.6
Number of full sisters	1.1	1.3	3.4	0.7	0.6	1.4	0.7	1.2	1.4	0.8	1.2	1.2	1.7	1.0	1.8	0.4
Overall health rating	1.1	2.3	6.8	1.8	1.9	1.7	1.8	-2.2	-0.9	-1.7	-1.1	0.2	-0.9	-0.6	-0.1	2.6
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.6	1.5	1.6	1.3	1.6	0.4	1.1	0.4	0.8	1.1	1.0	0.9	0.9	1.3
Knee pain experienced in last month	1.1	1.7	3.2	1.0	1.2	1.2	1.2	1.2	1.6	1.4	0.7	1.8	1.5	0.7	1.7	1.0
Arm fat percentage (left)	1.1	4.4	8.8	2.2	2.3	3.0	2.4	1.1	1.9	0.5	1.1	2.2	2.4	1.2	2.7	2.5
Ever had prostate specific antigen (PSA) test	1.1	1.3	3.4	-1.5	-1.4	-1.9	-1.5	-0.2	-1.0	-0.7	-0.9	-1.6	0.0	-0.7	-0.8	-0.9
Pain experienced in last month	1.1	1.8	3.1	-1.1	-1.3	-0.8	-1.3	-1.5	-1.7	-1.3	-1.3	-1.4	-1.8	-1.3	-1.4	-0.7
Alzheimer’s Disease (in mother)	1.0	1.1	2.0	1.3	1.4	1.0	1.4	1.0	0.7	1.0	0.8	1.3	0.6	0.7	0.9	1.2
Mean Putamen Volume	1.0	1.1	2.7	-0.7	-0.8	-0.7	-0.7	1.6	1.1	1.1	1.0	0.6	1.6	1.0	1.2	-0.8
Medication: Metformin	1.0	1.4	3.7	-0.4	-0.4	0.2	-0.3	1.4	1.5	1.9	1.4	0.7	1.6	1.3	1.0	-1.1
Past tobacco smoking	1.0	1.8	4.3	-0.7	-0.6	-1.1	-0.7	-0.6	-2.1	-1.1	-1.8	-1.3	-1.9	-1.8	-1.9	0.3
Arm fat percentage (right)	1.0	3.8	8.3	2.1	2.2	2.9	2.3	0.7	1.7	0.2	0.8	2.0	2.2	1.0	2.6	2.6
Medication: Lansoprazole	1.0	1.1	2.8	-0.2	-0.2	-0.2	-0.3	-0.9	-1.6	-1.3	-1.5	-0.9	-1.7	-1.3	-1.3	0.4
Alcohol intake frequency.	1.0	2.2	6.0	2.0	2.1	2.4	2.1	1.1	0.5	0.2	0.2	1.5	0.3	-0.2	1.0	2.4
Chest pain or discomfort	1.0	1.4	3.4	1.8	1.8	1.8	1.7	-1.2	0.1	-0.1	0.3	1.0	-0.7	0.7	0.1	1.4
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.6	0.8	0.9	0.8	0.9	1.2	1.4	0.8	1.6	0.9	1.1	1.3	1.2	-0.1
Qualifications: nursing, teaching	1.0	1.5	3.8	-1.9	-1.8	-1.7	-1.8	0.9	-0.1	0.1	-0.5	-1.2	0.6	-0.6	-0.4	-1.7
Medication for cholesterol	1.0	1.5	3.5	0.4	0.3	0.3	0.4	1.9	1.5	1.4	1.6	1.2	1.5	1.3	1.8	-0.4
Number of self-reported non-cancer illnesses	1.0	1.7	4.7	0.7	0.8	1.5	0.8	1.1	1.6	1.1	1.3	1.6	1.6	1.2	2.2	0.4
Eye problems/disorders: Glaucoma	1.0	1.2	2.6	-0.3	-0.4	-0.9	-0.5	-1.4	-1.2	-1.3	-1.5	-1.2	-1.1	-1.3	-1.6	0.3
Ever smoked	1.0	1.8	4.6	0.2	0.3	0.4	0.3	0.8	2.1	1.4	1.7	1.3	2.0	1.6	1.9	-0.5
Alcohol drinker status: Previous	1.0	1.1	3.2	-1.1	-1.2	-0.5	-1.1	1.8	1.0	0.4	0.4	-0.3	1.8	-0.0	1.0	-1.2
Verbal and Numeric Reasoning (VNR)	0.9	2.2	5.4	-2.0	-2.3	-1.7	-2.2	1.4	0.9	0.9	0.3	-0.4	1.2	0.3	0.6	-2.3
Prostate Cancer	0.9	1.3	2.6	1.3	1.2	0.9	1.1	0.2	1.5	1.1	1.6	1.3	1.0	1.6	0.9	0.2
Fasting Glucose	0.9	1.0	2.7	0.8	1.0	1.1	1.1	0.7	1.6	1.4	0.9	1.0	1.1	0.6	0.8	0.2
HbA1C	0.9	1.0	2.6	-0.3	-0.7	-0.3	-0.7	-1.6	-1.5	-1.2	-1.2	-0.5	-1.6	-0.3	-0.9	0.4
Number of treatments/medications taken	0.9	1.7	5.7	1.5	1.5	2.4	1.5	0.5	1.2	0.6	0.7	1.4	1.0	0.8	1.3	1.3
Ever used hormone-replacement therapy (HRT)	0.9	1.2	3.1	0.7	0.7	0.1	0.6	1.0	1.3	1.7	1.8	0.9	0.9	1.7	0.7	-0.5
Qualifications: CSEs or equivalent	0.9	1.1	2.7	1.6	1.6	1.5	1.5	-0.6	-0.2	-0.1	0.4	0.9	-1.2	0.1	-0.4	1.3
Neuroticism score	0.9	1.8	2.8	-1.1	-1.1	-1.6	-1.1	-1.5	-1.4	-1.4	-1.3	-1.7	-1.2	-1.2	-1.6	-0.8
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	3.3	-1.6	-1.8	-1.7	-1.8	0.4	-0.0	0.5	-0.2	-0.8	0.3	0.0	-0.3	-1.5
Chronic bronchitis/emphysema (mother)	0.9	1.0	3.2	-1.4	-1.5	-0.5	-1.4	0.3	1.0	-0.0	0.2	-0.7	1.8	-0.1	0.7	-1.4
Body fat percentage	0.9	3.6	9.1	2.2	2.3	3.0	2.4	0.6	1.4	-0.1	0.7	1.9	1.9	0.7	2.4	2.6
Age at first live birth	0.9	1.7	2.2	-1.3	-1.5	-1.1	-1.5	-1.1	-1.3	-1.1	-1.3	-1.4	-1.3	-1.2	-1.5	-1.0
Shortness of breath walking on level ground	0.9	1.0	3.3	-0.6	-0.5	0.2	-0.3	1.0	1.3	1.3	0.5	1.2	1.7	0.6	1.8	-0.1
Medication: Lisinopril	0.9	1.2	2.9	-1.7	-1.6	-1.4	-1.6	-0.3	-0.9	-0.4	-0.8	-1.2	-0.1	-0.7	-0.7	-1.1
Depressed Affect (Nagel 2018)	0.8	1.7	4.1	2.0	2.0	1.8	2.0	-0.4	0.1	-0.3	0.2	1.1	-0.1	0.4	0.8	2.0
Angina	0.8	1.1	2.9	1.1	1.4	1.3	1.2	-1.1	0.7	0.7	1.3	1.1	-0.1	1.7	0.3	0.3
Medication: Levothyroxine sodium	0.8	1.4	3.6	1.6	1.9	1.9	1.8	-0.2	0.7	0.1	0.9	1.2	-0.0	0.7	0.6	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	5.8	0.1	0.2	-0.4	0.1	-2.4	-1.3	-1.5	-1.1	-1.1	-1.3	-0.7	-1.4	0.2
Pulse wave Arterial Stiffness index	0.8	0.9	3.8	-1.0	-0.7	-0.9	-0.8	-2.0	-0.7	-0.8	-1.0	-0.9	-0.7	-0.7	-1.0	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.7	1.6	1.6	1.5	1.6	-0.7	0.3	0.0	0.6	1.2	-0.0	0.6	1.0	1.2
Glaucoma (self-reported)	0.8	0.9	2.1	-1.3	-1.5	-1.3	-1.4	-0.2	-0.3	-0.2	-0.8	-1.1	0.4	-0.9	-0.6	-0.8
Angina (self-reported)	0.8	1.0	2.4	1.1	1.4	1.4	1.2	-1.1	0.6	0.6	1.2	1.0	-0.2	1.5	0.4	0.4
Mood swings	0.8	1.5	3.7	-0.4	-0.3	-0.7	-0.3	-1.9	-1.6	-1.4	-1.3	-1.2	-1.8	-1.0	-1.7	-0.1
Hearing aid user	0.8	0.9	1.7	0.7	0.5	0.9	0.6	1.1	1.0	1.1	1.1	1.3	0.8	1.0	1.3	0.2
Number of operations (self-reported)	0.8	1.2	3.6	0.9	0.8	0.6	0.8	0.3	1.4	1.9	1.5	1.3	0.6	1.5	0.6	-0.2
Intelligence (Savage-Jansen 2018)	0.7	2.0	5.3	-2.2	-2.3	-2.0	-2.3	1.1	-0.0	0.2	-0.2	-1.1	0.8	-0.2	0.2	-1.9
Schizophrenia vs Biploar Disorder	0.7	1.0	1.6	1.1	1.1	0.9	1.1	1.0	1.1	1.0	1.2	0.7	1.0	1.3	0.7	0.4
Irritable Bowel Disease (IBD)	0.7	1.6	3.1	1.0	1.1	1.1	1.1	0.3	1.6	1.2	1.8	1.4	1.4	1.6	1.6	0.2
Triglycerides	0.7	1.1	2.8	0.2	0.1	1.1	0.2	0.8	1.5	0.9	1.2	0.9	1.7	1.0	1.7	-0.2
Hearing difficulty/problems: Yes	0.7	1.1	2.5	-0.9	-0.7	-0.9	-0.7	-1.6	-1.4	-1.4	-1.6	-0.9	-0.9	-1.1	-0.6	0.3
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.6	0.2	0.3	1.3	0.4	-0.2	0.9	1.0	0.8	1.6	0.5	1.0	1.4	0.2
Serious illness, injury or assault to yourself	0.7	0.9	2.9	0.7	0.8	0.3	0.7	-1.1	-1.2	-0.4	-1.0	0.0	-1.7	-0.5	-1.0	1.2
Had other major operations	0.7	0.9	2.1	1.3	1.1	0.8	1.0	0.2	1.2	1.4	1.1	0.7	0.4	1.1	-0.1	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	4.8	0.9	1.1	1.2	1.1	-1.6	-1.3	-2.2	-1.3	-0.4	-1.1	-1.2	-0.3	1.9
Medication: Ramipril	0.7	0.9	2.1	1.4	1.4	1.3	1.4	-0.5	-0.7	-0.3	0.1	0.7	-0.9	0.7	0.1	1.4
Depression (self-reported)	0.7	0.8	2.1	1.2	1.2	1.1	1.3	-0.9	-0.1	-0.9	-0.1	0.6	-0.2	0.1	0.8	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.4	-0.0	0.0	0.5	0.0	-0.9	-1.1	-1.5	-1.6	-0.6	-0.7	-1.2	-0.5	1.1
Comparative height size at age 10	0.7	4.0	9.9	3.1	3.1	2.8	3.0	-0.1	0.8	0.9	1.6	2.0	-0.5	1.5	0.6	2.0
Had major operations	0.7	0.8	2.1	-1.4	-1.2	-1.5	-1.2	0.3	0.0	1.1	0.2	-0.1	0.1	0.3	-0.2	-1.2
Neuroticism (Nagel 2018)	0.6	1.4	2.8	-1.6	-1.6	-1.7	-1.5	-0.9	-0.9	-0.9	-1.0	-1.5	-0.1	-0.8	-0.6	-1.2
Average weekly spirits intake	0.6	0.7	1.8	0.5	0.4	0.9	0.4	0.4	1.4	1.0	1.0	0.8	1.3	0.8	1.1	0.0
Systolic blood pressure, automated reading	0.6	1.7	4.1	-1.9	-2.0	-1.6	-2.0	1.4	0.0	0.1	0.4	-0.8	1.1	0.5	0.5	-1.8
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.4	0.7	0.7	0.0	0.6	-0.4	0.9	1.5	1.3	0.6	0.3	1.6	-0.0	-0.6
Happiness	0.6	0.7	1.7	-0.5	-0.5	-0.2	-0.4	1.0	1.2	1.3	0.9	0.4	1.1	0.7	0.6	-1.3
Asthma	0.6	1.2	2.8	-1.2	-1.3	-0.1	-1.2	1.6	1.2	1.7	0.4	0.8	1.2	0.1	1.2	-1.2
Medication: Cholesterol lowering	0.6	0.9	2.0	-0.2	0.0	0.9	0.1	0.5	1.4	1.3	1.2	0.9	1.2	1.1	1.2	-0.6
Exposure to tobacco smoke at home	0.6	0.7	2.8	1.1	1.2	1.7	1.2	-0.5	0.2	-0.1	0.0	0.8	-0.4	-0.1	0.3	1.1
Pulse wave reflection index	0.6	0.8	2.0	-0.5	-0.2	-0.3	-0.2	-1.4	-1.2	-1.4	-1.3	-0.5	-0.9	-1.1	-0.3	0.5
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.1	-1.3	-1.4	-0.5	-1.3	0.3	-0.2	-0.5	-1.0	-1.0	0.6	-1.2	-0.0	-0.7
High blood pressure (siblings)	0.6	0.9	1.8	-1.3	-1.3	-0.5	-1.3	-0.1	-1.0	-1.0	-1.0	-1.0	-0.4	-0.8	-0.4	-0.8
Health satisfaction	0.6	0.8	1.7	0.5	0.7	0.6	0.7	0.3	1.3	1.1	0.9	1.0	1.3	1.2	1.2	0.2
Medication for pain relief, constipation, heartburn	0.6	1.0	1.9	-0.5	-0.6	-1.1	-0.6	-1.1	-1.4	-1.1	-1.2	-1.1	-1.2	-0.9	-1.1	-0.1
Heart disease (mother)	0.6	0.7	2.1	-0.8	-0.8	-1.2	-0.9	-0.3	0.4	0.7	0.8	-0.4	0.8	1.1	0.1	-1.4
Ever taken oral contraceptive pill	0.6	0.7	1.7	1.2	1.0	0.7	1.0	-1.3	-0.3	-1.0	-0.1	-0.1	-0.8	-0.1	-0.6	0.8
Mother’s age at death	0.6	0.8	3.0	-1.3	-1.1	-1.3	-1.1	0.2	0.4	0.5	0.1	-0.8	0.4	0.2	-0.5	-1.7
Breast Cancer	0.5	1.2	3.4	0.1	0.4	0.6	0.4	0.3	1.6	0.6	1.6	0.8	1.8	1.4	1.7	-0.3
HDL Cholesterol	0.5	0.8	1.7	-1.1	-1.0	-1.3	-1.0	0.1	-0.3	0.7	-0.6	-0.5	-0.8	-0.7	-1.3	-1.0
Waist Hip Ratio (WHR)	0.5	2.3	7.4	-1.7	-1.9	-1.4	-1.7	2.7	0.9	1.6	0.4	-0.2	1.7	0.2	1.0	-1.9
Systolic Blood Pressure	0.5	2.6	7.9	-2.2	-2.5	-2.2	-2.5	0.3	-0.7	-0.0	0.4	-1.5	-0.3	0.6	-0.8	-2.8
Respiratory disease	0.5	1.1	2.7	-1.1	-1.0	0.2	-0.8	1.6	1.1	1.6	0.4	1.0	1.0	0.2	1.4	-0.9
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.7	1.0	1.2	0.9	1.2	-1.0	-0.2	-0.9	-0.4	0.3	-0.2	-0.3	0.4	1.3
Supplements: Zinc	0.5	0.6	2.1	-0.5	-0.3	-0.4	-0.3	1.5	0.8	0.6	0.6	0.1	1.4	0.4	1.0	-0.6
Diabetes (father)	0.5	0.6	1.2	1.1	1.1	0.8	1.0	0.2	0.7	0.9	1.0	0.6	0.1	1.0	-0.0	0.2
Fed-up feelings	0.5	0.9	2.1	1.4	1.4	1.4	1.4	-0.5	0.3	0.2	0.1	1.2	-0.3	0.2	0.5	1.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.5	1.9	0.6	0.5	0.7	0.6	-0.0	-0.7	-1.4	-0.7	-0.1	-0.1	-0.8	0.5	1.4
Alcohol usually taken with meals	0.5	0.8	2.7	-1.5	-1.2	-1.3	-1.2	0.2	0.2	0.6	0.2	-0.5	0.3	0.1	-0.2	-1.6
Financial difficulties in last 2 years	0.5	0.7	2.0	-0.1	0.2	0.7	0.2	-0.7	-0.8	-1.2	-1.4	-0.3	-0.4	-1.4	-0.1	1.1
Father’s age at death	0.5	0.7	1.8	1.1	1.3	0.7	1.3	-0.7	-0.5	-0.4	0.2	0.4	-1.1	0.2	-0.4	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	4.0	2.0	2.0	1.6	2.0	0.1	0.4	-0.1	1.0	1.1	-0.1	0.7	0.5	1.5
Length of working week for main job	0.5	0.6	1.2	1.1	1.1	0.6	1.0	0.5	0.4	0.3	0.5	0.8	0.4	0.8	0.5	1.1
Forced vital capacity (FVC), Best measure	0.5	1.9	4.7	2.2	2.1	1.7	2.1	0.2	0.9	0.2	1.5	1.2	0.2	1.1	0.5	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	2.6	0.7	0.9	0.6	0.9	-1.6	-0.6	-1.1	-0.4	-0.0	-0.7	-0.3	0.1	0.8
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.2	0.8	0.9	0.9	0.9	-0.6	-0.9	-0.5	-0.5	0.3	-1.5	-0.4	-0.4	0.9
Medication: Blood pressure	0.5	0.9	1.8	1.1	1.2	1.3	1.2	0.0	0.5	0.7	1.0	1.0	0.2	1.3	0.7	0.7
Medication: Allopurinol	0.5	0.6	1.2	0.9	0.9	1.1	0.9	0.7	0.8	0.5	0.7	0.8	0.6	0.5	0.9	0.6
Leg pain on walking	0.5	0.7	1.9	0.3	0.4	0.4	0.5	0.8	1.0	1.4	0.9	1.1	0.7	0.9	0.9	0.0
Asthma (self-reported)	0.5	1.0	2.4	-1.1	-1.2	0.0	-1.1	1.3	1.1	1.5	0.1	0.7	1.0	-0.1	0.9	-1.0
Financial situation satisfaction	0.5	0.6	1.5	1.0	1.1	1.1	1.1	0.1	0.5	0.1	-0.1	0.8	0.5	0.0	0.8	1.2
Cholesterol lowering medication	0.5	0.7	2.4	-1.0	-1.0	-0.7	-1.0	-0.6	-0.9	-0.5	-1.6	-0.7	-0.2	-1.3	-0.4	0.2
Schizophrenia (2018)	0.4	0.7	1.6	-0.2	-0.1	-0.5	-0.1	-1.2	-1.2	-1.3	-0.8	-1.3	-0.9	-0.6	-1.1	-0.1
Alzheimer’s Disease (in father)	0.4	0.5	2.1	-0.5	-0.4	-0.5	-0.4	0.5	0.9	0.3	0.7	-0.1	1.4	0.7	0.9	-0.7
Lung FEV1/FVC ratio	0.4	2.2	6.4	2.0	2.0	1.8	2.1	0.3	-0.1	-1.1	0.3	1.3	0.2	0.4	1.8	2.5
Lung FVC	0.4	2.2	4.1	1.8	2.0	1.8	2.0	1.2	1.4	0.7	1.2	1.5	1.2	0.9	1.5	1.5
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	2.7	0.7	0.9	0.8	0.9	0.1	-0.3	-0.4	-0.4	0.5	0.3	-0.1	0.7	1.6
Trunk fat percentage	0.4	1.5	4.0	1.3	1.4	2.0	1.5	0.2	1.0	-0.3	0.4	0.9	1.5	0.4	1.5	1.6
Sitting height	0.4	2.9	7.4	2.7	2.7	2.5	2.5	-0.4	1.4	0.3	1.9	1.3	-0.0	1.2	0.1	1.0
Qualifications: None of the above	0.4	0.8	2.7	0.6	1.0	1.4	1.1	0.7	0.4	0.1	-0.4	0.8	0.7	-0.5	0.9	1.7
Time employed in main current job	0.4	0.5	1.6	-0.8	-0.8	-0.8	-0.8	0.7	0.4	0.9	0.6	-0.1	0.4	0.5	0.1	-1.3
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	3.3	1.8	1.8	1.6	1.8	0.4	0.7	-0.1	1.1	1.1	0.3	0.7	0.7	1.3
Pulse rate	0.4	0.6	2.2	0.5	0.6	0.3	0.6	0.3	1.2	1.5	0.9	0.9	0.4	1.0	0.1	-0.2
Noisy workplace	0.4	0.5	1.0	0.8	0.8	0.7	0.8	0.7	0.4	0.4	0.7	0.7	0.6	0.9	1.0	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.1	0.2	0.4	0.0	0.4	-0.1	-1.1	-0.7	-1.0	-0.3	-1.0	-1.1	-0.4	1.0
Tense / ‘highly strung’	0.4	0.7	1.7	-0.9	-0.7	-1.3	-0.7	-0.7	-0.9	-0.6	-0.6	-1.2	-0.6	-0.4	-1.0	-0.8
Peak expiratory flow (PEF)	0.4	0.9	3.0	1.4	1.2	1.7	1.2	-0.4	-0.1	-0.8	-0.2	0.6	-0.4	-0.5	0.2	1.5
Blood clot in the leg (DVT)	0.4	0.5	1.2	-1.0	-1.1	-0.5	-0.9	1.1	0.2	0.3	-0.5	-0.2	0.7	-0.7	0.7	-0.7
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.6	-0.5	-0.7	-1.1	-0.7	-0.0	-1.0	-1.1	-1.0	-0.8	-0.6	-1.2	-0.5	-0.0
Neck or shoulder pain in last month	0.4	0.6	2.7	0.3	0.5	-0.1	0.5	0.7	1.0	1.6	0.9	0.9	0.2	1.0	0.0	-0.5
Medication: Omeprazole	0.4	0.4	0.8	0.6	0.6	0.4	0.6	0.8	0.7	0.8	0.5	0.8	0.7	0.6	0.9	0.5
Family relationship satisfaction	0.4	0.5	2.4	-0.4	-0.5	-0.3	-0.5	0.4	0.8	0.9	0.8	-0.1	0.4	0.7	-0.1	-1.6
Average weekly red wine intake	0.4	0.6	1.6	-1.2	-1.3	-0.8	-1.2	0.0	-0.4	0.0	-0.3	-0.7	-0.5	-0.5	-0.5	-1.2
Commuting to job workplace: Walk	0.4	0.4	1.1	-0.8	-0.8	-1.0	-0.8	-0.2	-0.3	0.1	-0.1	-0.6	-0.3	0.0	-0.8	-1.1
Breast cancer (self-reported)	0.4	0.4	1.0	-0.5	-0.7	-0.8	-0.8	-0.7	-0.4	-0.1	-0.4	-0.7	-0.6	-0.5	-1.0	-0.7
High cholesterol (Self-reported)	0.4	0.7	1.5	-0.8	-0.6	-0.5	-0.7	-0.8	-0.8	-0.9	-1.1	-1.2	-0.4	-1.0	-0.9	-0.1
Medication: Bendroflumethiazide	0.4	0.6	1.8	-1.3	-1.3	-0.9	-1.3	-0.3	-0.4	-0.2	-0.6	-0.9	-0.0	-0.5	-0.6	-0.8
Supplements: Calcium	0.4	0.5	1.4	0.5	0.5	0.0	0.5	-0.2	0.9	1.2	1.2	0.5	0.2	0.9	0.2	-0.6
Major Depression (MDD)	0.3	0.4	1.0	1.0	1.0	0.2	0.9	-0.9	-0.4	-0.7	0.1	0.1	-0.5	0.2	-0.1	0.7
Ovarian Cancer	0.3	0.4	4.1	-0.2	-0.2	-0.5	-0.3	-2.0	0.2	-0.2	-0.1	-0.4	0.5	0.4	-0.3	-0.2
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.9	-0.6	-0.7	-0.2	-0.7	0.7	-0.1	0.1	-0.0	-0.7	-0.0	-0.5	-0.6	-0.9
Blood White Count	0.3	1.9	4.5	2.1	2.1	1.6	2.1	0.9	1.0	0.9	1.4	1.3	0.3	1.0	0.5	1.1
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.8	-0.4	-0.4	0.7	-0.3	0.7	1.0	1.4	0.8	0.5	1.2	0.4	0.7	-0.6
Medication for hormone replacement therapy	0.3	0.4	1.1	1.0	1.1	0.5	1.0	-0.2	0.3	0.1	0.5	0.0	-0.5	0.3	-0.7	0.1
Average weekly fortified wine intake	0.3	0.4	0.8	-0.7	-0.9	-0.7	-0.9	-0.9	-0.7	-0.5	-0.8	-0.4	-0.1	-0.4	0.1	-0.0
Age when periods started (menarche)	0.3	0.7	1.9	-0.7	-0.8	-1.1	-0.8	-0.0	-0.3	-0.6	-0.5	-1.4	-0.3	-0.7	-1.2	-1.2
Multivitamins +/- minerals	0.3	0.4	1.0	0.5	0.6	0.1	0.5	-0.6	-0.7	-0.7	-0.4	-0.4	-1.0	-0.6	-1.0	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	2.1	0.9	0.9	0.3	0.8	-1.4	-0.3	-0.6	-0.2	0.0	-0.5	0.2	-0.2	0.7
Forced vital capacity (FVC)	0.3	1.1	2.9	1.7	1.7	1.3	1.6	0.0	0.7	-0.1	1.2	0.7	0.2	0.8	0.3	0.9
Mouth/teeth dental problems	0.3	0.4	1.4	-0.6	-0.6	-1.2	-0.7	-0.4	-0.6	-0.9	-0.2	-0.8	-0.2	-0.3	-0.8	-0.4
Pain all over the body in last month	0.3	0.4	1.0	0.7	0.8	0.8	0.8	0.0	-0.1	-0.4	0.0	0.5	0.2	0.2	1.0	0.9
Diabetes (self-reported)	0.3	0.5	1.6	0.6	0.5	1.3	0.5	0.2	0.8	1.1	0.7	0.7	0.6	0.5	0.3	0.2
Illnesses of siblings	0.3	0.4	1.3	0.6	0.5	0.1	0.5	-1.1	-0.5	-1.0	-0.6	-0.2	-0.5	-0.6	-0.2	1.1
Loud music exposure frequency	0.3	0.3	0.6	-0.3	-0.5	-0.2	-0.4	-0.7	-0.5	-0.1	-0.8	-0.8	-0.3	-0.7	-0.7	-0.4
Number of children fathered	0.3	0.4	1.7	-0.7	-0.7	-0.5	-0.7	0.4	0.6	0.3	0.1	0.0	1.3	0.2	0.9	-0.5
Medication: Ibuprofen	0.3	0.4	0.8	0.4	0.5	0.6	0.5	-0.9	-0.6	-0.6	-0.5	0.1	-0.9	-0.6	-0.6	0.8
Medication: Seretide 50 evohaler	0.3	0.4	1.0	-0.7	-1.0	0.1	-0.8	0.7	0.2	-0.3	-0.3	-0.2	0.9	-0.5	0.8	-0.2
Supplements: Vitamin C	0.3	0.4	0.9	0.7	0.8	0.3	0.7	-0.2	0.7	0.5	1.0	0.4	0.2	0.9	-0.1	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.2	-1.1	-1.1	-0.8	-1.0	0.7	0.1	0.2	-0.4	-0.6	0.8	-0.4	0.3	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.2	1.1	1.2	1.1	1.2	-0.0	-0.0	-0.4	0.2	0.7	0.1	0.2	0.8	1.5
Supplements: Fish oil (including cod liver oil)	0.3	0.3	1.4	0.3	0.4	0.1	0.3	-0.2	0.8	1.2	0.7	0.8	-0.1	0.7	-0.2	-0.4
Medication: Paracetamol	0.3	0.4	1.3	-0.1	-0.1	0.1	-0.1	-0.5	-1.1	-1.1	-0.9	-0.6	-0.8	-0.9	-0.5	0.5
Fractured/broken bones in last 5 years	0.3	0.4	1.0	0.3	0.4	0.1	0.3	0.6	1.0	1.0	0.8	0.6	0.9	0.7	0.4	-0.1
Basal cell carcinoma (self-reported)	0.3	0.4	1.2	-0.1	-0.3	-0.4	-0.2	-0.5	-0.8	-0.2	-0.8	-0.4	-1.1	-0.9	-0.9	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.0	-0.9	-0.9	-0.3	-0.8	1.0	0.2	0.1	-0.5	-0.1	0.5	-0.8	0.6	-0.5
Bipolar Disorder or Schizophrenia	0.2	0.4	0.8	-0.7	-0.6	-0.6	-0.5	-0.6	-0.9	-0.7	-0.6	-0.9	-0.5	-0.6	-0.5	-0.4
Alzheimer’s Disease (including proxy)	0.2	0.2	0.6	0.3	0.5	-0.1	0.5	0.7	0.5	0.7	0.5	0.5	0.6	0.4	0.5	0.2
Reaction Time	0.2	0.4	1.2	0.8	1.1	0.9	1.1	-0.1	-0.2	0.1	-0.0	0.5	-0.7	-0.1	-0.1	0.8
Schizophrenia (2014)	0.2	0.4	0.8	0.9	0.9	0.5	0.9	-0.6	-0.5	-0.6	-0.0	-0.3	-0.6	0.1	-0.6	0.6
Blood Eosinophil Count	0.2	1.4	5.3	-0.7	-0.7	0.2	-0.4	1.3	1.4	0.7	1.0	0.6	2.2	0.7	2.3	-0.9
Blood Platelet Count	0.2	2.0	5.8	-0.5	-0.8	-1.3	-0.9	-1.8	-1.7	-2.4	-1.3	-1.9	-1.4	-1.1	-1.4	-0.4
Hypothyroidism (self reported)	0.2	0.4	1.1	0.6	0.8	0.8	0.7	-0.1	0.7	0.5	0.4	1.0	0.3	0.5	0.5	0.7
Chronotype (morning person)	0.2	0.5	0.9	-0.8	-0.8	-1.0	-0.9	0.2	-0.5	0.4	-0.5	-0.6	-0.6	-0.3	-1.0	-0.8
Tanning	0.2	2.2	5.2	2.3	2.2	2.2	2.2	0.4	0.6	0.5	1.0	1.7	-0.4	0.7	0.8	1.8
Vitamin and mineral supplements	0.2	0.3	0.8	-0.8	-0.9	-0.4	-0.8	0.2	-0.4	-0.0	-0.8	0.1	0.0	-0.5	0.4	0.3
Diabetes (mother)	0.2	0.3	0.9	-0.5	-0.6	-0.7	-0.6	-0.2	-0.5	0.3	-0.6	-0.5	-0.7	-0.4	-0.9	-0.4
High blood pressure	0.2	0.6	1.4	0.6	0.6	0.4	0.5	-0.9	-1.2	-1.1	-0.5	-0.4	-0.8	-0.0	-0.6	1.2
Stomach or abdominal pain in last month	0.2	0.2	0.5	-0.3	-0.1	-0.2	-0.1	0.0	0.6	0.6	0.6	0.3	0.7	0.6	0.7	-0.5
Supplements: Glucosamine	0.2	0.3	1.3	-0.0	-0.2	0.3	-0.2	1.1	0.2	0.5	0.0	0.8	0.5	-0.0	1.0	0.6
Fluid intelligence score	0.2	0.3	0.9	-0.8	-1.0	-0.9	-0.9	0.2	0.0	-0.3	-0.1	-0.5	0.2	0.0	0.2	-0.9
Falls in the last year	0.2	0.2	0.7	0.6	0.8	0.3	0.8	-0.6	0.3	0.2	0.3	0.5	0.3	0.4	0.3	0.5
Breastfed as a baby	0.2	0.3	2.0	0.2	0.2	0.3	0.2	-1.4	-0.2	-0.9	0.3	-0.3	-0.2	0.3	-0.2	-0.0
Hair/balding pattern: Pattern 4	0.2	0.5	1.8	0.6	0.4	0.7	0.4	-0.6	-0.3	-1.4	-0.4	0.2	0.3	-0.3	1.0	1.2
Comparative body size at age 10	0.2	0.7	2.7	0.7	0.9	0.7	0.8	-1.6	-0.7	-0.9	-0.6	-0.2	-0.5	-0.1	-0.3	1.3
Migraine (self-reported)	0.2	0.2	0.6	-0.5	-0.4	-0.5	-0.4	0.1	0.3	0.2	0.3	-0.2	0.8	0.4	0.6	-0.5
Hypertension (Self-reported)	0.2	0.6	1.4	0.7	0.8	0.7	0.7	-1.2	-1.0	-1.0	-0.4	-0.3	-0.9	0.0	-0.6	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.9	0.9	1.0	0.7	0.9	0.2	0.7	0.3	0.8	0.7	0.3	0.7	0.2	0.3
Diabetes diagnosed by doctor	0.2	0.4	2.1	0.6	0.5	1.4	0.6	0.1	0.2	0.8	0.1	0.8	-0.2	-0.0	-0.1	0.6
Eye problems/disorders: Cataract	0.2	0.2	0.9	-0.4	-0.6	-0.2	-0.5	0.5	0.7	0.3	0.2	0.1	0.9	0.1	0.6	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	1.0	-0.5	-0.6	-0.2	-0.5	1.0	0.3	0.9	0.2	0.3	0.6	0.2	0.5	-0.4
Osteoporosis (self-reported)	0.2	0.2	0.9	0.4	0.4	0.9	0.4	-0.5	0.6	0.2	0.4	0.5	0.2	0.2	0.5	-0.1
Medication: Aspirin	0.2	0.3	0.9	-0.1	-0.1	0.9	-0.1	0.2	1.0	0.5	0.3	0.5	0.9	0.3	0.7	-0.1
Illnesses of father: None of the above (group 1)	0.2	0.2	0.9	-0.1	-0.2	-0.1	-0.1	0.9	0.1	0.1	0.7	0.2	0.1	0.4	0.6	-0.7
Risk taking	0.2	0.3	1.0	-0.9	-1.0	0.1	-0.8	0.4	0.2	0.5	-0.6	0.1	0.2	-0.6	0.4	-0.5
Ever depressed for a whole week	0.2	0.3	0.9	0.9	0.7	0.3	0.7	-0.5	-0.0	0.4	0.4	0.6	-0.2	0.7	0.2	0.6
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.8	-0.7	-0.8	-0.9	-0.8	0.5	0.2	0.4	-0.2	-0.2	0.7	-0.0	0.4	-0.4
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.7	-0.7	-0.5	-0.3	-0.5	-0.6	-0.2	0.1	0.1	-0.5	-0.2	0.3	-0.4	-0.9
Bipolar Disorder (2018)	0.1	0.2	0.8	-0.9	-0.7	-0.2	-0.6	0.6	0.2	0.4	0.1	0.1	0.3	-0.2	0.5	-0.5
Crohns Disease (2017)	0.1	0.2	0.7	0.0	0.2	0.3	0.1	-0.0	0.5	0.4	0.8	0.2	0.4	0.7	0.5	-0.5
Age at First Birth	0.1	0.1	0.4	-0.1	-0.6	-0.2	-0.6	0.3	-0.2	-0.2	-0.4	0.0	0.5	0.0	0.6	0.1
Crohns Disease (2012)	0.1	0.1	0.8	-0.1	-0.0	-0.2	-0.0	-0.3	0.5	0.1	0.2	-0.2	0.9	0.4	0.4	-0.2
Rheumatoid Arthritis	0.1	0.2	0.5	0.5	0.6	0.4	0.6	0.7	0.1	-0.1	-0.1	0.2	0.3	0.0	0.1	0.7
Heel T-Score	0.1	0.7	2.8	-1.0	-1.2	-1.0	-1.2	-0.1	0.2	0.3	0.5	-0.6	0.1	0.2	-0.5	-1.7
Height	0.1	1.3	3.1	1.4	1.2	0.9	1.1	-1.4	-0.8	-1.3	-0.1	-0.7	-1.7	-0.3	-1.8	0.6
Cardiovascular Disease	0.1	0.5	2.6	0.0	-0.0	0.7	-0.1	-1.6	-0.8	-0.7	-0.6	-0.3	-0.9	-0.1	-0.7	0.3
Hand grip strength (left)	0.1	0.4	0.6	-0.3	-0.7	-0.1	-0.6	0.8	0.6	0.8	0.7	0.2	0.8	0.6	0.5	-0.7
Maternal smoking around birth	0.1	0.2	0.5	0.2	0.4	0.5	0.5	0.7	0.2	0.5	-0.1	0.5	0.5	-0.3	0.5	0.7
Taking other prescription medications	0.1	0.1	0.5	-0.1	-0.1	0.5	-0.1	0.3	0.5	0.6	-0.0	0.3	0.7	-0.1	0.4	0.2
Had menopause	0.1	0.1	0.3	0.1	0.1	-0.0	0.1	-0.2	0.3	-0.1	0.2	-0.3	0.5	0.4	0.2	-0.3
Heart attack	0.1	0.1	0.6	-0.5	-0.3	-0.1	-0.3	-0.4	-0.0	0.3	0.3	-0.2	-0.2	0.4	-0.2	-0.7
Medication: Simvastatin	0.1	0.1	0.8	-0.4	-0.3	0.9	-0.2	-0.1	0.4	0.5	-0.2	0.4	0.2	-0.1	0.4	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.4	0.3	0.4	0.2	0.3	-0.3	0.1	0.3	0.1	0.1	-0.3	0.1	-0.6	0.0
Illnesses of mother	0.1	0.1	0.3	0.1	0.1	0.3	0.1	-0.1	-0.4	-0.6	-0.1	-0.2	-0.6	-0.4	-0.2	-0.0
Standing height	0.1	0.8	2.6	1.2	1.1	1.0	1.0	0.2	1.0	0.7	1.6	0.4	-0.1	1.0	-0.4	-0.5
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.6	0.3	0.2	-0.1	0.1	-0.6	-0.6	-0.6	-0.0	-0.2	-0.8	0.1	-0.5	0.1
Headache pain in last month	0.1	0.1	0.6	0.3	0.4	0.2	0.4	0.1	-0.5	-0.2	-0.4	0.0	-0.3	-0.4	-0.1	0.8
Gout (self-reported)	0.1	0.2	0.6	-0.4	-0.3	0.3	-0.2	0.5	0.0	-0.6	-0.4	-0.2	0.7	-0.6	0.8	0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.6	0.3	0.5	0.4	0.4	-0.1	0.6	0.5	0.4	0.7	0.3	0.5	0.4	0.2
Eye problems/disorders: None of the above	0.1	0.1	0.4	0.5	0.6	0.2	0.5	0.2	-0.0	0.3	0.3	0.1	-0.1	0.3	-0.3	0.2
Mean time to correctly identify matches	0.1	0.2	0.6	0.0	0.3	0.1	0.3	-0.5	-0.5	-0.1	-0.6	0.0	-0.8	-0.5	-0.4	0.5
Pulse rate, automated reading	0.1	0.2	0.6	0.1	0.0	-0.1	0.0	-0.7	-0.5	-0.2	-0.7	-0.2	-0.7	-0.5	-0.8	0.4
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	-0.2	-0.4	0.0	-0.3	-0.1	0.0	-0.5	0.3	-0.1	0.3	0.4	0.4	-0.3
Medication: Aspirin	0.1	0.2	0.6	-0.0	-0.1	0.8	-0.0	-0.1	0.7	0.2	0.2	0.5	0.7	0.2	0.6	0.0
Ever had bowel cancer screening	0.1	0.1	0.4	0.4	0.4	-0.1	0.4	-0.2	-0.1	-0.4	0.1	-0.6	-0.1	0.2	-0.4	-0.0
Mineral and other dietary supplements	0.1	0.1	0.4	-0.1	-0.2	0.0	-0.1	0.2	-0.5	-0.6	-0.4	-0.4	0.1	-0.3	-0.0	0.4
Miserableness	0.1	0.2	0.5	0.5	0.7	0.1	0.7	0.4	0.1	0.7	0.2	0.5	0.0	0.3	0.1	0.5
Irritability	0.1	0.1	0.5	0.3	0.4	0.1	0.4	-0.3	-0.4	-0.4	-0.3	0.0	-0.2	-0.2	0.0	0.7
Myopia	0.1	0.1	0.3	-0.3	-0.4	-0.5	-0.5	0.3	0.2	0.5	0.1	-0.1	0.5	0.3	-0.1	-0.2
Vascular/heart problems diagnosed by doctor	0.1	0.3	1.0	-0.4	-0.5	-0.4	-0.4	1.0	0.8	0.6	0.1	0.1	0.7	-0.4	0.5	-0.7
Hair Pigment	0.0	1.1	3.1	1.3	1.2	1.4	1.2	-0.3	-0.9	-0.4	-0.5	0.7	-1.3	-0.6	0.1	1.8
Hand grip strength (right)	0.0	0.1	0.3	-0.1	-0.4	-0.0	-0.4	-0.1	0.2	0.2	0.4	-0.2	0.2	0.2	-0.2	-0.6
Medication: Paracetamol	0.0	0.0	0.1	-0.1	0.0	0.0	0.0	0.3	-0.2	-0.3	-0.2	-0.2	0.2	-0.3	0.1	0.3
Birth weight	0.0	0.1	0.7	-0.0	0.0	-0.5	0.1	0.8	0.0	-0.2	0.4	-0.2	-0.1	0.2	0.0	-0.4
Number of full brothers	0.0	0.1	0.2	-0.1	0.1	0.4	0.1	-0.1	0.0	0.3	-0.1	0.3	-0.4	-0.3	-0.4	0.2
Tinnitus: Yes, now most or all of the time	0.0	0.1	0.3	-0.2	-0.2	-0.1	-0.2	0.5	-0.1	0.3	0.2	0.3	-0.1	0.1	0.2	-0.0
Commuting to job workplace: Public transport	0.0	0.0	0.2	-0.0	-0.0	-0.4	-0.1	-0.2	0.2	0.1	0.2	-0.1	0.0	0.0	-0.0	-0.4
Medication: Atorvastatin	0.0	0.1	0.2	-0.2	0.0	0.2	0.0	-0.3	0.1	-0.1	0.1	0.2	0.4	0.2	0.5	0.2
Diastolic blood pressure, automated reading	0.0	0.1	0.3	-0.4	-0.5	-0.5	-0.6	0.1	-0.2	-0.4	-0.5	-0.1	0.5	-0.2	0.1	0.4

Hub : Genes

KIAA1429

Models

Trait associations