Best TWAS P=8.73e-09 · Best GWAS P=3.69e-11 conditioned to 0.00016
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | MARK3 | 0.10 | 0.03 | blup | 61 | 0.03 | 4.0e-04 | -5.2 | -5.8 | 8.7e-09 | 0.04 | 0.03 | 0.16 | TRUE |
| 4 | METSIM | Adipose | TRAF3 | 0.04 | 0.02 | enet | 7 | 0.04 | 4.5e-06 | 5.7 | 5.7 | 1.1e-08 | 0.79 | 0.05 | 0.94 | TRUE |
| 1 | GTEx | Esophagus Mucosa | MARK3 | 0.11 | 0.03 | lasso | 4 | 0.04 | 1.5e-03 | 5.8 | 5.6 | 1.7e-08 | -0.01 | 0.04 | 0.80 | TRUE |
| 5 | YFS | Blood | MARK3 | 0.04 | 0.04 | lasso | 3 | 0.04 | 1.6e-12 | 5.7 | 5.7 | 1.5e-08 | -0.01 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Thyroid | TRMT61A | 0.11 | 0.03 | lasso | 4 | 0.02 | 1.2e-02 | 5.9 | -5.5 | 2.9e-08 | -0.01 | 0.01 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CKB | 0.06 | 0.03 | lasso | 3 | 0.03 | 2.5e-06 | -5.2 | -5.4 | 7.1e-08 | 0.04 | 0.13 | 0.84 | FALSE |
| 2 | GTEx | Skin Not Sun Exposed Suprapubic | CKB | 0.28 | 0.26 | lasso | 4 | 0.25 | 6.4e-14 | -5.2 | -5.2 | 1.9e-07 | 0.04 | 0.26 | 0.74 | FALSE |