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chr12:14,220,891-15,743,444

Best TWAS P=9.42e-12 · Best GWAS P=1.49e-11 conditioned to 0.00829

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	C12orf60	0.28	0.25	lasso	4	0.24	2.0e-29	4.9	5.6	1.9e-08	-0.49	0.98	0.02	FALSE
2	GTEx	Artery Tibial	WBP11	0.09	0.06	lasso	2	0.06	3.8e-05	-5.4	5.6	2.2e-08	-0.48	0.83	0.11	FALSE
3	GTEx	Brain Cortex	C12orf60	0.44	0.28	lasso	3	0.29	1.2e-08	5.1	5.6	2.4e-08	-0.42	0.73	0.09	FALSE
4	GTEx	Brain Nucleus accumbens basal ganglia	RP11-174G6.5	0.23	0.13	lasso	4	0.11	8.9e-04	-5.7	5.7	1.6e-08	-0.48	0.19	0.17	FALSE
5	GTEx	Brain Putamen basal ganglia	C12orf60	0.33	0.32	lasso	3	0.29	1.5e-07	5.1	5.2	1.9e-07	-0.37	0.34	0.21	FALSE
6	GTEx	Heart Left Ventricle	C12orf60	0.24	0.23	lasso	5	0.26	7.1e-14	4.9	5.2	1.5e-07	-0.42	0.98	0.02	FALSE
7	GTEx	Heart Left Ventricle	H2AFJ	0.16	0.07	lasso	8	0.05	1.1e-03	-6.4	-6.4	1.4e-10	0.85	0.03	0.97	FALSE
8	GTEx	Liver	H2AFJ	0.18	0.11	lasso	8	0.04	2.7e-02	-6.4	-5.5	3.8e-08	0.79	0.04	0.76	FALSE
9	GTEx	Skin Sun Exposed Lower leg	C12orf60	0.09	0.06	enet	11	0.05	4.0e-05	4.9	5.1	2.7e-07	-0.44	0.78	0.16	FALSE
10	GTEx	Thyroid	C12orf60	0.16	0.10	enet	9	0.12	8.1e-10	4.4	5.4	5.1e-08	-0.37	0.99	0.01	FALSE
11	ROSMAP	Brain Pre-frontal Cortex	WBP11	0.10	0.05	lasso	4	0.06	1.2e-08	-5.4	6.8	9.4e-12	-0.72	0.07	0.93	TRUE
12	YFS	Blood	H2AFJ	0.05	0.02	bslmm	360	0.03	2.9e-10	-6.4	-5.8	5.6e-09	0.68	0.02	0.98	FALSE
13	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C12orf60	0.17	0.03	blup	56	0.07	2.9e-06	4.4	5.3	1.1e-07	-0.63	0.04	0.85	FALSE
14	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C12orf60	0.10	0.04	enet	7	0.05	2.0e-06	-4.4	5.2	1.5e-07	-0.49	0.31	0.45	FALSE
15	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C12orf60	0.12	0.07	enet	8	0.07	5.4e-05	5.1	6.1	1.2e-09	-0.64	0.07	0.82	FALSE
16	The Cancer Genome Atlas	Brain Lower Grade Glioma	C12orf60	0.14	0.14	lasso	4	0.13	2.2e-14	5.1	5.5	5.0e-08	-0.43	0.97	0.03	FALSE
17	The Cancer Genome Atlas	Brain Lower Grade Glioma	WBP11	0.03	0.03	blup	57	0.02	2.3e-03	-6.4	6.7	2.5e-11	-0.90	0.01	0.94	FALSE
18	The Cancer Genome Atlas	Lung Adenocarcinoma	C12orf60	0.07	0.05	enet	7	0.05	1.5e-06	5.1	5.3	1.2e-07	-0.42	0.93	0.06	FALSE
19	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C12orf60	0.05	0.05	lasso	3	0.04	1.1e-05	5.1	5.4	6.0e-08	-0.43	0.92	0.05	FALSE
20	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C12orf60	0.10	0.01	blup	56	0.07	1.6e-05	4.4	5.8	8.0e-09	-0.49	0.08	0.19	FALSE
21	The Cancer Genome Atlas	Thyroid Carcinoma	C12orf60	0.16	0.16	enet	10	0.18	1.3e-17	5.1	6.3	2.8e-10	-0.61	0.97	0.03	FALSE