Best TWAS P=1.68e-39 · Best GWAS P=9.59e-138 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FTO | 0.11 | 0.00 | bslmm | 739 | 0.02 | 1.6e-03 | -0.23 | 12.8 | 1.6e-37 | 0.38 | 0.09 | 0.55 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | RBL2 | 0.22 | 0.24 | enet | 15 | 0.26 | 1.8e-31 | 5.75 | -7.4 | 1.6e-13 | 0.02 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | RBL2 | 0.34 | 0.28 | enet | 18 | 0.30 | 1.0e-24 | 5.83 | -6.7 | 1.9e-11 | 0.02 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Adipose Visceral Omentum | RBL2 | 0.30 | 0.27 | lasso | 2 | 0.27 | 4.3e-14 | 5.83 | -5.8 | 5.9e-09 | 0.04 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Adrenal Gland | RBL2 | 0.35 | 0.27 | enet | 22 | 0.25 | 2.3e-09 | 5.83 | -5.4 | 8.0e-08 | 0.04 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Artery Aorta | RBL2 | 0.27 | 0.21 | enet | 14 | 0.19 | 1.5e-10 | 5.75 | -5.9 | 4.3e-09 | 0.04 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Artery Coronary | RBL2 | 0.36 | 0.33 | enet | 14 | 0.27 | 1.4e-09 | 5.85 | -5.7 | 1.6e-08 | 0.05 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Artery Tibial | RBL2 | 0.16 | 0.17 | enet | 11 | 0.20 | 2.1e-15 | 5.87 | -7.2 | 4.8e-13 | 0.02 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Brain Cerebellar Hemisphere | RBL2 | 0.55 | 0.55 | enet | 20 | 0.46 | 2.1e-13 | 5.83 | -6.3 | 3.0e-10 | 0.04 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Brain Cerebellum | RBL2 | 0.66 | 0.72 | enet | 16 | 0.70 | 5.7e-28 | 5.85 | -6.1 | 1.2e-09 | 0.05 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Brain Cortex | RBL2 | 0.51 | 0.45 | enet | 12 | 0.46 | 3.5e-14 | 5.24 | -7.3 | 3.6e-13 | 0.02 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Breast Mammary Tissue | RBL2 | 0.36 | 0.35 | lasso | 3 | 0.36 | 3.0e-19 | 5.77 | -5.8 | 9.1e-09 | 0.04 | 1.00 | 0.00 | FALSE |
| 13 | GTEx | Breast Mammary Tissue (Male) | RBL2 | 0.40 | 0.29 | lasso | 2 | 0.25 | 1.4e-06 | 5.77 | -5.8 | 7.9e-09 | 0.04 | 0.60 | 0.02 | FALSE |
| 14 | GTEx | Breast Mammary Tissue (Female) | RBL2 | 0.47 | 0.27 | lasso | 7 | 0.20 | 1.1e-06 | 5.24 | -5.4 | 5.6e-08 | 0.04 | 0.97 | 0.00 | TRUE |
| 15 | GTEx | Colon Sigmoid | RBL2 | 0.38 | 0.37 | lasso | 12 | 0.29 | 8.4e-11 | 5.83 | -6.7 | 1.9e-11 | 0.03 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Colon Transverse | RBL2 | 0.59 | 0.44 | enet | 13 | 0.52 | 4.4e-28 | 5.83 | -5.5 | 3.5e-08 | 0.05 | 1.00 | 0.00 | FALSE |
| 17 | GTEx | Esophagus Gastroesophageal Junction | RBL2 | 0.38 | 0.40 | enet | 17 | 0.38 | 1.1e-14 | 5.85 | -5.6 | 2.1e-08 | 0.05 | 1.00 | 0.00 | FALSE |
| 18 | GTEx | Esophagus Mucosa | RBL2 | 0.36 | 0.36 | enet | 37 | 0.37 | 2.9e-26 | 5.83 | -6.7 | 1.8e-11 | 0.00 | 1.00 | 0.00 | TRUE |
| 19 | GTEx | Esophagus Muscularis | RBL2 | 0.36 | 0.38 | enet | 10 | 0.41 | 6.8e-27 | 5.80 | -5.7 | 1.2e-08 | 0.05 | 1.00 | 0.00 | FALSE |
| 20 | GTEx | Heart Atrial Appendage | RBL2 | 0.28 | 0.14 | enet | 25 | 0.23 | 8.6e-11 | 5.75 | -6.0 | 1.9e-09 | 0.03 | 1.00 | 0.00 | FALSE |
| 21 | GTEx | Heart Left Ventricle | RBL2 | 0.12 | 0.11 | enet | 12 | 0.08 | 3.3e-05 | 5.75 | -6.1 | 1.1e-09 | -0.03 | 0.94 | 0.01 | FALSE |
| 22 | GTEx | Lung | RBL2 | 0.29 | 0.37 | enet | 16 | 0.35 | 9.1e-28 | 5.83 | -6.3 | 2.8e-10 | 0.03 | 1.00 | 0.00 | FALSE |
| 23 | GTEx | Muscle Skeletal | RBL2 | 0.11 | 0.00 | lasso | 5 | 0.00 | 2.9e-01 | 8.19 | -10.9 | 1.0e-27 | -0.10 | 0.28 | 0.23 | FALSE |
| 24 | GTEx | Nerve Tibial | RBL2 | 0.46 | 0.52 | enet | 19 | 0.53 | 1.6e-43 | 5.75 | -6.3 | 3.1e-10 | 0.04 | 1.00 | 0.00 | FALSE |
| 25 | GTEx | Pancreas | RBL2 | 0.36 | 0.36 | enet | 26 | 0.36 | 5.9e-16 | 5.80 | -5.9 | 4.6e-09 | 0.08 | 1.00 | 0.00 | FALSE |
| 26 | GTEx | Pituitary | RBL2 | 0.36 | 0.39 | lasso | 6 | 0.40 | 4.5e-11 | 5.85 | 5.9 | 3.2e-09 | -0.04 | 0.98 | 0.00 | FALSE |
| 27 | GTEx | Prostate | RBL2 | 0.55 | 0.45 | lasso | 4 | 0.45 | 1.0e-12 | 5.76 | -5.9 | 4.0e-09 | 0.04 | 0.99 | 0.00 | FALSE |
| 28 | GTEx | Skin Not Sun Exposed Suprapubic | RBL2 | 0.35 | 0.33 | enet | 16 | 0.34 | 2.6e-19 | 5.76 | -6.4 | 2.0e-10 | 0.03 | 1.00 | 0.00 | FALSE |
| 29 | GTEx | Skin Sun Exposed Lower leg | RBL2 | 0.35 | 0.39 | enet | 25 | 0.37 | 2.9e-32 | 5.76 | -6.3 | 3.2e-10 | 0.03 | 1.00 | 0.00 | FALSE |
| 30 | GTEx | Spleen | RBL2 | 0.59 | 0.47 | enet | 51 | 0.46 | 3.2e-13 | 5.85 | -7.1 | 1.3e-12 | -0.06 | 1.00 | 0.00 | FALSE |
| 31 | GTEx | Stomach | RBL2 | 0.33 | 0.26 | enet | 20 | 0.26 | 8.7e-13 | 5.83 | -6.0 | 2.1e-09 | 0.04 | 1.00 | 0.00 | FALSE |
| 32 | GTEx | Testis | AKTIP | 0.19 | 0.00 | enet | 26 | 0.00 | 1.9e-01 | 5.24 | 13.2 | 1.7e-39 | 0.51 | 0.03 | 0.40 | TRUE |
| 33 | GTEx | Thyroid | RBL2 | 0.34 | 0.47 | lasso | 4 | 0.45 | 3.6e-38 | 5.83 | -6.0 | 2.2e-09 | 0.04 | 1.00 | 0.00 | FALSE |
| 34 | GTEx | Vagina | RBL2 | 0.41 | 0.37 | enet | 13 | 0.34 | 1.6e-08 | 6.08 | -6.5 | 8.7e-11 | 0.03 | 0.89 | 0.01 | FALSE |
| 35 | NTR | Blood | RBL2 | 0.09 | 0.11 | bslmm | 419 | 0.11 | 1.1e-33 | 5.83 | -5.4 | 7.8e-08 | 0.06 | 1.00 | 0.00 | FALSE |
| 36 | YFS | Blood | AKTIP | 0.19 | 0.27 | lasso | 13 | 0.30 | 3.3e-99 | 8.91 | 8.0 | 1.5e-15 | -0.01 | 1.00 | 0.00 | TRUE |
| 37 | The Cancer Genome Atlas | Esophageal Carcinoma | RBL2 | 0.08 | 0.04 | lasso | 3 | 0.03 | 4.4e-02 | 8.91 | 7.3 | 3.9e-13 | 0.00 | 0.01 | 0.82 | TRUE |
| 38 | The Cancer Genome Atlas | Glioblastoma Multiforme | FTO | 0.27 | 0.16 | enet | 13 | 0.14 | 6.7e-05 | -2.33 | 9.6 | 1.0e-21 | 0.33 | 0.11 | 0.32 | TRUE |
| 39 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AKTIP | 0.04 | 0.03 | blup | 42 | 0.05 | 1.9e-06 | 5.76 | -5.5 | 3.7e-08 | 0.04 | 0.98 | 0.01 | FALSE |
| 40 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RBL2 | 0.03 | 0.06 | enet | 5 | 0.05 | 8.2e-07 | 5.24 | -6.6 | 4.9e-11 | 0.04 | 0.83 | 0.17 | FALSE |
| 41 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | RBL2 | 0.11 | 0.08 | blup | 44 | 0.06 | 1.5e-03 | 8.18 | -8.1 | 7.3e-16 | -0.03 | 0.01 | 0.78 | FALSE |