TWAS hub - RAD54B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0289	0.0099	8.8e-05	0.019	0.015	0.016	0.016	0.016	6.2e-07	7.4e-06	4.2e-06	6e-06	3.7e-06
2	TCGA	Lung Adenocarcinoma	0.0445	0.0257	9.4e-03	0.004	0.006	0.007	NA	0.006	9.2e-02	6.0e-02	5.0e-02	NA	6.0e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Impedance of arm (left)	5.7	26.6	37.2	6.1	4.0
Hip circumference	5.2	22.4	31.7	-5.6	-3.6
Qualifications: College or University degree	5.2	16.3	23.2	4.8	3.1
Medication: Atenolol	5.0	6.3	10.3	-3.2	-1.5
Leg fat mass (right)	4.9	19.0	28.6	-5.3	-3.1
Leg fat mass (left)	4.9	19.2	28.7	-5.4	-3.1
Pack years adult smoking proportion	4.8	7.4	10.6	-3.3	-2.0
Nervous feelings	4.7	8.7	13.2	3.6	2.1
Body mass index (BMI)	4.5	19.3	28.5	-5.3	-3.2
Relative age of first facial hair	4.4	9.0	15.4	3.9	1.6
Impedance of arm (right)	4.4	20.5	32.1	5.7	3.0
Medication: Co-codamol	4.3	5.0	7.9	-1.4	-2.8
Pack years of smoking	4.3	6.3	9.1	-3.0	-1.9
Arm predicted mass (left)	4.1	20.8	31.1	-5.6	-3.2
Arm fat-free mass (right)	4.0	20.6	32.3	-5.7	-3.0
Arm predicted mass (right)	4.0	20.6	32.1	-5.7	-3.0
Impedance of whole body	4.0	20.3	28.8	5.4	3.4
Current tobacco smoking	3.9	6.4	8.4	-2.9	-2.1
Waist circumference	3.9	14.2	22.6	-4.8	-2.4
Weight	3.9	19.3	29.0	-5.4	-3.1
Smoking status: Current	3.9	6.3	8.3	-2.9	-2.1
Arm fat-free mass (left)	3.8	19.2	29.7	-5.5	-2.9
BMI	3.6	21.1	27.4	-5.2	-3.9
Sensitivity / hurt feelings	3.5	6.0	9.9	3.1	1.5
Wears glasses or contact lenses	3.5	4.0	4.2	2.0	2.0
Leg fat percentage (left)	3.5	12.8	19.0	-4.4	-2.6
Worry (Nagel 2018)	3.4	7.1	9.6	3.1	2.1
Smoking Status	3.4	8.1	11.3	-3.4	-2.2
Basal metabolic rate	3.4	18.6	27.4	-5.2	-3.1
Leg fat percentage (right)	3.3	11.9	17.5	-4.2	-2.5
Eye problems/disorders: Diabetes related eye disease	3.2	3.5	5.3	-1.3	-2.3
Whole body water mass	3.2	18.0	26.4	-5.1	-3.1
Age started oral contraceptive pill	3.2	4.1	7.2	2.7	1.0
Trunk predicted mass	3.1	17.6	26.8	-5.2	-2.9
Trunk fat-free mass	3.0	17.1	25.9	-5.1	-2.9
Whole body fat-free mass	3.0	17.4	25.5	-5.0	-3.0
Qualifications: CSEs or equivalent	2.9	3.8	5.7	-1.4	-2.4
Severe depression (siblings)	2.8	3.1	3.3	1.7	1.8
Whole body fat mass	2.8	11.9	17.6	-4.2	-2.5
Leg fat-free mass (left)	2.7	14.4	20.6	-4.5	-2.9
Leg predicted mass (left)	2.7	14.5	20.7	-4.6	-2.9
Arm fat mass (right)	2.7	11.3	16.8	-4.1	-2.4
Arm fat mass (left)	2.7	10.9	16.9	-4.1	-2.2
Ever had prostate specific antigen (PSA) test	2.7	3.1	3.6	1.6	1.9
Emphysema/chronic bronchitis	2.6	2.9	3.1	1.8	1.6
Leg fat-free mass (right)	2.5	13.3	18.8	-4.3	-2.8
Illnesses of father: Heart disease	2.4	3.3	4.6	2.1	1.4
Leg predicted mass (right)	2.4	13.0	18.5	-4.3	-2.7
Neuroticism	2.3	5.6	8.2	2.9	1.7
Qualifications: A levels/AS levels or equivalent	2.3	5.1	6.8	2.6	1.8
Medication: Lisinopril	2.3	2.9	5.1	2.3	0.9
Average weekly beer plus cider intake	2.3	3.4	5.2	-2.3	-1.2
Alcohol intake versus 10 years previously	2.2	3.3	4.8	-1.4	-2.2
Ever unenthusiastic/disinterested for a whole week	2.1	2.6	4.9	2.2	0.6
Angina (self-reported)	2.1	2.7	4.5	-0.9	-2.1
Medication: Levothyroxine sodium	2.0	3.4	4.0	-1.7	-2.0
Worrier / anxious feelings	2.0	3.8	6.3	2.5	1.2
Worry too long after embarrassment	2.0	3.3	6.4	2.5	0.5
Pain type(s) experienced in last month: Hip pain	2.0	2.6	4.2	-2.0	-1.0
Neuroticism (2016)	1.9	2.8	5.1	2.2	0.7
Diabetes (mother)	1.9	2.5	4.3	2.1	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.5	3.3	-1.3	-1.8
Trunk fat mass	1.9	8.2	12.2	-3.5	-2.1
Heart disease (mother)	1.9	2.3	3.9	2.0	0.8
Back pain experienced in last month	1.9	2.7	3.7	-1.9	-1.3
Exposure to tobacco smoke at home	1.8	2.1	3.0	-1.7	-1.1
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	2.9	1.7	1.3
Angina	1.7	2.2	4.0	-0.7	-2.0
Fed-up feelings	1.7	3.1	4.3	-1.4	-2.1
Heel bone mineral density (BMD) T-score, automated (left)	1.7	4.0	4.5	-2.1	-1.8
Hearing difficulty/problems with background noise	1.7	2.7	3.1	1.8	1.5
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	3.4	1.4	1.8
Schizophrenia vs Biploar Disorder	1.6	2.1	3.4	-0.9	1.8
Ever had bowel cancer screening	1.6	1.9	3.7	0.2	1.9
Commuting to job workplace: Walk	1.6	1.7	3.2	1.8	0.4
Depression (Nagel 2018)	1.5	2.2	2.4	-1.5	-1.4
Intelligence (Savage-Jansen 2018)	1.5	4.6	6.2	1.7	2.5
Supplements: Zinc	1.5	1.6	3.2	-0.1	1.8
Mouth/teeth dental problems: Dentures	1.5	2.4	4.7	-2.2	-0.4
Body fat percentage	1.5	5.8	8.3	-2.9	-1.8
Impedance of leg (right)	1.4	6.5	9.1	3.0	2.0
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	3.1	-1.8	-0.4
Chronic bronchitis/emphysema (father)	1.4	1.7	2.6	-1.6	-0.9
Impedance of leg (left)	1.4	6.8	9.3	3.0	2.1
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	3.2	1.8	-0.1
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	2.3	-1.5	-1.0
Qualifications: nursing, teaching	1.4	2.2	2.3	1.4	1.5
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	1.8	1.3	1.2
Bipolar Disorder (2011)	1.3	1.3	2.5	1.6	-0.3
Medication: Ramipril	1.3	1.6	2.5	-0.9	-1.6
Father’s age at death	1.3	1.8	3.1	-0.7	-1.8
Peak expiratory flow (PEF)	1.3	3.1	4.7	-2.2	-1.2
Had major operations	1.3	1.5	2.8	1.7	0.5
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.0	-0.4	-1.7
Osteoporosis (self-reported)	1.3	1.6	1.7	-1.2	-1.3
LDL Cholesterol	1.2	2.0	3.9	2.0	0.2
Depression (self-reported)	1.2	1.5	2.6	-0.6	-1.6
Loneliness, isolation	1.2	1.6	3.2	-1.8	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	1.5	1.2	1.2
Arm fat percentage (right)	1.1	4.5	6.3	-2.5	-1.6
Tense / ‘highly strung’	1.1	1.8	2.4	1.5	1.1
Loud music exposure frequency	1.1	1.2	1.6	0.9	1.3
Glaucoma (self-reported)	1.1	1.2	1.5	1.0	1.2
Medication: Ibuprofen	1.1	1.4	2.5	-0.4	-1.6
Suffer from ‘nerves’	1.1	1.7	2.5	1.6	1.0
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.3	-1.5	-0.5
Arm fat percentage (left)	1.1	4.3	6.7	-2.6	-1.4
Friendships satisfaction	1.1	1.3	2.6	1.6	0.2
Ever taken oral contraceptive pill	1.1	1.3	2.1	-1.4	-0.7
Cholesterol lowering medication	1.1	1.6	2.4	1.6	0.9
Body Mass Index (BMI) (2010)	1.0	1.3	1.9	-1.4	-0.9
Coronary Artery Disease (CAD)	1.0	1.2	2.2	1.5	0.5
Fasting Glucose	1.0	1.2	1.4	-1.0	1.2
Waist Hip Ratio (WHR)	1.0	4.5	6.7	1.5	2.6
Ever had hysterectomy (womb removed)	1.0	1.1	1.2	-1.0	-1.1
Had other major operations	1.0	1.2	1.9	0.7	1.4
Hair/balding pattern: Pattern 4	1.0	2.3	2.5	-1.6	-1.5
Pulse wave peak to peak time	1.0	1.2	1.3	-1.2	1.0
Mouth/teeth dental problems: Loose teeth	1.0	1.2	1.7	-0.8	-1.3
HbA1C	0.9	1.0	1.4	-0.8	-1.2
Average weekly fortified wine intake	0.9	1.0	1.8	1.3	-0.5
Number of incorrect matches in round	0.9	1.4	2.5	1.6	-0.6
Had menopause	0.9	1.1	1.6	0.7	1.3
Pulse wave Arterial Stiffness index	0.9	1.1	1.2	0.9	-1.1
Medication: Amlodipine	0.9	1.2	2.3	-1.5	-0.4
Wheeze or whistling in the chest in last year	0.9	1.6	1.7	-1.3	-1.2
Breast cancer (self-reported)	0.9	1.0	1.2	1.1	0.9
Commuting to job workplace: Cycle	0.9	1.0	1.2	1.1	0.9
Heart disease (siblings)	0.9	1.0	1.6	1.3	0.7
Neuroticism (Nagel 2018)	0.8	1.9	2.8	1.7	1.0
Ulcerative Colitis (UC)	0.8	1.4	2.7	-1.6	-0.3
Chronotype (morning person)	0.8	1.9	3.5	1.9	0.5
Systolic blood pressure, automated reading	0.8	2.2	3.8	1.9	0.8
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.4	-1.2	-0.6
Neuroticism score	0.8	1.6	3.0	1.7	0.5
Exposure to tobacco smoke outside home	0.8	1.1	2.1	-1.4	-0.3
Number of full sisters	0.8	0.9	1.8	-1.4	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.8	-1.3	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	3.2	-1.8	-0.2
Lung FEV1/FVC ratio	0.7	3.7	4.5	-2.1	-1.7
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.1	1.0	0.8
Maternal smoking around birth	0.7	1.1	2.0	0.4	1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	2.3	-1.5	-0.9
Forced expiratory volume in 1-second (FEV1)	0.7	2.2	4.0	-2.0	-0.6
Lung cancer (father)	0.7	0.8	1.7	1.3	-0.0
Migraine (self-reported)	0.7	0.9	1.0	1.0	0.9
Osteoarthritis (self-reported)	0.7	1.0	1.8	-0.3	-1.4
Guilty feelings	0.7	1.0	1.5	1.2	0.7
High cholesterol (Self-reported)	0.7	1.2	1.5	0.9	1.2
Unable to work because of sickness or disability	0.7	1.0	1.8	-1.4	-0.3
Depressed Affect (Nagel 2018)	0.6	1.3	1.7	-1.3	-1.0
Ulcerative Colitis	0.6	0.9	1.1	-1.0	-0.9
Blood Red Count	0.6	6.1	9.3	-3.0	-1.7
Systolic Blood Pressure	0.6	2.8	5.5	2.3	0.3
Hypothyroidism (self reported)	0.6	1.5	2.7	-0.5	-1.6
Trunk fat percentage	0.6	2.6	3.7	-1.9	-1.2
Serious illness, injury or assault to yourself	0.6	0.7	1.1	1.0	0.5
Hayfever, allergic rhinitis or eczema	0.6	1.2	1.6	1.3	0.9
Sitting height	0.6	4.0	4.9	-2.2	-1.7
Past tobacco smoking	0.6	1.1	1.3	1.1	1.0
Breastfed as a baby	0.6	0.7	0.8	-0.8	-0.9
Headache pain in last month	0.6	1.1	1.9	1.4	0.6
Medication: Seretide 50 evohaler	0.6	0.7	1.2	-1.1	-0.4
Chest pain or discomfort	0.6	0.9	1.8	0.3	-1.3
Illnesses of siblings: Diabetes	0.6	0.8	1.4	0.5	1.2
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.6	-0.1	-1.3
Ever depressed for a whole week	0.6	0.8	1.6	1.3	0.0
Prostate Cancer	0.5	0.7	0.8	-0.9	-0.8
Triglycerides	0.5	0.8	1.5	-1.2	-0.2
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.2	-0.0	1.1
Medication: Metformin	0.5	0.7	0.9	0.8	0.9
Relative age voice broke	0.5	0.7	1.4	1.2	-0.2
Age when periods started (menarche)	0.5	1.1	1.6	0.8	1.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.2	-1.1	-0.3
Hair/balding pattern: Pattern 2	0.5	0.7	1.1	-1.0	0.6
Number of live births	0.5	0.7	1.2	-1.1	0.3
Illnesses of mother	0.5	0.6	0.8	-0.9	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	3.1	-1.8	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.1	-0.5	-1.1
High blood pressure (siblings)	0.5	0.7	1.1	0.6	-1.1
Forced vital capacity (FVC), Best measure	0.5	1.7	3.2	-1.8	-0.4
Number of full brothers	0.5	0.6	0.9	-0.5	-0.9
Medication: Aspirin	0.5	0.6	1.0	-0.5	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	0.9	0.6	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	1.3	-0.9	-1.2
Illnesses of father: None of the above (group 1)	0.5	0.6	0.9	-0.6	-0.9
Alzheimer’s Disease (including proxy)	0.4	0.6	1.1	0.3	1.0
HDL Cholesterol	0.4	0.7	1.0	1.0	0.6
Respiratory disease	0.4	0.9	1.1	-1.0	-0.9
Lung FVC	0.4	2.3	3.4	-1.8	1.1
Number of treatments/medications taken	0.4	0.8	1.0	-0.7	-1.0
Average weekly spirits intake	0.4	0.4	0.6	-0.5	0.8
Taking other prescription medications	0.4	0.6	0.7	0.8	0.7
Stomach or abdominal pain in last month	0.4	0.5	0.5	0.7	0.7
Pain all over the body in last month	0.4	0.4	0.4	-0.6	-0.7
Illnesses of siblings	0.4	0.6	1.2	-1.1	0.1
Time employed in main current job	0.4	0.4	0.6	0.8	0.5
Birth weight of first child	0.4	0.7	1.2	1.1	-0.5
Pulse wave reflection index	0.4	0.5	0.8	0.3	-0.9
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	0.8	-0.6	-0.9
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.7	-0.1	-1.3
Number of children fathered	0.4	0.5	0.9	0.3	0.9
Overall health rating	0.4	0.8	1.2	-0.7	-1.1
Age at last live birth	0.4	0.6	1.2	1.1	0.1
Supplements: Vitamin C	0.4	0.4	0.7	-0.3	-0.9
Mood swings	0.4	0.7	0.9	1.0	-0.7
Mineral and other dietary supplements	0.4	0.6	1.1	-0.1	1.1
Medication: Gliclazide	0.4	0.5	1.0	0.1	1.0
Miserableness	0.4	0.7	1.0	0.6	1.0
Medication: Bendroflumethiazide	0.4	0.5	1.0	0.3	1.0
Risk taking	0.4	0.5	1.1	-1.0	0.2
Alcohol drinker status: Previous	0.4	0.5	1.0	0.0	1.0
Bipolar Disorder or Schizophrenia	0.3	0.6	0.7	0.8	0.8
Schizophrenia (2018)	0.3	0.7	0.8	0.7	0.9
Alzheimer’s Disease (in mother)	0.3	0.3	0.4	-0.5	0.7
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.1	0.5	1.0
Ovarian Cancer	0.3	0.4	0.8	0.9	-0.2
Age at First Birth	0.3	0.4	0.5	0.7	-0.5
Rheumatoid Arthritis	0.3	0.4	0.6	-0.4	0.8
Allergy or Eczema	0.3	0.7	1.1	1.0	0.6
Cardiovascular Disease	0.3	1.0	1.9	-0.2	-1.4
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.1	0.1	1.1
Supplements: Glucosamine	0.3	0.4	0.7	0.8	-0.2
Forced vital capacity (FVC)	0.3	1.2	2.4	-1.5	-0.1
Qualifications: None of the above	0.3	0.7	1.4	-1.2	0.2
Allergy	0.3	0.6	0.7	-0.8	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.7	0.8	-0.5
Prospective memory result	0.3	0.4	0.4	-0.6	0.6
Blood clot in the leg (DVT)	0.3	0.4	0.5	-0.7	0.5
Gout (self-reported)	0.3	0.4	0.6	-0.8	0.5
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.6	0.2	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.4	-0.5	-0.7
Comparative height size at age 10	0.3	1.8	1.8	-1.4	-1.3
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.6	-0.8	0.2
Medication: Aspirin	0.3	0.4	0.6	-0.6	-0.8
Number of self-reported non-cancer illnesses	0.3	0.6	0.7	-0.8	-0.7
Average weekly champagne plus white wine intake	0.3	0.5	0.9	1.0	-0.1
Hearing aid user	0.3	0.3	0.4	-0.6	-0.5
Mother’s age at death	0.3	0.3	0.4	0.5	0.6
Financial situation satisfaction	0.3	0.3	0.4	-0.6	-0.5
Medication: Atorvastatin	0.3	0.4	0.7	-0.2	-0.8
Fractured/broken bones in last 5 years	0.3	0.4	0.8	0.3	0.9
Myopia	0.3	0.4	0.5	0.6	0.7
Basal cell carcinoma (self-reported)	0.3	0.4	0.6	0.4	0.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.8	-0.9	0.1
Alzheimer’s Disease (in father)	0.2	0.2	0.3	-0.1	0.6
Irritable Bowel Disease (IBD)	0.2	0.6	1.0	-1.0	-0.3
Major Depression (MDD)	0.2	0.2	0.4	-0.1	-0.6
Breast Cancer	0.2	0.5	0.5	-0.7	-0.6
Schizophrenia (2014)	0.2	0.4	0.8	0.0	0.9
Tanning	0.2	2.7	3.1	-1.8	-1.5
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.5	-0.2	-0.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.5	0.1	0.7
Hand grip strength (right)	0.2	0.6	0.9	-1.0	0.4
Townsend deprivation index at recruitment	0.2	0.3	0.5	-0.3	0.7
Multivitamins +/- minerals	0.2	0.2	0.4	0.7	0.1
Mouth/teeth dental problems	0.2	0.3	0.3	0.5	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.5	-0.2	0.7
Asthma	0.2	0.4	0.5	-0.6	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.3	0.4	-0.5
Medication: Cholesterol lowering	0.2	0.3	0.6	-0.8	-0.3
Medication: Lansoprazole	0.2	0.3	0.5	0.7	-0.1
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.3	0.5	0.3
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.6	-0.2	0.7
Eye problems/disorders: None of the above	0.2	0.2	0.3	0.3	0.5
Medication for pain relief, constipation, heartburn	0.2	0.4	0.5	0.7	0.6
Neck or shoulder pain in last month	0.2	0.3	0.6	0.8	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.2	-0.5	-0.5
Alcohol intake frequency.	0.2	0.4	0.7	-0.8	-0.4
Family relationship satisfaction	0.2	0.2	0.4	0.6	-0.1
Knee pain experienced in last month	0.2	0.3	0.5	-0.7	-0.3
Smoking status: Previous	0.2	0.2	0.3	-0.6	-0.4
Long-standing illness, disability or infirmity	0.2	0.3	0.6	-0.3	-0.8
Asthma (self-reported)	0.2	0.4	0.4	-0.7	-0.5
Commuting to job workplace: Public transport	0.2	0.3	0.4	0.4	0.7
Medication: Paracetamol	0.2	0.3	0.5	-0.3	-0.7
Illnesses of father: High blood pressure	0.2	0.3	0.6	-0.8	-0.0
Alcohol drinker status: Never	0.2	0.2	0.4	-0.6	-0.2
Ever smoked	0.2	0.4	0.4	-0.7	-0.6
Bipolar Disorder (2018)	0.1	0.1	0.2	0.4	0.1
Reaction Time	0.1	0.3	0.4	-0.4	-0.6
Crohns Disease (2012)	0.1	0.2	0.3	0.5	0.4
Lupus	0.1	0.2	0.3	0.5	0.4
Primary Biliary Cirrhosis	0.1	0.1	0.2	0.2	0.4
Blood Eosinophil Count	0.1	1.1	2.3	-1.5	-0.1
Blood Platelet Count	0.1	0.7	0.9	0.7	-1.0
Blood White Count	0.1	0.6	1.0	-1.0	-0.4
Height	0.1	1.2	2.1	-1.4	-0.6
Hand grip strength (left)	0.1	0.3	0.5	-0.4	0.7
Hearing difficulty/problems: Yes	0.1	0.1	0.2	0.5	0.1
Medication for hormone replacement therapy	0.1	0.1	0.1	-0.3	0.3
Diabetes (father)	0.1	0.1	0.3	0.2	0.5
High blood pressure (mother)	0.1	0.2	0.4	-0.6	-0.2
Alcohol usually taken with meals	0.1	0.1	0.2	0.1	0.5
Diabetes (self-reported)	0.1	0.2	0.4	-0.0	0.7
Medication: Simvastatin	0.1	0.2	0.4	-0.6	-0.2
Falls in the last year	0.1	0.1	0.2	0.2	-0.5
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	0.4	-0.3
Pulse rate	0.1	0.2	0.4	-0.1	-0.6
Length of working week for main job	0.1	0.1	0.1	-0.2	-0.3
Birth weight	0.1	0.2	0.3	0.3	0.5
Age at first live birth	0.1	0.2	0.2	0.5	-0.5
Health satisfaction	0.1	0.2	0.3	0.2	-0.5
Shortness of breath walking on level ground	0.1	0.1	0.2	-0.1	-0.5
Medication: Blood pressure	0.1	0.1	0.2	-0.2	-0.5
Medication: Allopurinol	0.1	0.2	0.3	-0.6	0.1
Medication: Omeprazole	0.1	0.1	0.1	0.0	0.4
Mean time to correctly identify matches	0.1	0.1	0.1	0.4	-0.4
Pulse rate, automated reading	0.1	0.4	0.5	0.7	-0.6
Average weekly red wine intake	0.1	0.1	0.1	-0.4	0.3
Medication for cholesterol	0.1	0.1	0.2	-0.4	0.1
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.2	0.5	-0.3
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.4	0.2
Medication: Blood pressure	0.1	0.2	0.3	0.5	0.4
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.4	-0.3	0.7
Pain experienced in last month	0.1	0.1	0.1	-0.3	-0.3
Crohns Disease (2017)	0.0	0.1	0.1	-0.2	-0.3
Mean Putamen Volume	0.0	0.0	0.0	-0.2	-0.1
Heel T-Score	0.0	0.3	0.7	0.8	-0.2
Hair Pigment	0.0	1.4	2.4	-1.6	-0.6
Vitamin and mineral supplements	0.0	0.0	0.0	-0.2	0.0
High blood pressure	0.0	0.1	0.3	0.5	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.1	0.1	-0.3
Financial difficulties in last 2 years	0.0	0.1	0.1	-0.2	-0.3
Heart attack	0.0	0.0	0.0	0.2	-0.1
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.1	-0.2	0.1
Fluid intelligence score	0.0	0.0	0.0	0.1	0.1
Happiness	0.0	0.1	0.1	0.1	0.3
Noisy workplace	0.0	0.0	0.1	-0.1	0.2
Standing height	0.0	0.3	0.6	-0.8	-0.2
Medication: Paracetamol	0.0	0.0	0.1	-0.0	0.2
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.1	-0.0	0.2
Comparative body size at age 10	0.0	0.0	0.0	-0.1	0.2
Leg pain on walking	0.0	0.0	0.1	0.2	-0.1
Hypertension (Self-reported)	0.0	0.1	0.1	0.1	-0.4
Diabetes diagnosed by doctor	0.0	0.0	0.0	-0.2	-0.2
Eye problems/disorders: Cataract	0.0	0.0	0.0	0.1	-0.2
Number of operations (self-reported)	0.0	0.0	0.0	0.1	-0.1
Irritability	0.0	0.0	0.1	0.3	-0.1
Diastolic blood pressure, automated reading	0.0	0.1	0.1	0.3	-0.4
Supplements: Calcium	0.0	0.0	0.0	0.2	0.2
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.1	0.2	0.1

Hub : Genes

RAD54B

Models

Trait associations